TDMS Study 96003-04 Pathology Tables
NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:45:38 FINAL#1/MICE Facility: BIORELIANCE Chemical CAS #: 106-95-6 Lock Date: 10/18/00 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:45:38 ____________________________________________________________________________________________________________________________________ MICE:FVB/N FEMALE VEHICLE 8 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 Early Deaths Moribund Sacrifice 1 Survivors Terminal Sacrifice 15 14 Animals Examined Microscopically 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) Hepatocyte, Necrosis, Focal 2 (13%) 2 (13%) Hepatocyte, Vacuolization Cytoplasmic, Diffuse 2 (13%) 2 (13%) Hepatocyte, Vacuolization Cytoplasmic, Focal 2 (13%) 3 (20%) Hepatocyte, Centrilobular, Vacuolization Cytoplasmic 1 (7%) Kupffer Cell, Hyperplasia, Diffuse 1 (7%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) Atrophy 2 (13%) 2 (13%) Subcapsular, Hyperplasia, Focal 8 (53%) 9 (60%) Zona Reticularis, Vacuolization Cytoplasmic, Diffuse 12 (80%) 13 (87%) Zona Reticularis, Vacuolization Cytoplasmic, Focal 2 (13%) 2 (13%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:45:38 ____________________________________________________________________________________________________________________________________ MICE:FVB/N FEMALE VEHICLE 8 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (15) (15) Hemorrhage, Focal 2 (13%) Inflammation, Acute, Focal 1 (7%) Inflammation, Chronic Active, Focal 1 (7%) Uterus (15) (15) Hydrometra 2 (13%) 1 (7%) Endometrium, Hyperplasia, Cystic 14 (93%) 15 (100%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (15) (15) Hematopoietic Cell Proliferation 15 (100%) 15 (100%) Pigmentation 15 (100%) 14 (93%) Lymphoid Follicle, Hyperplasia 1 (7%) Thymus (15) (14) Atrophy, Focal 4 (27%) 3 (21%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) Alveolar Epithelium, Hyperplasia, Focal 1 (7%) Alveolus, Hemorrhage, Focal 1 (7%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:45:38 ____________________________________________________________________________________________________________________________________ MICE:FVB/N FEMALE VEHICLE 8 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) Renal Tubule, Dilatation, Focal 2 (13%) 2 (13%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:45:38 ____________________________________________________________________________________________________________________________________ MICE:FVB/N MALE VEHICLE 8 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 Early Deaths Dosing Accident 1 Survivors Terminal Sacrifice 15 14 Animals Examined Microscopically 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (1) Epithelium, Hyperplasia, Diffuse 1 (100%) Muscularis, Periesophageal Tissue, Inflammation, Chronic Active, Focal 1 (100%) Liver (15) (15) Tension Lipidosis 1 (7%) Hepatocyte, Necrosis, Focal 1 (7%) 1 (7%) Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (7%) Hepatocyte, Centrilobular, Vacuolization Cytoplasmic 3 (20%) 2 (13%) Hepatocyte, Centrilobular, Vacuolization Cytoplasmic, Focal 1 (7%) Serosa, Mineralization, Focal 1 (7%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (14) Atrophy 15 (100%) 14 (100%) Hypertrophy, Focal 13 (87%) 14 (100%) Subcapsular, Hyperplasia, Focal 1 (7%) Thyroid Gland (15) (15) Ectopic Thymus 1 (7%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:45:38 ____________________________________________________________________________________________________________________________________ MICE:FVB/N MALE VEHICLE 8 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (2) (2) Ectasia 2 (100%) 2 (100%) Infiltration Cellular, Focal, Lymphocyte 1 (50%) Testes (15) (15) Germinal Epithelium, Degeneration, Focal 2 (13%) 2 (13%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mediastinal (14) (15) Hyperplasia 1 (7%) Spleen (15) (15) Hematopoietic Cell Proliferation 15 (100%) 13 (87%) Pigmentation 11 (73%) 11 (73%) Lymphoid Follicle, Atrophy 1 (7%) Thymus (15) (15) Atrophy, Diffuse 1 (7%) Atrophy, Focal 2 (13%) 3 (20%) Hyperplasia, Focal 1 (7%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (15) (15) Subcutaneous Tissue, Inflammation, Chronic Active, Focal 1 (7%) 1 (7%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 96003-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:45:38 ____________________________________________________________________________________________________________________________________ MICE:FVB/N MALE VEHICLE 8 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) Hemorrhage, Focal 1 (7%) Alveolar Epithelium, Hyperplasia, Focal 1 (7%) 1 (7%) Mediastinum, Inflammation, Acute, Focal 1 (7%) Perivascular, Infiltration Cellular, Focal, Lymphocyte 1 (7%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) Renal Tubule, Degeneration, Focal 1 (7%) Renal Tubule, Dilatation, Diffuse 1 (7%) Renal Tubule, Dilatation, Focal 1 (7%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------