TDMS Study 55323-03 Pathology Tables
NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97
Route: SKIN APPLICATION Time: 12:22:52
CORE STUDY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 120-40-1
Lock Date: 07/13/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97
Route: SKIN APPLICATION Time: 12:22:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Natural Death 11 12 22
Moribund Sacrifice 10 12 5
Accidently Killed 1 1
Survivors
Terminal Sacrifice 28 26 22
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (45) (46) (43)
Parasite Metazoan 2 (4%) 4 (9%) 3 (7%)
Intestine Large, Rectum (42) (45) (43)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 2 (5%) 2 (4%) 1 (2%)
Intestine Large, Cecum (40) (40) (31)
Inflammation, Chronic Active 1 (3%)
Intestine Small, Duodenum (49) (49) (49)
Inflammation, Chronic Active 1 (2%)
Ulcer 1 (2%)
Intestine Small, Jejunum (42) (43) (38)
Mineralization 1 (2%)
Intestine Small, Ileum (48) (42) (37)
Parasite Metazoan 1 (3%)
Liver (50) (50) (50)
Basophilic Focus 1 (2%) 1 (2%)
Clear Cell Focus 1 (2%) 3 (6%) 2 (4%)
Eosinophilic Focus 3 (6%) 2 (4%)
Hepatodiaphragmatic Nodule 12 (24%) 17 (34%) 12 (24%)
Inflammation, Chronic Active 13 (26%) 15 (30%) 4 (8%)
Mixed Cell Focus 1 (2%)
Necrosis 4 (8%)
Vacuolization Cytoplasmic 3 (6%) 6 (12%) 2 (4%)
Bile Duct, Hyperplasia 1 (2%)
Central Vein, Dilatation 1 (2%)
Hepatocyte, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Mesentery (5) (2) (4)
Necrosis 1 (50%)
Fat, Inflammation, Chronic Active 4 (80%) 1 (50%) 3 (75%)
Fat, Mineralization 2 (50%)
Oral Mucosa (1) (1)
Hyperplasia 1 (100%)
Pancreas (50) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97
Route: SKIN APPLICATION Time: 12:22:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
Acinus, Atrophy 3 (6%) 5 (10%) 1 (2%)
Arteriole, Thrombosis 1 (2%)
Stomach, Forestomach (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%)
Ulcer 2 (4%) 2 (4%) 1 (2%)
Stomach, Glandular (50) (50) (49)
Erosion 3 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Heart (50) (50) (49)
Hemorrhage 1 (2%)
Mineralization 1 (2%)
Myocardium, Inflammation, Chronic Active 27 (54%) 31 (62%) 35 (71%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50)
Accessory Adrenal Cortical Nodule 2 (4%) 2 (4%) 3 (6%)
Angiectasis 2 (4%)
Degeneration 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 2 (4%) 2 (4%) 1 (2%)
Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Hypertrophy 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 5 (10%) 4 (8%) 7 (14%)
Adrenal Medulla (50) (50) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (47) (40) (45)
Hyperplasia 1 (2%) 2 (4%)
Pituitary Gland (50) (50) (49)
Cyst 8 (16%) 5 (10%) 3 (6%)
Hemorrhage 1 (2%)
Hyperplasia 4 (8%) 2 (4%)
Thrombosis 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 2 (4%)
Pars Distalis, Hyperplasia 1 (2%) 2 (4%)
Thyroid Gland (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97
Route: SKIN APPLICATION Time: 12:22:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
C-Cell, Hyperplasia 2 (4%) 5 (10%) 3 (6%)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (48) (48)
Cyst 4 (8%) 1 (2%)
Inflammation, Chronic Active 30 (61%) 34 (71%) 36 (75%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Ovary (50) (50) (50)
Follicle, Cyst 3 (6%) 1 (2%) 1 (2%)
Periovarian Tissue, Cyst 5 (10%) 8 (16%) 5 (10%)
Uterus (50) (50) (50)
Congestion 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Hydrometra 4 (8%) 4 (8%) 8 (16%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Inflammation, Chronic Active 2 (4%)
Myelofibrosis 1 (2%)
Lymph Node (3) (3) (1)
Hemorrhage 1 (33%)
Pigmentation, Hemosiderin 1 (33%)
Lymph Node, Mandibular (49) (50) (49)
Atrophy 1 (2%)
Hemorrhage 1 (2%)
Lymph Node, Mesenteric (50) (50) (50)
Ectasia 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Pigmentation, Lipofuscin 2 (4%) 4 (8%)
Arteriole, Inflammation, Chronic Active 1 (2%)
Spleen (50) (50) (50)
Angiectasis 1 (2%)
Congestion 1 (2%) 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97
Route: SKIN APPLICATION Time: 12:22:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Necrosis 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Thrombosis 3 (6%)
Thymus (44) (49) (48)
Atrophy 2 (5%) 1 (2%)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Dilatation 35 (70%) 40 (80%) 32 (64%)
Fibrosis 1 (2%)
Galactocele 1 (2%)
Hyperplasia, Cystic, Focal 1 (2%)
Hyperplasia, Focal 2 (4%) 3 (6%) 2 (4%)
Skin (50) (50) (50)
Parakeratosis 1 (2%) 1 (2%)
Epidermis, Skin, Site of Application,
Hyperplasia 5 (10%) 33 (66%) 44 (88%)
Sebaceous Gland, Skin, Site of Application,
Hyperplasia 3 (6%) 41 (82%) 45 (90%)
Skin, Site of Application, Hyperkeratosis 20 (40%) 29 (58%)
Skin, Site of Application, Inflammation,
Chronic Active 3 (6%) 35 (70%) 34 (68%)
Skin, Site of Application, Parakeratosis 2 (4%) 12 (24%) 25 (50%)
Skin, Site of Application, Ulcer 3 (6%) 2 (4%) 10 (20%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Hemorrhage 2 (4%)
Inflammation, Chronic Active 1 (2%)
Spinal Cord (1) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97
Route: SKIN APPLICATION Time: 12:22:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 1 (2%) 3 (6%)
Hemorrhage 2 (4%)
Inflammation, Chronic Active 2 (4%) 2 (4%) 8 (16%)
Mineralization 23 (46%) 18 (36%) 19 (38%)
Interstitium, Fibrosis 2 (4%) 2 (4%)
Nose (50) (50) (50)
Inflammation, Suppurative 4 (8%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (6)
Cataract 1 (17%)
Synechia 1 (100%)
Lens, Mineralization 1 (100%) 3 (50%)
Posterior Chamber, Hemorrhage 1 (17%)
Retina, Degeneration 1 (100%) 1 (17%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 2 (4%) 2 (4%)
Inflammation, Chronic Active 2 (4%)
Mineralization 24 (48%) 23 (46%) 27 (54%)
Necrosis 1 (2%)
Nephropathy 40 (80%) 41 (82%) 40 (80%)
Pigmentation, Hemosiderin 2 (4%) 2 (4%) 2 (4%)
Renal Tubule, Regeneration 2 (4%) 4 (8%) 2 (4%)
Urinary Bladder (49) (49) (47)
Inflammation, Chronic Active 3 (6%)
Mineralization 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97
Route: SKIN APPLICATION Time: 12:22:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund Sacrifice 31 29 25
Natural Death 7 3 8
Accidently Killed 1
Survivors
Terminal Sacrifice 12 18 16
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (50) (46)
Cyst 1 (2%)
Parasite Metazoan 4 (8%)
Intestine Large, Rectum (48) (49) (47)
Parasite Metazoan 2 (4%) 2 (4%) 5 (11%)
Intestine Large, Cecum (41) (47) (44)
Ulcer 1 (2%)
Intestine Small, Duodenum (50) (50) (50)
Ulcer 1 (2%)
Intestine Small, Jejunum (45) (50) (46)
Inflammation, Chronic 1 (2%)
Liver (50) (50) (50)
Eosinophilic Focus 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 5 (10%) 8 (16%) 6 (12%)
Hypertrophy 1 (2%)
Inflammation, Chronic Active 6 (12%) 4 (8%) 3 (6%)
Necrosis 2 (4%) 2 (4%)
Vacuolization Cytoplasmic 11 (22%) 14 (28%) 15 (30%)
Bile Duct, Hyperplasia 7 (14%) 6 (12%) 6 (12%)
Periportal, Fibrosis 1 (2%)
Mesentery (12) (8) (6)
Arteriole, Inflammation, Chronic Active 1 (13%)
Fat, Inflammation, Chronic Active 12 (100%) 6 (75%) 2 (33%)
Fat, Mineralization 6 (50%) 4 (50%) 1 (17%)
Fat, Necrosis 1 (17%)
Pancreas (50) (50) (50)
Cyst 1 (2%)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 5 (10%) 5 (10%) 11 (22%)
Arteriole, Inflammation, Chronic Active 1 (2%)
Salivary Glands (50) (50) (50)
Atrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97
Route: SKIN APPLICATION Time: 12:22:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (50) (50) (50)
Edema 2 (4%)
Fibrosis 1 (2%)
Hyperkeratosis 1 (2%) 2 (4%) 1 (2%)
Hyperplasia 1 (2%) 2 (4%)
Inflammation, Chronic Active 10 (20%) 6 (12%) 7 (14%)
Mineralization 1 (2%)
Ulcer 11 (22%) 5 (10%) 3 (6%)
Stomach, Glandular (50) (50) (50)
Erosion 1 (2%)
Mineralization 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50)
Mineralization 2 (4%)
Heart (50) (50) (50)
Mineralization 2 (4%) 2 (4%)
Thrombosis 1 (2%) 1 (2%)
Myocardium, Inflammation, Chronic Active 36 (72%) 39 (78%) 41 (82%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%) 7 (14%) 6 (12%)
Degeneration 1 (2%) 1 (2%)
Hyperplasia 3 (6%)
Mineralization 1 (2%)
Pigmentation, Lipofuscin 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 19 (38%) 21 (42%) 22 (44%)
Adrenal Medulla (50) (50) (50)
Hyperplasia 4 (8%) 2 (4%) 1 (2%)
Mineralization 1 (2%)
Parathyroid Gland (47) (45) (47)
Hyperplasia 16 (34%) 17 (38%) 13 (28%)
Pituitary Gland (50) (50) (50)
Cyst 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Mineralization 1 (2%)
Thyroid Gland (50) (50) (50)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 3 (6%) 3 (6%)
Follicle, Cyst 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97
Route: SKIN APPLICATION Time: 12:22:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Penis (1)
Congestion 1 (100%)
Preputial Gland (50) (50) (50)
Cyst 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 50 (100%) 46 (92%) 43 (86%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Prostate (50) (50) (49)
Cyst 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Inflammation, Chronic Active 7 (14%) 5 (10%) 3 (6%)
Seminal Vesicle (50) (50) (49)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%)
Testes (50) (50) (50)
Degeneration 15 (30%) 16 (32%) 17 (34%)
Inflammation, Chronic Active 2 (4%) 4 (8%) 5 (10%)
Mineralization 4 (8%) 6 (12%) 7 (14%)
Necrosis 1 (2%)
Interstitial Cell, Hyperplasia 3 (6%) 2 (4%) 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Myelofibrosis 1 (2%)
Necrosis 1 (2%)
Lymph Node (2) (4)
Angiectasis 1 (50%)
Congestion 1 (25%)
Lymph Node, Mandibular (50) (50) (50)
Hyperplasia 1 (2%)
Lymph Node, Mesenteric (50) (50) (50)
Amyloid Deposition 1 (2%)
Atrophy 2 (4%) 1 (2%)
Congestion 1 (2%)
Ectasia 1 (2%) 2 (4%) 1 (2%)
Necrosis 1 (2%)
Spleen (50) (50) (50)
Congestion 8 (16%) 5 (10%) 5 (10%)
Fibrosis 3 (6%) 3 (6%) 3 (6%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97
Route: SKIN APPLICATION Time: 12:22:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Lymphoid Follicle, Depletion Cellular 1 (2%)
Red Pulp, Hyperplasia 1 (2%)
Thymus (44) (50) (47)
Atrophy 7 (16%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49)
Dilatation 28 (56%) 34 (68%) 31 (63%)
Galactocele 6 (12%) 7 (14%) 9 (18%)
Hyperplasia 8 (16%) 9 (18%) 5 (10%)
Hyperplasia, Cystic, Focal 1 (2%)
Hyperplasia, Focal 5 (10%) 8 (16%) 5 (10%)
Pigmentation, Hemosiderin 1 (2%)
Skin (50) (50) (50)
Hemorrhage 1 (2%)
Hyperkeratosis 1 (2%)
Parakeratosis 1 (2%)
Epidermis, Pinna, Hyperplasia 1 (2%)
Epidermis, Skin, Site of Application,
Hyperplasia 29 (58%) 44 (88%)
Pinna, Parakeratosis 1 (2%)
Sebaceous Gland, Skin, Site of Application,
Hyperplasia 27 (54%) 44 (88%)
Skin, Site of Application, Edema 1 (2%)
Skin, Site of Application, Hyperkeratosis 23 (46%) 25 (50%)
Skin, Site of Application, Inflammation,
Chronic Active 10 (20%) 28 (56%)
Skin, Site of Application, Parakeratosis 21 (42%) 33 (66%)
Skin, Site of Application, Ulcer 4 (8%) 25 (50%)
Subcutaneous Tissue, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 1 (2%)
Osteosclerosis 1 (2%)
Skeletal Muscle (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 55323-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/17/97
Route: SKIN APPLICATION Time: 12:22:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Hydrocephalus 1 (2%) 1 (2%)
Mineralization 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%) 3 (6%) 4 (8%)
Mineralization 21 (42%) 22 (44%) 34 (68%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%)
Interstitium, Fibrosis 2 (4%)
Nose (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 11 (22%) 5 (10%) 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2)
Mineralization 1 (50%)
Lens, Mineralization 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 7 (14%) 4 (8%) 6 (12%)
Fibrosis 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 1 (2%) 3 (6%)
Nephropathy 42 (84%) 40 (80%) 40 (80%)
Pigmentation, Hemosiderin 2 (4%) 2 (4%)
Renal Tubule, Regeneration 2 (4%) 1 (2%) 1 (2%)
Urinary Bladder (50) (50) (50)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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