Urinary Bladder - Vacuolation, Cytoplasmic
Cytoplasmic vacuolation of urothelial cells is regarded as a nonspecific lesion that may occur secondary to cell injury by a variety of bladder toxicants or carcinogens. It may or may not be related to degeneration. Vacuolation is usually noted in “umbrella” cells or more superficial urothelial cells (Figure 1 and Figure 2). Uniform urothelial cell vacuolation (typically within the basal cell layer) may be an artifact resulting from autolysis (Figure 3).
Cytoplasmic vacuolation should be diagnosed and given a severity grade.
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, Bube A. 2012. Proliferative and non-proliferative lesions in the rat and mouse urinary system. Toxicol Pathol 40:14S-86S.Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22637735