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Annual Report for Fiscal Year 2018

Annual Report for Fiscal Year 2018
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https://ntp.niehs.nih.gov/go/860738

Genetic Toxicity Studies

Genetic toxicity test results are used to help interpret general toxicity, carcinogenicity, or other in vivo test results and to provide a database for use in structure-activity relationship analysis. Substances evaluated during FY 2018 are listed below.

Genetic Toxicology Studies in FY 2018

Test Article CASRN* Species/ Cell Line Testing Battery Status Study Scientist
1,2,4-Trimethylbenzene 95-63-6 Mice Micronucleus in vivo Ongoing Kristine Witt
1,2,4-Trimethylbenzene 95-63-6 Rats Micronucleus in vivo Ongoing Kristine Witt
1020 Long multiwalled carbon nanotube N/A Mice Micronucleus in vivo Ongoing Kristine Witt
1020 Long multiwalled carbon nanotube N/A Rats Micronucleus in vivo Ongoing Kristine Witt
1H-Isoindole-1,3(2H)-diimine 3468-11-9 TK6 cells Micronucleus in vitro Planned Kristine Witt
1H-Isoindole-1,3(2H)-diimine 3468-11-9 Salmonella Salmonella Ongoing Kristine Witt
2-(Thiocyanomethylthio)benzothiazole 21564-17-0 TK6 cells Micronucleus in vitro Planned Kristine Witt
2-(Thiocyanomethylthio)benzothiazole 21564-17-0 Salmonella Salmonella Ongoing Kristine Witt
2,2'-Dimorpholinodiethyl ether 6425-39-4 Salmonella Salmonella Completed Kristine Witt
2,2'-Dimorpholinodiethyl ether 6425-39-4 Mice Micronucleus in vivo Ongoing Kristine Witt
2,2'-Dimorpholinodiethyl ether 6425-39-4 Rats Micronucleus in vivo Ongoing Kristine Witt
2-Acetylaminofluorene 53-96-3 Rats Comet assay Completed Kristine Witt
2-Chloro-N-(2-methyl-4-bromophenyl)acetamide 96686-51-0 Salmonella Salmonella Ongoing Kristine Witt
2-Chloro-N-(2-methyl-4-bromophenyl)acetamide 96686-51-0 TK6 cells Micronucleus in vitro Planned Kristine Witt
2-Hydroxy-4-methoxybenzophenone 131-57-7 Salmonella Salmonella Completed Kristine Witt
4-(Hexyloxy)phenol 18979-55-0 TK6 cells Micronucleus in vitro Planned Kristine Witt
4-(Hexyloxy)phenol 18979-55-0 Salmonella Salmonella Ongoing Kristine Witt
Acrylamide 79-06-1 Mice Comet assay Completed Kristine Witt
Bisphenol S 80-09-1 Rats (female dams) Micronucleus in vivo Planned Kristine Witt
Bisphenol S 80-09-1 Rats (PND28 pups) Micronucleus in vivo Planned Kristine Witt
Black cohosh 84776-26-1 Salmonella Salmonella Completed Kristine Witt
Cell phone radiation: CDMA N/A Mice Comet assay Completed Kristine Witt
Cell phone radiation: CDMA N/A Rats Comet assay Completed Kristine Witt
Cell phone radiation: GSM N/A Mice Comet assay Completed Kristine Witt
Cell phone radiation: GSM N/A Rats Comet assay Completed Kristine Witt
Deoxynivalenol 51481-10-8 Rats Micronucleus in vivo Ongoing Kristine Witt
Dipentaerythritol pentaacrylate 60506-81-2 TK6 cells Micronucleus in vitro Planned Kristine Witt
Dipentaerythritol pentaacrylate 60506-81-2 Salmonella Salmonella Ongoing Kristine Witt
Dipyrithione 3696-28-4 TK6 cells Micronucleus in vitro Planned Kristine Witt
Dipyrithione 3696-28-4 Salmonella Salmonella Ongoing Kristine Witt
Echinacea purpurea root extract 90028-20-9 Rats (female dams) Micronucleus in vivo Planned Kristine Witt
Echinacea purpurea root extract 90028-20-9 Rats (PND28 pups) Micronucleus in vivo Planned Kristine Witt
Echinacea purpurea root extract 90028-20-9 Rats (90 day) Micronucleus in vivo Planned Kristine Witt
Emtricitabine (FTC) 143491-57-0 Mice Comet assay Completed Kristine Witt
Indium trichloride 10025-82-8 TK6 cells Micronucleus in vitro Completed Kristine Witt
N-Butylbenzenesulfonamide 3622-84-2 Mice Micronucleus in vivo Ongoing Kristine Witt
N-Butylbenzenesulfonamide 3622-84-2 Rats Micronucleus in vivo Ongoing Kristine Witt
N-Nitrosodimethylamine 62-75-9 Rats Comet assay Planned Kristine Witt
p-Chloro-a,a,a-trifluorotoluene 98-56-6 Salmonella Salmonella Completed Kristine Witt
Phenolic benzotriazoles (2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol) 70321-86-7 Rats Micronucleus in vivo Ongoing Kristine Witt
Phenolic benzotriazoles (2-(2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylpropyl)phenol) 25973-55-1 Rats Micronucleus in vivo Ongoing Kristine Witt
Phenolic benzotriazoles (2-(2H-Benzotriazol-2-yl)-4-tert-butylphenol) 3147-76-0 Rats Micronucleus in vivo Ongoing Kristine Witt
Phenolic benzotriazoles (2-(2H-Benzotriazol-2-yl)phenol) 10096-91-0 Rats Micronucleus in vivo Ongoing Kristine Witt
Phenolic benzotriazoles (2-(5-Chloro-2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylethyl)phenol) 3864-99-1 Rats Micronucleus in vivo Ongoing Kristine Witt
Phenolic benzotriazoles (3-(2H-Benzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid, octyl ester) 84268-23-5 Rats Micronucleus in vivo Completed Kristine Witt
Phenolic benzotriazoles (Bumetrizole) 3896-11-5 Rats Micronucleus in vivo Ongoing Kristine Witt
Phenolic benzotriazoles (Drometrizole) 2440-22-4 Rats Micronucleus in vivo Ongoing Kristine Witt
Phenolic benzotriazoles (Octrizole) 3147-75-9 Rats Micronucleus in vivo Ongoing Kristine Witt
Potassium dicyanoaurate 13967-50-5 TK6 cells Micronucleus in vitro Planned Kristine Witt
Potassium dicyanoaurate 13967-50-5 Salmonella Salmonella Ongoing Kristine Witt
Pubertal vinclozolin study 50471-44-8 Mice Comet assay Completed Kristine Witt
Sodium metavanadate 13718-26-8 Mice Micronucleus in vivo Ongoing Kristine Witt
Sodium metavanadate 13718-26-8 Rats Micronucleus in vivo Ongoing Kristine Witt
Sodium tungstate dihydrate 10213-10-2 Mice Comet assay Completed Kristine Witt
Sodium tungstate dihydrate 10213-10-2 Rats Comet assay Completed Kristine Witt
Stachybotrys chartarum 67892-26-6 Mice Micronucleus in vivo Ongoing Kristine Witt
Sulfolane 126-33-0 Mice Micronucleus in vivo Completed Kristine Witt
Sulfolane 126-33-0 Rats Micronucleus in vivo Completed Kristine Witt
Triclosan 3380-34-5 Rats (female dams) Micronucleus in vivo Planned Kristine Witt
Tris(4-chlorophenyl)methane 27575-78-6 Rats Micronucleus in vivo Ongoing Kristine Witt
Vanadyl sulfate 27774-13-6 Mice Micronucleus in vivo Ongoing Kristine Witt
Vanadyl sulfate 27774-13-6 Rats Micronucleus in vivo Ongoing Kristine Witt
Vincristine sulfate salt 2068-78-2 Rats Comet assay Completed Kristine Witt
Vinpocetine 42971-09-5 Mice Micronucleus in vivo Completed Kristine Witt
Vinpocetine 42971-09-5 TK6 cells Micronucleus in vitro Completed Kristine Witt
Vinpocetine 42971-09-5 Mice Comet assay Completed Kristine Witt

*CASRN = Chemical Abstracts Service Registry Number

Related Links:
Disposition, Metabolism, and Toxicokinetic Studies Genetic Toxicity Studies 
Organ System Toxicity Studies 
Modified One-Generation Reproduction Studies
Toxicology and Carcinogenicity Studies
Toxicogenomic Studies