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Annual Report for Fiscal Year 2018

Annual Report for Fiscal Year 2018
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https://ntp.niehs.nih.gov/go/860714

Organ System Toxicity Studies

NTP studies toxicity of environmental substances on development, reproduction, and on the nervous and immune systems. Organ systems toxicity studies Conducted during FY 2018 are listed below.

Neurotoxicity, Developmental Toxicity, and Reproductive Toxicity Studies During FY 2018

Test Article CASRN* Species Testing Battery Length Route Status Study Scientist
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rabbit Teratology pilot GD 7-28 Gavage Initiated Vicki Sutherland
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rabbit Conventional teratology GD 7-28 Gavage Initiated Vicki Sutherland
3,3',4,4'-Tetrachloroazobenzene 14047-09-7 Rats Immunotoxicity 28 days Gavage Ongoing Mamta Behl
2,3-Butanedione 431-03-8 Mice Immunotoxicity 28 days Inhalation Ongoing Dan Morgan
Benz(j)aceanthrylene 202-33-5 Mice Immunotoxicity 28 days Gavage Initiated Cynthia Rider
Dibenz(a,h)anthracene 53-70-3 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Dibenz(a,h)anthracene 53-70-3 Mice Immunotoxicity 28 days Subcutaneous injection Ongoing Cynthia Rider
Dibenzo(a,l)pyrene 191-30-0 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Dibenzothiophene 132-65-0 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Perfluorodecanoic acid 335-76-2 Rats Immunotoxicity 28 days Gavage Ongoing Chad Blystone
Vinclozolin 50471-44-8 Rats Continuous breeding 9 months Gavage Ongoing Barry McIntyre
Tenofovir disoproxil fumarate (TDF) 202138-50-9 Mice Teratology pilot GD 5 - PND 21 Gavage Ongoing Anika Dzierlenga
Dibenzo(a,l)pyrene 191-30-0 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Dibenzothiophene 132-65-0 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Perfluorodecanoic acid 335-76-2 Rats Immunotoxicity 28 days Gavage Ongoing Chad Blystone
1020 Long multiwalled carbon nanotube N/A Rats Immunotoxicity 30 days Inhalation Ongoing Dan Morgan
1020 Long multiwalled carbon nanotube N/A Mice Immunotoxicity 30 days Inhalation Ongoing Dan Morgan
1020 Long multiwalled carbon nanotube N/A Mice Immunotoxicity 90 days Inhalation Ongoing Dan Morgan
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rats Conventional teratology GD 6-21 Gavage Ongoing Vicki Sutherland
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rabbit Conventional teratology GD 7-28 Gavage Ongoing Vicki Sutherland
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rats Immunotoxicity 28 days Gavage Ongoing Vicki Sutherland, Barry McIntyre
2-Hydroxy-4-methoxybenzophenone 131-57-7 Rats Developmental toxicity GD 6 - PND 21 Dosed-feed Ongoing Dr. D. Hansen
4-Methylcyclohexanemethanol 34885-03-5 Mice Immunotoxicity 7 days Topical application Ongoing Scott Auerbach
4-Methylimidazole 822-36-6 Rats Continuous breeding Continuous Dosed-feed Ongoing Mamta Behl
Acenaphthenequinone 82-86-0 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Arsenic 7440-38-2 Rats Developmental toxicity Pregnant dams through PND21 Gavage & dosed-water Completed Nigel Walker
Benzo(a)pyrene 50-32-8 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Benzo(b)fluoranthene 205-99-2 Mice Immunotoxicity 28 days Gavage Initiated Cynthia Rider
Benzo(c)fluorene 205-12-9 Mice Immunotoxicity 28 days Gavage Initiated Cynthia Rider
Benzo(k)fluoranthene 207-08-9 Mice Immunotoxicity 28 days Gavage Initiated Cynthia Rider
Bisphenol AF 1478-61-1 Rats Immunotoxicity GD 6 - PND 96 Dosed-feed Ongoing Vicki Sutherland
Chrysene 218-01-9 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Crude 4-methylcyclohexanemethanol N/A Mice Immunotoxicity 7 days Topical application Ongoing Scott Auerbach
Diisobutyl phthalate 84-69-5 Rats Continuous breeding Continuous Dosed-feed Ongoing Chad Blystone
Echinacea purpurea root extract 90028-20-9 Rats Immunotoxicity 28 days Gavage Planned Kristen Ryan
Gum guggul extract N/A Mice Immunotoxicity 28 days Gavage Ongoing Dori Germolec
Indeno(1,2,3-cd)pyrene 193-39-5 Mice Immunotoxicity 28 days Gavage Initiated Cynthia Rider
Lovastatin 75330-75-5 Mice Immunotoxicity 28 days Gavage Ongoing Dori Germolec
N-Butylbenzenesulfonamide 3622-84-2 Rats Immunotoxicity GD 6 - PND 42 Dosed-feed Ongoing Cynthia Rider
Nelfinavir mesylate 159989-65-8 Mice Immunotoxicity 28 days Gavage Ongoing Dori Germolec
Phenanthrene 85-01-8 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Pyrene 129-00-0 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Sodium metavanadate 13718-26-8 Mice Immunotoxicity 28 days Dosed-water Ongoing Georgia Roberts
Sulfolane 126-33-0 Mice Immunotoxicity 13 weeks Gavage Ongoing Chad Blystone
Sulfolane 126-33-0 Rats Immunotoxicity 13 weeks Gavage Ongoing Chad Blystone
Tricombination FTC:TDF:EFV (1:1.5:3) N/A Mice Teratology pilot GD 5-18, GD 5-15 Gavage Ongoing Barry McIntyre
Tricresyl phosphate 1330-78-5 Rats Immunotoxicity 21 days Dosed-feed Planned Mamta Behl
Tris(chloropropyl)phosphate 13674-84-5 Rats Immunotoxicity GD 6 - PND 127 Dosed-feed Ongoing Kristen Ryan



*CASRN = Chemical Abstracts Service Registry Number
 
Related Links:
Disposition, Metabolism, and Toxicokinetic Studies
Genetic Toxicity Studies 
Modified One-Generation Reproduction Studies
Toxicology and Carcinogenicity Studies
Toxicogenomic Studies