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Annual Report for Fiscal Year 2018

Annual Report for Fiscal Year 2018
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https://ntp.niehs.nih.gov/go/860725

Toxicology and Carcinogenicity Studies

NTP performs toxicity studies to provide dose-setting information for chronic studies and to address specific deficiencies in the toxicology database for the chemical. Toxicology and carcinogenicity studies fall into two categories: prechronic toxicity studies and chronic two-year toxicology and carcinogenicity studies. Studies are generally conducted in rats and mice.

Each study type is performed according to the Specifications for the Conduct of Studies to Evaluate the Reproductive and Developmental Toxicity of Chemical, Biological and Physical Agents in Laboratory Animals for the National Toxicology Program (NTP) (May 2011). Prechronic and chronic toxicity studies and carcinogenicity studies, that were initiated, ongoing, or completed during FY 2018, are listed below.

Prechronic Toxicology and Carcinogenicity Studies FY 2018

Test Article CASRN* Species Length Route Status Study Scientist
1,2,4-Trimethylbenzene 95-63-6 Mice, rats 13 weeks Inhalation Ongoing Dan Morgan
1,2-Bis(2,4,6-tribromophenoxy)ethane 37853-59-1 Rats 5 days Gavage Ongoing June Dunnick
1,2-bis(pentabromophenyl)ethane 84852-53-9 Rats 5 days Gavage Completed June Dunnick
1,3,5,7,9,11-Hexabromocyclododecane 25637-99-4 Rats 5 days Gavage Completed June Dunnick
1020 Long multiwalled carbon nanotube N/A Mice, rats 30 days Inhalation Ongoing Dan Morgan
1020 Long multiwalled carbon nanotube N/A Mice, rats 2 years Inhalation Ongoing Dan Morgan
2,2',4,4'-Tetrabromodiphenyl ether 5436-43-1 Rats 5 days Gavage Completed June Dunnick
2,2'-Dimorpholinodiethyl ether 6425-39-4 Mice 28 days Gavage Ongoing Troy Hubbard
2,3-Butanedione 431-03-8 Mice, rats 2 years Inhalation Completed Dan Morgan
2-Ethylhexyl-2,3,4,5-tetrabromobenzoate 183658-27-7 Rats 5 days Gavage Completed June Dunnick
2-Ethyltoluene 611-14-3 Mice, rats 2 weeks, 90 days Inhalation Initiated Dan Morgan
2-Hydroxy-4-methoxybenzophenone 131-57-7 Mice, Rats 2 years Dosed-feed Ongoing Barry McIntyre
3,3',4,4'-Tetrachloroazobenzene 14047-09-7 Rats 5 days Gavage Ongoing Mamta Behl
Acetaminophen (4-hydroxyacetanilide) 103-90-2 Rats 90 days Gavage Initiated Vicki Sutherland
Acrylamide 79-06-1 Rats 5 days Gavage Ongoing William Gwinn
Aging cohort study: 12951/SvlmJ mouse N/A Mice 2 years Not applicable Ongoing June Dunnick
Aging cohort study: A/J mouse N/A Mice 2 years Not applicable Ongoing June Dunnick
Aging cohort study: B6C3F1J mouse N/A Mice 2 years Not applicable Ongoing June Dunnick
Aging cohort study: C3H/HeJ mouse N/A Mice 2 years Not applicable Ongoing June Dunnick
Aging cohort study: C57/BL/6J mouse N/A Mice 2 years Not applicable Ongoing June Dunnick
Aging cohort study: CAST/EiJ mouse N/A Mice 2 years Not applicable Ongoing June Dunnick
Aging cohort study: NOD. B10Sn-H2(b)/J N/A Mice 2 years Not applicable Ongoing June Dunnick
Aging cohort study: NZO/HiLtJ mouse N/A Mice 2 years Not applicable Ongoing June Dunnick
Aging cohort study: PWK/PhJ mouse N/A Mice 2 years Not applicable Ongoing June Dunnick
Aging cohort study: WSB/EIJ mouse N/A Mice 2 years Not applicable Ongoing June Dunnick
Aloin 1415-73-2 Rats 13 weeks Dosed-water Completed Alex Boudreau
alpha/beta Thujone mixture 76231-76-0 Rats 5 days Gavage Ongoing William Gwinn
alpha-Pinene 80-56-8 Mice, rats 2 years Inhalation Ongoing Cynthia Rider
Antimony Trioxide 1309-64-4 Mice, rats 2 years Inhalation Completed Matt Stout
Arsenic 7440-38-2 Mice, rats acute Gavage & dosed-water Ongoing Nigel Walker
Arsenic 7440-38-2 Monkey acute Gavage Ongoing Nigel Walker
Aspergillus fumigatus mold N/A Mice 13 weeks Inhalation Ongoing Dori Germolec
Bis(2-ethylhexyl) tetrabromophthalate 26040-51-7 Rats 5 days Gavage Completed June Dunnick
Bisphenol A 80-05-7 Rats 2 years Gavage Completed Barry Delclos
Bisphenol AF 1478-61-1 Rats 5 days Gavage Ongoing Vicki Sutherland
Bisphenol S 80-09-1 Mice 14 days Dosed-feed Ongoing Vicki Sutherland
Black cohosh 84776-26-1 Mice, rats 2 years Gavage Ongoing Chad Blystone
Brominated vegetable oil 8016-94-2 Rats 90 days Dosed-feed Ongoing Nigel Walker
Cell phone radiation: CDMA N/A Mice, rats 2 years Whole body exposure Completed Michael Wyde
Cell phone radiation: GSM N/A Mice, rats 2 years Whole body exposure Completed Michael Wyde
Coumarin 91-64-5 Rats 5 days Gavage Ongoing June Dunnick
Crumbrubber various N/A Mice 14 days N/A Completed Georgia Roberts
Damp building mold mixture N/A Mice 90 days Inhalation Planned Dori Germolec
Decabromodiphenyl ether 1163-19-5 Rats 5 days Gavage Completed June Dunnick
Di(2-ethylhexyl) phthalate 117-81-7 Rats 5 days Gavage Ongoing Troy Hubbard
Di(2-ethylhexyl) phthalate 117-81-7 Rats Perinatal + 2 years, 2 yeaars Dosed-feed Ongoing Paul Foster
Dibutyl phthalate 84-74-2 Mice, rats 2 years Dosed-feed Ongoing Chad Blystone
Dimethylamine borane 74-94-2 Mice 2 weeks Dermal Completed AtLee Watson
Ethinyl estradiol 57-63-6 Rats 5 days Gavage Ongoing William Gwinn
Fenofibrate 49562-28-9 Rats 5 days Gavage Ongoing Barry McIntyre
Furan 110-00-9 Rats 5 days Gavage Ongoing William Gwinn
Garcinia cambogia extract 90045-23-1 Mice, rats 14 days Dosed-feed Ongoing Cynthia Rider
Ginkgo biloba extract 90045-36-6 Rats 5 days Gavage Completed Cynthia Rider
Ginseng 50647-08-0 Rats 5 days Gavage Ongoing Po Chan
Goldenseal extract 84603-60-1 Rats 5 days Gavage Completed Cynthia Rider
Green tea extract N/A Rats 5 days Gavage Completed Cynthia Rider
Hexachlorobenzene 118-74-1 Rats 5 days Gavage Ongoing Mike Devito
Hexachlorobenzene 118-74-1 Rats 90 days Gavage Ongoing Mike Devito
Hexachlorocyclopentadienyl-dibromocyclooctane 51936-55-1 Rats 5 days Gavage Completed June Dunnick
Insertional mutagenesis – definitive vector study N/A Mice 14 months Intravenous Completed Dori Germolec
Ionic liquid: 1-Butyl-1-methylpyrrolidinium Chloride 479500-35-1 Mice, rats 90 days Dosed-water Ongoing Kristen Ryan
Ionic liquid: 1-Butyl-3-methylimidazolium Chloride 79917-90-1 Mice, rats 90 days Dosed-water Ongoing Kristen Ryan
Ionic liquid: 1-Ethyl-3-methylimidazolium Chloride 65039-09-0 Mice, rats 90 days Dosed-water Ongoing Kristen Ryan
Ionic liquid: N-Butylpyridinium Chloride 1124-64-7 Mice, rats 90 days Dosed-water Ongoing Kristen Ryan
Isopropylated phenol phosphate 68937-41-7 Mice 2 weeks Dosed-feed Ongoing Mamta Behl
Libby amphibole 2007 N/A Rats 30 days Inhalation Planned Matt Stout
Melamine + cyanuric acid combination N/A Rats 90 days Gavage Ongoing Gonçalo Gamboa da Costa
Melamine + cyanuric acid combination N/A Not applicable N/A Not applicable Ongoing Nigel Walker
Melamine + cyanuric acid combination N/A Rats 90 days + recovery Gavage Ongoing Gonçalo Gamboa da Costa
Methyleugenol 93-15-2 Rats 5 days Gavage Ongoing William Gwinn
Microbiome N/A Not applicable N/A Not applicable Ongoing Carl Cerniglia
Microcystin LR 101043-37-2 Mice Gestation day 6 to postnatal day 35 Gavage Planned Vicki Sutherland
Milk thistle extract 84604-20-6 Rats 5 days Gavage Ongoing June Dunnick
Mixed xylenes N/A Mice, rats 30 days Inhalation Planned Dan Morgan
N-Butylbenzenesulfonamide 3622-84-2 Mice, rats 14 days, 13 weeks Dosed-feed Completed Cynthia Rider
p-Chloro-a,a,a-trifluorotoluene 98-56-6 Mice, rats 90 days Inhalation Completed Matt Stout
PCN 66/67 comparison study N/A Rats 2 weeks Gavage Ongoing Mike Devito
PCN 66/67 comparison study N/A Rats 13 weeks Gavage Ongoing Mike Devito
Pentabromodiphenyl ether mixture [DE-71 (technical grade)] 32534-81-9 Rats 5 days Gavage Ongoing June Dunnick
Perfluorohexanoic acid (PFHXA) 307-24-4 Rats 28 days Gavage Ongoing Chad Blystone
Perfluorooctanoic acid 335-67-1 Rats 2 years Dosed-feed Ongoing Chad Blystone
Perfluorooctanoic acid 335-67-1 Rats 5 days, 28 days Gavage Ongoing Chad Blystone
Phenolic benzotriazoles (2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol) 70321-86-7 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic benzotriazoles (2-(2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylpropyl)phenol) 25973-55-1 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic benzotriazoles (2-(2H-Benzotriazol-2-yl)-4-tert-butylphenol) 3147-76-0 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic benzotriazoles (2-(2H-Benzotriazol-2-yl)phenol) 10096-91-0 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic benzotriazoles (2-(5-Chloro-2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylethyl)phenol) 3864-99-1 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic benzotriazoles (3-(2H-Benzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid, octyl ester) 84268-23-5 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic benzotriazoles (Bumetrizole) 3896-11-5 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic benzotriazoles (Drometrizole) 2440-22-4 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic benzotriazoles (Octrizole) 3147-75-9 Rats 14 days Gavage Ongoing Chad Blystone
Pulegone 89-82-7 Rats 5 days Gavage Ongoing Scott Auerbach
Resveratrol 501-36-0 Mice, rats 2 years Gavage Ongoing Anika Dzierlenga
Sodium metavanadate 13718-26-8 Mice, rats 90 days Dosed-water Ongoing Georgia Roberts
Sodium tungstate dihydrate 10213-10-2 Mice, rats 2 years Dosed-water Ongoing Mamta Behl
Stachybotrys chartarum strain 1 mold (macrocyclic trichothecene chemotype) N/A Mice 90 days Inhalation Planned Dori Germolec
Stachybotrys chartarum strain 2 mold (atranone chemotype) N/A Mice 90 days Inhalation Planned Dori Germolec
Sulfolane 126-33-0 Guinea gigs, mice, rats 28 days Gavage Ongoing Chad Blystone
Sulfolane 126-33-0 Mice, rats 2 years Dosed-water Ongoing Chad Blystone
Tetrabromobisphenol A 79-94-7 Rats 5 days Gavage Ongoing June Dunnick
Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) 21850-44-2 Rats 90 days Gavage Completed June Dunnick
Thallium (I) sulfate 7446-18-6 Mice 2 weeks Dosed-water Initiated Troy Hubbard
Thallium (I) sulfate 7446-18-6 Rats Gestation day 6 to postnatal day 28 Dosed-water Initiated Troy Hubbard
Triclosan 3380-34-5 Rats 5 days Gavage Ongoing Vicki Sutherland
Triclosan 3380-34-5 Mice 2 years Dermal Ongoing Jia-Long Fang
Trimethylsilyldiazomethane (TMSD) 18107-18-1 Mice, rats 10 days Inhalation Ongoing William Gwinn
Triphenyl phosphate 115-86-6 Mice 2 weeks Dosed-feed Ongoing Mamta Behl
Tris(chloropropyl)phosphate 13674-84-5 Rats 5 days Gavage Ongoing Kristen Ryan
Tris(chloropropyl)phosphate 13674-84-5 Mice, rats 90 days Dosed-feed Ongoing Kristen Ryan
Tris(chloropropyl)phosphate 13674-84-5 Mice, rats 2 years Dosed-feed Ongoing Kristen Ryan
Valerian (Valeriana officinalis L.) root extract 8057-49-6 Mice 90 days Gavage Ongoing Troy Hubbard
Vanadyl sulfate 27774-13-6 Mice, rats 90 days Dosed-water Ongoing Georgia Roberts
Water damaged building mold mixture N/A Mice, rats 90 days Inhalation Planned Dori Germolec
Water disinfection byproducts (Bromodichloroacetic acid) 71133-14-7 Rats 5 days Gavage Ongoing Mike Devito
Zinc carbonate, basic 5263-02-5 Rats 2 years Dosed-feed Ongoing Natasha Catlin
*CASRN = Chemical Abstracts Service Registry Number