TDMS Study 55323-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus LAURIC ACID DIETHANOLAMINE CONDENSATE DATE: 07/30/97
EXPERIMENT: 55323 TEST: 04 TIME: 07:35:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-15314 ROUTE: SKIN APPLICATION NTP C#: 55323B
PATHOLOGIST: M. RYAN CAS: 120-40-1
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHRONIC
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus LAURIC ACID DIETHANOLAMINE CONDENSATE DATE: 07/30/97
EXPERIMENT: 55323 TEST: 04 TIME: 07:35:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-15314 ROUTE: SKIN APPLICATION NTP C#: 55323B
PATHOLOGIST: M. RYAN CAS: 120-40-1
LAURIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 344 353 541 562 584 616 622 636 646 670 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 164 415 462 528 595 626 637 638 668 706 |
| 706 717 719 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 444 492 519 554 560 573 611 643 730 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
LAURIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 96.0 96.0 96.0 94.0 90.0 82.0 80.0 |
| | |
| | |
|100 | 100.0 98.0 98.0 98.0 96.0 94.0 92.0 90.0 84.0 74.0 |
|MG/KG | |
| | |
|200 | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 88.0 84.0 82.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 100 200 |
| MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 74.0% 82.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.901N P=0.684 P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 557.4 583.2 569.6 |
|NATURAL DEATHS (C) | (36.9) (44.1) (28.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 699.5 695.5 705.2 |
|(STANDARD ERROR) | (12.4) (14.6) (10.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
LAURIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 410 542 562 562 602 624 629 638 643 646 |
| 671 719 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 1 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 481 574 638 638 651 656 666 668 731 |
| CENSORED DEATHS |
| 205 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 1 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 414 457 476 517 523 539 583 596 615 616 |
| 617 625 625 646 650 653 680 720 720 728 |
| CENSORED DEATHS |
| 84 |
| |
==================================================================================
LAURIC ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 98.0 98.0 96.0 90.0 80.0 74.0 |
| | |
| | |
|100 | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 95.9 87.8 81.6 |
|MG/KG | |
| | |
|200 | 100.0 100.0 100.0 100.0 98.0 93.9 87.8 83.7 67.3 59.2 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 100 200 |
| MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.0% 81.6% 59.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.109 P=0.445N P=0.158 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 612.9 633.7 600.0 |
|NATURAL DEATHS (C) | (22.7) (23.4) (19.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 704.0 707.0 668.6 |
|(STANDARD ERROR) | ( 9.6) (12.3) (17.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
LAURIC ACID DIETHANOLAMINE CONDENSATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
100 MG/KG = 2
200 MG/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
|
| 2 11 2 3 3
| 1 2 2 3 3 1
P 95 +
E | 2 32 1 31
R | 2 1 1 2
C |
E 90 + 3 3 1 2 1 2
N |
T | 3 1122
| 31 12
S 85 +
U | 121 2 3
R | 1 1 2 3
V |
I 80 + 1 1
V |
A | 2 2
L |
75 +
| 2 2
|
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.
LAURIC ACID DIETHANOLAMINE CONDENSATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
100 MG/KG = 2
200 MG/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 13 2
|
| 13 3 2 1 2
| 3 3 1 12 2
95 +
| 3 3
| 1 1
| 3 3 22
90 + 3 3 1 1 22
|
P | 3 3 2 2
E | 3 3 1 1
R 85 +
C | 3 3 2 2
E | 11
N | 22
T 80 + 33 1 1
|
S | 33 1 1
U |
R 75 +
V | 3 3 1 1
I |
V |
A 70 + 33
L |
| 3 3
|
65 + 3 3
|
|
| 33
60 +
| 3 3
|
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 2 obs hidden.