TDMS Study 88032-05 Pathology Tables
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:32:12 14 WEEK SSAC Facility: Battelle Columbus Laboratory Chemical CAS #: 434-07-01 Lock Date: 01/02/96 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 07/21/93 - 07/22/93 Treatment Groups: Include 002 0 MG/KG Include 004 3 MG/KG Include 006 30 MG/KG Include 008 100 MG/KG Include 001 0 MG/KG Include 003 3 MG/KG Include 005 30 MG/KG Include 007 150 MG/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:32:12 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 90 90 90 90 Scheduled Sacrifice 10 10 10 10 Early Deaths Survivors Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Small, Jejunum (10) (10) (10) (10) Peyer's Patch, Mineralization 2 (20%) Liver (10) (10) (10) (10) Hepatodiaphragmatic Nodule 2 (20%) 4 (40%) 1 (10%) 1 (10%) Inflammation, Chronic Active 1 (10%) 1 (10%) Mesentery (1) Fat, Inflammation, Chronic Active 1 (100%) Pancreas (10) (10) (10) (10) Acinus, Atrophy 2 (20%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) (10) (10) Myocardium, Degeneration, Chronic 1 (10%) 6 (60%) 3 (30%) 4 (40%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Accessory Adrenal Cortical Nodule 1 (10%) Thyroid Gland (10) (10) (10) (10) Ultimobranchial Cyst 1 (10%) 2 (20%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:32:12 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (10) (9) (10) (10) Inflammation, Chronic Active 6 (60%) 5 (56%) 9 (90%) 9 (90%) Ovary (10) (10) (9) (9) DYSGENESIS 9 (100%) Periovarian Tissue, Cyst 1 (10%) 2 (20%) 2 (22%) 1 (11%) Uterus (10) (10) (10) (10) Hydrometra 3 (30%) 2 (20%) 7 (70%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (10) (10) (10) (10) Lobular, Hyperplasia 2 (20%) 9 (90%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) Inflammation, Chronic Active 2 (20%) 6 (60%) 4 (40%) 4 (40%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:32:12 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) Mineralization 10 (100%) 9 (90%) 9 (90%) 10 (100%) Nephropathy 8 (80%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:32:12 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 90 90 90 90 Scheduled Sacrifice 10 10 10 9 Early Deaths Survivors Animals Examined Microscopically 10 10 10 9 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (10) (10) (10) (9) Muscularis, Inflammation, Chronic Active 1 (10%) Intestine Small, Jejunum (10) (10) (10) (9) Inflammation, Chronic Active 1 (10%) Peyer's Patch, Mineralization 1 (10%) Liver (10) (10) (10) (9) Hepatodiaphragmatic Nodule 2 (20%) 2 (20%) 1 (10%) 1 (11%) Inflammation, Chronic Active 3 (30%) 1 (10%) Centrilobular, Congestion 1 (10%) Centrilobular, Vacuolization Cytoplasmic 1 (10%) 5 (50%) 5 (50%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) (10) (9) Hemorrhage 1 (10%) Myocardium, Degeneration, Chronic 10 (100%) 9 (90%) 7 (70%) 4 (44%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (9) Accessory Adrenal Cortical Nodule 2 (20%) Vacuolization Cytoplasmic 8 (80%) 6 (60%) 8 (89%) Thyroid Gland (10) (10) (10) (9) Ultimobranchial Cyst 1 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:32:12 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150 MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (10) (10) (10) (9) Inflammation, Chronic Active 8 (80%) 7 (70%) 10 (100%) 6 (67%) Prostate (10) (10) (10) (9) Inflammation, Chronic Active 1 (10%) 1 (10%) Testes (10) (10) (10) (9) Mineralization 1 (11%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mesenteric (10) (10) (9) (9) Hemorrhage 1 (11%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (10) (10) (9) (9) Dilatation 8 (89%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (9) Inflammation, Chronic Active 1 (10%) 4 (40%) 3 (30%) 4 (44%) Mineralization 2 (20%) 1 (11%) Vacuolization Cytoplasmic 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:32:12 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150 MG/KG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (9) Mineralization 2 (20%) 2 (20%) 8 (89%) Nephropathy 8 (80%) 7 (70%) 9 (90%) 8 (89%) Renal Tubule, Hyperplasia 1 (11%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 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