U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NTP Logo

Annual Report for Fiscal Year 2018

Annual Report for Fiscal Year 2018
Menu
https://ntp.niehs.nih.gov/go/860732

Modified One-Generation Reproduction Studies

NTP modified one-generation study design emphasizes a full evaluation of the first-generation offspring of animals and uses fewer animals than the classical multigenerational study design. These studies generate information on the effects of substances on prenatal development, postnatal development, and reproduction. Planned or ongoing modified one-generation studies are listed below.

Modified One-Generation Studies in FY 2018

Test Article CASRN* Species Testing Battery Status Study Scientist
Bisphenol AF 1478-61-1 Rats Dose range finding Ongoing Vicki Sutherland
Echinacea purpurea root extract 90028-20-9 Rats Conventional teratology Ongoing Kristen Ryan
Echinacea purpurea root extract 90028-20-9 Rats Fertility assessment Ongoing Kristen Ryan
Echinacea purpurea root extract 90028-20-9 Rats Subchronic Ongoing Kristen Ryan
Resveratrol 501-36-0 Rats Developmental toxicity, F0 generation, fertility assessment Ongoing Anika Dzierlenga
2,2'-Dimorpholinodiethyl ether 6425-39-4 Rats Repeated dose Ongoing Georgia Roberts
2-Ethylhexyl p-methoxycinnamate 5466-77-3 Rats Subchronic Ongoing Barry McIntyre
2-Hydroxy-4-methoxybenzophenone 131-57-7 Rats Developmental toxicity Ongoing Barry McIntyre
Bisphenol S 80-09-1 Rats Dose range finding Ongoing Vicki Sutherland
Bisphenol S 80-09-1 Rats F0 generation Planned Vicki Sutherland
Boric acid 10043-35-3 Rats Dose range finding Ongoing AtLee Watson
Deoxynivalenol 51481-10-8 Rats Dose range finding Ongoing Dori Germolec
Echinacea purpurea root extract 90028-20-9 Rats Dose range finding Ongoing Kristen Ryan
Ethylene glycol 2-ethylhexyl ether 1559-35-9 Rats Dose range finding Ongoing Chad Blystone
Hydroquinone 123-31-9 Rats Dose range finding Planned Vicki Sutherland
N-Butylbenzenesulfonamide 3622-84-2 Rats F0 generation Ongoing Cynthia Rider
N-Butylbenzenesulfonamide 3622-84-2 Rats Maternal transfer Ongoing Cynthia Rider
N-Butylbenzenesulfonamide 3622-84-2 Rats Developmental toxicity Ongoing Cynthia Rider
N-Butylbenzenesulfonamide 3622-84-2 Rats Neurotoxicology assessment Ongoing Cynthia Rider
N-Butylbenzenesulfonamide 3622-84-2 Rats Subchronic Ongoing Cynthia Rider
Simvastatin 79902-63-9 Rats Dose range finding Ongoing Barry McIntyre
Triclosan 3380-34-5 Rats Dose range finding Ongoing Vicki Sutherland
Tricombination FTC:TDF:EFV (1:1.5:3) N/A Mice F0 generation Initiated Anika Dzierlenga
Tricombination FTC:TDF:EFV (1:1.5:3) N/A Mice Subchronic Planned Anika Dzierlenga
Tricombination ABC:DTG:3TC N/A Rats Dose range finding Planned Kristen Ryan
Tris(4-chlorophenyl)methane 27575-78-6 Rats Dose range finding Ongoing Troy Hubbard
Valerian (Valeriana officinalis L.) root extract 8057-49-6 Rats Dose range finding Ongoing Georgia Roberts

*CASRN = Chemical Abstracts Service Registry Number

Related Links:
Disposition, Metabolism, and Toxicokinetic Studies
Genetic Toxicity Studies 
Organ System Toxicity Studies 
Toxicology and Carcinogenicity Studies
Toxicogenomic Studies