TDMS Study 05094-02 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
BUTYL BENZYL PHTHALATE
NTP Experiment-Test: 05094-02 Report: PEIRPT09
Study Type: CHRONIC Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
CORE STUDY
Facility: Southern Research Institute
Chemical CAS #: 85-68-7
Lock Date: 11/25/92
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 UNTREATDCONTROL
Include 002 UNTREATDCONTROL
Include 003 0.3%
Include 004 0.6%
Include 005 0.6%
Include 006 1.2%
Include 007 1.2%
Include 008 2.4%
Page 1
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 3| 0| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 9| 1| 1| 3| 2| 6| 3| 2| 0| 3| 0| 1| 3| 1| 3| 3| 3| 0| 3| 1| 2| 6| 3|
| 6| 1| 8| 6| 7| 7| 5| 8| 9| 5| 2| 6| 2| 7| 7| 2| 6| 6| 6| 3| 7| 7| 5| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Developmental Malformation | X |
Eosinophilic Focus | X X X X X X X X |
Granuloma | 3 1 1|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Subacute | |
Mixed Cell Focus | X X X X X X X|
Bile Duct, Hyperplasia | 2 2 2 3 1 2 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 3 |
Kupffer Cell, Hyperplasia | 3 |
Kupffer Cell, Pigmentation | 3 2 |
Lobules, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Accessory Spleen | X |
Fat, Necrosis | 3 2 2 2 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 1 1 1 1|
Acinus, Cytoplasmic Alteration | |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 3| 0| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 9| 1| 1| 3| 2| 6| 3| 2| 0| 3| 0| 1| 3| 1| 3| 3| 3| 0| 3| 1| 2| 6| 3|
| 6| 1| 8| 6| 7| 7| 5| 8| 9| 5| 2| 6| 2| 7| 7| 2| 6| 6| 6| 3| 7| 7| 5| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 2 |
Ulcer | 3 2 |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 2 1 1 2 1 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 |
Angiectasis | 1 2 1 2 2 3 2 2 2 1 2|
Degeneration, Fatty | 2 2 2 3 3 3 2 2 |
Hyperplasia, Focal | 1 1 2 |
Hypertrophy, Focal | 3 2 2 2 3 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 3 |
Pars Distalis, Cyst | X X X X X X X X X X X X |
Pars Distalis, Hyperplasia, Focal | 3 2 1 1 1 2 2 1 1|
Pars Intermedia, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 2 3 |
Hyperplasia | 2 |
Inflammation, Chronic | 2 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 3| 0| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 9| 1| 1| 3| 2| 6| 3| 2| 0| 3| 0| 1| 3| 1| 3| 3| 3| 0| 3| 1| 2| 6| 3|
| 6| 1| 8| 6| 7| 7| 5| 8| 9| 5| 2| 6| 2| 7| 7| 2| 6| 6| 6| 3| 7| 7| 5| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Vagina | M + M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
Myelofibrosis | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Pigmentation | 4 |
Pancreatic, Pigmentation | 3 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 1 1 |
Hyperplasia, Lymphoid | 2 3 |
Pigmentation | 2 2 2 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 2 3 1 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 1 1 2 4 2 3 1 |
Necrosis | 3 |
Pigmentation, Hemosiderin | 3 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Ectasia | 1 1 3 4 4 |
Hyperplasia | 2 1 1 2 1 1 1 3 2 1 1 1 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 3| 0| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 9| 1| 1| 3| 2| 6| 3| 2| 0| 3| 0| 1| 3| 1| 3| 3| 3| 0| 3| 1| 2| 6| 3|
| 6| 1| 8| 6| 7| 7| 5| 8| 9| 5| 2| 6| 2| 7| 7| 2| 6| 6| 6| 3| 7| 7| 5| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Cranium, Osteopetrosis | 2 2 2 2 |
Femur, Osteopetrosis | 2 3 2 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 4 4 |
Gliosis | |
Hydrocephalus | 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 3 1|
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X |
Foreign Body | 2 |
Fungus | 3 |
Mucosa, Hyperplasia | 1 2 |
Mucosa, Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 3 2 3 2 1 2 2 2 2 2 2 2 2 3 2 2|
Nephropathy | 2 1 1 1 1 1 1 1 2 1 2 3 2 |
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Dilatation | |
Renal Tubule, Necrosis | 2 |
Renal Tubule, Pigmentation | 1 2 1 2 1 1 1 1 1 1 2 2 2 2 1 2 1 2 1 1 2 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia | 1 |
Mucosa, Hyperplasia | 2 1 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 7| 3| 2| 3| 9| 3| 3| 8| 1| 3| 3| 7| 8| 3| |
| 6| 7| 3| 6| 6| 7| 6| 7| 4| 6| 6| 0| 7| 6| 6| 1| 7| 6| 7| 9| 7| 6| 0| 1| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 2 2.0|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 37 |
Clear Cell Focus | X X | 3 |
Developmental Malformation | | 1 |
Eosinophilic Focus | X X X X X X X X X X X | 19 |
Granuloma | 2 1 2| 6 1.7|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X X X X | 9 |
Inflammation, Subacute | 2 2 1 | 3 1.7|
Mixed Cell Focus | X X X| 10 |
Bile Duct, Hyperplasia | 3 1 1 2 | 10 1.9|
Centrilobular, Necrosis | 2 | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 4 | 7 3.1|
Kupffer Cell, Hyperplasia | | 1 3.0|
Kupffer Cell, Pigmentation | 2 2 | 4 2.3|
Lobules, Necrosis | 1 1 3 3 1 | 6 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + | 10 |
Accessory Spleen | | 1 |
Fat, Necrosis | 3 3 2 | 9 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 1 1 1 1 2 1 2 1| 18 1.2|
Acinus, Cytoplasmic Alteration | 3 | 1 3.0|
Acinus, Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 7| 3| 2| 3| 9| 3| 3| 8| 1| 3| 3| 7| 8| 3| |
| 6| 7| 3| 6| 6| 7| 6| 7| 4| 6| 6| 0| 7| 6| 6| 1| 7| 6| 7| 9| 7| 6| 0| 1| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | | 2 2.5|
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 1 1.0|
Inflammation, Chronic | | 1 3.0|
Mineralization | | 1 2.0|
Ulcer | 4 | 3 3.0|
__________________________________________________________________________|____________|
Tongue | + + | 3 |
Epithelium, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 2 2 | 16 1.5|
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 2 2 | 5 1.6|
Angiectasis | 1 2 2 2 1 2 1 2 1 1 1| 22 1.6|
Degeneration, Fatty | 2 2 | 10 2.3|
Hyperplasia, Focal | 2 1 1 2 1 1 | 9 1.3|
Hypertrophy, Focal | 2 2 | 9 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + M + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 3 4 4 | 7 3.1|
Pars Distalis, Cyst | X X X X X X X X X X X X| 24 |
Pars Distalis, Hyperplasia, Focal | 2 3 3| 12 1.8|
Pars Intermedia, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Ultimobranchial Cyst | X | 2 |
C-Cell, Hyperplasia | 2 1| 6 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 7| 3| 2| 3| 9| 3| 3| 8| 1| 3| 3| 7| 8| 3| |
| 6| 7| 3| 6| 6| 7| 6| 7| 4| 6| 6| 0| 7| 6| 6| 1| 7| 6| 7| 9| 7| 6| 0| 1| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 3 2 3 3 3 3 2 | 12 2.8|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 3 2 | 4 2.5|
Inflammation, Suppurative | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 X | 3 3.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 | 2 2.5|
Hyperplasia, Cystic | 1 2 1 | 4 1.5|
__________________________________________________________________________|____________|
Vagina | M M M | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | | 1 3.0|
Myelofibrosis | 3 4 | 4 3.3|
__________________________________________________________________________|____________|
Lymph Node | + + + | 12 |
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Pigmentation | 3 | 2 3.5|
Pancreatic, Pigmentation | | 1 3.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Ectasia | | 1 2.0|
Hemorrhage | 3 2 1| 5 1.6|
Hyperplasia, Lymphoid | 2 2 2 2 | 6 2.2|
Pigmentation | 2 2 2 2 2 2 | 12 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 1 2.0|
Hemorrhage | | 3 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 2 1 | 10 1.8|
Necrosis | | 1 3.0|
Pigmentation, Hemosiderin | 2 3 3 2 2 2 2 2 2 3 | 19 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 7| 3| 2| 3| 9| 3| 3| 8| 1| 3| 3| 7| 8| 3| |
| 6| 7| 3| 6| 6| 7| 6| 7| 4| 6| 6| 0| 7| 6| 6| 1| 7| 6| 7| 9| 7| 6| 0| 1| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 3 3 3 3 3 2 2 | 12 2.7|
Hyperplasia | 1 1 1 1 1 2 3 1 1 1 2 2 1 2 2 2| 30 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 | 1 1.0|
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | 2 2 2 | 3 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 2 3 3 | 7 2.3|
Femur, Osteopetrosis | 2 | 5 2.2|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 3 4 3 3 2 | 9 3.1|
Gliosis | 3 | 1 3.0|
Hydrocephalus | | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 2 1| 21 1.1|
Inflammation, Subacute | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X | 6 |
Foreign Body | 2 2 2 2 | 5 2.0|
Fungus | 2 3 | 3 2.7|
Mucosa, Hyperplasia | 3 | 3 2.0|
Mucosa, Metaplasia, Squamous | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 7| 3| 2| 3| 9| 3| 3| 8| 1| 3| 3| 7| 8| 3| |
| 6| 7| 3| 6| 6| 7| 6| 7| 4| 6| 6| 0| 7| 6| 6| 1| 7| 6| 7| 9| 7| 6| 0| 1| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Atrophy | 4 | 1 4.0|
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 2 2 2 2 2 1 2 2 1 2 2 2 2 2 3 2 3 2 2 2 2 3 3| 43 2.1|
Nephropathy | 1 2 1 1 1 1 2 2 1 2 1 1 2 2 1 1 1 1 3 1 1| 34 1.4|
Renal Tubule, Cytoplasmic Alteration | 3 | 1 3.0|
Renal Tubule, Dilatation | 2 | 1 2.0|
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Pigmentation | 1 2 1 1 1 2 1 2 2 2 2 2 1 2 1 1 1 1 1 2 1 1 1 1 1| 49 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Hyperplasia | | 1 1.0|
Mucosa, Hyperplasia | | 2 1.5|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 2| 3| 3| 2| 9| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3|
| 8| 9| 5| 2| 6| 6| 5| 3| 7| 6| 7| 9| 6| 6| 7| 5| 6| 6| 6| 7| 6| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.6% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + M + + + + + + + + M + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Cyst | |
Eosinophilic Focus | X X X X X X X X|
Granuloma | 2 1 1 1 3 1 |
Hepatodiaphragmatic Nodule | X X X X |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 2 1 2 2 2 |
Hepatocyte, Hyperplasia, Focal | |
Hepatocyte, Vacuolization Cytoplasmic| 3 4 3 3 2 |
Kupffer Cell, Hyperplasia | 2 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 4 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 1 1 1 2 1 1 1|
Edema | 3 |
Acinus, Cytoplasmic Alteration | 3 |
Acinus, Hyperplasia, Focal | 3 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | 4 |
Mucosa, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 2| 3| 3| 2| 9| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3|
| 8| 9| 5| 2| 6| 6| 5| 3| 7| 6| 7| 9| 6| 6| 7| 5| 6| 6| 6| 7| 6| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.6% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 2 2 1 1 1 3 2 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | 3 2 1 1 1 2 1 3 1 1 1 2 1|
Degeneration, Fatty | 2 1 2 2 3 2 1 1 2 1 |
Hemorrhage | 2 |
Hyperplasia, Focal | 1 2 |
Hypertrophy, Focal | 2 2 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 4 2 |
Pars Distalis, Cyst | X X X X X X X X X X X|
Pars Distalis, Hyperplasia, Focal | 1 1 2 3 3 3 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 2 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 4 3 3 3 3 3 3 3 4 2 3|
Hyperplasia | 2 2 |
Inflammation, Chronic | 2 4 |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Hyperplasia, Cystic | 2 3 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 2| 3| 3| 2| 9| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3|
| 8| 9| 5| 2| 6| 6| 5| 3| 7| 6| 7| 9| 6| 6| 7| 5| 6| 6| 6| 7| 6| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.6% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Vagina | M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 4 |
Myelofibrosis | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Iliac, Pigmentation | |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Pigmentation | 3 3 3 3 |
Pancreatic, Pigmentation | 3 2 |
Renal, Hemorrhage | 1 |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Pigmentation | 3 4 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 3 2 3 2 1 2 |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 3 |
Hematopoietic Cell Proliferation | 4 2 2 2 1 1 |
Hemorrhage | 2 |
Pigmentation, Hemosiderin | 2 2 2 2 3 2 2 3 2 3 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 2 |
Hyperplasia | 1 1 2 1 1 2 2 2 2 2 1 1 2 2 2 2 1 1 1 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | 3|
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 2| 3| 3| 2| 9| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 0| 3| 3| 0| 3| 3| 3|
| 8| 9| 5| 2| 6| 6| 5| 3| 7| 6| 7| 9| 6| 6| 7| 5| 6| 6| 6| 7| 6| 6| 7| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.6% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Femur, Osteopetrosis | 3 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 4 |
Hemorrhage | 2 |
Hydrocephalus | 2 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Foreign Body | |
Fungus | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 3 1 1 2 1 2 1 2 1 2 2 1 3 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Atrophy | |
Renal Tubule, Pigmentation | 1 3 1 2 2 1 2 4 2 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 3| 3| 6| 1| 0| 3| 8| 3| 0| 3| 3| 0| 3| 2| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 2| |
| 7| 6| 3| 8| 5| 6| 2| 7| 1| 6| 6| 3| 7| 6| 5| 7| 1| 6| 6| 7| 6| 6| 7| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.6% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X | 38 |
Clear Cell Focus | | 3 |
Cyst | X | 1 |
Eosinophilic Focus | X X X X X X X | 15 |
Granuloma | 1 1 1 1 1 | 11 1.3|
Hepatodiaphragmatic Nodule | X X | 6 |
Mixed Cell Focus | X X X | 4 |
Bile Duct, Hyperplasia | 2 3 1 1 2 1 1 | 12 1.7|
Hepatocyte, Hyperplasia, Focal | 3 | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 6 3.0|
Kupffer Cell, Hyperplasia | | 1 2.0|
Kupffer Cell, Pigmentation | 1 | 1 1.0|
Lobules, Necrosis | 2 | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Fat, Necrosis | 3 3 2 4 3 | 7 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 1 2 2 2 1 2 3 | 18 1.6|
Edema | | 1 3.0|
Acinus, Cytoplasmic Alteration | | 1 3.0|
Acinus, Hyperplasia, Focal | 2 | 4 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Ulcer | | 1 4.0|
Mucosa, Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 3| 3| 6| 1| 0| 3| 8| 3| 0| 3| 3| 0| 3| 2| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 2| |
| 7| 6| 3| 8| 5| 6| 2| 7| 1| 6| 6| 3| 7| 6| 5| 7| 1| 6| 6| 7| 6| 6| 7| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.6% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 2 1.5|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 3 2 1 2 1 2 1 2 | 21 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 1 3 1 2 1 | 6 1.8|
Angiectasis | 1 1 3 2 2 1 2 2 1 1 | 23 1.6|
Degeneration, Fatty | 2 3 1 3 1 | 15 1.8|
Hemorrhage | | 1 2.0|
Hyperplasia, Focal | 3 1 | 4 1.8|
Hypertrophy, Focal | 2 3 1 1 2 1| 11 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + I + + + + + + + + +| 49 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 4 4 | 7 3.3|
Pars Distalis, Cyst | X X X X X X X X X| 20 |
Pars Distalis, Hyperplasia, Focal | 2 1 1 2 1 | 11 1.8|
Pars Intermedia, Angiectasis | 2 3 | 3 2.3|
Pars Intermedia, Cyst | X X | 2 |
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 2 2 2 | 6 1.7|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 3| 3| 6| 1| 0| 3| 8| 3| 0| 3| 3| 0| 3| 2| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 2| |
| 7| 6| 3| 8| 5| 6| 2| 7| 1| 6| 6| 3| 7| 6| 5| 7| 1| 6| 6| 7| 6| 6| 7| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.6% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 3 4 3 3 2 3 2 3 | 21 3.0|
Hyperplasia | 3 2 | 4 2.3|
Inflammation, Chronic | 2 2 | 4 2.5|
Inflammation, Suppurative | 3 2 4 | 5 2.6|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X | 5 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 | 1 2.0|
Hyperplasia, Cystic | 2 1 | 4 2.0|
__________________________________________________________________________|____________|
Vagina | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 3| 2 3.5|
Myelofibrosis | 1 | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node | + + + | 11 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Iliac, Pigmentation | 3 | 1 3.0|
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Pigmentation | 3 | 5 3.0|
Pancreatic, Pigmentation | | 2 2.5|
Renal, Hemorrhage | 3 | 2 2.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Pigmentation | 4 3 | 5 3.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 2 2| 4 2.0|
Hemorrhage | 3 1 1| 9 2.0|
Hyperplasia, Lymphoid | 3 2 2 2 | 6 2.2|
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 | 23 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 3 | 3 2.3|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 2 3.5|
Hematopoietic Cell Proliferation | 1 2 2 1 2 3| 12 1.9|
Hemorrhage | | 1 2.0|
Pigmentation, Hemosiderin | 1 2 2 2 2 2 2 2| 20 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 3| 3| 6| 1| 0| 3| 8| 3| 0| 3| 3| 0| 3| 2| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 2| |
| 7| 6| 3| 8| 5| 6| 2| 7| 1| 6| 6| 3| 7| 6| 5| 7| 1| 6| 6| 7| 6| 6| 7| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.6% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 2 3 3 3 | 9 2.8|
Hyperplasia | 1 1 1 2 1 1 1 2 1 1 1 2 1 2 1 1 1 2 | 39 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 3 | 2 3.0|
Hyperkeratosis | 2 | 2 2.5|
Ulcer | 2 3 3 | 4 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 2 2 2 3 3 3 | 10 2.5|
Femur, Osteopetrosis | 2 2 3 | 6 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 3 3 2 | 6 2.8|
Hemorrhage | | 1 2.0|
Hydrocephalus | 2 2 | 3 2.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 2 3.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 3 1 2 1 1 | 22 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X | 3 |
Foreign Body | 2 2 | 2 2.0|
Fungus | 3 | 1 3.0|
Mucosa, Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 3| 3| 6| 1| 0| 3| 8| 3| 0| 3| 3| 0| 3| 2| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 2| |
| 7| 6| 3| 8| 5| 6| 2| 7| 1| 6| 6| 3| 7| 6| 5| 7| 1| 6| 6| 7| 6| 6| 7| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0.6% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 2 2 3 3 2 2 1 1 2 1 2 1 2 1 2 2 1 2| 34 1.7|
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1| 47 1.1|
Renal Tubule, Atrophy | 2 | 1 2.0|
Renal Tubule, Pigmentation | 1 1 2 1 1 2 1 2 2 1 1 1 2 2 1 1 2 2 2 2 2 1 1 1 2| 49 1.5|
Transitional Epithelium, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 0| 3| 4| 0| 3| 3| 4| 4| 6| 3| 3| 3| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3|
| 6| 6| 4| 3| 7| 4| 9| 6| 6| 7| 7| 6| 7| 6| 6| 2| 7| 6| 6| 7| 7| 6| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + M + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + M|
Edema | |
Parasite Metazoan | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X|
Cyst | |
Eosinophilic Focus | X X X X X|
Granuloma | 1 1 1 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X X |
Thrombosis | |
Bile Duct, Hyperplasia | 2 3 2 1 1 1 1 |
Centrilobular, Necrosis | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Kupffer Cell, Pigmentation | 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 4 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 3 1 2 1 1 1|
Acinus, Cytoplasmic Alteration | 2 |
Acinus, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Mucosa, Hyperplasia | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | |
Ulcer | 3 |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 0| 3| 4| 0| 3| 3| 4| 4| 6| 3| 3| 3| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3|
| 6| 6| 4| 3| 7| 4| 9| 6| 6| 7| 7| 6| 7| 6| 6| 2| 7| 6| 6| 7| 7| 6| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 1 1 2 2 2 2 2 3 2 3 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 2 2 2 1 |
Angiectasis | 2 2 1 3 1 2 2 2 2 1 2 2 2 2 1|
Degeneration, Fatty | 2 3 2 1 1|
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | 2 1|
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + M + +|
Pars Distalis, Angiectasis | 3 2 4 3 3 |
Pars Distalis, Cyst | X X X X X X X X|
Pars Distalis, Hyperplasia, Focal | 3 3 2 2 2 |
Pars Intermedia, Angiectasis | 4 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 1 2 1|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 2 3 4 2 2 3 |
Hyperplasia | 3 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hydrometra | 2 |
Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 0| 3| 4| 0| 3| 3| 4| 4| 6| 3| 3| 3| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3|
| 6| 6| 4| 3| 7| 4| 9| 6| 6| 7| 7| 6| 7| 6| 6| 2| 7| 6| 6| 7| 7| 6| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | 3 2 3 |
Pancreatic, Hemorrhage | |
Pancreatic, Pigmentation | 3 3 |
Renal, Hemorrhage | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 2 2 2 |
Hyperplasia, Lymphoid | |
Pigmentation | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 |
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 3 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 1 2 2 3 3 2 2 2 1 2 |
Hyperplasia | 2 2 2 1 3 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Developmental Malformation | X |
Hemorrhage | 3 1 |
Hyperkeratosis | 2 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 3 3 2 |
Femur, Osteopetrosis | 2 2 3 |
Femur, Osteosclerosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 0| 3| 4| 0| 3| 3| 4| 4| 6| 3| 3| 3| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3|
| 6| 6| 4| 3| 7| 4| 9| 6| 6| 7| 7| 6| 7| 6| 6| 2| 7| 6| 6| 7| 7| 6| 5| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Compression | 2 2 4 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1|
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | 3 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X |
Foreign Body | |
Fungus | 4 |
Mucosa, Hyperplasia | 2 |
Mucosa, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | |
Mineralization | 1 2 1 1 1 2 2 1 1 1 2 1 1 2 1 2 2|
Nephropathy | 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Atrophy | 1 1 |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | 1 1 1 1 1 1 2 1 1 1 3 1 1 2 2 3 1 1 1 1 2 1 1 1 1|
Transitional Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 4 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 2| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 4| 7| 3| 3| 3| 3| 7| 3| 2| 3| 3| 2| 7| 3| 3| 3| 3| 5| 8| 3| 3| 3| |
| 7| 5| 6| 6| 2| 7| 7| 7| 7| 0| 8| 6| 8| 8| 4| 9| 7| 8| 8| 7| 1| 5| 3| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.2% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X X| 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 4 | 2 3.5|
Parasite Metazoan | X | 1 |
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 2 | 4 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 41 |
Clear Cell Focus | X X X X| 8 |
Cyst | X X | 2 |
Eosinophilic Focus | X X X X | 9 |
Granuloma | 3 1 1| 6 1.3|
Hepatodiaphragmatic Nodule | X X X | 6 |
Mixed Cell Focus | X X X | 5 |
Thrombosis | X | 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 | 12 1.3|
Centrilobular, Necrosis | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 2 3.0|
Kupffer Cell, Pigmentation | 4 2 2 | 5 2.6|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Accessory Spleen | | 1 |
Fat, Necrosis | 3 | 6 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 1 1 1 1 1 3| 16 1.4|
Acinus, Cytoplasmic Alteration | | 1 2.0|
Acinus, Hyperplasia, Focal | 3 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Mucosa, Hyperplasia | 3 | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 2| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 4| 7| 3| 3| 3| 3| 7| 3| 2| 3| 3| 2| 7| 3| 3| 3| 3| 5| 8| 3| 3| 3| |
| 7| 5| 6| 6| 2| 7| 7| 7| 7| 0| 8| 6| 8| 8| 4| 9| 7| 8| 8| 7| 1| 5| 3| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.2% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 1 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Epithelium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 2 2 3 1 1 1 1 2 | 23 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 2 | 8 1.9|
Angiectasis | 1 2 1 1 1 1 2 1 1 1 3 | 26 1.6|
Degeneration, Fatty | 2 3 2 3 3 1| 11 2.1|
Hyperplasia, Focal | | 2 2.0|
Hypertrophy, Focal | 3 2 1 2 2| 7 1.9|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 2 3 4| 8 3.0|
Pars Distalis, Cyst | X X X X X X X X | 16 |
Pars Distalis, Hyperplasia, Focal | 2 3 1 4| 9 2.4|
Pars Intermedia, Angiectasis | 3 | 3 3.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 1 2 1 | 7 1.3|
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 3 2 3 3 | 13 2.8|
Hyperplasia | 2| 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 2| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 4| 7| 3| 3| 3| 3| 7| 3| 2| 3| 3| 2| 7| 3| 3| 3| 3| 5| 8| 3| 3| 3| |
| 7| 5| 6| 6| 2| 7| 7| 7| 7| 0| 8| 6| 8| 8| 4| 9| 7| 8| 8| 7| 1| 5| 3| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.2% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 2 | 3 2.3|
Inflammation, Suppurative | 1 3 2 | 6 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X| 6 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Hydrometra | 3 3 | 3 2.7|
Hyperplasia, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 3 2| 6 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 16 |
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Pigmentation | 3 2 3 4 2 2 | 9 2.7|
Pancreatic, Hemorrhage | 3 | 1 3.0|
Pancreatic, Pigmentation | 3 | 3 3.0|
Renal, Hemorrhage | 1 3 | 2 2.0|
Renal, Pigmentation | 3 4 3 | 3 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 3 | 2 2.5|
Hemorrhage | | 3 2.0|
Hyperplasia, Lymphoid | 2 3 3 | 3 2.7|
Pigmentation | 2 2 2 2 2 2| 13 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 3 2.7|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 4 | 3 3.0|
Hematopoietic Cell Proliferation | 2 1 1 | 8 1.9|
Pigmentation, Hemosiderin | 2 3 3 3 2 2 3 2 3 3 2 | 21 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 2 2 3 3 3 3 3 | 20 2.3|
Hyperplasia | 1 1 1 1 1 2 2 2 1 1 1| 22 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 2| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 4| 7| 3| 3| 3| 3| 7| 3| 2| 3| 3| 2| 7| 3| 3| 3| 3| 5| 8| 3| 3| 3| |
| 7| 5| 6| 6| 2| 7| 7| 7| 7| 0| 8| 6| 8| 8| 4| 9| 7| 8| 8| 7| 1| 5| 3| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.2% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Developmental Malformation | | 1 |
Hemorrhage | | 2 2.0|
Hyperkeratosis | 4 | 3 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 3 3 2 2 2 | 9 2.6|
Femur, Osteopetrosis | 4 3 2 | 6 2.7|
Femur, Osteosclerosis | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 1 2 2 3 2 | 9 2.3|
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 1 4.0|
Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 1 1 3 3 1| 18 1.3|
Inflammation, Subacute | 1 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | 1 3 | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | | 2 |
Foreign Body | 2 | 1 2.0|
Fungus | | 1 4.0|
Mucosa, Hyperplasia | 2 | 2 2.0|
Mucosa, Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 2| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 4| 7| 3| 3| 3| 3| 7| 3| 2| 3| 3| 2| 7| 3| 3| 3| 3| 5| 8| 3| 3| 3| |
| 7| 5| 6| 6| 2| 7| 7| 7| 7| 0| 8| 6| 8| 8| 4| 9| 7| 8| 8| 7| 1| 5| 3| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.2% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hydronephrosis | 4 | 1 4.0|
Mineralization | 1 1 2 1 1 2 2 1 1 1 2 1 1 2 2 1 2 2 2 1| 37 1.4|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 3 1 1| 43 1.1|
Renal Tubule, Atrophy | 2 | 3 1.3|
Renal Tubule, Dilatation | 3 2 | 2 2.5|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 2 2 1 1 1 2 3 1 2 2 4 1 3 1 2 1 2| 49 1.4|
Transitional Epithelium, Hyperplasia | 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Hemorrhage | | 1 4.0|
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 4| 5| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 3| 8| 5| 5| 3| 2| 2| 3| 3| 0| 5| 3| 0| 3| 3| 3| 3| 3| 5| 3| 0| 8|
| 1| 8| 7| 8| 7| 2| 1| 8| 2| 5| 7| 8| 7| 2| 8| 4| 7| 8| 8| 7| 8| 2| 8| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
2.4% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Edema | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Cyst | X |
Eosinophilic Focus | X X X X X X X X X|
Granuloma | |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X X X X X|
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 1 1 1 2 1 |
Kupffer Cell, Pigmentation | 2 2 1 1 2 |
Lobules, Necrosis | 1 1 1|
__________________________________________________________________________|
Mesentery | + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 3 3 2 2 |
__________________________________________________________________________|
Oral Mucosa | |
Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 |
Mineralization | |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 4| 5| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 3| 8| 5| 5| 3| 2| 2| 3| 3| 0| 5| 3| 0| 3| 3| 3| 3| 3| 5| 3| 0| 8|
| 1| 8| 7| 8| 7| 2| 1| 8| 2| 5| 7| 8| 7| 2| 8| 4| 7| 8| 8| 7| 8| 2| 8| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
2.4% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 2 |
Angiectasis | 1 1 3 1 2 3 3 2 2 1 1 3 |
Cyst | X|
Degeneration, Fatty | 1 |
Hemorrhage | 2 |
Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Hepatocyte | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 3 2 |
Pars Distalis, Cyst | X X X X X X X X X X X |
Pars Distalis, Hyperplasia, Focal | 1 3 3 1 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 3 2 3 |
Hyperplasia | |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 2|
Hyperplasia, Cystic | 1 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Pigmentation | 2 3 4 |
Pancreatic, Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 4| 5| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 3| 8| 5| 5| 3| 2| 2| 3| 3| 0| 5| 3| 0| 3| 3| 3| 3| 3| 5| 3| 0| 8|
| 1| 8| 7| 8| 7| 2| 1| 8| 2| 5| 7| 8| 7| 2| 8| 4| 7| 8| 8| 7| 8| 2| 8| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
2.4% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Pigmentation | 4 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | |
Pigmentation | 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 2 2 2 1 1 2 4 2|
Pigmentation, Hemosiderin | 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + + + I + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 3 2 2 2|
Hyperplasia | 2 1 1 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 2 3 2 2 |
Femur, Osteopetrosis | 1 |
Rib, Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 4 4 2 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 2 3 1 2 1 1 1 1 1 1|
Inflammation, Subacute | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 4| 5| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 1| 3| 3| 3| 8| 5| 5| 3| 2| 2| 3| 3| 0| 5| 3| 0| 3| 3| 3| 3| 3| 5| 3| 0| 8|
| 1| 8| 7| 8| 7| 2| 1| 8| 2| 5| 7| 8| 7| 2| 8| 4| 7| 8| 8| 7| 8| 2| 8| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
2.4% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Exudate | X X X|
Mucosa, Hyperplasia | |
Mucosa, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 3 |
Hemorrhage | |
Retina, Degeneration | 2 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Cyst | X |
Hydronephrosis | 2 |
Mineralization | 2 2 1 2 2 2 1 1 2 1 2 2 1 1 1 |
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Atrophy | 3 |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Necrosis | 1 |
Renal Tubule, Pigmentation | 2 1 2 2 1 2 3 1 2 1 2 4 1 1 1 2 1 1 1 1 2 1 1 2|
Transitional Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Ureter | + |
Dilatation | 3 |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 1| 3| 8| 3| 3| 3| 9| 3| 3| 3| 0| 3| 0| 3| 3| 0| 8| 3| 8| 3| 3| |
| 7| 7| 8| 8| 7| 7| 1| 8| 7| 8| 2| 7| 8| 8| 7| 7| 3| 8| 8| 3| 4| 7| 4| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2.4% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 | 1 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 39 |
Clear Cell Focus | X X X X X | 9 |
Cyst | X | 2 |
Eosinophilic Focus | X X X X X X X X X X X | 20 |
Granuloma | 3 2 | 2 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X X X | 12 |
Mixed Cell Focus | X X X | 6 |
Bile Duct, Hyperplasia | 2 2 2 1| 9 1.4|
Kupffer Cell, Pigmentation | 2 1 2 2 3 | 10 1.8|
Lobules, Necrosis | 2 1 1 | 6 1.2|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Accessory Spleen | | 1 |
Fat, Necrosis | 2 | 6 2.5|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 1 2 1 2 | 12 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
Mucosa, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 1| 3| 8| 3| 3| 3| 9| 3| 3| 3| 0| 3| 0| 3| 3| 0| 8| 3| 8| 3| 3| |
| 7| 7| 8| 8| 7| 7| 1| 8| 7| 8| 2| 7| 8| 8| 7| 7| 3| 8| 8| 3| 4| 7| 4| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2.4% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 1 1 1 2 2 3 1 1 | 13 1.3|
Mineralization | 1 | 1 1.0|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 2 1 | 6 1.7|
Angiectasis | 2 2 3 1 1 3 3 2 2 2 2 2 3 2 3 2 2 | 29 2.1|
Cyst | | 1 |
Degeneration, Fatty | 1 3 1 | 4 1.5|
Hemorrhage | | 1 2.0|
Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Hepatocyte | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 4 2 2 3 | 7 2.9|
Pars Distalis, Cyst | X X X X X X X X| 19 |
Pars Distalis, Hyperplasia, Focal | 1 3 3 2 2 1 2| 11 2.0|
Pars Distalis, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 | 3 1.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 3 2 4 | 10 2.6|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 1| 3| 8| 3| 3| 3| 9| 3| 3| 3| 0| 3| 0| 3| 3| 0| 8| 3| 8| 3| 3| |
| 7| 7| 8| 8| 7| 7| 1| 8| 7| 8| 2| 7| 8| 8| 7| 7| 3| 8| 8| 3| 4| 7| 4| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2.4% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | 2 1 2 1 2 2 1| 11 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | | 1 2.0|
Myelofibrosis | 2 3 1 3 2 | 6 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 15 |
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Pigmentation | 3 4 3 3 2 3 | 9 3.0|
Pancreatic, Pigmentation | 3 3 | 3 2.7|
Renal, Pigmentation | 3 4 | 4 3.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 2| 3 2.0|
Hemorrhage | 3 2 1 1 1 | 5 1.6|
Pigmentation | 2 2 2 2 2 2 2 2 2 | 16 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | | 1 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 1 1 2 | 14 1.6|
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 1 3 3 2 | 29 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 1 2 2| 11 1.9|
Hyperplasia | 1 2 1 2 1 1 1 1 1 2 1 2 | 17 1.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 | 1 3.0|
Ulcer | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 2 | 6 2.2|
Femur, Osteopetrosis | 2 2 | 3 1.7|
Rib, Osteopetrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 1| 3| 8| 3| 3| 3| 9| 3| 3| 3| 0| 3| 0| 3| 3| 0| 8| 3| 8| 3| 3| |
| 7| 7| 8| 8| 7| 7| 1| 8| 7| 8| 2| 7| 8| 8| 7| 7| 3| 8| 8| 3| 4| 7| 4| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2.4% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 3 2 3 | 8 2.9|
Hydrocephalus | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | 19 1.2|
Inflammation, Subacute | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X | 4 |
Mucosa, Hyperplasia | 2 | 1 2.0|
Mucosa, Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | | 2 3.0|
Hemorrhage | 4 | 1 4.0|
Retina, Degeneration | | 2 2.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | X | 1 |
Cyst | X | 2 |
Hydronephrosis | | 1 2.0|
Mineralization | 1 2 2 1 1 1 1 1 1 2 1 1 1 2 1 1 2 1 2 2| 35 1.4|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
Renal Tubule, Atrophy | 2 | 2 2.5|
Renal Tubule, Dilatation | | 1 3.0|
Renal Tubule, Necrosis | | 1 1.0|
Renal Tubule, Pigmentation | 1 2 3 1 3 1 2 1 2 1 1 2 1 1 4 1 2 1 1 3 2 2 1 | 47 1.6|
Transitional Epithelium, Hyperplasia | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 1| 3| 8| 3| 3| 3| 9| 3| 3| 3| 0| 3| 0| 3| 3| 0| 8| 3| 8| 3| 3| |
| 7| 7| 8| 8| 7| 7| 1| 8| 7| 8| 2| 7| 8| 8| 7| 7| 3| 8| 8| 3| 4| 7| 4| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2.4% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Dilatation | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 2 2 2 2 1 3 2| 10 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 7| 2| 6| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 4|
DAY ON TEST | 7| 3| 4| 2| 0| 2| 3| 5| 3| 4| 2| 4| 3| 2| 2| 3| 1| 9| 2| 2| 1| 5| 3| 2| 7|
| 7| 0| 4| 9| 7| 9| 0| 5| 1| 4| 9| 1| 0| 9| 9| 0| 8| 3| 9| 9| 7| 7| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +|
Dilatation | 3 |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +|
Edema | 2 3 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X X X X X X |
Degeneration, Cystic | 3 2 2 1 2 |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 2 2 3 3 3 2 2 3 1 1 2 2 4 2 2 2 3 3 1 3|
Centrilobular, Necrosis | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 3 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Angiectasis | 3 |
Fat, Necrosis | 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 1 2 1 1 1 1 2 1 1 2|
Acinus, Cytoplasmic Alteration | 3 |
Acinus, Hyperplasia, Focal | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Ulcer | 4 4 |
Mucosa, Hyperplasia | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Erosion | 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 7| 2| 6| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 4|
DAY ON TEST | 7| 3| 4| 2| 0| 2| 3| 5| 3| 4| 2| 4| 3| 2| 2| 3| 1| 9| 2| 2| 1| 5| 3| 2| 7|
| 7| 0| 4| 9| 7| 9| 0| 5| 1| 4| 9| 1| 0| 9| 9| 0| 8| 3| 9| 9| 7| 7| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 2 2 3 3 1 2 3 3 3 2 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 2 1 2 |
Degeneration, Fatty | 1 1 |
Hemorrhage | 2 |
Hyperplasia, Focal | 1 |
Hypertrophy, Focal | 1 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 1 |
Pars Distalis, Hyperplasia | |
Pars Intermedia, Angiectasis | 3 3 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | |
Follicle, Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X 3 3 3 3 3 3 3 3 3 |
Hypospermia | 3 3 3 3 3 3 3 3 3 3 4 3 3 3 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 3 2 2 |
Hyperplasia | |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 3 2|
Inflammation, Suppurative | 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 2 2 3 2 2 3 3|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 7| 2| 6| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 4|
DAY ON TEST | 7| 3| 4| 2| 0| 2| 3| 5| 3| 4| 2| 4| 3| 2| 2| 3| 1| 9| 2| 2| 1| 5| 3| 2| 7|
| 7| 0| 4| 9| 7| 9| 0| 5| 1| 4| 9| 1| 0| 9| 9| 0| 8| 3| 9| 9| 7| 7| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 1 2 2 2 3 2 3 3 1 3 3 3 3 2|
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1 1 2|
Seminiferous Tubule, Atrophy | 4 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 4 |
Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Iliac, Hemorrhage | 2 |
Iliac, Hyperplasia, Lymphoid | 3 |
Iliac, Pigmentation | |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Pigmentation | 3 3 3 |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 2 3|
Hemorrhage | 2 1 2 3 |
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 4 2 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Metaplasia, Osseous | |
Necrosis | 3 |
Pigmentation, Hemosiderin | 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + + + + + + + + + + + + + + + M + + M + +|
Hyperplasia | 2 2 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 7| 2| 6| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 4|
DAY ON TEST | 7| 3| 4| 2| 0| 2| 3| 5| 3| 4| 2| 4| 3| 2| 2| 3| 1| 9| 2| 2| 1| 5| 3| 2| 7|
| 7| 0| 4| 9| 7| 9| 0| 5| 1| 4| 9| 1| 0| 9| 9| 0| 8| 3| 9| 9| 7| 7| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 2 |
Metaplasia, Osseous | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 4 |
Hydrocephalus | 3 |
Mineralization | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | 1 3 1 1 3 1 1 1 |
Inflammation, Subacute | 3 |
Inflammation, Suppurative | |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X X X|
Foreign Body | 2 2 2 2 2 2|
Fungus | 4 3 2 3 X|
Mucosa, Hyperplasia | 2 1 2 3 2 3 |
Mucosa, Metaplasia, Squamous | 3 3 2 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 1 2 1 2 2 1 3 1 1 4 3 3 2 2 1 3 3 2 1 2 3 1|
Renal Tubule, Pigmentation | 1 1 1 2 4 2 1 1 1 1 1 3 2 1 1 1 2 1 2 1 3 2 1 1 1|
Transitional Epithelium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 5| 6| 6| 7| 7| 5| 7| 7| 7| 6| 4| |
DAY ON TEST | 2| 3| 3| 2| 3| 7| 3| 2| 1| 3| 2| 2| 2| 6| 6| 6| 1| 2| 2| 7| 2| 3| 3| 1| 3| |
| 9| 1| 0| 9| 0| 7| 0| 9| 8| 0| 9| 9| 9| 1| 2| 2| 4| 9| 9| 6| 9| 0| 1| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + M + + M + + + + + + + + + + M + + + M M + + + +| 44 |
Dilatation | | 1 3.0|
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X X X| 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + M + + + A + + + + + + + + + + +| 47 |
Edema | 2 | 3 2.3|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X| 22 |
Clear Cell Focus | X X X X X X X X | 15 |
Degeneration, Cystic | 2 1 | 7 1.9|
Eosinophilic Focus | X | 3 |
Hepatodiaphragmatic Nodule | X | 1 |
Mixed Cell Focus | X X X | 6 |
Bile Duct, Hyperplasia | 4 2 2 2 3 1 2 3 2 2 3 3 4 1 2 1 2 2 3 | 39 2.3|
Centrilobular, Necrosis | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 | 6 2.5|
Kupffer Cell, Pigmentation | 3 | 1 3.0|
Lobules, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Angiectasis | | 1 3.0|
Fat, Necrosis | 3 3 | 5 3.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 3 2 2 1 3 1 2 1 2 1 2 2 3 1 | 29 1.6|
Acinus, Cytoplasmic Alteration | | 1 3.0|
Acinus, Hyperplasia, Focal | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Ulcer | | 2 4.0|
Mucosa, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 2 2.0|
Erosion | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 5| 6| 6| 7| 7| 5| 7| 7| 7| 6| 4| |
DAY ON TEST | 2| 3| 3| 2| 3| 7| 3| 2| 1| 3| 2| 2| 2| 6| 6| 6| 1| 2| 2| 7| 2| 3| 3| 1| 3| |
| 9| 1| 0| 9| 0| 7| 0| 9| 8| 0| 9| 9| 9| 1| 2| 2| 4| 9| 9| 6| 9| 0| 1| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 2 | 2 2.0|
Inflammation, Subacute | 2 | 2 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 3 3 3 3 3 3 1 2 2 3 2 3 1 3 3 | 32 2.4|
Thrombosis | X X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 2 2 2 3 2 | 11 1.8|
Degeneration, Fatty | 1 | 3 1.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Focal | 1 1 2 1 1 1 | 7 1.1|
Hypertrophy, Focal | 2 | 2 1.5|
Vacuolization Cytoplasmic | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 2 1 | 6 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 | 3 2.7|
Pars Distalis, Cyst | X X | 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 3 4 2 1 | 7 2.1|
Pars Distalis, Hyperplasia | 3 | 1 3.0|
Pars Intermedia, Angiectasis | 3 | 3 3.0|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 2 |
C-Cell, Hyperplasia | 3 3 3 2 | 4 2.8|
Follicle, Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 5| 6| 6| 7| 7| 5| 7| 7| 7| 6| 4| |
DAY ON TEST | 2| 3| 3| 2| 3| 7| 3| 2| 1| 3| 2| 2| 2| 6| 6| 6| 1| 2| 2| 7| 2| 3| 3| 1| 3| |
| 9| 1| 0| 9| 0| 7| 0| 9| 8| 0| 9| 9| 9| 1| 2| 2| 4| 9| 9| 6| 9| 0| 1| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | 28 3.0|
Hypospermia | 4 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 4 | 34 3.1|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 3 3 2 2 3 | 11 2.4|
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 2 2 2 2 2 3 2 2 2 2 2 2 2 3| 25 2.1|
Inflammation, Suppurative | 2 3 2 2 2 2 | 9 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 2 2 3 2 2 2 2 3 | 17 2.3|
Inflammation, Suppurative | 1 3 3 2 3 1 2 1 1 1 2 2 2 1 2| 29 2.1|
Epithelium, Hyperplasia | 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 3 3| 4 3.3|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | | 4 1.3|
Seminiferous Tubule, Atrophy | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | | 1 4.0|
Myelofibrosis | 3 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 23 |
Iliac, Hemorrhage | | 1 2.0|
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Iliac, Pigmentation | 3 | 1 3.0|
Mediastinal, Hemorrhage | 3 3 3 3 | 5 2.8|
Mediastinal, Pigmentation | 3 3 | 5 3.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Pigmentation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Congestion | 3 | 1 3.0|
Ectasia | 2 2 3 2 | 6 2.3|
Hemorrhage | | 4 2.0|
Hyperplasia, Lymphoid | 3 3 | 3 2.7|
Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 4 2 | 6 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 5| 6| 6| 7| 7| 5| 7| 7| 7| 6| 4| |
DAY ON TEST | 2| 3| 3| 2| 3| 7| 3| 2| 1| 3| 2| 2| 2| 6| 6| 6| 1| 2| 2| 7| 2| 3| 3| 1| 3| |
| 9| 1| 0| 9| 0| 7| 0| 9| 8| 0| 9| 9| 9| 1| 2| 2| 4| 9| 9| 6| 9| 0| 1| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 4 2 2 | 5 2.6|
Hematopoietic Cell Proliferation | 3 2 | 2 2.5|
Metaplasia, Osseous | 4 | 1 4.0|
Necrosis | | 1 3.0|
Pigmentation, Hemosiderin | 1 2 2 2 1 1 2 3 2 2 1| 14 1.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 45 |
Hyperplasia | 4 2 2 2 3| 10 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 2.0|
Metaplasia, Osseous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | +| 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X| 4 3.3|
Hydrocephalus | 3| 2 3.0|
Mineralization | 1| 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + | 3 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 1 1 1 | 13 1.5|
Inflammation, Subacute | | 1 3.0|
Inflammation, Suppurative | 1 | 1 1.0|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 2 | 7 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 5| 6| 6| 7| 7| 5| 7| 7| 7| 6| 4| |
DAY ON TEST | 2| 3| 3| 2| 3| 7| 3| 2| 1| 3| 2| 2| 2| 6| 6| 6| 1| 2| 2| 7| 2| 3| 3| 1| 3| |
| 9| 1| 0| 9| 0| 7| 0| 9| 8| 0| 9| 9| 9| 1| 2| 2| 4| 9| 9| 6| 9| 0| 1| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X X X | 17 |
Foreign Body | 2 3 | 8 2.1|
Fungus | 3 2 4 3 3 3 3 | 12 3.0|
Mucosa, Hyperplasia | 3 2 3 2 2 | 11 2.3|
Mucosa, Metaplasia, Squamous | 3 2 2 2 | 9 2.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 2 2 3 2 2 1 2 3 3 2 3 3 2 1 3 2 1 2 2 3 2 3 2 3| 48 2.1|
Renal Tubule, Pigmentation | 3 1 1 1 1 2 1 1 2 1 1 2 2 3 2 1 1 1 2 1 1 1 1 1| 49 1.5|
Transitional Epithelium, Hyperplasia | 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 7| 3| 4| 7| 7| 7| 4| 6| 6| 4| 6| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 6| 6| 4|
DAY ON TEST | 7| 3| 0| 9| 3| 3| 3| 5| 0| 0| 9| 2| 3| 4| 2| 3| 0| 2| 3| 9| 3| 3| 0| 4| 7|
| 8| 0| 3| 9| 1| 0| 0| 0| 7| 7| 9| 6| 1| 9| 3| 1| 1| 7| 0| 8| 1| 0| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.3% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + M + + M + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | X X X X X |
Degeneration, Cystic | 3 2 1 1 3 |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 1 2 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 2 4 1 2 1 1 3 3 1 2 1 3 2 3 3 3 3 2 2 1 |
Centrilobular, Necrosis | 4 2 3 |
Hepatocyte, Hyperplasia, Focal | 3 |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Pigmentation | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 1 3 3 2 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 1 1 2 1 3 1 2 1 1 1 3 |
Acinus, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 1 3 2 |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 7| 3| 4| 7| 7| 7| 4| 6| 6| 4| 6| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 6| 6| 4|
DAY ON TEST | 7| 3| 0| 9| 3| 3| 3| 5| 0| 0| 9| 2| 3| 4| 2| 3| 0| 2| 3| 9| 3| 3| 0| 4| 7|
| 8| 0| 3| 9| 1| 0| 0| 0| 7| 7| 9| 6| 1| 9| 3| 1| 1| 7| 0| 8| 1| 0| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.3% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 1 3 1 3 2 2 2 3 2 1 3 3 1 1 2 |
Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 2 2 1 1 |
Angiectasis | 2 |
Degeneration, Fatty | 1 1 |
Hyperplasia, Focal | 1 2 |
Hypertrophy, Focal | |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 3 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Metaplasia, Hepatocyte | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X|
Pars Distalis, Hyperplasia, Focal | 3 1 1 2 1 3 2 |
Pars Distalis, Hyperplasia | |
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia | 2 1 1 1 1 |
Follicle, Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3 3 3 3 3 3 3 3 3 3 3 3 3 |
Hypospermia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 3 2 2 3 |
Hyperplasia | 2 |
Inflammation, Chronic | 2 2 2 2 2 3 3 2 2 |
Inflammation, Suppurative | 3 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 2 2 2 2 2 2 2 2 2 2 2 |
Hemorrhage | |
Inflammation, Suppurative | 1 2 3 1 3 4 1 4 3 1 3 2 3 1 3 3 1|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 7| 3| 4| 7| 7| 7| 4| 6| 6| 4| 6| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 6| 6| 4|
DAY ON TEST | 7| 3| 0| 9| 3| 3| 3| 5| 0| 0| 9| 2| 3| 4| 2| 3| 0| 2| 3| 9| 3| 3| 0| 4| 7|
| 8| 0| 3| 9| 1| 0| 0| 0| 7| 7| 9| 6| 1| 9| 3| 1| 1| 7| 0| 8| 1| 0| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.3% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Interstitial Cell, Hyperplasia | 1 2 1 3 |
Seminiferous Tubule, Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 2 |
Myelofibrosis | 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Mediastinal, Hemorrhage | 3 3 4|
Mediastinal, Pigmentation | 2 3 3 |
Pancreatic, Hemorrhage | 4 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3|
Ectasia | 2 |
Hemorrhage | 2 1 |
Hyperplasia, Lymphoid | |
Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 3 3 3 2 |
Hematopoietic Cell Proliferation | 1 3 2 4 |
Hemorrhage | |
Pigmentation, Hemosiderin | |
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 3 3 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 3 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 7| 3| 4| 7| 7| 7| 4| 6| 6| 4| 6| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 6| 6| 4|
DAY ON TEST | 7| 3| 0| 9| 3| 3| 3| 5| 0| 0| 9| 2| 3| 4| 2| 3| 0| 2| 3| 9| 3| 3| 0| 4| 7|
| 8| 0| 3| 9| 1| 0| 0| 0| 7| 7| 9| 6| 1| 9| 3| 1| 1| 7| 0| 8| 1| 0| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.3% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X 4 4 |
Hydrocephalus | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2|
Foreign Body | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 1 |
Inflammation, Subacute | |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X |
Foreign Body | 2 |
Fungus | 2 |
Mucosa, Hyperplasia | 2 2 1 2 |
Mucosa, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Suppurative | 1 1 |
Mineralization | |
Nephropathy | 3 3 3 3 3 3 1 1 1 2 2 2 1 1 2 2 2 2 3 3 2 3 3 1|
Papilla, Inflammation, Suppurative | |
Papilla, Necrosis | |
Renal Tubule, Atrophy | 3 |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | 1 2 1 1 1 1 1 3 2 1 1 1 1 2 1 2 2 2 2 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 6| 7| 3| 4| 7| 7| 7| 4| 6| 6| 4| 6| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 6| 6| 4|
DAY ON TEST | 7| 3| 0| 9| 3| 3| 3| 5| 0| 0| 9| 2| 3| 4| 2| 3| 0| 2| 3| 9| 3| 3| 0| 4| 7|
| 8| 0| 3| 9| 1| 0| 0| 0| 7| 7| 9| 6| 1| 9| 3| 1| 1| 7| 0| 8| 1| 0| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.3% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 8| 3| 3| 1| 0| 4| 2| 6| 3| 3| 3| 3| 3| 3| 6| 3| 9| 1| 4| 0| 4| 5| 3| 3| 8| |
| 4| 0| 1| 9| 8| 4| 3| 5| 1| 0| 0| 0| 0| 1| 9| 1| 4| 1| 4| 8| 1| 0| 0| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.3% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 2 | 2 2.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X | 20 |
Clear Cell Focus | X X X | 8 |
Degeneration, Cystic | 2 2 | 7 2.0|
Eosinophilic Focus | X X X X X X | 8 |
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | X X X | 4 |
Mixed Cell Focus | X X | 3 |
Bile Duct, Hyperplasia | 2 1 1 1 1 3 3 2 3 2 2 1 3 1 3 1 3 3 3 1 2| 41 2.1|
Centrilobular, Necrosis | 2 | 4 2.8|
Hepatocyte, Hyperplasia, Focal | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 | 2 3.0|
Kupffer Cell, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 13 |
Accessory Spleen | X X | 3 |
Fat, Necrosis | 3 3 2 | 8 2.5|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 1 1 1 3 1 1 1 2 4 1 1 3 2 1 3 2 2 2| 33 1.7|
Acinus, Hyperplasia, Focal | 2 1 2 3 3 | 7 2.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 5 2.2|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 8| 3| 3| 1| 0| 4| 2| 6| 3| 3| 3| 3| 3| 3| 6| 3| 9| 1| 4| 0| 4| 5| 3| 3| 8| |
| 4| 0| 1| 9| 8| 4| 3| 5| 1| 0| 0| 0| 0| 1| 9| 1| 4| 1| 4| 8| 1| 0| 0| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.3% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 3 2 2 3 2 2 1 3 3 3 3 2 3 2 2| 32 2.2|
Thrombosis | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 2 1 2 2| 11 1.5|
Angiectasis | | 1 2.0|
Degeneration, Fatty | 2 1 1 | 5 1.2|
Hyperplasia, Focal | 1 1 1 1 | 6 1.2|
Hypertrophy, Focal | 1 2 | 2 1.5|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 1 2 2 | 12 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 | 2 1.0|
Metaplasia, Hepatocyte | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X X | 5 |
Pars Distalis, Hyperplasia, Focal | 1 1 2 2 | 11 1.7|
Pars Distalis, Hyperplasia | 3 | 1 3.0|
Pars Intermedia, Cyst | X | 1 |
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 2 |
C-Cell, Hyperplasia | 1 1 1 1 1| 10 1.1|
Follicle, Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 3 3 3 3 3 3 3 3 3 3 3 3 3 | 26 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 8| 3| 3| 1| 0| 4| 2| 6| 3| 3| 3| 3| 3| 3| 6| 3| 9| 1| 4| 0| 4| 5| 3| 3| 8| |
| 4| 0| 1| 9| 8| 4| 3| 5| 1| 0| 0| 0| 0| 1| 9| 1| 4| 1| 4| 8| 1| 0| 0| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.3% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hypospermia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 37 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 4 4 3 3 2 2 | 14 2.6|
Hyperplasia | 2 | 2 2.0|
Inflammation, Chronic | 2 3 2 3 2 2 2 2 | 17 2.2|
Inflammation, Suppurative | 3 3 2 3 3 | 9 2.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 3 2 2 2 2 3 2 3 2 2 2 2 2 3 2 2| 28 2.1|
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | 1 3 1 2 2 2 3 2 1 1 2 2| 29 2.1|
Epithelium, Hyperplasia | 1 1 1 1 | 6 1.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 2 3.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 | 1 4.0|
Interstitial Cell, Hyperplasia | 2 2 1 | 7 1.7|
Seminiferous Tubule, Atrophy | 4 3 4| 5 3.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 2 3 | 4 2.3|
Myelofibrosis | 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + +| 22 |
Mediastinal, Hemorrhage | 3 4 | 5 3.4|
Mediastinal, Pigmentation | 3 3 3 3| 7 2.9|
Pancreatic, Hemorrhage | | 1 4.0|
Renal, Pigmentation | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 2 3.0|
Ectasia | 2 2 | 3 2.0|
Hemorrhage | 1 | 3 1.3|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Pigmentation | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 3 | 4 3.0|
Hemorrhage | 2 3 | 3 2.7|
Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 8| 3| 3| 1| 0| 4| 2| 6| 3| 3| 3| 3| 3| 3| 6| 3| 9| 1| 4| 0| 4| 5| 3| 3| 8| |
| 4| 0| 1| 9| 8| 4| 3| 5| 1| 0| 0| 0| 0| 1| 9| 1| 4| 1| 4| 8| 1| 0| 0| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.3% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | 3 2 3 3 2 3 2 | 11 2.6|
Hematopoietic Cell Proliferation | 2 2 2 1 | 8 2.1|
Hemorrhage | 2 | 1 2.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Lymphoid Follicle, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Hyperplasia | 3 2 2 2 2 3 4 | 16 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 2 3.0|
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | | 2 3.0|
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 | 5 3.5|
Hydrocephalus | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 2.0|
Foreign Body | 2| 1 2.0|
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 2 1 1 1 3 | 12 1.3|
Inflammation, Subacute | 3 2 3| 3 2.7|
Metaplasia, Osseous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 8| 3| 3| 1| 0| 4| 2| 6| 3| 3| 3| 3| 3| 3| 6| 3| 9| 1| 4| 0| 4| 5| 3| 3| 8| |
| 4| 0| 1| 9| 8| 4| 3| 5| 1| 0| 0| 0| 0| 1| 9| 1| 4| 1| 4| 8| 1| 0| 0| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.3% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | 2 2 2 | 4 2.0|
Fungus | 4 3 3 3 | 5 3.0|
Mucosa, Hyperplasia | 2 1 2 2 | 8 1.8|
Mucosa, Metaplasia, Squamous | 2 3 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 2 |
Inflammation, Suppurative | 1 | 3 1.0|
Mineralization | 1 | 1 1.0|
Nephropathy | 2 4 1 1 1 1 3 2 3 3 1 2 3 2 2 3 2 2 2 3 3 3 1| 47 2.2|
Papilla, Inflammation, Suppurative | 3 | 1 3.0|
Papilla, Necrosis | 4 | 1 4.0|
Renal Tubule, Atrophy | | 1 3.0|
Renal Tubule, Dilatation | 2 | 1 2.0|
Renal Tubule, Pigmentation | 3 1 2 2 1 1 2 2 2 1 3 3 1 1 1 2 1 1 1 2 1 1 1 3| 48 1.5|
Transitional Epithelium, Hyperplasia | 2 2 2 1 1 1 | 10 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 6| 4| 4| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 7| 9| 9| 0| 3| 0| 8| 3| 7| 8| 8| 3| 3| 3| 3| 2| 3| 5| 2|
| 1| 2| 7| 0| 1| 0| 4| 7| 4| 0| 1| 2| 1| 1| 4| 4| 3| 0| 1| 1| 0| 3| 1| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X|
Clear Cell Focus | X X |
Degeneration, Cystic | 1 1 2 2 1 2 1 |
Eosinophilic Focus | X X X X X |
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 1 3 3 3 1 1 2 2 2 1 3 2 1 3 2 2 1 3 3 4 3 |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Fat, Necrosis | 3 3 2 3 2 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 1 1 1 2 2 2 1 1 2|
Edema | 3 |
Acinus, Cytoplasmic Alteration | 3 |
Acinus, Hyperplasia, Focal | 1 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Ulcer | 4 2 3 4 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Erosion | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 3 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 6| 4| 4| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 7| 9| 9| 0| 3| 0| 8| 3| 7| 8| 8| 3| 3| 3| 3| 2| 3| 5| 2|
| 1| 2| 7| 0| 1| 0| 4| 7| 4| 0| 1| 2| 1| 1| 4| 4| 3| 0| 1| 1| 0| 3| 1| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Subacute | 3 |
Thrombosis | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 1 2 3 2 2 1 2 2 3 1 |
Thrombosis | |
Schwann Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 2 2 |
Angiectasis | 1 1 |
Degeneration, Fatty | 1 3 |
Hyperplasia, Focal | 2 1 1 |
Hypertrophy, Focal | 1 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 2 2 2 2 2 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 1 3 |
Pars Distalis, Hyperplasia | 3 |
Pars Intermedia, Angiectasis | 3 |
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 |
Hypospermia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 2 3 3 3 2 3 3 3|
Hyperplasia | 2 |
Inflammation, Chronic | 2 2 2 2 2 2 2 3 2 |
Inflammation, Suppurative | 3 1 2 3 3 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/18/95
Route: DOSED FEED Time: 17:37:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 6| 4| 4| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 7| 9| 9| 0| 3| 0| 8| 3| 7| 8| 8| 3| 3| 3| 3| 2| 3| 5| 2|
| 1| 2| 7| 0| 1| 0| 4| 7| 4| 0| 1| 2| 1| 1| 4| 4| 3| 0| 1| 1| 0| 3| 1| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Corpora Amylacea | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Suppurative | 1 3 3 2 1 2 1 2 3 1 3 3 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1 |
Seminiferous Tubule, Atrophy | 3 3 4 2 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____