TDMS Study 05184-05 Pathology Tables
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
2 YEAR CHRONIC
Facility: Battelle Northwest
Chemical CAS #: 111-30-8
Lock Date: 07/28/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| 5| 5| 7| 7| 1| 7|
DAY ON TEST | 3| 3| 0| 0| 3| 3| 3| 3| 3| 9| 9| 9| 3| 8| 3| 3| 3| 1| 3| 8| 6| 3| 3| 1| 3|
| 1| 1| 8| 3| 1| 0| 1| 1| 1| 4| 8| 8| 0| 9| 1| 3| 0| 8| 0| 9| 6| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | 1 1 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Basophilic Focus, Multiple | |
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X |
Necrosis | |
Vacuolization Cytoplasmic | 4 4 2|
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 2 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 |
Ulcer | 4 4 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
Degeneration | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
Myocardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| 5| 5| 7| 7| 1| 7|
DAY ON TEST | 3| 3| 0| 0| 3| 3| 3| 3| 3| 9| 9| 9| 3| 8| 3| 3| 3| 1| 3| 8| 6| 3| 3| 1| 3|
| 1| 1| 8| 3| 1| 0| 1| 1| 1| 4| 8| 8| 0| 9| 1| 3| 0| 8| 0| 9| 6| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Vacuolization Cytoplasmic | 3 3 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
__________________________________________________________________________|
Vagina | |
Inflammation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 3 |
Hematopoietic Cell Proliferation | 4 4 |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| 5| 5| 7| 7| 1| 7|
DAY ON TEST | 3| 3| 0| 0| 3| 3| 3| 3| 3| 9| 9| 9| 3| 8| 3| 3| 3| 1| 3| 8| 6| 3| 3| 1| 3|
| 1| 1| 8| 3| 1| 0| 1| 1| 1| 4| 8| 8| 0| 9| 1| 3| 0| 8| 0| 9| 6| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 |
Metaplasia, Squamous | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | 3 |
Subcutaneous Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Hydrocephalus | 2 2 2 2 3 |
__________________________________________________________________________|
Spinal Cord | + |
Neuron, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Epiglottis, Inflammation, Suppurative| 4 |
Glands, Inflammation | 1 1 1 1 1 1 3 2 4 1 |
Squamous Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 4 |
Necrosis | |
Alveolar Epithelium, Hyperplasia | 1 1 1 2 |
Alveolus, Hemorrhage | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 1 2 1 1 3 1 4 1 1 2 1 3 1 |
Alveolus, Inflammation, Suppurative | 2 1 |
Interstitium, Fibrosis | 3 1 1 1 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 2 |
Foreign Body | X |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | |
Nasolacrimal Duct, Inflammation | 3 2 |
Olfactory Epithelium, Degeneration, | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 5| 7| 5| 7| 5| 5| 7| 7| 1| 7|
DAY ON TEST | 3| 3| 0| 0| 3| 3| 3| 3| 3| 9| 9| 9| 3| 8| 3| 3| 3| 1| 3| 8| 6| 3| 3| 1| 3|
| 1| 1| 8| 3| 1| 0| 1| 1| 1| 4| 8| 8| 0| 9| 1| 3| 0| 8| 0| 9| 6| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyaline | 1 1 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Inflammation | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Squamous Epithelium, Hyperplasia | 1 1 |
Squamous Epithelium, Inflammation | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + +|
Cataract | 3|
Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Nephropathy, Chronic | 2 3 2 1 1 2 1 3 3 3 1 1 1 2 2 2 1 1|
Pelvis, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7| |
DAY ON TEST | 6| 8| 8| 3| 5| 3| 3| 3| 2| 3| 6| 5| 8| 3| 3| 3| 3| 1| 7| 3| 8| 3| 3| 4| 3| |
| 0| 2| 0| 1| 1| 1| 1| 1| 2| 1| 6| 0| 9| 0| 0| 0| 1| 2| 4| 1| 0| 8| 1| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Parasite Metazoan | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Parasite Metazoan | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Parasite Metazoan | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X | 1 |
Basophilic Focus, Multiple | X | 1 |
Clear Cell Focus | X X X X X | 6 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 3 |
Necrosis | 3 3 | 2 3.0|
Vacuolization Cytoplasmic | 4 3 | 5 3.4|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 10 |
Fat, Necrosis | 3 3 3 3 2 3 | 9 2.7|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 | 3 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Inflammation, Suppurative | 2 | 3 2.3|
Ulcer | 4 | 3 4.0|
Epithelium, Hyperplasia | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7| |
DAY ON TEST | 6| 8| 8| 3| 5| 3| 3| 3| 2| 3| 6| 5| 8| 3| 3| 3| 3| 1| 7| 3| 8| 3| 3| 4| 3| |
| 0| 2| 0| 1| 1| 1| 1| 1| 2| 1| 6| 0| 9| 0| 0| 0| 1| 2| 4| 1| 0| 8| 1| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Atrium, Thrombosis | 4 | 1 4.0|
Myocardium, Fibrosis | 1 1 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Vacuolization Cytoplasmic | 1 2 3 3 | 7 2.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M M + M + + M + + M M M + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 | 3 3.0|
Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 3 | 3 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Hyperplasia | 3 3 4 4 | 4 3.5|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 4 | 2 3.0|
Bilateral, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7| |
DAY ON TEST | 6| 8| 8| 3| 5| 3| 3| 3| 2| 3| 6| 5| 8| 3| 3| 3| 3| 1| 7| 3| 8| 3| 3| 4| 3| |
| 0| 2| 0| 1| 1| 1| 1| 1| 2| 1| 6| 0| 9| 0| 0| 0| 1| 2| 4| 1| 0| 8| 1| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M M + + + + + + + + + + + + + + + + + + M +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 | 5 2.6|
Hematopoietic Cell Proliferation | | 2 4.0|
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 3 | 2 3.5|
Metaplasia, Squamous | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis | 3 | 2 3.0|
Subcutaneous Tissue, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Hemorrhage | 4 | 3 2.7|
Hydrocephalus | 3 3 3 4 3| 10 2.7|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Neuron, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Foreign Body | X X | 4 |
Epiglottis, Inflammation, Suppurative| | 1 4.0|
Glands, Inflammation | 2 1 1 1 1 2 1 1 2 1 | 20 1.5|
Squamous Epithelium, Hyperplasia | 2 2 1 | 5 2.2|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 5| 7| |
DAY ON TEST | 6| 8| 8| 3| 5| 3| 3| 3| 2| 3| 6| 5| 8| 3| 3| 3| 3| 1| 7| 3| 8| 3| 3| 4| 3| |
| 0| 2| 0| 1| 1| 1| 1| 1| 2| 1| 6| 0| 9| 0| 0| 0| 1| 2| 4| 1| 0| 8| 1| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 4.0|
Necrosis | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | 1 3 1 | 7 1.4|
Alveolus, Hemorrhage | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 1 2 1 1 1 2 1 1 1 1 1 2 1 | 29 1.5|
Alveolus, Inflammation, Suppurative | | 2 1.5|
Interstitium, Fibrosis | 1 1 2 | 9 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Concretion | 2 | 2 2.0|
Foreign Body | X X X X | 5 |
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation | 4 4| 4 3.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 | 4 1.0|
Respiratory Epithelium, Hyperplasia | 3 | 1 3.0|
Respiratory Epithelium, Inflammation | 2 2 3 2 | 5 2.2|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
Squamous Epithelium, Hyperplasia | 2 | 3 1.3|
Squamous Epithelium, Inflammation | 3 1 2 4| 6 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 3.0|
Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Mineralization | | 1 1.0|
Nephropathy, Chronic | 3 2 2 2 1 2 1 3 2 1 2 4 3 3 1 2 2 3 3 4| 38 2.1|
Pelvis, Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 5| 1| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 1| 3| 3| 4| 8| 3| 9| 6| 7| 9| 3| 3| 3| 3| 6| 1| 3| 2| 2|
| 1| 0| 1| 1| 1| 0| 5| 0| 1| 2| 9| 1| 4| 1| 8| 3| 7| 1| 0| 0| 6| 7| 1| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X |
Clear Cell Focus, Multiple | X X |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Granulomatous | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 3 1 3 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 4 3 |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Erosion | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Tongue | |
Hyperkeratosis | |
Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
Degeneration | 4 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
Thrombosis | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 2 |
Myocardium, Fibrosis | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 5| 1| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 1| 3| 3| 4| 8| 3| 9| 6| 7| 9| 3| 3| 3| 3| 6| 1| 3| 2| 2|
| 1| 0| 1| 1| 1| 0| 5| 0| 1| 2| 9| 1| 4| 1| 8| 3| 7| 1| 0| 0| 6| 7| 1| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Vacuolization Cytoplasmic | 2 1 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + M M M + + M + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 4 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Myometrium, Hypertrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 4 3 |
Hematopoietic Cell Proliferation | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 5| 1| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 1| 3| 3| 4| 8| 3| 9| 6| 7| 9| 3| 3| 3| 3| 6| 1| 3| 2| 2|
| 1| 0| 1| 1| 1| 0| 5| 0| 1| 2| 9| 1| 4| 1| 8| 3| 7| 1| 0| 0| 6| 7| 1| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hydrocephalus | 1 4 2 2 1 2 2 |
__________________________________________________________________________|
Spinal Cord | + |
Demyelination | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X |
Glands, Inflammation | 1 1 2 1 1 2 |
Squamous Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 1 1 1 1 1 3 1 1 1 1 1 1|
Alveolus, Inflammation, Suppurative | 1 |
Interstitium, Fibrosis | 1 1 1 1 1 1 1 1|
Venule, Thrombosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 |
Nasolacrimal Duct, Inflammation | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Inflammation | 1 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Squamous Epithelium, Hyperplasia | 2 1 2 2 1|
Squamous Epithelium, Inflammation | 2 1 1 1 1 1 1 1 2 1 1 3 1|
__________________________________________________________________________|
Pleura | |
Hyperplasia, Focal | |
Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
Cataract | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 6| 5| 1| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 1| 3| 3| 4| 8| 3| 9| 6| 7| 9| 3| 3| 3| 3| 6| 1| 3| 2| 2|
| 1| 0| 1| 1| 1| 0| 5| 0| 1| 2| 9| 1| 4| 1| 8| 3| 7| 1| 0| 0| 6| 7| 1| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 3 3 2 2 3 3 1 2 2 1 2 2 1 3 2 1 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 7| 7| 3| |
| 0| 0| 0| 2| 1| 1| 0| 1| 0| 1| 0| 1| 1| 1| 7| 0| 6| 1| 1| 0| 1| 1| 4| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Parasite Metazoan | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Clear Cell Focus | | 4 |
Clear Cell Focus, Multiple | X | 3 |
Hepatodiaphragmatic Nodule | X | 6 |
Inflammation, Granulomatous | | 1 2.0|
Vacuolization Cytoplasmic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 9 |
Fat, Necrosis | 2 2 3 | 9 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 | 4 3.3|
Ulcer | 4 4 | 2 4.0|
Epithelium, Hyperplasia | 4 2 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | +| 1 |
Hyperkeratosis | 3| 1 3.0|
Hyperplasia | 3| 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Degeneration | 1 | 2 2.5|
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 7| 7| 3| |
| 0| 0| 0| 2| 1| 1| 0| 1| 0| 1| 0| 1| 1| 1| 7| 0| 6| 1| 1| 0| 1| 1| 4| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | | 1 2.0|
Myocardium, Fibrosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Vacuolization Cytoplasmic | 2 2 3 | 6 2.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + M + + + M + M + + + + + + M + +| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 4 3 4 | 4 3.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 4| 4 3.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 3 4 | 7 3.6|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cervix, Myometrium, Hypertrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + M + + + M + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 7| 7| 3| |
| 0| 0| 0| 2| 1| 1| 0| 1| 0| 1| 0| 1| 1| 1| 7| 0| 6| 1| 1| 0| 1| 1| 4| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | 2 3 2 3 | 7 2.9|
Hematopoietic Cell Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 | 2 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Hydrocephalus | 2 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
Demyelination | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 3 |
Glands, Inflammation | 2 1 1 1 1 1 1 1 1 2 | 16 1.3|
Squamous Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 1 1 3 | 4 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 1 1 1 2 1 1 1 1| 24 1.2|
Alveolus, Inflammation, Suppurative | | 1 1.0|
Interstitium, Fibrosis | 2 1 1 2 2 | 13 1.2|
Venule, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 3 |
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 1 1 | 3 1.3|
Nasolacrimal Duct, Inflammation | 3 | 2 2.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 | 5 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 0| 3| 3| 3| 3| 3| 7| 7| 3| |
| 0| 0| 0| 2| 1| 1| 0| 1| 0| 1| 0| 1| 1| 1| 7| 0| 6| 1| 1| 0| 1| 1| 4| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Hyperplasia | 2 2 1 2 2 1 | 6 1.7|
Respiratory Epithelium, Inflammation | 1 4 1 2 1 2 | 9 1.7|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 | 1 3.0|
Squamous Epithelium, Hyperplasia | 1 2 1 3 1 1 1 2 2 3 | 15 1.7|
Squamous Epithelium, Inflammation | 2 3 1 1 4 2 1 1 1 2 1 1 2 | 26 1.5|
__________________________________________________________________________|____________|
Pleura | + + | 2 |
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Atrophy | | 1 4.0|
Cataract | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 4 1 2 2 2 3 3 1 3 3 3 2 1 2 2 1 2 1 2 1 1| 42 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 6| 6| 4| 5| 6| 7| 7| 5| 5| 3| 3| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5|
DAY ON TEST | 7| 1| 5| 1| 3| 2| 3| 8| 4| 5| 5| 3| 6| 7| 8| 3| 7| 0| 8| 1| 3| 3| 1| 1| 0|
| 4| 4| 5| 3| 8| 4| 0| 3| 4| 5| 7| 0| 0| 6| 9| 0| 6| 3| 0| 6| 0| 0| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | |
Basophilic Focus, Multiple | X X |
Clear Cell Focus | X X X|
Clear Cell Focus, Multiple | X X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X|
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Granulomatous | |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation, Suppurative | |
Ulcer | 4 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Fibrosis | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 |
Vacuolization Cytoplasmic | 2 1 1 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 6| 6| 4| 5| 6| 7| 7| 5| 5| 3| 3| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5|
DAY ON TEST | 7| 1| 5| 1| 3| 2| 3| 8| 4| 5| 5| 3| 6| 7| 8| 3| 7| 0| 8| 1| 3| 3| 1| 1| 0|
| 4| 4| 5| 3| 8| 4| 0| 3| 4| 5| 7| 0| 0| 6| 9| 0| 6| 3| 0| 6| 0| 0| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 4 2 |
__________________________________________________________________________|
Oviduct | + |
Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hydrometra | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 3 2 1 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 6| 6| 4| 5| 6| 7| 7| 5| 5| 3| 3| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5|
DAY ON TEST | 7| 1| 5| 1| 3| 2| 3| 8| 4| 5| 5| 3| 6| 7| 8| 3| 7| 0| 8| 1| 3| 3| 1| 1| 0|
| 4| 4| 5| 3| 8| 4| 0| 3| 4| 5| 7| 0| 0| 6| 9| 0| 6| 3| 0| 6| 0| 0| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Hair Follicle, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 4 3 1 2|
Hydrocephalus | 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Epiglottis, Inflammation, Suppurative| |
Glands, Inflammation | 1 1 1 1 1 2 1 2 |
Squamous Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 1 |
Alveolus, Hemorrhage | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 2 1 1 3 3 1 1 2 2 1|
Interstitium, Fibrosis | 2 1 1 2 1 1 2 2 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 1 1 1 |
Nasolacrimal Duct, Inflammation | 4 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 1 1 1 1 |
Olfactory Epithelium, Inflammation | |
Respiratory Epithelium, Hyperplasia | 2 2 2 2 2 2 3 2 2 2 |
Respiratory Epithelium, Inflammation | 3 2 2 1 4 2 3 2 1 1 3 4 3 2 1 2 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 2 2 2 1 2 2 |
Septum, Respiratory Epithelium, Ulcer| 4 |
Squamous Epithelium, Hyperplasia | 3 2 2 3 2 1 2 1 3 2 1 3 3 3 3 2 2 3 |
Squamous Epithelium, Inflammation | 4 3 2 2 3 1 2 1 4 1 4 3 1 1 4 4 4 3 1 2 2 3 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 6| 6| 4| 5| 6| 7| 7| 5| 5| 3| 3| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 5|
DAY ON TEST | 7| 1| 5| 1| 3| 2| 3| 8| 4| 5| 5| 3| 6| 7| 8| 3| 7| 0| 8| 1| 3| 3| 1| 1| 0|
| 4| 4| 5| 3| 8| 4| 0| 3| 4| 5| 7| 0| 0| 6| 9| 0| 6| 3| 0| 6| 0| 0| 9| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 1 3 2 1 2 1 3 2 2 2 1 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 5| 7| 6| 7| 5| 6| 7| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| |
DAY ON TEST | 7| 0| 3| 1| 3| 6| 3| 3| 3| 3| 5| 5| 3| 1| 6| 3| 3| 4| 3| 3| 1| 3| 3| 7| 3| |
| 4| 9| 0| 1| 0| 9| 3| 0| 4| 1| 8| 4| 0| 7| 2| 1| 1| 3| 3| 0| 5| 0| 8| 6| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.0|
Basophilic Focus | X| 1 |
Basophilic Focus, Multiple | | 2 |
Clear Cell Focus | X| 4 |
Clear Cell Focus, Multiple | | 2 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | X | 3 |
__________________________________________________________________________|____________|
Mesentery | + + + + +| 7 |
Inflammation, Granulomatous | 3 | 1 3.0|
Fat, Necrosis | 2 2 4 3 3| 7 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 | 3 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 3.0|
Inflammation, Suppurative | 2 3 | 2 2.5|
Ulcer | 4 | 2 4.0|
Epithelium, Hyperplasia | 1 3 | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 4.0|
Inflammation, Suppurative | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Fibrosis | 2 1 | 4 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 5| 7| 6| 7| 5| 6| 7| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| |
DAY ON TEST | 7| 0| 3| 1| 3| 6| 3| 3| 3| 3| 5| 5| 3| 1| 6| 3| 3| 4| 3| 3| 1| 3| 3| 7| 3| |
| 4| 9| 0| 1| 0| 9| 3| 0| 4| 1| 8| 4| 0| 7| 2| 1| 1| 3| 3| 0| 5| 0| 8| 6| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
Vacuolization Cytoplasmic | 3 2 1 1 1 2 1 | 11 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + M M + + + + M + + + + + + + +| 44 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 1 | 3 2.0|
Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 2 3 3 | 4 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 | 4 2.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | +| 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 3 2 | 7 2.6|
__________________________________________________________________________|____________|
Oviduct | | 1 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Hydrometra | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + M + + + + + + + + + + + + +| 48 |
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 5| 7| 6| 7| 5| 6| 7| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| |
DAY ON TEST | 7| 0| 3| 1| 3| 6| 3| 3| 3| 3| 5| 5| 3| 1| 6| 3| 3| 4| 3| 3| 1| 3| 3| 7| 3| |
| 4| 9| 0| 1| 0| 9| 3| 0| 4| 1| 8| 4| 0| 7| 2| 1| 1| 3| 3| 0| 5| 0| 8| 6| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Fibrosis | 2 3 1 3 3 | 8 2.3|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hemorrhage | 4 | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 3 | 2 3.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
Hair Follicle, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 | 7 2.1|
Hydrocephalus | 1 2 | 7 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 2 |
Epiglottis, Inflammation, Suppurative| 2 1 | 2 1.5|
Glands, Inflammation | 1 1 2 2 1 1 1 1 2 1| 18 1.3|
Squamous Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Alveolus, Hemorrhage | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 1 1 2 3 1 2 1 1 | 22 1.6|
Interstitium, Fibrosis | 2 1 1 1 1 1 | 17 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 5| 7| 6| 7| 5| 6| 7| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| |
DAY ON TEST | 7| 0| 3| 1| 3| 6| 3| 3| 3| 3| 5| 5| 3| 1| 6| 3| 3| 4| 3| 3| 1| 3| 3| 7| 3| |
| 4| 9| 0| 1| 0| 9| 3| 0| 4| 1| 8| 4| 0| 7| 2| 1| 1| 3| 3| 0| 5| 0| 8| 6| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 2 2 | 5 1.4|
Nasolacrimal Duct, Inflammation | 2 | 2 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 1 | 12 1.1|
Olfactory Epithelium, Inflammation | 3 | 1 3.0|
Respiratory Epithelium, Hyperplasia | 2 1 1 2 1 | 15 1.9|
Respiratory Epithelium, Inflammation | 1 3 3 2 2 4 1 1 1| 26 2.1|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 1 | 11 1.6|
Septum, Respiratory Epithelium, Ulcer| | 1 4.0|
Squamous Epithelium, Hyperplasia | 2 1 1 2 2 2 2 1 2 1 2 | 29 2.0|
Squamous Epithelium, Inflammation | 1 2 1 2 1 1 1 3 2 1 4 1 1 2 1 4 1 1 4 | 42 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 3 2 2 2 1 1 2 1 2 1 2 2 1 2 4 2 2 4 1 2| 37 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 4| 5| 4| 1| 7| 7| 7| 3| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 5| 0|
DAY ON TEST | 3| 3| 1| 3| 1| 3| 6| 7| 1| 3| 3| 3| 7| 0| 1| 1| 0| 3| 6| 3| 1| 3| 3| 1| 3|
| 0| 0| 6| 0| 4| 2| 9| 4| 3| 1| 1| 0| 5| 8| 8| 7| 2| 0| 7| 0| 2| 0| 0| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Basophilic Focus, Multiple | X 1 |
Clear Cell Focus | X X |
Clear Cell Focus, Multiple | X |
Hepatodiaphragmatic Nodule | X X |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Suppurative | 1 2 1 |
Ulcer | 4 4 |
Epithelium, Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Vacuolization Cytoplasmic | 1 2 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 4| 5| 4| 1| 7| 7| 7| 3| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 5| 0|
DAY ON TEST | 3| 3| 1| 3| 1| 3| 6| 7| 1| 3| 3| 3| 7| 0| 1| 1| 0| 3| 6| 3| 1| 3| 3| 1| 3|
| 0| 0| 6| 0| 4| 2| 9| 4| 3| 1| 1| 0| 5| 8| 8| 7| 2| 0| 7| 0| 2| 0| 0| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M + + M M + + M + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
Cyst, Multiple | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + M + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 3 |
Hemorrhage | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 4| 5| 4| 1| 7| 7| 7| 3| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 5| 0|
DAY ON TEST | 3| 3| 1| 3| 1| 3| 6| 7| 1| 3| 3| 3| 7| 0| 1| 1| 0| 3| 6| 3| 1| 3| 3| 1| 3|
| 0| 0| 6| 0| 4| 2| 9| 4| 3| 1| 1| 0| 5| 8| 8| 7| 2| 0| 7| 0| 2| 0| 0| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Sternum, Cyst | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | 2 |
__________________________________________________________________________|
Spinal Cord | + |
Demyelination | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X|
Epiglottis, Inflammation, Suppurative| 2 |
Epiglottis, Metaplasia, Squamous | |
Glands, Inflammation | 2 2 1 1 1 2 2 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 1 1 1 |
Alveolus, Emphysema | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 4 2 1 2 1 1 2 2 1 1 1 1 1 1 1 2 1 |
Alveolus, Inflammation, Suppurative | 1 |
Interstitium, Fibrosis | 1 3 2 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 3 1 2 |
Nasolacrimal Duct, Inflammation | |
Olfactory Epithelium, Atrophy | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 2 2 1 2 3 2 2 2 2 1 2 1 1 |
Respiratory Epithelium, Inflammation | 3 2 2 2 3 4 3 3 1 1 3 3 2 3 3 3 1 1 2 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 2 2 2 2 3 3 |
Squamous Epithelium, Hyperplasia | 2 2 3 2 3 3 3 3 2 2 3 3 4 1 3 4 3 3 2 2 2|
Squamous Epithelium, Inflammation | 3 2 4 2 4 2 4 4 4 2 3 1 2 4 4 1 4 4 4 3 1 2 3 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 4| 5| 4| 1| 7| 7| 7| 3| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 5| 0|
DAY ON TEST | 3| 3| 1| 3| 1| 3| 6| 7| 1| 3| 3| 3| 7| 0| 1| 1| 0| 3| 6| 3| 1| 3| 3| 1| 3|
| 0| 0| 6| 0| 4| 2| 9| 4| 3| 1| 1| 0| 5| 8| 8| 7| 2| 0| 7| 0| 2| 0| 0| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | |
Nephropathy, Chronic | 1 4 2 1 1 1 1 1 2 2 1 3 1 3 2 1 1 2 1 |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 7| 4| 6| 1| 7| 1| 6| 5| 6| 6| 4| 2| 7| 7| 5| 6| 6| 6| 7| 6| |
DAY ON TEST | 3| 2| 1| 3| 3| 1| 7| 8| 0| 3| 0| 5| 8| 4| 5| 6| 5| 1| 2| 2| 5| 7| 9| 3| 5| |
| 0| 8| 3| 1| 1| 6| 4| 0| 8| 0| 6| 4| 3| 1| 4| 3| 3| 7| 1| 8| 4| 7| 8| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Diverticulum | | 1 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Parasite Metazoan | | 3 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Basophilic Focus, Multiple | | 2 1.0|
Clear Cell Focus | X | 3 |
Clear Cell Focus, Multiple | | 1 |
Hepatodiaphragmatic Nodule | X | 3 |
Vacuolization Cytoplasmic | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 3 | 3 2.7|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 3 1 2 | 4 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Inflammation, Suppurative | 3 | 4 1.8|
Ulcer | | 2 4.0|
Epithelium, Hyperplasia | 3 2 | 5 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Degeneration | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Fibrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 7| 4| 6| 1| 7| 1| 6| 5| 6| 6| 4| 2| 7| 7| 5| 6| 6| 6| 7| 6| |
DAY ON TEST | 3| 2| 1| 3| 3| 1| 7| 8| 0| 3| 0| 5| 8| 4| 5| 6| 5| 1| 2| 2| 5| 7| 9| 3| 5| |
| 0| 8| 3| 1| 1| 6| 4| 0| 8| 0| 6| 4| 3| 1| 4| 3| 3| 7| 1| 8| 4| 7| 8| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hemorrhage | | 1 1.0|
Vacuolization Cytoplasmic | 1 2 2 3 1 | 9 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + M M M M M M + + M + + + + + + + + +| 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Cyst | 2 2 | 2 2.0|
Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 4 3 1 3 3 | 7 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 4 | 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 2 4.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Cyst | 2 | 3 2.3|
Cyst, Multiple | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + M M + + M + + + M M + M + + + + + +| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Fibrosis | 3 3 3 | 4 3.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 7| 4| 6| 1| 7| 1| 6| 5| 6| 6| 4| 2| 7| 7| 5| 6| 6| 6| 7| 6| |
DAY ON TEST | 3| 2| 1| 3| 3| 1| 7| 8| 0| 3| 0| 5| 8| 4| 5| 6| 5| 1| 2| 2| 5| 7| 9| 3| 5| |
| 0| 8| 3| 1| 1| 6| 4| 0| 8| 0| 6| 4| 3| 1| 4| 3| 3| 7| 1| 8| 4| 7| 8| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sternum, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 2 3 | 3 2.7|
Hydrocephalus | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + | 4 |
Demyelination | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Foreign Body | X X | 6 |
Epiglottis, Inflammation, Suppurative| 2 4 2 2 | 5 2.4|
Epiglottis, Metaplasia, Squamous | 2 | 1 2.0|
Glands, Inflammation | 1 3 2 2 2 1 2 1 1| 19 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + I + + + + + + + + +| 49 |
Inflammation, Chronic | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 4 | 4 1.8|
Alveolus, Emphysema | 1 | 2 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 3 2 3 3 1 1 2 3 1 2 1 1 2 2 1| 35 1.6|
Alveolus, Inflammation, Suppurative | | 1 1.0|
Interstitium, Fibrosis | 1 1 2 2 1 2 2 2 1 2 2 1| 24 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 1 2 1 1| 8 1.6|
Nasolacrimal Duct, Inflammation | 2 | 1 2.0|
Olfactory Epithelium, Atrophy | 2 | 2 2.0|
Olfactory Epithelium, Degeneration, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 7| 4| 6| 1| 7| 1| 6| 5| 6| 6| 4| 2| 7| 7| 5| 6| 6| 6| 7| 6| |
DAY ON TEST | 3| 2| 1| 3| 3| 1| 7| 8| 0| 3| 0| 5| 8| 4| 5| 6| 5| 1| 2| 2| 5| 7| 9| 3| 5| |
| 0| 8| 3| 1| 1| 6| 4| 0| 8| 0| 6| 4| 3| 1| 4| 3| 3| 7| 1| 8| 4| 7| 8| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hyaline | 1 1 1 1 1 1 1 | 15 1.1|
Respiratory Epithelium, Hyperplasia | 2 3 1 2 1 3 2 2 2 2 3 2 2 2 2 2| 29 1.9|
Respiratory Epithelium, Inflammation | 3 2 2 2 3 3 4 2 2 2 3 2 3 1 4 3 3 3 3 3 2 2| 42 2.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 3 3 2 2 1 2 2 2 | 16 2.3|
Squamous Epithelium, Hyperplasia | 3 3 3 2 3 4 2 4 4 2 3 3 3 2 3 3 3 2 3 3 2 2 3 3| 45 2.7|
Squamous Epithelium, Inflammation | 4 3 4 2 4 4 4 4 4 3 4 4 4 2 4 4 4 3 4 4 3 3 4 2| 48 3.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Nephropathy, Chronic | 1 2 4 1 1 2 3 2 3 1 2 1 1 2| 33 1.7|
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 5| 6| 7| 1| 4| 7| 7| 3| 4| 6| 7| 5| 7| 5| 5| 5| 6| 7| 6| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 4| 1| 0| 1| 9| 0| 2| 9| 9| 1| 2| 0| 0| 5| 5| 8| 0| 1| 3| 2| 2| 5| 2| 8| 8|
| 4| 2| 8| 7| 5| 8| 9| 2| 8| 2| 9| 2| 2| 6| 5| 0| 1| 7| 7| 9| 9| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | 2 |
Muscularis, Mineralization | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | 1 1 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Focal, Suppurative | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Suppurative | |
Necrosis | |
Thrombosis | 4 |
Vacuolization Cytoplasmic | 4 3 3 3 3 3 |
Bile Duct, Hyperplasia | 2 |
Hepatocyte, Degeneration, Focal | 2 3|
Hepatocyte, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 4 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
Acinus, Atrophy | 1 3 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 1 |
Mineralization | 4 3|
Ulcer | 4 4 |
Epithelium, Hyperplasia | 3 4 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Epithelium, Mineralization | 1 3 3 3 3 3|
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
Degeneration | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 5| 6| 7| 1| 4| 7| 7| 3| 4| 6| 7| 5| 7| 5| 5| 5| 6| 7| 6| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 4| 1| 0| 1| 9| 0| 2| 9| 9| 1| 2| 0| 0| 5| 5| 8| 0| 1| 3| 2| 2| 5| 2| 8| 8|
| 4| 2| 8| 7| 5| 8| 9| 2| 8| 2| 9| 2| 2| 6| 5| 0| 1| 7| 7| 9| 9| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
Mineralization | 4 4 4 4|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 3 4 4|
Atrium, Thrombosis | 2 4 |
Myocardium, Fibrosis | 1 4 2 3 1 1 1 2 4|
Valve, Thrombosis | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Vacuolization Cytoplasmic | 2 2 2 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 1 1 1|
Bilateral, Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + M + M + + + + + + + + + + +|
Hyperplasia | 2 2 2 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 4|
Hemorrhage | |
Pars Distalis, Hyperplasia | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation | 3 |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 2 2 1 |
Germinal Epithelium, Atrophy | 4 4 4 4 4 3 3 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 5| 6| 7| 1| 4| 7| 7| 3| 4| 6| 7| 5| 7| 5| 5| 5| 6| 7| 6| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 4| 1| 0| 1| 9| 0| 2| 9| 9| 1| 2| 0| 0| 5| 5| 8| 0| 1| 3| 2| 2| 5| 2| 8| 8|
| 4| 2| 8| 7| 5| 8| 9| 2| 8| 2| 9| 2| 2| 6| 5| 0| 1| 7| 7| 9| 9| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 2 2 3 3 3|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + I + + + + + + + + + + M + M + M + M M + + + M|
Fibrosis | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + M M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + + + + I + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 4 3 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + I + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tibia, Fracture | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hydrocephalus | 4 4 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Epiglottis, Inflammation, Suppurative| 2 |
Glands, Inflammation | 1 1 1 2 1 1 1 1 1 2 2|
Squamous Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 2 4 2 |
Alveolus, Emphysema | 4 |
Alveolus, Hemorrhage | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 1 2 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 5| 6| 7| 1| 4| 7| 7| 3| 4| 6| 7| 5| 7| 5| 5| 5| 6| 7| 6| 7| 7| 6| 7| 6| 6|
DAY ON TEST | 4| 1| 0| 1| 9| 0| 2| 9| 9| 1| 2| 0| 0| 5| 5| 8| 0| 1| 3| 2| 2| 5| 2| 8| 8|
| 4| 2| 8| 7| 5| 8| 9| 2| 8| 2| 9| 2| 2| 6| 5| 0| 1| 7| 7| 9| 9| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Mineralization | 2 3|
Interstitium, Fibrosis | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 |
Olfactory Epithelium, Foreign Body | X|
Olfactory Epithelium, Inflammation | 4|
Respiratory Epithelium, Hyperplasia | 1 1 |
Respiratory Epithelium, Inflammation | 1 2 3 2 2 3 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
Squamous Epithelium, Foreign Body | |
Squamous Epithelium, Hyperplasia | |
Squamous Epithelium, Inflammation | 1 |
__________________________________________________________________________|
Pleura | + + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 3 4|
Nephropathy, Chronic | 3 4 3 2 4 4 3 3 4 2 4 4 4 4 3 4 4 2 4 4 4 4|
Papilla, Transitional Epithelium, | |
Hyperplasia | |
Pelvis, Dilatation | |
Pelvis, Inflammation, Suppurative | |
Renal Tubule, Atrophy | |
Renal Tubule, Atypia Cellular | 3 |
Renal Tubule, Regeneration | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6| |
DAY ON TEST | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5| |
| 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 4.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 | 2 2.0|
Muscularis, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + A + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | | 3 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + A + + + + + + + + A + + + + + + + +| 46 |
Inflammation, Focal, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 2 2.0|
Basophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Suppurative | 1 | 1 1.0|
Necrosis | 2| 1 2.0|
Thrombosis | | 1 4.0|
Vacuolization Cytoplasmic | 3| 7 3.1|
Bile Duct, Hyperplasia | 3 3 | 3 2.7|
Hepatocyte, Degeneration, Focal | 3 | 3 2.7|
Hepatocyte, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + +| 10 |
Fat, Necrosis | 2 2 2 2| 8 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Hemorrhage | 3 | 1 3.0|
Acinus, Atrophy | 3 3 2 2 2 2 | 9 2.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 3 3 2 2 2 4| 8 2.5|
Mineralization | 2 3 | 4 3.0|
Ulcer | 4 4 4| 5 4.0|
Epithelium, Hyperplasia | 2 2 2 2 1 2 3| 11 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 3 | 1 3.0|
Epithelium, Mineralization | 2 3 3 | 9 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6| |
DAY ON TEST | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5| |
| 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Inflammation | | 1 4.0|
Mineralization | 3 4 4 | 7 3.9|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 4 | 6 3.7|
Atrium, Thrombosis | 2 | 3 2.7|
Myocardium, Fibrosis | 1 2 3 | 12 2.1|
Valve, Thrombosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Vacuolization Cytoplasmic | 1 1 2 | 9 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 1 2 4 2 4| 12 2.3|
Bilateral, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + M + + + + + + + + + + + + M + + M +| 42 |
Hyperplasia | 3 2 4| 7 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 3.0|
Hemorrhage | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 2 4 3 1 | 6 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 2 3 | 6 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Spermatocele | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6| |
DAY ON TEST | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5| |
| 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 3 3 4 3 3 | 5 3.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 4 4 4 2 4 | 9 3.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 4 4 | 3 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arteriole, Inflammation | | 1 3.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 4 1.8|
Germinal Epithelium, Atrophy | 3 3 3 4 | 12 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 7 2.7|
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + M + + + + + M + + + + + + + +| 39 |
Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 3 3 3 3 2 3 2 3 | 15 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Galactocele | 2 | 2 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X X | 2 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tibia, Fracture | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6| |
DAY ON TEST | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5| |
| 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage | 1 1 | 3 1.3|
Hydrocephalus | 2 4 | 5 3.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Epiglottis, Inflammation, Suppurative| | 1 2.0|
Glands, Inflammation | 1 1 1 1 4 2 1 2 2 1 1 1 2 1 1 1 1| 28 1.4|
Squamous Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 2 4 1 1 4 | 9 2.3|
Alveolus, Emphysema | | 1 4.0|
Alveolus, Hemorrhage | 1 3 | 3 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 1 1 1 2 3 1 1 1 1 1 | 23 1.3|
Alveolus, Mineralization | 3 4 | 4 3.0|
Interstitium, Fibrosis | 1 1 1 1 2 1 | 8 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 2 |
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 | 4 1.0|
Olfactory Epithelium, Foreign Body | | 1 |
Olfactory Epithelium, Inflammation | | 1 4.0|
Respiratory Epithelium, Hyperplasia | 4 2 2 2 | 6 2.0|
Respiratory Epithelium, Inflammation | 1 4 2 3 1 2 2 1 2 3 | 17 2.1|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
Squamous Epithelium, Foreign Body | X | 1 |
Squamous Epithelium, Hyperplasia | 2 2 2 | 3 2.0|
Squamous Epithelium, Inflammation | 2 3 1 3 2 | 6 2.0|
__________________________________________________________________________|____________|
Pleura | | 2 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 5| 6| 5| 6| 7| 7| 6| |
DAY ON TEST | 2| 0| 5| 9| 1| 5| 5| 2| 2| 2| 1| 3| 2| 9| 0| 8| 7| 2| 8| 0| 4| 3| 1| 2| 5| |
| 9| 2| 2| 4| 7| 2| 2| 9| 9| 9| 4| 7| 9| 4| 2| 3| 6| 9| 3| 2| 3| 8| 7| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 3 3.7|
Nephropathy, Chronic | 4 4 2 4 4 4 4 4 4 3 4 3 2 4 2 4 3 2 4 4 4| 43 3.5|
Papilla, Transitional Epithelium, | | |
Hyperplasia | 4 | 1 4.0|
Pelvis, Dilatation | 4 | 1 4.0|
Pelvis, Inflammation, Suppurative | 4 | 1 4.0|
Renal Tubule, Atrophy | 4 | 1 4.0|
Renal Tubule, Atypia Cellular | | 1 3.0|
Renal Tubule, Regeneration | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 2| 2| 4| 2| 2| 2| 0| 5| 5| 3| 1| 2| 2| 1| 2| 6| 1| 9| 3| 1| 2| 2| 2| 7| 8|
| 4| 5| 7| 9| 9| 1| 8| 4| 0| 3| 3| 9| 9| 2| 9| 6| 6| 4| 2| 2| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | X |
Clear Cell Focus | X X X |
Hepatodiaphragmatic Nodule | X |
Necrosis | 4 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Necrosis | 3 3 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 3 |
Mineralization | 4 |
Ulcer | 4 4 4 4 |
Epithelium, Hyperplasia | 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2|
Ulcer | 4 4 |
Epithelium, Mineralization | 4 |
__________________________________________________________________________|
Tongue | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
Atrium, Thrombosis | |
Myocardium, Fibrosis | 2 1 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 2| 2| 4| 2| 2| 2| 0| 5| 5| 3| 1| 2| 2| 1| 2| 6| 1| 9| 3| 1| 2| 2| 2| 7| 8|
| 4| 5| 7| 9| 9| 1| 8| 4| 0| 3| 3| 9| 9| 2| 9| 6| 6| 4| 2| 2| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + M + M M + + M M + + + M + + + + + + + + +|
Hyperplasia | 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | 2 |
Pars Distalis, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 4 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 4 4 4 4 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | M M + + + + M + + + + + + + + + + M + + + + M + +|
Fibrosis | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 3 3 3 3 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 2| 2| 4| 2| 2| 2| 0| 5| 5| 3| 1| 2| 2| 1| 2| 6| 1| 9| 3| 1| 2| 2| 2| 7| 8|
| 4| 5| 7| 9| 9| 1| 8| 4| 0| 3| 3| 9| 9| 2| 9| 6| 6| 4| 2| 2| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 4 3 |
Hydrocephalus | 3 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Glands, Inflammation | 1 1 1 1 1 2 2 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hemorrhage | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 1 1 3 1 |
Alveolus, Inflammation, Suppurative | 2 |
Alveolus, Metaplasia, Osseous | 1 |
Alveolus, Mineralization | 3 |
Interstitium, Fibrosis | 1 2 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Nasolacrimal Duct, Inflammation | 3 2|
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 1 1 2|
Olfactory Epithelium, Hyperplasia | 2|
Olfactory Epithelium, Inflammation | 3|
Respiratory Epithelium, Hyperplasia | 3 2 |
Respiratory Epithelium, Inflammation | 1 2 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
Squamous Epithelium, Hyperplasia | 2 2 1 2 2 2 |
Squamous Epithelium, Inflammation | 1 1 2 1 2 1 2 1 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 2| 2| 4| 2| 2| 2| 0| 5| 5| 3| 1| 2| 2| 1| 2| 6| 1| 9| 3| 1| 2| 2| 2| 7| 8|
| 4| 5| 7| 9| 9| 1| 8| 4| 0| 3| 3| 9| 9| 2| 9| 6| 6| 4| 2| 2| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 2 |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Mineralization | 4 |
Nephropathy, Chronic | 4 4 4 4 3 4 2 2 4 2 3 4 3 3 2 4 4 4 2 3 4 3 2 4 4|
Papilla, Transitional Epithelium, | |
Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 5| 4| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 7| 4| 7| 5| 6| |
DAY ON TEST | 2| 2| 0| 5| 7| 4| 7| 3| 2| 1| 2| 0| 9| 5| 3| 7| 0| 6| 2| 9| 2| 9| 1| 6| 1| |
| 9| 9| 8| 6| 7| 9| 5| 4| 9| 5| 9| 7| 4| 2| 8| 1| 8| 6| 9| 4| 9| 5| 2| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A A + + + + + + A + + + + + + + + + + + + +| 46 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A A + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A A + + + + + + A + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A A + + + + + + A + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 2 3.5|
Basophilic Focus | | 1 |
Clear Cell Focus | X | 4 |
Hepatodiaphragmatic Nodule | X | 2 |
Necrosis | 4 | 2 4.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Fat, Necrosis | 3 3 | 6 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 4 | 3 2.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 | 3 3.0|
Mineralization | | 1 4.0|
Ulcer | 4 4 4 | 7 4.0|
Epithelium, Hyperplasia | 2 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 2.0|
Ulcer | | 2 4.0|
Epithelium, Mineralization | 4 4 4 4 | 5 4.0|
__________________________________________________________________________|____________|
Tongue | + + | 2 |
Hyperkeratosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 4 4 | 2 4.0|
Mineralization | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 5| 4| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 7| 4| 7| 5| 6| |
DAY ON TEST | 2| 2| 0| 5| 7| 4| 7| 3| 2| 1| 2| 0| 9| 5| 3| 7| 0| 6| 2| 9| 2| 9| 1| 6| 1| |
| 9| 9| 8| 6| 7| 9| 5| 4| 9| 5| 9| 7| 4| 2| 8| 1| 8| 6| 9| 4| 9| 5| 2| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Mineralization | 4 | 2 4.0|
Atrium, Thrombosis | 3 3 | 2 3.0|
Myocardium, Fibrosis | 2 2 2 3 3 1 | 10 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 2 3 1 2 | 6 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 3 2| 9 2.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M M + + + M M + + M + + + + +| 38 |
Hyperplasia | 4 4 3 3 3 3 | 7 3.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 2 2.0|
Pars Distalis, Hyperplasia | 4 4 | 5 3.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 1 4.0|
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Inflammation | 3 | 4 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 4 4 | 9 3.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 3 2 2 | 5 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 5| 4| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 7| 4| 7| 5| 6| |
DAY ON TEST | 2| 2| 0| 5| 7| 4| 7| 3| 2| 1| 2| 0| 9| 5| 3| 7| 0| 6| 2| 9| 2| 9| 1| 6| 1| |
| 9| 9| 8| 6| 7| 9| 5| 4| 9| 5| 9| 7| 4| 2| 8| 1| 8| 6| 9| 4| 9| 5| 2| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + M + + M + + + + + + + + + + + + M| 42 |
Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 3 4 3 2 4 2 3 | 15 3.0|
Hematopoietic Cell Proliferation | 2| 1 2.0|
Hemorrhage | 3 | 1 3.0|
Infarct | 4 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X X | 2 |
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 4 3.5|
Hydrocephalus | 3 2 3 2 | 7 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 2 |
Glands, Inflammation | 1 1 2 1 2 2 1 1 2| 18 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 1 3 1| 3 1.7|
Alveolus, Hemorrhage | 2 4 | 2 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 1 1 1 1 1 1 2 1| 15 1.3|
Alveolus, Inflammation, Suppurative | 1 | 2 1.5|
Alveolus, Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 3| 5| 4| 6| 6| 7| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 6| 7| 4| 7| 5| 6| |
DAY ON TEST | 2| 2| 0| 5| 7| 4| 7| 3| 2| 1| 2| 0| 9| 5| 3| 7| 0| 6| 2| 9| 2| 9| 1| 6| 1| |
| 9| 9| 8| 6| 7| 9| 5| 4| 9| 5| 9| 7| 4| 2| 8| 1| 8| 6| 9| 4| 9| 5| 2| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Mineralization | 4 1 | 3 2.7|
Interstitium, Fibrosis | 1 1 1 1 1 2 1 2 1| 14 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 2 |
Nasolacrimal Duct, Inflammation | 2| 3 2.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 | 8 1.3|
Olfactory Epithelium, Hyperplasia | | 1 2.0|
Olfactory Epithelium, Inflammation | | 1 3.0|
Respiratory Epithelium, Hyperplasia | 2 2 1 | 5 2.0|
Respiratory Epithelium, Inflammation | 1 1 2 1 1 3 | 10 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 2 1.5|
Squamous Epithelium, Hyperplasia | 1 1 1 2 2 | 11 1.6|
Squamous Epithelium, Inflammation | 1 1 2 2 1 1 3 1 | 17 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | 1 | 3 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3 | 2 3.5|
Infarct | 4 | 1 4.0|
Mineralization | | 1 4.0|
Nephropathy, Chronic | 4 4 2 4 2 1 4 3 4 2 4 4 4 4 3 3 4 3 2 3 1 4 2| 48 3.2|
Papilla, Transitional Epithelium, | | |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 4| 6| 5| 7| 6| 7| 6| 7| 6| 7| 5| 6| 3| 6| 6| 7| 5| 6| 5| 7| 7|
DAY ON TEST | 6| 1| 8| 5| 8| 3| 2| 0| 0| 1| 8| 2| 5| 0| 1| 6| 6| 8| 6| 2| 9| 1| 2| 2| 2|
| 1| 7| 7| 2| 1| 8| 6| 8| 8| 6| 8| 9| 6| 5| 2| 4| 5| 2| 6| 6| 3| 7| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Clear Cell Focus | X |
Clear Cell Focus, Multiple | X |
Necrosis | 3 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | + + + +|
Hemorrhage | 3|
Thrombosis | |
Fat, Necrosis | 2 4 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Mineralization | |
Ulcer | 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4 |
Inflammation, Suppurative | 3 |
Epithelium, Mineralization | 2 2|
Epithelium, Necrosis | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Atrium, Thrombosis | 4 |
Myocardium, Fibrosis | 2 2 2 2|
Myocardium, Ventricle, Hypertrophy | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 4| 6| 5| 7| 6| 7| 6| 7| 6| 7| 5| 6| 3| 6| 6| 7| 5| 6| 5| 7| 7|
DAY ON TEST | 6| 1| 8| 5| 8| 3| 2| 0| 0| 1| 8| 2| 5| 0| 1| 6| 6| 8| 6| 2| 9| 1| 2| 2| 2|
| 1| 7| 7| 2| 1| 8| 6| 8| 8| 6| 8| 9| 6| 5| 2| 4| 5| 2| 6| 6| 3| 7| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1|
Vacuolization Cytoplasmic | 2 3 3 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 4 3 1 1|
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 4 3 |
Inflammation, Suppurative | 4 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation | 3 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Germinal Epithelium, Atrophy | 4 3 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + M M + + + + + M + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 4| 6| 5| 7| 6| 7| 6| 7| 6| 7| 5| 6| 3| 6| 6| 7| 5| 6| 5| 7| 7|
DAY ON TEST | 6| 1| 8| 5| 8| 3| 2| 0| 0| 1| 8| 2| 5| 0| 1| 6| 6| 8| 6| 2| 9| 1| 2| 2| 2|
| 1| 7| 7| 2| 1| 8| 6| 8| 8| 6| 8| 9| 6| 5| 2| 4| 5| 2| 6| 6| 3| 7| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 4 4 4 4 4 4 3 3 4 |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 3 1 3 4 4 |
Hydrocephalus | 1 2 3 2 4 |
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Glands, Inflammation | 2 1 1 3 1 2 1 1 3 1 1|
Squamous Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
Alveolar Epithelium, Hyperplasia | 2 1 2 2 |
Alveolus, Hemorrhage | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 3 2 3 4 1 1 1 3 3 |
Alveolus, Metaplasia, Osseous | 4 |
Alveolus, Mineralization | |
Bronchiole, Hyperplasia | 3 |
Bronchiole, Inflammation, Suppurative| |
Interstitium, Fibrosis | 1 1 1 2 3 2 4 1 2 1 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 2 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1|
Olfactory Epithelium, Foreign Body | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 4| 6| 5| 7| 6| 7| 6| 7| 6| 7| 5| 6| 3| 6| 6| 7| 5| 6| 5| 7| 7|
DAY ON TEST | 6| 1| 8| 5| 8| 3| 2| 0| 0| 1| 8| 2| 5| 0| 1| 6| 6| 8| 6| 2| 9| 1| 2| 2| 2|
| 1| 7| 7| 2| 1| 8| 6| 8| 8| 6| 8| 9| 6| 5| 2| 4| 5| 2| 6| 6| 3| 7| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
500 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Inflammation | |
Respiratory Epithelium, Hyperplasia | 1 2 4 3 2 2 1 2 |
Respiratory Epithelium, Inflammation | 1 2 2 2 1 1 4 2 2 2 4 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 3 2 3 1 |
Squamous Epithelium, Hyperplasia | 2 1 2 2 2 3 1 2 2 2 2 2 3 2 2 2 3 2 2 2 2 1|
Squamous Epithelium, Inflammation | 2 1 2 2 3 3 2 2 4 2 2 2 4 3 2 2 3 4 3 3 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Nephropathy, Chronic | 2 4 4 3 4 3 3 4 4 3 3 1 3 3 3 1 4 4 2 3 1 4 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 5| 6| 6| 3| 6| 6| 5| 6| 6| |
DAY ON TEST | 1| 3| 2| 2| 1| 0| 2| 8| 5| 2| 2| 2| 5| 2| 8| 2| 2| 8| 6| 9| 0| 8| 8| 4| 3| |
| 2| 3| 1| 9| 1| 2| 9| 9| 4| 5| 9| 9| 2| 9| 6| 9| 4| 9| 1| 3| 9| 8| 1| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + A + + + + + + + +| 48 |
Mineralization | 4| 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Parasite Metazoan | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + A + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | 1 1 1 1 1 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + A + + + + A + A + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + A + + + + A + A + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Clear Cell Focus | | 1 |
Clear Cell Focus, Multiple | X | 2 |
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic | 3 | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + +| 6 |
Hemorrhage | | 1 3.0|
Thrombosis | 4 | 1 4.0|
Fat, Necrosis | 4 3| 5 3.2|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 3 | 3 3.0|
Mineralization | 4| 1 4.0|
Ulcer | 4 4 4 | 4 4.0|
Epithelium, Hyperplasia | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 4.0|
Inflammation, Suppurative | | 1 3.0|
Epithelium, Mineralization | 4| 3 2.7|
Epithelium, Necrosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4| 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 5| 6| 6| 3| 6| 6| 5| 6| 6| |
DAY ON TEST | 1| 3| 2| 2| 1| 0| 2| 8| 5| 2| 2| 2| 5| 2| 8| 2| 2| 8| 6| 9| 0| 8| 8| 4| 3| |
| 2| 3| 1| 9| 1| 2| 9| 9| 4| 5| 9| 9| 2| 9| 6| 9| 4| 9| 1| 3| 9| 8| 1| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Mineralization | 4| 1 4.0|
Atrium, Thrombosis | | 1 4.0|
Myocardium, Fibrosis | 3 3 2 2 | 8 2.3|
Myocardium, Ventricle, Hypertrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Vacuolization Cytoplasmic | 3 2 3 2| 8 2.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 3 3 | 6 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + M + M + + + M + + + + + + + + +| 45 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Hemorrhage | 4 4 | 3 4.0|
Pars Distalis, Hyperplasia | 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 2 | 8 2.1|
Follicular Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Hyperplasia | | 2 3.5|
Inflammation, Suppurative | | 3 3.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.0|
Inflammation | 3 2 | 5 2.4|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Interstitial Cell, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 5| 6| 6| 3| 6| 6| 5| 6| 6| |
DAY ON TEST | 1| 3| 2| 2| 1| 0| 2| 8| 5| 2| 2| 2| 5| 2| 8| 2| 2| 8| 6| 9| 0| 8| 8| 4| 3| |
| 2| 3| 1| 9| 1| 2| 9| 9| 4| 5| 9| 9| 2| 9| 6| 9| 4| 9| 1| 3| 9| 8| 1| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 1 2.0|
Germinal Epithelium, Atrophy | 4 4 4 4 4 4 4 4 4| 13 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3| 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + M M + + M + + + + + + + M + + + + +| 40 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 3 2 2 3 3| 16 3.4|
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 2 1 2 | 5 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 3 4 4 | 10 3.2|
Hydrocephalus | 3 3 3 3 3 | 10 2.7|
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 3 |
Glands, Inflammation | 2 2 1 1 2 1 2 | 18 1.6|
Squamous Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 4 | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 5| 6| 6| 3| 6| 6| 5| 6| 6| |
DAY ON TEST | 1| 3| 2| 2| 1| 0| 2| 8| 5| 2| 2| 2| 5| 2| 8| 2| 2| 8| 6| 9| 0| 8| 8| 4| 3| |
| 2| 3| 1| 9| 1| 2| 9| 9| 4| 5| 9| 9| 2| 9| 6| 9| 4| 9| 1| 3| 9| 8| 1| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
500 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Hemorrhage | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 2 | 14 2.1|
Alveolus, Metaplasia, Osseous | | 1 4.0|
Alveolus, Mineralization | 4| 1 4.0|
Bronchiole, Hyperplasia | | 1 3.0|
Bronchiole, Inflammation, Suppurative| 4 | 1 4.0|
Interstitium, Fibrosis | 2 2 1 1 2| 17 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 1 2 2| 6 1.8|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 1 1 | 9 1.1|
Olfactory Epithelium, Foreign Body | X | 1 |
Olfactory Epithelium, Inflammation | 3 | 1 3.0|
Respiratory Epithelium, Hyperplasia | 2 2 2 1 2 1 2 2 2| 17 1.9|
Respiratory Epithelium, Inflammation | 3 2 3 2 3 2 2 1 3 2 3 4 4| 25 2.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 2 1 2 2| 11 2.0|
Squamous Epithelium, Hyperplasia | 2 3 3 2 3 3 3 2 2 2 3 3 2 2 2 3 2| 39 2.2|
Squamous Epithelium, Inflammation | 3 3 4 3 3 4 4 2 3 3 3 3 3 2 3 1 4 1 4| 41 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | | 2 1.5|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Nephropathy, Chronic | 3 1 3 2 3 3 4 4 3 3 4 4 3 2 3 3 3 4 4 2 2 3 2 3 4| 48 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 2| 4| 7| 1| 1| 7| 1| 4| 6| 0| 7| 7| 6| 6| 6| 0| 1| 7| 7| 5| 6| 7| 5| 7| 6|
DAY ON TEST | 6| 6| 0| 0| 0| 1| 1| 9| 8| 2| 2| 2| 7| 2| 3| 9| 0| 2| 2| 6| 4| 2| 8| 1| 3|
| 2| 8| 8| 6| 5| 2| 1| 2| 9| 3| 9| 9| 3| 5| 8| 9| 0| 9| 9| 4| 6| 1| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + A A + + + + A + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + A A + + + + + + + + + + + + A + + + +|
Diverticulum | X |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + A A + + + + A + + + + + + + A + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + A A + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + A A + + + + A + + + + + + + A + + + +|
Necrosis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + A A + + + + A + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Clear Cell Focus | X|
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | |
Hepatocyte, Degeneration, Focal | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + A A + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + A + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Suppurative | 4 3 |
Ulcer | 4 |
Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + A + + + + + + + + + + + + + + + + + +|
Erosion | |
Epithelium, Mineralization | 4 3 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + + + |
Degeneration | 3 3 3 3 3 3 |
Inflammation | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 4 |
Myocardium, Fibrosis | 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 2| 4| 7| 1| 1| 7| 1| 4| 6| 0| 7| 7| 6| 6| 6| 0| 1| 7| 7| 5| 6| 7| 5| 7| 6|
DAY ON TEST | 6| 6| 0| 0| 0| 1| 1| 9| 8| 2| 2| 2| 7| 2| 3| 9| 0| 2| 2| 6| 4| 2| 8| 1| 3|
| 2| 8| 8| 6| 5| 2| 1| 2| 9| 3| 9| 9| 3| 5| 8| 9| 0| 9| 9| 4| 6| 1| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + M M M M + + + + + M + + + + + + M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 4 4 4 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 4 3 |
Germinal Epithelium, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M M M + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 3 3 3 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 2| 4| 7| 1| 1| 7| 1| 4| 6| 0| 7| 7| 6| 6| 6| 0| 1| 7| 7| 5| 6| 7| 5| 7| 6|
DAY ON TEST | 6| 6| 0| 0| 0| 1| 1| 9| 8| 2| 2| 2| 7| 2| 3| 9| 0| 2| 2| 6| 4| 2| 8| 1| 3|
| 2| 8| 8| 6| 5| 2| 1| 2| 9| 3| 9| 9| 3| 5| 8| 9| 0| 9| 9| 4| 6| 1| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Epiglottis, Inflammation, Suppurative| 1 |
Glands, Inflammation | 2 2 1 1 1 2 2 1 1 1 1 1 1 1|
Squamous Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Alveolar Epithelium, Hyperplasia | 1 1 |
Alveolus, Hemorrhage | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 2 1 1 1 |
Alveolus, Inflammation, Suppurative | 3 |
Alveolus, Mineralization | 3 1 |
Bronchiole, Foreign Body | X |
Interstitium, Fibrosis | 1 1 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 1 1 1|
Olfactory Epithelium, Atrophy | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 1 1 2 1 1 1|
Respiratory Epithelium, Hyperplasia | 2 3 3 1 2 2 3 1 2 1 2 3 2 2 1 |
Respiratory Epithelium, Inflammation | 4 4 3 3 4 4 4 4 4 3 4 2 4 3 3 3 3 3 4 3 4 1 4 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 3 3 1 3 2 2 2 2 3 3 1 3 2 2 1|
Squamous Epithelium, Hyperplasia | 4 3 3 3 3 4 4 4 4 2 3 3 3 3 3 4 2 4 4 2 2 4 3 3|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
_____________________________________________________________________________________________________________________
| 2| 4| 7| 1| 1| 7| 1| 4| 6| 0| 7| 7| 6| 6| 6| 0| 1| 7| 7| 5| 6| 7| 5| 7| 6|
DAY ON TEST | 6| 6| 0| 0| 0| 1| 1| 9| 8| 2| 2| 2| 7| 2| 3| 9| 0| 2| 2| 6| 4| 2| 8| 1| 3|
| 2| 8| 8| 6| 5| 2| 1| 2| 9| 3| 9| 9| 3| 5| 8| 9| 0| 9| 9| 4| 6| 1| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
750 PPB | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Squamous Epithelium, Inflammation | 4 4 4 3 4 4 4 4 4 4 4 3 4 4 4 4 3 3 4 3 2 4 1 4 4|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Nephropathy, Chronic | 2 4 4 4 3 4 4 3 3 4 3 3 3 2 3 2 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + A A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 3| 6| 6| 6| 4| 6| 5| 7| 5| 7| 4| 1| 6| 5| 5| 7| 7| 1| 1| 7| 6| 7| |
DAY ON TEST | 0| 0| 8| 9| 8| 0| 5| 7| 3| 9| 2| 8| 0| 4| 0| 6| 0| 6| 2| 0| 0| 0| 2| 2| 1| |
| 8| 3| 9| 3| 3| 8| 2| 4| 4| 3| 9| 6| 8| 9| 6| 6| 2| 1| 0| 8| 7| 6| 9| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Diverticulum | | 1 |
Parasite Metazoan | 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Parasite Metazoan | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| 44 |
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 | 3 1.7|
Clear Cell Focus | | 1 |
Vacuolization Cytoplasmic | 3 | 1 3.0|
Bile Duct, Hyperplasia | 1 2 | 2 1.5|
Hepatocyte, Degeneration, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 7 |
Fat, Necrosis | 2 1 3 4 4 3 | 6 2.8|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Atrophy | 2 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | 4 3 2 | 5 3.2|
Ulcer | 4 | 2 4.0|
Epithelium, Hyperplasia | 3 2 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Erosion | 2 3 | 2 2.5|
Epithelium, Mineralization | 3 4 | 4 3.5|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 8 |
Degeneration | 4 4 | 8 3.3|
Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 4 | 4 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 3| 6| 6| 6| 4| 6| 5| 7| 5| 7| 4| 1| 6| 5| 5| 7| 7| 1| 1| 7| 6| 7| |
DAY ON TEST | 0| 0| 8| 9| 8| 0| 5| 7| 3| 9| 2| 8| 0| 4| 0| 6| 0| 6| 2| 0| 0| 0| 2| 2| 1| |
| 8| 3| 9| 3| 3| 8| 2| 4| 4| 3| 9| 6| 8| 9| 6| 6| 2| 1| 0| 8| 7| 6| 9| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 2 | 4 3.3|
Myocardium, Fibrosis | 2 3 3 3 | 7 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 | 2 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 41 |
Hyperplasia | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Hemorrhage | | 3 4.0|
Pars Distalis, Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 | 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 4 | 3 2.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | 2 2 | 4 2.8|
Germinal Epithelium, Atrophy | 4 4 3 3 3 | 6 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 3| 6| 6| 6| 4| 6| 5| 7| 5| 7| 4| 1| 6| 5| 5| 7| 7| 1| 1| 7| 6| 7| |
DAY ON TEST | 0| 0| 8| 9| 8| 0| 5| 7| 3| 9| 2| 8| 0| 4| 0| 6| 0| 6| 2| 0| 0| 0| 2| 2| 1| |
| 8| 3| 9| 3| 3| 8| 2| 4| 4| 3| 9| 6| 8| 9| 6| 6| 2| 1| 0| 8| 7| 6| 9| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 4 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + +| 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + + M + + + + M + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Fibrosis | 3 3 2 3 3| 9 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 4 | 1 4.0|
Hyperplasia | 3 | 1 3.0|
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Hydrocephalus | 2 3 3 | 5 2.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 2 |
Epiglottis, Inflammation, Suppurative| | 1 1.0|
Glands, Inflammation | 1 2 1 2 3 1 1 1 1 1 1 1| 26 1.3|
Squamous Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | 3 4 | 4 2.3|
Alveolus, Hemorrhage | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 1 2 3 | 11 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 05184-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC GLUTARALDEHYDE Date: 09/14/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:29:41
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 3| 6| 6| 6| 4| 6| 5| 7| 5| 7| 4| 1| 6| 5| 5| 7| 7| 1| 1| 7| 6| 7| |
DAY ON TEST | 0| 0| 8| 9| 8| 0| 5| 7| 3| 9| 2| 8| 0| 4| 0| 6| 0| 6| 2| 0| 0| 0| 2| 2| 1| |
| 8| 3| 9| 3| 3| 8| 2| 4| 4| 3| 9| 6| 8| 9| 6| 6| 2| 1| 0| 8| 7| 6| 9| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
750 PPB | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Inflammation, Suppurative | 2 | 2 2.5|
Alveolus, Mineralization | 3 3 | 4 2.5|
Bronchiole, Foreign Body | | 1 |
Interstitium, Fibrosis | 1 2 | 7 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 2 1 1 | 6 1.2|
Olfactory Epithelium, Atrophy | 3 2 2 | 4 2.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 1 1 | 14 1.1|
Respiratory Epithelium, Hyperplasia | 2 2 2 3 2 2 1 2 2 2 2 2 2 1 1 1 2 2 2 1| 35 1.9|
Respiratory Epithelium, Inflammation | 3 3 4 4 2 3 3 4 3 3 3 3 3 2 3 3 3 3 3| 43 3.2|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 2 2 3 2 3 2 1| 24 2.2|
Squamous Epithelium, Hyperplasia | 4 2 2 3 3 3 3 2 3 2 3 4 3 3 3 2 2 2 3 2 2 3 2 2| 48 2.9|
Squamous Epithelium, Inflammation | 4 2 2 4 4 4 3 4 4 4 4 4 4 4 4 4 3 3 4 3 4 4 3 4| 49 3.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 2 1.5|
Nephropathy, Chronic | 1 4 2 1 4 2 2 1 2 1 4 4 4 2 3 4 4 3 4 1 2| 38 2.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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