TDMS Study 88032-05 Pathology Tables
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 10:32:12
14 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 434-07-01
Lock Date: 01/02/96
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 07/21/93 - 07/22/93
Treatment Groups: Include 002 0 MG/KG
Include 004 3 MG/KG
Include 006 30 MG/KG
Include 008 100 MG/KG
Include 001 0 MG/KG
Include 003 3 MG/KG
Include 005 30 MG/KG
Include 007 150 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 10:32:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 90 90 90 90
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (10) (10) (10) (10)
Peyer's Patch, Mineralization 2 (20%)
Liver (10) (10) (10) (10)
Hepatodiaphragmatic Nodule 2 (20%) 4 (40%) 1 (10%) 1 (10%)
Inflammation, Chronic Active 1 (10%) 1 (10%)
Mesentery (1)
Fat, Inflammation, Chronic Active 1 (100%)
Pancreas (10) (10) (10) (10)
Acinus, Atrophy 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10)
Myocardium, Degeneration, Chronic 1 (10%) 6 (60%) 3 (30%) 4 (40%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Ultimobranchial Cyst 1 (10%) 2 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 10:32:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (9) (10) (10)
Inflammation, Chronic Active 6 (60%) 5 (56%) 9 (90%) 9 (90%)
Ovary (10) (10) (9) (9)
DYSGENESIS 9 (100%)
Periovarian Tissue, Cyst 1 (10%) 2 (20%) 2 (22%) 1 (11%)
Uterus (10) (10) (10) (10)
Hydrometra 3 (30%) 2 (20%) 7 (70%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (10) (10) (10) (10)
Lobular, Hyperplasia 2 (20%) 9 (90%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation, Chronic Active 2 (20%) 6 (60%) 4 (40%) 4 (40%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 10:32:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Mineralization 10 (100%) 9 (90%) 9 (90%) 10 (100%)
Nephropathy 8 (80%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 10:32:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 90 90 90 90
Scheduled Sacrifice 10 10 10 9
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 9
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (10) (10) (10) (9)
Muscularis, Inflammation, Chronic Active 1 (10%)
Intestine Small, Jejunum (10) (10) (10) (9)
Inflammation, Chronic Active 1 (10%)
Peyer's Patch, Mineralization 1 (10%)
Liver (10) (10) (10) (9)
Hepatodiaphragmatic Nodule 2 (20%) 2 (20%) 1 (10%) 1 (11%)
Inflammation, Chronic Active 3 (30%) 1 (10%)
Centrilobular, Congestion 1 (10%)
Centrilobular, Vacuolization Cytoplasmic 1 (10%) 5 (50%) 5 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (9)
Hemorrhage 1 (10%)
Myocardium, Degeneration, Chronic 10 (100%) 9 (90%) 7 (70%) 4 (44%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (9)
Accessory Adrenal Cortical Nodule 2 (20%)
Vacuolization Cytoplasmic 8 (80%) 6 (60%) 8 (89%)
Thyroid Gland (10) (10) (10) (9)
Ultimobranchial Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 10:32:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10) (10) (9)
Inflammation, Chronic Active 8 (80%) 7 (70%) 10 (100%) 6 (67%)
Prostate (10) (10) (10) (9)
Inflammation, Chronic Active 1 (10%) 1 (10%)
Testes (10) (10) (10) (9)
Mineralization 1 (11%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mesenteric (10) (10) (9) (9)
Hemorrhage 1 (11%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (10) (10) (9) (9)
Dilatation 8 (89%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (9)
Inflammation, Chronic Active 1 (10%) 4 (40%) 3 (30%) 4 (44%)
Mineralization 2 (20%) 1 (11%)
Vacuolization Cytoplasmic 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 10:32:12
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (9)
Mineralization 2 (20%) 2 (20%) 8 (89%)
Nephropathy 8 (80%) 7 (70%) 9 (90%) 8 (89%)
Renal Tubule, Hyperplasia 1 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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