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Annual Report for Fiscal Year 2018

Annual Report for Fiscal Year 2018

ICCVAM Meetings

NICEATM supported eight teleconferences and two in-person meetings held by ICCVAM in FY 2018. NICEATM also supported eight ad hoc ICCVAM workgroups focused on acute systemic toxicity, ocular and dermal irritation, developmental and reproductive toxicity, skin sensitization, use of read-across in toxicity testing applications, in vitro-to-in vivo extrapolation, nanomaterials, and ecotoxicology.

The fourth ICCVAM Communities of Practice webinar was held on January 23, 2018. The webinar explored the fundamentals of machine learning approaches, including how they work, how they are interpreted, and precautions that should be taken when evaluating their output. Sean Ekins, Ph.D., Chief Executive Officer of Collaborations Pharmaceuticals, Inc., and NICEATM Deputy Director Nicole Kleinstreuer, Ph.D., addressed issues specific to machine learning approaches used in a regulatory context. Case studies were presented to highlight where such techniques have been successfully applied both nationally and internationally. Presentations from the webinar are available on the NTP website.

ICCVAM, with NICEATM support, held its fifth public forum on May 24, 2018, at the National Institutes of Health in Bethesda, Maryland. Representatives from eight ICCVAM member agencies were joined by attendees representing stakeholder groups and over 100 webcast viewers. ICCVAM members provided information about their agency activities on the development and validation of test methods and approaches that could replace, reduce, or refine animal use.

A main focus of this meeting was implementation of the strategic roadmap for establishing new approaches to evaluate the safety of chemicals and medical products in the United States. Commenters offered suggestions on specific actions that should be taken to advance the goals of the strategic roadmap and encouraged less active ICCVAM partners to take a greater role. The meeting agenda and presentations are available on the NTP website.

Related Annual Report Pages:
Strategic Roadmap for New Approaches to Evaluate the Safety of Chemicals and Medical Products
ICCVAM Test Method Evaluation Activities
ICCVAM International Validation Activities