TDMS Study 55323-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus LAURIC ACID DIETHANOLAMINE CONDENSATE DATE: 07/17/97
EXPERIMENT: 55323 TEST: 03 TIME: 12:31:16
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-15314 ROUTE: SKIN APPLICATION NTP C#: 55323B
PATHOLOGIST: J. YARRINGTON CAS: 120-40-1
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus LAURIC ACID DIETHANOLAMINE CONDENSATE DATE: 07/17/97
EXPERIMENT: 55323 TEST: 03 TIME: 12:31:16
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-15314 ROUTE: SKIN APPLICATION NTP C#: 55323B
PATHOLOGIST: J. YARRINGTON CAS: 120-40-1
LAURIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 38 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 500 506 509 535 563 565 565 565 569 583 |
| 589 589 607 609 618 624 626 634 641 645 |
| 646 654 668 670 674 680 684 689 691 702 |
| 703 708 710 710 715 715 716 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 32 CENSORED DEATHS 0 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 430 485 500 526 526 527 537 544 557 578 |
| 582 589 597 613 614 618 620 625 626 626 |
| 634 646 653 658 662 663 674 680 684 696 |
| 705 719 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 1 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 266 513 522 527 555 557 558 583 583 589 |
| 589 589 603 603 606 632 642 645 654 670 |
| 683 684 689 695 696 703 703 703 717 719 |
| 719 726 727 |
| CENSORED DEATHS |
| 106 |
| |
==================================================================================
LAURIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 92.0 76.0 56.0 24.0 |
| | |
| | |
|50 MG/KG | 100.0 100.0 100.0 100.0 100.0 96.0 84.0 74.0 48.0 36.0 |
| | |
| | |
|100 | 100.0 100.0 98.0 98.0 98.0 98.0 91.8 71.4 61.2 32.7 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 50 MG/KG 100 |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 24.0% 36.0% 32.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.413N P=0.614N P=0.405N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 634.3 606.1 625.8 |
|NATURAL DEATHS (C) | (10.7) (12.3) (16.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 657.0 650.3 648.4 |
|(STANDARD ERROR) | (10.0) (11.5) (16.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
LAURIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 1 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 322 374 416 471 475 479 499 521 527 564 |
| 617 640 654 662 667 669 682 688 691 694 |
| 707 |
| CENSORED DEATHS |
| 219 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 238 403 458 489 518 522 527 534 575 582 |
| 582 588 591 594 605 623 627 634 645 680 |
| 696 710 717 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 1 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 323 347 361 363 364 398 427 465 507 525 |
| 535 588 594 595 602 634 639 646 655 680 |
| 684 693 701 703 722 724 724 |
| CENSORED DEATHS |
| 36 |
| |
==================================================================================
LAURIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.0 93.9 87.8 81.6 79.6 71.4 57.1 |
| | |
| | |
|50 MG/KG | 100.0 100.0 98.0 98.0 96.0 94.0 84.0 70.0 62.0 52.0 |
| | |
| | |
|100 | 100.0 100.0 100.0 89.8 87.8 83.7 77.6 69.4 61.2 44.9 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 50 MG/KG 100 |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 57.1% 52.0% 44.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.274 P=0.734 P=0.301 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 572.3 577.8 562.9 |
|NATURAL DEATHS (C) | (25.7) (22.4) (26.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 653.0 656.4 625.5 |
|(STANDARD ERROR) | (17.7) (15.1) (21.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
LAURIC ACID DIETHANOLAMINE CONDENSATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
50 MG/KG = 2
100 MG/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 2 2 113
| 2 213 321
| 31 31
90 +
| 22
| 22 211 3
| 2 121 3
P 80 + 21 1
E | 2 2
R | 1212
C | 1 1
E 70 + 32113
N | 33
T | 21113
| 113
S 60 + 22 3 3 3
U | 2 11
R | 21 1 33
V | 2 211 33
I 50 + 11 33
V | 2 2
A | 211
L | 2121 3
40 + 22
| 1123
| 2 2
| 113 3
30 +
|
| 11 1
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 26 obs hidden.
LAURIC ACID DIETHANOLAMINE CONDENSATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
50 MG/KG = 2
100 MG/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 13
| 2 13 3 1 2
| 3 3 1 2 1 2 1 2
| 2 2
P 90 + 3 3 11 2 2
E | 3 3 1 1 22
R | 3 3 1 122 2
C | 3 3 11 1 22
E 80 + 3 3 1 1
N | 3 3 1 1
T | 2 2 1 1
| 232 1 11
S 70 + 32 2 3
U | 2233 1 1
R | 2232 11
V | 23 2
I 60 + 3 2111
V | 33212 1
A | 3 3222
L | 2 2
50 + 3 3
|
| 3 3
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 19 obs hidden.