TDMS Study 88032-05 Pathology Tables
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
CORE STUDY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 434-07-01
Lock Date: 01/02/96
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25018 Dosing Accident
25019 Moribund Sacrifice 25020 Natural Death
25026 Other 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 7| 5| 7| 7| 5| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 7| 6| 2| 0| 2| 2| 4| 2| 2| 2| 2| 8| 4| 0| 0| 2| 2| 2| 6| 0| 2| 2|
| 8| 3| 9| 3| 2| 9| 6| 8| 9| 0| 1| 9| 9| 5| 9| 8| 8| 7| 8| 8| 8| 6| 7| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 5| 6| 7| 8| 1| 6| 7| 8| 9| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + A A + + + + + + + + + + + + + + + + + A + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | A + + A + + + + + + + + + + + + + + + + + A + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | A + A A A + A + + + A + + A + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + A + + + A + + A + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X X |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 2|
Mixed Cell Focus | |
Necrosis | 1 |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 3 3 4 |
__________________________________________________________________________|
Mesentery | + +|
Fat, Inflammation, Chronic Active | 3|
Fat, Mineralization | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 3 |
Perforation | X |
Ulcer | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration, Chronic | 2 1 2 1 1 2 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 7| 5| 7| 7| 5| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 7| 6| 2| 0| 2| 2| 4| 2| 2| 2| 2| 8| 4| 0| 0| 2| 2| 2| 6| 0| 2| 2|
| 8| 3| 9| 3| 2| 9| 6| 8| 9| 0| 1| 9| 9| 5| 9| 8| 8| 7| 8| 8| 8| 6| 7| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 5| 6| 7| 8| 1| 6| 7| 8| 9| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | 2 2 2 2 2 2|
Mineralization | |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 4 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 1 4 2 2 1|
Hemorrhage | |
Hyperplasia | 3 1 |
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 3 |
Inflammation, Chronic Active | 1 1 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periovarian Tissue, Cyst | 3 3 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrometra | |
Inflammation, Chronic Active | 2 |
Cervix, Cyst | 3 |
Endometrium, Cyst | 2 |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + +|
Ectasia | 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 7| 5| 7| 7| 5| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 7| 6| 2| 0| 2| 2| 4| 2| 2| 2| 2| 8| 4| 0| 0| 2| 2| 2| 6| 0| 2| 2|
| 8| 3| 9| 3| 2| 9| 6| 8| 9| 0| 1| 9| 9| 5| 9| 8| 8| 7| 8| 8| 8| 6| 7| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 5| 6| 7| 8| 1| 6| 7| 8| 9| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal | 3|
Lymphoid Follicle, Depletion Cellular| |
__________________________________________________________________________|
Thymus | + + + + + + M + + + M + M + + + + + + + + + + + +|
Atrophy | 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 1 1 1 1 2 3 1 |
Galactocele | 3 |
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 |
Mineralization | 1 1 1 1 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 1 |
Interstitium, Fibrosis | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Mineralization | 2 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 7| 5| 7| 7| 5| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 7| 6| 2| 0| 2| 2| 4| 2| 2| 2| 2| 8| 4| 0| 0| 2| 2| 2| 6| 0| 2| 2|
| 8| 3| 9| 3| 2| 9| 6| 8| 9| 0| 1| 9| 9| 5| 9| 8| 8| 7| 8| 8| 8| 6| 7| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 5| 6| 7| 8| 1| 6| 7| 8| 9| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Mineralization | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 1 3 3 1 1 1 2 1 1 |
Pigmentation, Hemosiderin | 2 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| |
DAY ON TEST | 0| 2| 6| 4| 8| 2| 2| 2| 2| 2| 2| 2| 7| 7| 2| 0| 2| 2| 2| 9| 2| 7| 2| 2| 7| |
| 5| 8| 1| 3| 4| 9| 8| 8| 9| 9| 8| 9| 8| 3| 8| 6| 8| 8| 8| 3| 9| 8| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0 MG/KG | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| L |
| 9| 0| 2| 3| 4| 6| 7| 8| 9| 1| 5| 7| 8| 0| 1| 4| 5| 4| 8| 1| 2| 3| 4| 5| 6| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + A + + + + + + + + + + A| 44 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A A + + + + + + + + + + + + + + + + + A + + A| 38 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A A + + + + + + + + + A + + + + + + + + + + A| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A A + + + + + + + + + + + + + + + + + A + + A| 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 37 |
Clear Cell Focus | X X X | 5 |
Eosinophilic Focus | X X X | 8 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
Hepatodiaphragmatic Nodule | X X X X X X| 12 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 17 1.1|
Mixed Cell Focus | X X | 2 |
Necrosis | | 1 1.0|
Vacuolization Cytoplasmic, Focal | 4 | 1 4.0|
Bile Duct, Hyperplasia | 2 | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 3 2 3 | 7 3.0|
__________________________________________________________________________|____________|
Mesentery | + + +| 5 |
Fat, Inflammation, Chronic Active | 2| 2 2.5|
Fat, Mineralization | 3 | 1 3.0|
Fat, Necrosis | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 | 8 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
Perforation | | 1 |
Ulcer | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| |
DAY ON TEST | 0| 2| 6| 4| 8| 2| 2| 2| 2| 2| 2| 2| 7| 7| 2| 0| 2| 2| 2| 9| 2| 7| 2| 2| 7| |
| 5| 8| 1| 3| 4| 9| 8| 8| 9| 9| 8| 9| 8| 3| 8| 6| 8| 8| 8| 3| 9| 8| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0 MG/KG | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| L |
| 9| 0| 2| 3| 4| 6| 7| 8| 9| 1| 5| 7| 8| 0| 1| 4| 5| 4| 8| 1| 2| 3| 4| 5| 6| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Degeneration, Chronic | 1 1 1 1 1 1 2 2 1 2 1 2 1 1 2 1 1 | 29 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Angiectasis | 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 | 21 2.0|
Mineralization | 2 | 1 2.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 1 3 3 | 5 2.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Cyst | 3 2 3 2 | 10 2.3|
Hemorrhage | 2 | 1 2.0|
Hyperplasia | 2 | 3 2.0|
Pars Distalis, Angiectasis | | 1 4.0|
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 2 | 6 3.0|
Inflammation, Chronic Active | 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Periovarian Tissue, Cyst | 1| 4 2.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Hydrometra | 2 2 3 | 3 2.3|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| |
DAY ON TEST | 0| 2| 6| 4| 8| 2| 2| 2| 2| 2| 2| 2| 7| 7| 2| 0| 2| 2| 2| 9| 2| 7| 2| 2| 7| |
| 5| 8| 1| 3| 4| 9| 8| 8| 9| 9| 8| 9| 8| 3| 8| 6| 8| 8| 8| 3| 9| 8| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0 MG/KG | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| L |
| 9| 0| 2| 3| 4| 6| 7| 8| 9| 1| 5| 7| 8| 0| 1| 4| 5| 4| 8| 1| 2| 3| 4| 5| 6| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cervix, Cyst | | 1 3.0|
Endometrium, Cyst | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + | 4 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Hyperplasia, Focal | | 1 3.0|
Lymphoid Follicle, Depletion Cellular| 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + M + + + + + + + + +| 45 |
Atrophy | | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 1 1 2 1 1 4 2 1 3 1 1 2 2 2 2 1 2| 27 1.7|
Galactocele | 2 | 2 2.5|
Hyperplasia, Focal | 3 | 3 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosclerosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| |
DAY ON TEST | 0| 2| 6| 4| 8| 2| 2| 2| 2| 2| 2| 2| 7| 7| 2| 0| 2| 2| 2| 9| 2| 7| 2| 2| 7| |
| 5| 8| 1| 3| 4| 9| 8| 8| 9| 9| 8| 9| 8| 3| 8| 6| 8| 8| 8| 3| 9| 8| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0 MG/KG | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| L |
| 9| 0| 2| 3| 4| 6| 7| 8| 9| 1| 5| 7| 8| 0| 1| 4| 5| 4| 8| 1| 2| 3| 4| 5| 6| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 1 1 1 1 1 | 8 1.1|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 | 15 1.0|
Pigmentation | 1 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 1 4 1 | 4 1.8|
Interstitium, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Mineralization | | 1 2.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
Nephropathy | 1 1 1 1 1 1 2 1 1 3 1 1 1 2 1 1 1 | 32 1.3|
Pigmentation, Hemosiderin | 1 | 5 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 5| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 6|
DAY ON TEST | 8| 2| 7| 5| 5| 2| 2| 0| 3| 0| 2| 9| 2| 2| 2| 2| 2| 2| 1| 9| 2| 5| 2| 9| 4|
| 2| 9| 6| 2| 2| 9| 5| 5| 9| 2| 8| 9| 3| 8| 9| 8| 9| 9| 1| 0| 9| 6| 9| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
3 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9|
| 2| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 4| 6| 7| 9| 1| 2| 4| 5| 7| 0| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + A + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + A + A +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + A + + + + + + A + + A + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + A + + A + A +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + A + + + + + + A + + A + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Cyst | 3 |
Eosinophilic Focus | X 2 X X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic Active | 2 1 1 2 1 1 |
Mixed Cell Focus | X X X |
Necrosis | 1 1 |
Regeneration | 2 |
Bile Duct, Hyperplasia | |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 3 2 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | 2 4 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +|
Atrophy | |
Acinus, Atrophy | 2 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Ulcer | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration, Chronic | 2 2 1 1 1 1 1 3 1 1 2 1 2 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 5| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 6|
DAY ON TEST | 8| 2| 7| 5| 5| 2| 2| 0| 3| 0| 2| 9| 2| 2| 2| 2| 2| 2| 1| 9| 2| 5| 2| 9| 4|
| 2| 9| 6| 2| 2| 9| 5| 5| 9| 2| 8| 9| 3| 8| 9| 8| 9| 9| 1| 0| 9| 6| 9| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
3 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9|
| 2| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 4| 6| 7| 9| 1| 2| 4| 5| 7| 0| 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 2 2 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 1|
Hypertrophy | 3 |
Metaplasia, Osseous | |
Vacuolization Cytoplasmic | 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Hyperplasia | |
Pars Distalis, Angiectasis | 3|
Pars Distalis, Hyperplasia | 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia | |
Ultimobranchial Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 2 |
Inflammation, Chronic Active | 1 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + |
DYSGENESIS | 1 |
Corpus Luteum, Cyst | 2 |
Follicle, Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hydrometra | |
Endometrium, Cyst | 2 |
Endometrium, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 5| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 6|
DAY ON TEST | 8| 2| 7| 5| 5| 2| 2| 0| 3| 0| 2| 9| 2| 2| 2| 2| 2| 2| 1| 9| 2| 5| 2| 9| 4|
| 2| 9| 6| 2| 2| 9| 5| 5| 9| 2| 8| 9| 3| 8| 9| 8| 9| 9| 1| 0| 9| 6| 9| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
3 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9|
| 2| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 4| 6| 7| 9| 1| 2| 4| 5| 7| 0| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + A + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + A + + + + + + + + + + + + +|
Accessory Spleen | X |
Congestion | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 3|
Pigmentation, Hemosiderin | 2 |
Lymphoid Follicle, Depletion Cellular| 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 1 2 2 2 1 2 1 1 1 1 1 1 2 1 1 2|
Galactocele | |
Lobular, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosclerosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 2 2 1 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 |
Necrosis | 2 |
Pigmentation | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 1 |
Alveolar Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 5| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 6|
DAY ON TEST | 8| 2| 7| 5| 5| 2| 2| 0| 3| 0| 2| 9| 2| 2| 2| 2| 2| 2| 1| 9| 2| 5| 2| 9| 4|
| 2| 9| 6| 2| 2| 9| 5| 5| 9| 2| 8| 9| 3| 8| 9| 8| 9| 9| 1| 0| 9| 6| 9| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
3 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9|
| 2| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 4| 6| 7| 9| 1| 2| 4| 5| 7| 0| 4|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Mineralization | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation, Hemosiderin | 1 1 1 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic Active | 1 1 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7| |
DAY ON TEST | 2| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 2| 7| 2| 2| 2| 2| 2| 7| 6| 2| 2| 2| 3| 2| |
| 8| 8| 5| 9| 8| 8| 8| 8| 8| 1| 9| 8| 0| 8| 9| 8| 9| 9| 9| 2| 9| 9| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3 MG/KG | 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 6| 9| 1| 2| 4| 6| 0| 1| 2| 3| 6| 7| 1| 5| 7| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X | 40 |
Clear Cell Focus | X X X X X X X X X | 11 |
Cyst | | 1 3.0|
Eosinophilic Focus | X X | 6 2.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X | 6 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 13 1.2|
Mixed Cell Focus | X X X X | 7 |
Necrosis | | 2 1.0|
Regeneration | | 1 2.0|
Bile Duct, Hyperplasia | 2 1 2| 3 1.7|
Centrilobular, Vacuolization | | |
Cytoplasmic | 4 2 1| 8 2.3|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Inflammation, Chronic Active | 2 | 3 2.7|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Acinus, Atrophy | 1 4 1 | 7 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7| |
DAY ON TEST | 2| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 2| 7| 2| 2| 2| 2| 2| 7| 6| 2| 2| 2| 3| 2| |
| 8| 8| 5| 9| 8| 8| 8| 8| 8| 1| 9| 8| 0| 8| 9| 8| 9| 9| 9| 2| 9| 9| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3 MG/KG | 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 6| 9| 1| 2| 4| 6| 0| 1| 2| 3| 6| 7| 1| 5| 7| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Degeneration, Chronic | 2 1 1 1 1 1 2 1 1 1 1 1 2 1 1 2 | 34 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 2 2 2 2 2 2 1 2 3 3 3 2 2 2 | 26 2.1|
Hematopoietic Cell Proliferation | | 1 1.0|
Hypertrophy | 3 1 4 3 | 5 2.8|
Metaplasia, Osseous | 3 | 1 3.0|
Vacuolization Cytoplasmic | 3 2 | 5 2.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + M + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 2 2 2 2 3 | 9 2.1|
Hyperplasia | 2 2 | 2 2.0|
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 4.0|
Hyperplasia | 2 | 1 2.0|
Ultimobranchial Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Cyst | 3 2 4 | 6 2.7|
Inflammation, Chronic Active | 1 1 1 1 2 | 8 1.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
DYSGENESIS | | 1 1.0|
Corpus Luteum, Cyst | | 1 2.0|
Follicle, Cyst | 2| 2 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Hydrometra | 4 4 2 2 | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7| |
DAY ON TEST | 2| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 2| 7| 2| 2| 2| 2| 2| 7| 6| 2| 2| 2| 3| 2| |
| 8| 8| 5| 9| 8| 8| 8| 8| 8| 1| 9| 8| 0| 8| 9| 8| 9| 9| 9| 2| 9| 9| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3 MG/KG | 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 6| 9| 1| 2| 4| 6| 0| 1| 2| 3| 6| 7| 1| 5| 7| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Cyst | | 1 2.0|
Endometrium, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 1 4.0|
Myelofibrosis | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia | 3 | 1 3.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Spleen | | 1 |
Congestion | | 1 2.0|
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 1 | 6 2.2|
Pigmentation, Hemosiderin | | 1 2.0|
Lymphoid Follicle, Depletion Cellular| | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + M M +| 47 |
Atrophy | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 1 1 2 1 2 1 1 1 1 2 2 2 3 2 2 1| 34 1.5|
Galactocele | 2 | 1 2.0|
Lobular, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosclerosis | 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7| |
DAY ON TEST | 2| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 2| 7| 2| 2| 2| 2| 2| 7| 6| 2| 2| 2| 3| 2| |
| 8| 8| 5| 9| 8| 8| 8| 8| 8| 1| 9| 8| 0| 8| 9| 8| 9| 9| 9| 2| 9| 9| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3 MG/KG | 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 6| 9| 1| 2| 4| 6| 0| 1| 2| 3| 6| 7| 1| 5| 7| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Vacuolization Cytoplasmic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 2 1 1 1| 12 1.4|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 23 1.0|
Necrosis | | 1 2.0|
Pigmentation | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 1 1 1 1 1| 10 1.2|
Alveolar Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Lens, Mineralization | 3 | 1 3.0|
Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 | 31 1.0|
Necrosis | 3| 1 3.0|
Nephropathy | 2 2 1 1 1 1 2 1 1 1 2 1 1 1 1| 26 1.2|
Pigmentation, Hemosiderin | 1 1 2 | 7 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 4| 7| 1| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 4|
DAY ON TEST | 7| 2| 1| 2| 2| 4| 2| 9| 2| 2| 2| 7| 2| 7| 2| 2| 0| 2| 6| 2| 2| 2| 2| 2| 9|
| 8| 9| 8| 8| 8| 1| 8| 8| 8| 8| 9| 4| 9| 0| 8| 8| 8| 9| 1| 8| 9| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 MG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 2| 3| 5| 6| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 8| 9| 0| 2| 3| 5| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + A + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Mixed Cell Focus | X X X X |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 1 |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 2 1 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + |
Mineralization | |
Fat, Inflammation, Chronic Active | 2 2 2 2 1 |
Fat, Mineralization | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Acinus, Atrophy | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Ulcer | 2 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 4 |
Myocardium, Degeneration, Chronic | 1 2 1 2 2 1 2 1 1 3 2 1 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 4| 7| 1| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 4|
DAY ON TEST | 7| 2| 1| 2| 2| 4| 2| 9| 2| 2| 2| 7| 2| 7| 2| 2| 0| 2| 6| 2| 2| 2| 2| 2| 9|
| 8| 9| 8| 8| 8| 1| 8| 8| 8| 8| 9| 4| 9| 0| 8| 8| 8| 9| 1| 8| 9| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 MG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 2| 3| 5| 6| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 8| 9| 0| 2| 3| 5| 8|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 1 1 1 1 1 |
Pigmentation | 2 |
Vacuolization Cytoplasmic | 1 1 1 2 1 3 2 1 2 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + M + M + + + + + + + + + M + + + M|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
Hemorrhage | 3 |
Hyperplasia | |
Mineralization | |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 3 3 |
Pars Nervosa, Developmental | |
Malformation | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic Active | 1 3 1 1 1 2 1 1 |
Inflammation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
DYSGENESIS | 1 1 2 2 2 3 3 3 3 2 3 3 3 3 3 3 4 4 3 3 |
Follicle, Cyst | 2 |
Periovarian Tissue, Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hydrometra | 1 1 1 |
Endometrium, Cyst | 1 2 1 |
Endometrium, Hyperplasia, Cystic | 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + M + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 2 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 4| 7| 1| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 4|
DAY ON TEST | 7| 2| 1| 2| 2| 4| 2| 9| 2| 2| 2| 7| 2| 7| 2| 2| 0| 2| 6| 2| 2| 2| 2| 2| 9|
| 8| 9| 8| 8| 8| 1| 8| 8| 8| 8| 9| 4| 9| 0| 8| 8| 8| 9| 1| 8| 9| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 MG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 2| 3| 5| 6| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 8| 9| 0| 2| 3| 5| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Atrophy | 3 |
Ectasia | 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Focal | 3 |
Necrosis | |
Capsule, Fibrosis | |
Lymphoid Follicle, Depletion Cellular| 2 |
__________________________________________________________________________|
Thymus | + + + + + M M M + + + + + + + + + + M + + + + + +|
Atrophy | 3 2 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 1 2 1 1 2 2 2|
Galactocele | 3 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst, Squamous | 4 |
Inflammation, Chronic Active | 2 2 1 1 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 4| 7| 1| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 4|
DAY ON TEST | 7| 2| 1| 2| 2| 4| 2| 9| 2| 2| 2| 7| 2| 7| 2| 2| 0| 2| 6| 2| 2| 2| 2| 2| 9|
| 8| 9| 8| 8| 8| 1| 8| 8| 8| 8| 9| 4| 9| 0| 8| 8| 8| 9| 1| 8| 9| 9| 9| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 MG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 2| 3| 5| 6| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 8| 9| 0| 2| 3| 5| 8|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Metaplasia, Osseous | 2 |
Mineralization | 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Pigmentation, Hemosiderin | 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 2| 5| 6| 2| 2| 2| 6| 9| 1| 7| 2| 2| 2| 2| 2| 2| 2| 9| 2| 3| 7| 2| 2| 2| |
| 9| 8| 3| 5| 8| 9| 9| 0| 3| 3| 8| 9| 9| 9| 8| 8| 8| 9| 3| 8| 8| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
30 MG/KG | 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 9| 0| 1| 6| 8| 9| 0| 2| 3| 6| 7| 1| 4| 5| 7| 9| 1| 2| 5| 8| 3| 5| 6| 7| 8| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A M + + + + + + + + + + + + A + + +| 46 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + A + A + + + + + + + + + + M A + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + A + A + + + + + + + + + + A A + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + A + + + + + + + + + + A A + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 37 |
Clear Cell Focus | X X | 6 |
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | X | 3 |
Hepatodiaphragmatic Nodule | X X | 4 |
Inflammation, Chronic Active | 1 1 1 1 | 10 1.0|
Mixed Cell Focus | X X X X X | 9 |
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 | 6 1.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 1 | 6 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 12 |
Mineralization | 2| 1 2.0|
Fat, Inflammation, Chronic Active | 2 2 2 4 2| 10 2.1|
Fat, Mineralization | 2 1 1 | 3 1.3|
Fat, Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 | 2 1.0|
Acinus, Atrophy | 4 2 1 | 5 2.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
Ulcer | | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 2| 5| 6| 2| 2| 2| 6| 9| 1| 7| 2| 2| 2| 2| 2| 2| 2| 9| 2| 3| 7| 2| 2| 2| |
| 9| 8| 3| 5| 8| 9| 9| 0| 3| 3| 8| 9| 9| 9| 8| 8| 8| 9| 3| 8| 8| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
30 MG/KG | 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 9| 0| 1| 6| 8| 9| 0| 2| 3| 6| 7| 1| 4| 5| 7| 9| 1| 2| 5| 8| 3| 5| 6| 7| 8| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | | 1 4.0|
Myocardium, Degeneration, Chronic | 1 2 2 1 2 2 2 2 1 3 2 2 2 2 2 2 1 2 2 2 2 2 2| 40 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 2 1 1 2 2 | 15 1.3|
Pigmentation | 1 | 2 1.5|
Vacuolization Cytoplasmic | 3 1 3 1 1 1 1 1 1 1| 21 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + M + + +| 42 |
Hyperplasia | 3 | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 4 2.0|
Hemorrhage | 1 | 2 2.0|
Hyperplasia | 2 2| 2 2.0|
Mineralization | 2 | 1 2.0|
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | | 2 3.0|
Pars Nervosa, Developmental | | |
Malformation | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3 3 2| 5 3.0|
Inflammation, Chronic Active | 1 1 1 | 11 1.3|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
DYSGENESIS | 2 3 3 3 3 3 3 3 2 3 3 3 2 2 3 4 3 3 3 1 2 3 3| 43 2.7|
Follicle, Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 2| 5| 6| 2| 2| 2| 6| 9| 1| 7| 2| 2| 2| 2| 2| 2| 2| 9| 2| 3| 7| 2| 2| 2| |
| 9| 8| 3| 5| 8| 9| 9| 0| 3| 3| 8| 9| 9| 9| 8| 8| 8| 9| 3| 8| 8| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
30 MG/KG | 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 9| 0| 1| 6| 8| 9| 0| 2| 3| 6| 7| 1| 4| 5| 7| 9| 1| 2| 5| 8| 3| 5| 6| 7| 8| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Periovarian Tissue, Cyst | 3 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 2 2.5|
Hydrometra | 2 2 | 5 1.4|
Endometrium, Cyst | 1 2 2 1 2 2| 9 1.6|
Endometrium, Hyperplasia, Cystic | 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular | | 1 2.0|
Myelofibrosis | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Ectasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 3 | 3 2.7|
Hyperplasia, Focal | | 1 3.0|
Necrosis | 2 | 1 2.0|
Capsule, Fibrosis | 1 | 1 1.0|
Lymphoid Follicle, Depletion Cellular| | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + M + + + + +| 44 |
Atrophy | 2 2 | 7 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Dilatation | 2 2 1 1 2 | 13 1.6|
Galactocele | 2 2 | 3 2.3|
Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Cyst | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 2| 5| 6| 2| 2| 2| 6| 9| 1| 7| 2| 2| 2| 2| 2| 2| 2| 9| 2| 3| 7| 2| 2| 2| |
| 9| 8| 3| 5| 8| 9| 9| 0| 3| 3| 8| 9| 9| 9| 8| 8| 8| 9| 3| 8| 8| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
30 MG/KG | 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 9| 0| 1| 6| 8| 9| 0| 2| 3| 6| 7| 1| 4| 5| 7| 9| 1| 2| 5| 8| 3| 5| 6| 7| 8| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Cyst, Squamous | | 1 4.0|
Inflammation, Chronic Active | 1 1 | 7 1.3|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.0|
Pigmentation | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 3| 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Metaplasia, Osseous | | 1 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.1|
Nephropathy | 1 2 1 1 1 1 1 1 1 1 1 2 2 1 1 2 1 2 1 2| 38 1.2|
Pigmentation, Hemosiderin | 3 2 | 4 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 6|
DAY ON TEST | 3| 2| 2| 2| 1| 2| 7| 2| 5| 6| 2| 9| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 5| 2| 2|
| 9| 8| 9| 8| 0| 9| 4| 9| 9| 3| 8| 5| 9| 4| 8| 9| 5| 9| 8| 9| 7| 8| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7|
MG/KG | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 2| 4| 5| 7| 8| 0| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + A + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + M + M + + + + A + + + + + + + A|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + A + + + + + + + A|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + M + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | X X X |
Necrosis | 1 |
Regeneration | 2 |
Centrilobular, Necrosis | |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Inflammation, Chronic Active | 2 3 2 2 2 2 |
Fat, Mineralization | 1 2 2 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
Angiectasis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + M + + + + + + + + + + + + + + +|
Epicardium, Inflammation, Chronic | |
Active | 2 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 6|
DAY ON TEST | 3| 2| 2| 2| 1| 2| 7| 2| 5| 6| 2| 9| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 5| 2| 2|
| 9| 8| 9| 8| 0| 9| 4| 9| 9| 3| 8| 5| 9| 4| 8| 9| 5| 9| 8| 9| 7| 8| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7|
MG/KG | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 2| 4| 5| 7| 8| 0| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Degeneration, Chronic | 2 1 2 2 3 2 3 2 2 2 1 2 2 1 1 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +|
Angiectasis | |
Necrosis | |
Vacuolization Cytoplasmic | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 3 1 4 3 4 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + M + + + + + M + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia | |
Mineralization | 3 |
Pars Nervosa, Developmental | |
Malformation | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | 2 |
Ultimobranchial Cyst | 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic Active | 1 2 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
DYSGENESIS | 2 4 3 3 3 4 2 4 3 3 3 3 3 3 3 3 2 4 4 3 3 3 4 4 3|
Follicle, Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 3 |
Cervix, Angiectasis | 2 |
Cervix, Cyst | 2 |
Endometrium, Cyst | 3 1 |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 6|
DAY ON TEST | 3| 2| 2| 2| 1| 2| 7| 2| 5| 6| 2| 9| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 5| 2| 2|
| 9| 8| 9| 8| 0| 9| 4| 9| 9| 3| 8| 5| 9| 4| 8| 9| 5| 9| 8| 9| 7| 8| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7|
MG/KG | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 2| 4| 5| 7| 8| 0| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +|
Ectasia | 2 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +|
Accessory Spleen | |
Angiectasis | 4 |
Hematopoietic Cell Proliferation | 2 2 |
Necrosis | |
Lymphoid Follicle, Depletion Cellular| 3 |
__________________________________________________________________________|
Thymus | + + M + + + M + + M + + M + + + + + + + + + + + +|
Atrophy | 3 4 3 |
Inflammation | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 1 1 1 2 1 1 1 |
Galactocele | |
Hyperplasia, Focal | |
Lobular, Hyperplasia | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parakeratosis | |
Ulcer | |
Epidermis, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 1 1 1 1 2 3 2 3 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 3 1 1 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 6|
DAY ON TEST | 3| 2| 2| 2| 1| 2| 7| 2| 5| 6| 2| 9| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 5| 2| 2|
| 9| 8| 9| 8| 0| 9| 4| 9| 9| 3| 8| 5| 9| 4| 8| 9| 5| 9| 8| 9| 7| 8| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7|
MG/KG | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 2| 4| 5| 7| 8| 0| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | 3 |
Developmental Malformation | |
Inflammation, Chronic Active | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 2 2 2 1 1 2 1 2 1 2 2 1 1 2 3 2 2 1 2 1|
Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 7| 3| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 0| 2| 1| 2| 1| 9| 2| 2| 2| 5| 2| 8| 2| |
| 9| 0| 8| 8| 8| 8| 9| 9| 9| 8| 2| 8| 4| 8| 3| 8| 1| 0| 8| 9| 9| 9| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
100 | 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
MG/KG | 4| 5| 6| 8| 9| 1| 6| 7| 0| 1| 3| 4| 5| 7| 0| 1| 3| 4| 5| 0| 2| 3| 4| 8| 9| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X X X | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + A + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + A + + + + + + +| 44 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 46 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 41 |
Clear Cell Focus | X X X X X X X | 14 |
Degeneration, Cystic | 1 1 | 3 1.0|
Eosinophilic Focus | X X X | 3 |
Hepatodiaphragmatic Nodule | X X X | 9 |
Inflammation, Chronic Active | 1 1 1 1 | 5 1.0|
Mixed Cell Focus | X X X X | 7 |
Necrosis | | 1 1.0|
Regeneration | 2 | 2 2.0|
Centrilobular, Necrosis | 2 | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 1 | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Fat, Inflammation, Chronic Active | 2 2 2 1 | 10 2.0|
Fat, Mineralization | 1 1 | 5 1.4|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 2.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Angiectasis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 7| 3| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 0| 2| 1| 2| 1| 9| 2| 2| 2| 5| 2| 8| 2| |
| 9| 0| 8| 8| 8| 8| 9| 9| 9| 8| 2| 8| 4| 8| 3| 8| 1| 0| 8| 9| 9| 9| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
100 | 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
MG/KG | 4| 5| 6| 8| 9| 1| 6| 7| 0| 1| 3| 4| 5| 7| 0| 1| 3| 4| 5| 0| 2| 3| 4| 8| 9| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epicardium, Inflammation, Chronic | | |
Active | 3 | 2 2.5|
Myocardium, Degeneration, Chronic | 2 1 2 2 2 2 2 2 2 2 1 2 1 2 1 2 2 2 2 2 2 2 2 2 2| 45 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 1 2| 3 1.7|
Necrosis | 3 | 1 3.0|
Vacuolization Cytoplasmic | 1 3 1 1 2 2 1 1 1 1 1 1 1 4 1 1 1 1 1 2 1 1| 36 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 1 1 1 2 1 | 13 2.2|
Vacuolization Cytoplasmic | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M + + M + M M + + M + + M + + + +| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Hyperplasia | 1 | 1 1.0|
Mineralization | | 1 3.0|
Pars Nervosa, Developmental | | |
Malformation | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Ultimobranchial Cyst | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 3.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 | 18 1.1|
__________________________________________________________________________|____________|
Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
DYSGENESIS | 4 4 4 4 4 4 4 4 4 3 4 3 3 3 4 3 3 4 4 4 4 4 3 4| 49 3.4|
Follicle, Cyst | 4 | 1 4.0|
Periovarian Tissue, Cyst | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 7| 3| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 0| 2| 1| 2| 1| 9| 2| 2| 2| 5| 2| 8| 2| |
| 9| 0| 8| 8| 8| 8| 9| 9| 9| 8| 2| 8| 4| 8| 3| 8| 1| 0| 8| 9| 9| 9| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
100 | 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
MG/KG | 4| 5| 6| 8| 9| 1| 6| 7| 0| 1| 3| 4| 5| 7| 0| 1| 3| 4| 5| 0| 2| 3| 4| 8| 9| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hydrometra | 2 3 2 2 | 6 2.3|
Cervix, Angiectasis | | 1 2.0|
Cervix, Cyst | | 1 2.0|
Endometrium, Cyst | 1 | 3 1.7|
Endometrium, Hyperplasia, Cystic | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Ectasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 2 2| 4 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Spleen | X | 1 |
Angiectasis | | 1 4.0|
Hematopoietic Cell Proliferation | 3 | 3 2.3|
Necrosis | 1 | 1 1.0|
Lymphoid Follicle, Depletion Cellular| 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + M + + M + + + + + + + + + + + +| 42 |
Atrophy | 2 4 2 | 6 3.0|
Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 1 1 2 2 2 2 1 2| 17 1.4|
Galactocele | 2 1 | 2 1.5|
Hyperplasia, Focal | 2 | 1 2.0|
Lobular, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Parakeratosis | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
Epidermis, Cyst | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 7| 3| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 0| 2| 1| 2| 1| 9| 2| 2| 2| 5| 2| 8| 2| |
| 9| 0| 8| 8| 8| 8| 9| 9| 9| 8| 2| 8| 4| 8| 3| 8| 1| 0| 8| 9| 9| 9| 8| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
100 | 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
MG/KG | 4| 5| 6| 8| 9| 1| 6| 7| 0| 1| 3| 4| 5| 7| 0| 1| 3| 4| 5| 0| 2| 3| 4| 8| 9| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 1 1 1 1 | 17 1.4|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 2 2 | 9 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 3.0|
Developmental Malformation | X | 1 |
Inflammation, Chronic Active | 1 | 1 1.0|
Mineralization | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1| 36 1.0|
Nephropathy | 2 1 2 2 2 2 2 2 2 2 2 2 1 3 1 1 2 2 1 2 1| 41 1.7|
Pigmentation, Hemosiderin | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1|
| 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5|
| 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + A + + + + + +|
Mineralization | 1 |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + A + + M + A + + A A + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + A + + + + +|
Mineralization | 1 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A A + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + A A + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | |
Eosinophilic Focus | X X X |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Chronic Active | 1 1 1 1 |
Mixed Cell Focus | X X |
Necrosis | 1 1 |
Bile Duct, Hyperplasia | 1 2 2 1 1 1 1 2 2 1 3 1 1 2 3 1 1 2|
Centrilobular, Congestion | |
Centrilobular, Necrosis | 3 |
Centrilobular, Vacuolization | |
Cytoplasmic | 1 3 1 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Fat, Inflammation, Chronic Active | 2 2 2 3 3 3|
Fat, Mineralization | 2 2 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Oral Mucosa | + + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + A + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 3 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 2 2 2 |
Mineralization | 1 |
Ulcer | 2 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1|
| 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5|
| 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Mineralization | 4 1 2 4 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 4 |
Myocardium, Degeneration, Chronic | 1 1 3 2 1 2 2 3 2 1 3 1 1 1 2 3 2 1 3 3 2 2|
Pericardium, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 3 2 1 1 1 1 2 2 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 2 |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + A + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 3 2 3 2 2 3 4 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 |
Hyperplasia | |
Mineralization | 3 2 |
Necrosis | 3 |
Pars Distalis, Fibrosis | |
Pars Nervosa, Developmental | |
Malformation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1|
| 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5|
| 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | 3 |
Hyperplasia | |
Inflammation, Chronic Active | 2 1 2 2 1 2 1 1 1 1 2 1 1 1 2 1 1 1 1 3 1 1 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 3 1 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Granulomatous | |
Mineralization | 3 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration | 2 1 2 2 |
Mineralization | 2 2 2 1 1 2 1 1 2 1 2 |
Necrosis | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + M + + +|
Myelofibrosis | 2 |
Necrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + |
Ectasia | 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 1 1 2 |
Hematopoietic Cell Proliferation | 3 2 |
Necrosis | |
Lymphoid Follicle, Depletion Cellular| |
__________________________________________________________________________|
Thymus | M + + + + + M + + + + + + + M + + + M + + + + + +|
Atrophy | 1 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Dilatation | 1 1 1 1 2 2 2 2 1 1 1 2 1 2 2 2 |
Galactocele | 2 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1|
| 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5|
| 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Mineralization | 2 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parakeratosis | |
Epidermis, Cyst | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3 |
Osteosclerosis | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | M + + +|
__________________________________________________________________________|
Spinal Cord | + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic Active | 2 1 1 2 2 2 2 |
Mineralization | 1 1 1 1 2 1 1 1 2 1 1 1|
Necrosis | 3 |
Vacuolization Cytoplasmic | 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Interstitium, Fibrosis | |
__________________________________________________________________________|
Nose | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic Active | 1 |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration | |
Mineralization | 3 1 2 |
Nephropathy | 1 3 1 2 1 1 2 2 1 4 1 3 2 2 2 2 2 4 2 4 1|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1|
| 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5|
| 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 2 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | |
Muscularis, Inflammation, Suppurative| |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2|
| 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
Mineralization | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Mineralization | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + A A|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + A A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | X X|
Inflammation, Chronic Active | 2 1 1 1 1 |
Mixed Cell Focus | |
Necrosis | 1 |
Bile Duct, Hyperplasia | 1 1 2 2 1 1 1 2 1 1 |
Centrilobular, Congestion | 3 |
Centrilobular, Necrosis | |
Centrilobular, Vacuolization | |
Cytoplasmic | 4 1 2 1 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Inflammation, Chronic Active | 2 3 3 1 |
Fat, Mineralization | 2 1 2 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Oral Mucosa | |
Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Acinus, Atrophy | 2 1 1 2 1 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperkeratosis | |
Inflammation, Chronic Active | |
Mineralization | |
Ulcer | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2|
| 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 |
Mineralization | 1 1 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Myocardium, Degeneration, Chronic | 1 2 1 1 2 2 1 2 3 1 2 2 2 2 2 2 1 2 1 2 2 |
Pericardium, Inflammation, Chronic | |
Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 1 1 2 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 3 1 2 3 3 |
Necrosis | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + M + + + + + M M + + + + +|
Hyperplasia | 1 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 2 |
Mineralization | |
Necrosis | 3 |
Pars Distalis, Fibrosis | 3 |
Pars Nervosa, Developmental | |
Malformation | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2|
| 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | 3 4|
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 2 3 1 1 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 1 3 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Inflammation, Granulomatous | 2 |
Mineralization | |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Degeneration | 2 3 2 2 2 |
Mineralization | 2 2 2 2 2 2 |
Necrosis | 4 |
Interstitial Cell, Hyperplasia | 3 2 1 2 3 2 4 1 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + M +|
Myelofibrosis | |
Necrosis | |
__________________________________________________________________________|
Lymph Node | + |
Ectasia | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 |
Necrosis | |
Lymphoid Follicle, Depletion Cellular| 2|
__________________________________________________________________________|
Thymus | + + M + M M + + + + + + + + + + + M + + + + + + M|
Atrophy | 2 3 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Dilatation | 2 3 2 2 1 1 2 1 2 2 1 1 1 1 2 |
Galactocele | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2|
| 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Mineralization | 1 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parakeratosis | 4 |
Epidermis, Cyst | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Osteosclerosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 2 4 3 1 2|
Mineralization | 1 1 1 1 1 1 |
Necrosis | |
Vacuolization Cytoplasmic | 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Fibrosis | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Degeneration | 2 |
Mineralization | 1 1 2 |
Nephropathy | 2 2 1 1 2 2 1 3 2 1 2 4 1 2 2 4 2 3 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2|
| 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 3 1 1 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 1 |
Muscularis, Inflammation, Suppurative| 3 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 0| | A |
0 MG/KG | 8| | L |
| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 48 |
Mineralization | | 1 1.0|
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 49 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 43 |
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 48 |
Mineralization | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 44 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Angiectasis | | 1 1.0|
Basophilic Focus | | 23 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | | 6 |
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | | 7 |
Inflammation, Chronic Active | | 9 1.1|
Mixed Cell Focus | | 2 |
Necrosis | | 3 1.0|
Bile Duct, Hyperplasia | 1 | 29 1.4|
Centrilobular, Congestion | | 1 3.0|
Centrilobular, Necrosis | | 1 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 9 1.9|
__________________________________________________________________________|____________|
Mesentery | | 14 |
Fat, Inflammation, Chronic Active | | 10 2.4|
Fat, Mineralization | | 5 1.8|
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 3 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + | 49 |
Inflammation, Chronic Active | | 2 1.0|
Acinus, Atrophy | | 11 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Edema | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 0| | A |
0 MG/KG | 8| | L |
| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic Active | | 3 2.0|
Mineralization | | 1 1.0|
Ulcer | | 6 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Erosion | 2 | 2 1.5|
Mineralization | | 6 2.2|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 51 |
Mineralization | | 3 3.0|
__________________________________________________________________________|____________|
Heart | + | 51 |
Mineralization | | 3 3.0|
Myocardium, Degeneration, Chronic | | 43 1.8|
Pericardium, Inflammation, Chronic | | |
Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Vacuolization Cytoplasmic | 2 | 22 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Hyperplasia | 3 | 15 2.7|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + | 46 |
Hyperplasia | | 10 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + | 51 |
Cyst | | 2 1.0|
Hyperplasia | | 2 1.5|
Mineralization | | 2 2.5|
Necrosis | | 2 3.0|
Pars Distalis, Fibrosis | | 1 3.0|
Pars Nervosa, Developmental | | |
Malformation | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 0| | A |
0 MG/KG | 8| | L |
| 8| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 51 |
Degeneration | | 1 1.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 51 |
Cyst | | 3 3.3|
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | | 45 1.4|
__________________________________________________________________________|____________|
Prostate | + | 51 |
Inflammation, Chronic Active | | 10 1.8|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 51 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Granulomatous | | 1 2.0|
Mineralization | | 1 3.0|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + | 51 |
Cyst | | 1 2.0|
Degeneration | | 9 2.0|
Mineralization | | 17 1.7|
Necrosis | | 1 4.0|
Interstitial Cell, Hyperplasia | | 16 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 48 |
Myelofibrosis | | 1 2.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + | 4 |
Ectasia | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 51 |
Amyloid Deposition | | 1 4.0|
Ectasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 0| | A |
0 MG/KG | 8| | L |
| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | | 1 2.0|
Ectasia | | 3 2.0|
__________________________________________________________________________|____________|
Spleen | + | 51 |
Fibrosis | | 7 1.9|
Hematopoietic Cell Proliferation | | 3 2.3|
Necrosis | 3 | 1 3.0|
Lymphoid Follicle, Depletion Cellular| | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + | 42 |
Atrophy | | 6 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
Angiectasis | | 1 3.0|
Dilatation | | 31 1.5|
Galactocele | | 1 2.0|
Mineralization | | 2 1.5|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + | 51 |
Parakeratosis | | 1 4.0|
Epidermis, Cyst | | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
Fibrous Osteodystrophy | | 2 2.5|
Osteosclerosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 4 |
__________________________________________________________________________|____________|
Spinal Cord | | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | | 12 2.0|
Mineralization | 1 | 19 1.1|
Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 0| | A |
0 MG/KG | 8| | L |
| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Vacuolization Cytoplasmic | | 6 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Interstitium, Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + | 50 |
Inflammation, Chronic Active | 3 | 3 2.7|
Inflammation, Suppurative | | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + | 50 |
Inflammation, Chronic Active | | 1 1.0|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Cyst | | 1 2.0|
Degeneration | | 1 2.0|
Mineralization | | 6 1.7|
Nephropathy | 2 | 43 2.0|
Pigmentation, Hemosiderin | | 4 1.8|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 2 3.0|
Renal Tubule, Hyperplasia | 3 | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 1 1.0|
Muscularis, Inflammation, Suppurative| | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 4| 4| 3| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 6| 5| 7|
DAY ON TEST | 2| 0| 0| 9| 2| 8| 8| 2| 2| 5| 2| 2| 2| 2| 1| 0| 0| 7| 9| 2| 7| 2| 9| 9| 2|
| 0| 7| 0| 2| 4| 5| 5| 1| 8| 9| 8| 9| 8| 8| 4| 9| 6| 9| 3| 8| 9| 8| 2| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 9| 9| 9| 9| 9| 9| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 6| 8| 2| 9| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 8| 9| 0| 1| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A + + + + A + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + A A + + + + + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Degeneration, Cystic | 3 1 3 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | 1 1 1 |
Mixed Cell Focus | |
Necrosis | |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Centrilobular, Necrosis | 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | 1 1 3 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic Active | 3 2 |
Fat, Mineralization | 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + M + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Chronic Active | 1 |
Mineralization | 1 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Mineralization | 4 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 4| 4| 3| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 6| 5| 7|
DAY ON TEST | 2| 0| 0| 9| 2| 8| 8| 2| 2| 5| 2| 2| 2| 2| 1| 0| 0| 7| 9| 2| 7| 2| 9| 9| 2|
| 0| 7| 0| 2| 4| 5| 5| 1| 8| 9| 8| 9| 8| 8| 4| 9| 6| 9| 3| 8| 9| 8| 2| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 9| 9| 9| 9| 9| 9| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 6| 8| 2| 9| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 8| 9| 0| 1| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 3 3 |
Thrombosis | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + M + + + + + + + + + + + + +|
Mineralization | 2 3 3 |
Thrombosis | 3 |
Myocardium, Degeneration, Chronic | 3 2 2 1 2 1 2 2 2 2 3 2 2 2 1 1 2 2 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
Vacuolization Cytoplasmic | 2 1 1 2 2 1 2 3 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 2 3 3 2 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + M + + + + + + + + + + + M +|
Hyperplasia | 3 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 1 1 |
Mineralization | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Mineralization | 1 |
Ultimobranchial Cyst | 1 1 2 2 |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 1 |
Degeneration | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 |
Mineralization | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 4| 4| 3| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 6| 5| 7|
DAY ON TEST | 2| 0| 0| 9| 2| 8| 8| 2| 2| 5| 2| 2| 2| 2| 1| 0| 0| 7| 9| 2| 7| 2| 9| 9| 2|
| 0| 7| 0| 2| 4| 5| 5| 1| 8| 9| 8| 9| 8| 8| 4| 9| 6| 9| 3| 8| 9| 8| 2| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 9| 9| 9| 9| 9| 9| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 6| 8| 2| 9| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 8| 9| 0| 1| 3|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Mineralization | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 3 3 3 |
Mineralization | 2 2 1 1 1 |
Interstitial Cell, Hyperplasia | 1 2 2 4 1 2 2 3 2 3 2 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + |
Ectasia | 2 |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 3 3 |
Fibrosis | 3 1 2|
Hematopoietic Cell Proliferation | 2 |
Pigmentation, Hemosiderin | 3 |
Lymphoid Follicle, Depletion Cellular| 2 |
__________________________________________________________________________|
Thymus | + M M + + + + + + + + M + + + + M M + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Dilatation | 1 1 2 1 1 1 2 2 2|
Galactocele | 3 |
Hyperplasia | 3 |
Mineralization | 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parakeratosis | 4 |
Ulcer | 4 |
Epidermis, Cyst | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 2 4 4 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 4| 4| 3| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 6| 5| 7|
DAY ON TEST | 2| 0| 0| 9| 2| 8| 8| 2| 2| 5| 2| 2| 2| 2| 1| 0| 0| 7| 9| 2| 7| 2| 9| 9| 2|
| 0| 7| 0| 2| 4| 5| 5| 1| 8| 9| 8| 9| 8| 8| 4| 9| 6| 9| 3| 8| 9| 8| 2| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 9| 9| 9| 9| 9| 9| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 6| 8| 2| 9| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 8| 9| 0| 1| 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | |
Inflammation, Chronic Active | 1 1 2 2 3 1 1|
Mineralization | 2 1 1 1 1 1 1 1 1 1 1 1|
Proteinosis | |
Vacuolization Cytoplasmic | 1 1 2 2 1 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Interstitium, Fibrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + M + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | |
Lens, Mineralization | 3 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 2 2 |
Hyperplasia, Oncocytic | |
Inflammation, Chronic Active | |
Mineralization | 2 2 2 |
Nephropathy | 4 4 2 4 2 2 2 1 1 2 2 3 3 4 3 3 1 3 3 2 3 3 1 3|
Pigmentation, Hemosiderin | 3 3 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2| |
| 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3 MG/KG | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L |
| 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 | 1 1.0|
Mineralization | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + A + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A A + + + + + + + + A + A A + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 | 1 1.0|
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A A + + + + + A + + A + A A + + + + + + + + + +| 39 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A + + + + + + + + + + A A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X| 29 |
Clear Cell Focus | X | 2 |
Degeneration, Cystic | 2 | 4 2.3|
Eosinophilic Focus | X X X | 4 |
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Hepatodiaphragmatic Nodule | X X X | 3 |
Inflammation, Chronic Active | 1 | 4 1.0|
Mixed Cell Focus | X| 1 |
Necrosis | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 2 1 2 | 27 1.1|
Centrilobular, Necrosis | 2 3 | 3 2.3|
Centrilobular, Vacuolization | | |
Cytoplasmic | 2 2 | 6 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Fat, Inflammation, Chronic Active | 3 2 | 4 2.5|
Fat, Mineralization | 2 | 2 2.5|
Fat, Necrosis | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Atrophy | 1 2 1 | 7 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 1.0|
Inflammation, Chronic Active | 4 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2| |
| 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3 MG/KG | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L |
| 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 2 2.0|
Ulcer | 4 1 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Mineralization | 3 3 | 6 3.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 4 | 5 3.4|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 3 4 | 5 3.0|
Thrombosis | | 1 3.0|
Myocardium, Degeneration, Chronic | 1 2 2 2 2 1 2 2 3 1 2 2 1 3 2 2 1 2 1 2 2 1 2| 43 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 2.5|
Vacuolization Cytoplasmic | 1 1 1 1 4 1 1 1 2 1 2 2 | 23 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 4 4 3 1 1 3 | 17 2.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + M + M + +| 44 |
Hyperplasia | 2 2 2 3 2 3 2 3 2 3| 14 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 2.5|
Hyperplasia | | 2 1.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | | 1 1.0|
Ultimobranchial Cyst | 2 1 | 6 1.5|
Follicle, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2| |
| 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3 MG/KG | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L |
| 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Degeneration | 3 | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Cyst | 1 | 2 1.5|
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 1 1 2 1 2 1 2 1 1 2 1 2 1 1 2 1 2 1 1 1 | 37 1.3|
Mineralization | 1 | 2 1.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Inflammation, Chronic Active | 2 2 1 2 | 5 1.8|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 2 2 2 2 3 | 9 2.4|
Mineralization | 1 1 1 1 2 | 10 1.3|
Interstitial Cell, Hyperplasia | 1 1 2 2 4 2 2 1 2 1 | 22 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Myelofibrosis | 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 4 |
Ectasia | 2 | 2 2.0|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + A M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Ectasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Ectasia | 2 2 2 2| 5 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Congestion | | 2 3.0|
Fibrosis | | 3 2.0|
Hematopoietic Cell Proliferation | 2 2 | 3 2.0|
Pigmentation, Hemosiderin | | 1 3.0|
Lymphoid Follicle, Depletion Cellular| | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + M + + + + + + + + + + + + + M + + + + + + + +| 42 |
Atrophy | 2 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2| |
| 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3 MG/KG | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L |
| 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Dilatation | 2 2 2 2 2 1 1 1 1 2 1 2 1 2 1| 24 1.5|
Galactocele | 2 2 2 | 4 2.3|
Hyperplasia | | 1 3.0|
Mineralization | 1 | 4 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parakeratosis | | 1 4.0|
Ulcer | | 1 4.0|
Epidermis, Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | 3 4 2| 8 3.1|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 1 2 1 2 1 2 | 13 1.5|
Mineralization | 1 2 1 1 1 1 1 3 1 1 1 1 1 | 25 1.2|
Proteinosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 1 | 7 1.4|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Interstitium, Fibrosis | 1 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 2 2| 6 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Degeneration | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2| |
| 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
3 MG/KG | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L |
| 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Lens, Mineralization | | 1 3.0|
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 2| 7 2.4|
Hyperplasia, Oncocytic | 4 | 1 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 1 1 3 | 6 1.8|
Nephropathy | 3 2 2 2 4 2 4 3 4 3 2 1 4 1 3 3 3 2 1 2 3 2 4| 47 2.6|
Pigmentation, Hemosiderin | 2 1 | 4 2.3|
Renal Tubule, Hyperplasia | 4 4| 2 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 5| 6| 5| 7| 6| 6| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 8| 0| 2| 9| 9| 0| 1| 5| 6| 0| 4| 2| 2| 9| 2| 2| 8| 4| 2| 6| 4| 2| 2| 2| 9|
| 1| 6| 8| 2| 7| 0| 7| 3| 4| 5| 0| 9| 8| 3| 8| 8| 0| 4| 8| 6| 4| 8| 7| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 5| 6| 8| 0| 2| 3| 4| 6| 7| 8| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + A + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + A + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + A + A A + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + A + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + A A A + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Eosinophilic Focus | X |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | X X |
Necrosis | 2 |
Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 1 1 |
Centrilobular, Degeneration | |
Centrilobular, Necrosis | 3 |
Centrilobular, Vacuolization | |
Cytoplasmic | 1 2 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic Active | |
Fat, Mineralization | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic Active | 3 2 2 2 3 1 2 |
Mineralization | 4 2 |
Perforation | X 2 |
Ulcer | 4 4 2 |
Epithelium, Hyperplasia | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Erosion | 2 |
Mineralization | 2 3 3 3 3 |
__________________________________________________________________________|
Tongue | |
Vacuolization Cytoplasmic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 5| 6| 5| 7| 6| 6| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 8| 0| 2| 9| 9| 0| 1| 5| 6| 0| 4| 2| 2| 9| 2| 2| 8| 4| 2| 6| 4| 2| 2| 2| 9|
| 1| 6| 8| 2| 7| 0| 7| 3| 4| 5| 0| 9| 8| 3| 8| 8| 0| 4| 8| 6| 4| 8| 7| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 5| 6| 8| 0| 2| 3| 4| 6| 7| 8| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 4 2 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 2 4 2 4 |
Myocardium, Degeneration, Chronic | 2 2 2 3 1 2 1 2 3 1 1 3 3 2 2 2 3 2 2 2 1 1 2 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Vacuolization Cytoplasmic | 3 1 2 1 3 1 3 1 3 2 2 2 1 3 3 2 2 2 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 1 1 4 3 4 3 1 1 2 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 2 2 3 3 3 3 1 1 3 3 1|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Degeneration | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 2 1 1 1 3 1 1 2 1 2 3 2 2 1 2 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 3 3 2 2 3 3 1 2 3 3 1 2 2 3 2 2 2 3|
Mineralization | 1 2 2 1 1 1 1 1 1 2 2 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 5| 6| 5| 7| 6| 6| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 8| 0| 2| 9| 9| 0| 1| 5| 6| 0| 4| 2| 2| 9| 2| 2| 8| 4| 2| 6| 4| 2| 2| 2| 9|
| 1| 6| 8| 2| 7| 0| 7| 3| 4| 5| 0| 9| 8| 3| 8| 8| 0| 4| 8| 6| 4| 8| 7| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 5| 6| 8| 0| 2| 3| 4| 6| 7| 8| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | |
Ectasia | 2 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 |
Thrombosis | 3 |
Lymphoid Follicle, Depletion Cellular| 3 |
__________________________________________________________________________|
Thymus | + M + + + + M + + + + + + M + + M M + + M + + + +|
Atrophy | 3 4 4 3 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Dilatation | 2 1 2 3 1 3 2 1 3 1 2|
Galactocele | |
Hyperplasia, Focal | 1 |
Mineralization | 2 2 |
Lobular, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 3 3 3 1 2 4 1 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Meninges, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Demyelination | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Inflammation, Chronic Active | 2 2 2 2 1 |
Mineralization | 1 1 1 1 1 1 2 3 1 1 1 2 |
Necrosis | |
Vacuolization Cytoplasmic | 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 5| 6| 5| 7| 6| 6| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 8| 0| 2| 9| 9| 0| 1| 5| 6| 0| 4| 2| 2| 9| 2| 2| 8| 4| 2| 6| 4| 2| 2| 2| 9|
| 1| 6| 8| 2| 7| 0| 7| 3| 4| 5| 0| 9| 8| 3| 8| 8| 0| 4| 8| 6| 4| 8| 7| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 5| 6| 8| 0| 2| 3| 4| 6| 7| 8| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cornea, Inflammation, Suppurative | 2 |
Cornea, Mineralization | 1 |
Cornea, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2|
Mineralization | 1 3 2 3 2 3 |
Nephropathy | 4 1 3 4 2 4 2 2 4 4 2 1 4 3 3 4 4 3 2 3 3 4 4 4 3|
Pigmentation, Hemosiderin | 1 |
Renal Tubule, Hyperplasia | 3 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 2| 3| |
DAY ON TEST | 0| 6| 6| 2| 1| 3| 2| 0| 7| 3| 0| 1| 2| 2| 2| 2| 2| 0| 2| 0| 2| 0| 2| 8| 5| |
| 5| 6| 9| 8| 6| 8| 8| 7| 7| 7| 3| 9| 8| 7| 8| 2| 8| 9| 8| 3| 8| 1| 8| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
30 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 2| 5| 7| 9| 0| 1| 2| 4| 7| 8| 0| 3| 4| 5| 6| 7| 0| 3| 7| 8| 1| 2| 4| 7| 8| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + A + + + A + + + + + + + + +| 46 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + A + + + A + + + A + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + A + + + + + + + A + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + A + + + A + + + A + + + + +| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X | 41 |
Clear Cell Focus | X X | 6 |
Eosinophilic Focus | X X X | 4 |
Fatty Change | | 1 2.0|
Hematopoietic Cell Proliferation | 1 1| 2 1.0|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation, Chronic Active | 1 1 | 3 1.0|
Mixed Cell Focus | X X | 4 |
Necrosis | | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 3 1 1 1 2 1 1 1 1 1 1 | 24 1.2|
Centrilobular, Degeneration | 2 | 1 2.0|
Centrilobular, Necrosis | | 1 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 1 1 2 1 2 1 2 | 10 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 5 |
Fat, Inflammation, Chronic Active | 2 2 2 2 2 | 5 2.0|
Fat, Mineralization | 3 2 2 | 3 2.3|
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 2 2 1 1 | 11 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 1 | 1 1.0|
Inflammation, Chronic Active | 1 3 | 9 2.1|
Mineralization | | 2 3.0|
Perforation | | 2 2.0|
Ulcer | 3 | 4 3.3|
Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 2| 3| |
DAY ON TEST | 0| 6| 6| 2| 1| 3| 2| 0| 7| 3| 0| 1| 2| 2| 2| 2| 2| 0| 2| 0| 2| 0| 2| 8| 5| |
| 5| 6| 9| 8| 6| 8| 8| 7| 7| 7| 3| 9| 8| 7| 8| 2| 8| 9| 8| 3| 8| 1| 8| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
30 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 2| 5| 7| 9| 0| 1| 2| 4| 7| 8| 0| 3| 4| 5| 6| 7| 0| 3| 7| 8| 1| 2| 4| 7| 8| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 1 2.0|
Mineralization | 3 4 | 7 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Vacuolization Cytoplasmic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 3 | 6 3.2|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 4 | 8 3.0|
Myocardium, Degeneration, Chronic | 1 2 2 1 3 1 3 3 2 1 2 1 1 1 2 1 2 2 2 2 1 1 1 | 48 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3| 1 3.0|
Vacuolization Cytoplasmic | 3 3 2 2 1 1 2 1 2 2 3 1 1 1 2 1 1 1 2 1 3| 40 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 3 1 3 3 3 4| 20 2.5|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation, Hemosiderin | 1| 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 3 3 2 2 1 | 17 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 2 | 1 2.0|
Degeneration | 2| 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 3 1 2 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 42 1.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 2| 3| |
DAY ON TEST | 0| 6| 6| 2| 1| 3| 2| 0| 7| 3| 0| 1| 2| 2| 2| 2| 2| 0| 2| 0| 2| 0| 2| 8| 5| |
| 5| 6| 9| 8| 6| 8| 8| 7| 7| 7| 3| 9| 8| 7| 8| 2| 8| 9| 8| 3| 8| 1| 8| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
30 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 2| 5| 7| 9| 0| 1| 2| 4| 7| 8| 0| 3| 4| 5| 6| 7| 0| 3| 7| 8| 1| 2| 4| 7| 8| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 1 2 2 3 3 1 2 2 2 1 1 2 2 2 2 2 1 1| 37 2.1|
Mineralization | 1 2 1 2 1 1 1 2 2 2 1 1 1 1 1 1 | 33 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 2 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Ectasia | 3 2 | 3 2.3|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 2 2.5|
Hematopoietic Cell Proliferation | 3| 2 2.5|
Thrombosis | | 1 3.0|
Lymphoid Follicle, Depletion Cellular| | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + M + + M M + + + + + M + + + + M + + +| 38 |
Atrophy | 4 3 | 7 3.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 1 1 1 2 2 3 2 2 1 1 1 1 | 23 1.7|
Galactocele | 3 | 1 3.0|
Hyperplasia, Focal | | 1 1.0|
Mineralization | 1 | 3 1.7|
Lobular, Hyperplasia | | 4 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 2 2 | 13 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.5|
Meninges, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 2| 3| |
DAY ON TEST | 0| 6| 6| 2| 1| 3| 2| 0| 7| 3| 0| 1| 2| 2| 2| 2| 2| 0| 2| 0| 2| 0| 2| 8| 5| |
| 5| 6| 9| 8| 6| 8| 8| 7| 7| 7| 3| 9| 8| 7| 8| 2| 8| 9| 8| 3| 8| 1| 8| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
30 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
| 2| 5| 7| 9| 0| 1| 2| 4| 7| 8| 0| 3| 4| 5| 6| 7| 0| 3| 7| 8| 1| 2| 4| 7| 8| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + | 4 |
__________________________________________________________________________|____________|
Spinal Cord | + + + | 4 |
Demyelination | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 4.0|
Inflammation, Chronic Active | 1 3 3 1 1 1| 11 1.7|
Mineralization | 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1| 27 1.2|
Necrosis | 3 | 1 3.0|
Vacuolization Cytoplasmic | 1 1 | 7 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 2 3.0|
Inflammation, Suppurative | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Suppurative | | 1 2.0|
Cornea, Mineralization | | 1 1.0|
Cornea, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 4 2.0|
Mineralization | 2 3 1 | 9 2.2|
Nephropathy | 4 3 1 3 4 2 4 2 2 1 3 4 2 1 3 2 3 2 2 1 3 1 2 1 1| 50 2.7|
Pigmentation, Hemosiderin | 2 | 2 1.5|
Renal Tubule, Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 1| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 0| 4| 5| 6| 2| 7| 2| 6| 2| 6| 2| 2| 7| 2| 1| 3| 6| 2| 2| 3| 1| 5| 2| 2| 2|
| 3| 1| 1| 3| 8| 5| 8| 0| 8| 6| 8| 8| 5| 8| 4| 9| 1| 8| 8| 6| 1| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
150 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 2| 4| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 2| 4| 5| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Periesophageal Tissue, Hemorrhage | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + M + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + A + A + + + + + + + + + + + + + + + M + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + A + + + + + + M + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + A + A A + + + M + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A A + + + + + + + + + A + + + + + + M + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + M + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X|
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic Active | |
Mixed Cell Focus | X X |
Necrosis | |
Bile Duct, Fibrosis | |
Centrilobular, Congestion | |
Centrilobular, Necrosis | |
Centrilobular, Vacuolization | |
Cytoplasmic | 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + M + + + + +|
Acinus, Atrophy | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperkeratosis | |
Inflammation, Chronic Active | 2 4 2 |
Mineralization | |
Ulcer | 2 3 2 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + M + + + + +|
Mineralization | 3 3 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + M + + + + +|
Mineralization | 4 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + M + M + + +|
Mineralization | 4 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 1| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 0| 4| 5| 6| 2| 7| 2| 6| 2| 6| 2| 2| 7| 2| 1| 3| 6| 2| 2| 3| 1| 5| 2| 2| 2|
| 3| 1| 1| 3| 8| 5| 8| 0| 8| 6| 8| 8| 5| 8| 4| 9| 1| 8| 8| 6| 1| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
150 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 2| 4| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 2| 4| 5| 8| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Thrombosis | 3 |
Myocardium, Degeneration, Chronic | 3 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + M + + + + +|
Vacuolization Cytoplasmic | 3 1 1 1 3 3 1 3 1 3 1 1 2 2 2 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 3 2 3 3 3 4 3 |
Mineralization | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M M M + + + + +|
Hyperplasia | 2 3 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
Angiectasis | |
Cyst | 1 |
Hyperplasia | |
Vacuolization Cytoplasmic | 2 |
Pars Distalis, Hyperplasia | 1 |
Pars Nervosa, Developmental | |
Malformation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + M + + + + +|
Mineralization | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + A + + + + +|
Mineralization | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + A + + + + +|
Degeneration | 1 2 1 1 2 1 2 2 1 1 1 1 1 1 1 1|
Mineralization | 1 2 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 1| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 0| 4| 5| 6| 2| 7| 2| 6| 2| 6| 2| 2| 7| 2| 1| 3| 6| 2| 2| 3| 1| 5| 2| 2| 2|
| 3| 1| 1| 3| 8| 5| 8| 0| 8| 6| 8| 8| 5| 8| 4| 9| 1| 8| 8| 6| 1| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
150 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 2| 4| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 2| 4| 5| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 2 |
Ectasia | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + M + + + + +|
Accessory Spleen | |
Hematopoietic Cell Proliferation | 2 2 |
Lymphoid Follicle, Depletion Cellular| |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + M M M M + + M|
Atrophy | 3 3 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 1 1 1 2 2 2 1 2 1 1 1 |
Galactocele | 3 2 2 2 |
Hyperplasia, Focal | 2 |
Mineralization | 3 |
Lobular, Hyperplasia | 1 1 1 3 1 1 1 1 1 1 2 1 2 2 2 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parakeratosis | |
Hair Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 2 2 2 2 3 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + M + M + + +|
Congestion | 2 |
Edema | |
Hemorrhage | |
Inflammation, Chronic Active | 1 1 3 1 1 2 |
Mineralization | 3 1 1 1 1 1 1 1 1 1 1 1 1|
Vacuolization Cytoplasmic | 1 1 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 1| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 0| 4| 5| 6| 2| 7| 2| 6| 2| 6| 2| 2| 7| 2| 1| 3| 6| 2| 2| 3| 1| 5| 2| 2| 2|
| 3| 1| 1| 3| 8| 5| 8| 0| 8| 6| 8| 8| 5| 8| 4| 9| 1| 8| 8| 6| 1| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
150 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 2| 4| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 2| 4| 5| 8| 9|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Lens, Mineralization | 2 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | 2 2 2 |
Mineralization | 3 1 1 2 1 1 1 1 1|
Nephropathy | 4 1 2 2 3 4 2 3 2 3 2 3 2 3 1 3 1 4 3 2 4 4 3 2|
Pigmentation, Hemosiderin | 2 2 1 2 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Chronic Active | 1 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 0| 7| 5| 6| 1| 7| 7| 7| 5| 4| 1| 6| 0| 0| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 7| 4| 4| 2| 2| 2| 6| 3| 1| 8| 9| 8| 1| 2| 2| 2| 2| 1| 4| 2| 1| 2| 2|
| 4| 8| 7| 4| 5| 8| 8| 8| 3| 4| 5| 8| 2| 0| 6| 8| 8| 9| 4| 5| 6| 8| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5|
MG/KG | 0| 3| 5| 6| 7| 9| 1| 5| 6| 7| 8| 9| 0| 3| 5| 6| 0| 3| 8| 0| 2| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Hemorrhage | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + A + A + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X|
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic Active | 1|
Mixed Cell Focus | X X |
Necrosis | 2 |
Bile Duct, Fibrosis | 1 |
Centrilobular, Congestion | 2 |
Centrilobular, Necrosis | 3 |
Centrilobular, Vacuolization | |
Cytoplasmic | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 |
Inflammation, Chronic Active | 2 |
Mineralization | 1 3 |
Ulcer | 3 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | M + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 3 4 3 3 |
Ulcer | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 3 3 3 2 |
__________________________________________________________________________|
Heart | M + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 2 4 3 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 0| 7| 5| 6| 1| 7| 7| 7| 5| 4| 1| 6| 0| 0| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 7| 4| 4| 2| 2| 2| 6| 3| 1| 8| 9| 8| 1| 2| 2| 2| 2| 1| 4| 2| 1| 2| 2|
| 4| 8| 7| 4| 5| 8| 8| 8| 3| 4| 5| 8| 2| 0| 6| 8| 8| 9| 4| 5| 6| 8| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5|
MG/KG | 0| 3| 5| 6| 7| 9| 1| 5| 6| 7| 8| 9| 0| 3| 5| 6| 0| 3| 8| 0| 2| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Thrombosis | 2 |
Myocardium, Degeneration, Chronic | 3 1 1 2 2 2 2 1 3 3 1 3 2 2 3 1 3 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 3 1 1 1 2 2 2 2 1 3 1 2 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 3 2 2 3 3|
Mineralization | 1 |
__________________________________________________________________________|
Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + M + + M M + + + + + + + + + +|
Hyperplasia | 3 3 3 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 1 2 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | |
Pars Distalis, Hyperplasia | |
Pars Nervosa, Developmental | |
Malformation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 1 2 1 1 1 1 2 1 1 2 1 2 2 1 3 1 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + A + + + + + + + + + + + + + + +|
Mineralization | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 2 1 1 2 2 1 1 1 2 1 1|
Mineralization | 1 1 1 1 2 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 0| 7| 5| 6| 1| 7| 7| 7| 5| 4| 1| 6| 0| 0| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 7| 4| 4| 2| 2| 2| 6| 3| 1| 8| 9| 8| 1| 2| 2| 2| 2| 1| 4| 2| 1| 2| 2|
| 4| 8| 7| 4| 5| 8| 8| 8| 3| 4| 5| 8| 2| 0| 6| 8| 8| 9| 4| 5| 6| 8| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5|
MG/KG | 0| 3| 5| 6| 7| 9| 1| 5| 6| 7| 8| 9| 0| 3| 5| 6| 0| 3| 8| 0| 2| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | |
Ectasia | 1 2 |
__________________________________________________________________________|
Spleen | M + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Hematopoietic Cell Proliferation | 3 |
Lymphoid Follicle, Depletion Cellular| 2 2 |
__________________________________________________________________________|
Thymus | M M M + + + + M + + + M + + + + + + + + + + + +|
Atrophy | 3 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 1 1 2 1 1 3 2 |
Galactocele | 3 3 2 |
Hyperplasia, Focal | |
Mineralization | 2 |
Lobular, Hyperplasia | 2 2 1 1 1 1 1 1 1 2 2 1 1 2 3 2 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Parakeratosis | 3 |
Hair Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 2 3 3 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | M + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 3 |
Hemorrhage | 3 |
Inflammation, Chronic Active | 1 2 1 3 1 2 1 1|
Mineralization | 1 1 1 1 1 1 1 3 1 1 1 2 1 1|
Vacuolization Cytoplasmic | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
_____________________________________________________________________________________________________________________
| 0| 7| 5| 6| 1| 7| 7| 7| 5| 4| 1| 6| 0| 0| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 7| 4| 4| 2| 2| 2| 6| 3| 1| 8| 9| 8| 1| 2| 2| 2| 2| 1| 4| 2| 1| 2| 2|
| 4| 8| 7| 4| 5| 8| 8| 8| 3| 4| 5| 8| 2| 0| 6| 8| 8| 9| 4| 5| 6| 8| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
150 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5|
MG/KG | 0| 3| 5| 6| 7| 9| 1| 5| 6| 7| 8| 9| 0| 3| 5| 6| 0| 3| 8| 0| 2| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Lens, Mineralization | 2 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 3 3 |
Mineralization | 1 2 1 1 1 3 1 1 3 1 3 3 1 2 1|
Nephropathy | 2 4 4 1 3 2 2 3 1 1 4 1 1 4 3 4 3 3 4 3 4 2 3|
Pigmentation, Hemosiderin | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 3| | A |
150 | 6| | L |
MG/KG | 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 49 |
Periesophageal Tissue, Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 47 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 46 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 41 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 41 |
__________________________________________________________________________|____________|
Liver | + | 49 |
Basophilic Focus | X | 38 |
Clear Cell Focus | X | 12 |
Eosinophilic Focus | | 2 |
Hepatodiaphragmatic Nodule | | 6 |
Inflammation, Chronic Active | | 1 1.0|
Mixed Cell Focus | | 4 |
Necrosis | | 1 2.0|
Bile Duct, Fibrosis | | 1 1.0|
Centrilobular, Congestion | | 1 2.0|
Centrilobular, Necrosis | | 1 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Inflammation, Chronic Active | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + | 48 |
Acinus, Atrophy | 1 | 4 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 48 |
Hyperkeratosis | | 2 2.0|
Inflammation, Chronic Active | | 4 2.5|
Mineralization | | 2 2.0|
Ulcer | | 5 2.4|
Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 48 |
Mineralization | | 7 3.1|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 3| | A |
150 | 6| | L |
MG/KG | 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 48 |
Mineralization | | 7 2.9|
__________________________________________________________________________|____________|
Heart | + | 47 |
Mineralization | | 5 3.4|
Thrombosis | | 2 2.5|
Myocardium, Degeneration, Chronic | 2 | 42 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 49 |
Vacuolization Cytoplasmic | 2 | 33 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 49 |
Hyperplasia | | 15 2.6|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 48 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + | 43 |
Hyperplasia | | 15 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + | 49 |
Angiectasis | 4 | 1 4.0|
Cyst | | 3 1.3|
Hyperplasia | | 1 1.0|
Vacuolization Cytoplasmic | | 1 2.0|
Pars Distalis, Hyperplasia | | 1 1.0|
Pars Nervosa, Developmental | | |
Malformation | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 49 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 49 |
__________________________________________________________________________|____________|
Preputial Gland | + | 49 |
Inflammation, Chronic Active | 2 | 36 1.3|
__________________________________________________________________________|____________|
Prostate | + | 49 |
Mineralization | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 48 |
Mineralization | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 3| | A |
150 | 6| | L |
MG/KG | 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + | 49 |
Degeneration | | 28 1.3|
Mineralization | 1 | 19 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 49 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 49 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 48 |
Atrophy | | 1 2.0|
Ectasia | 2 | 5 2.0|
__________________________________________________________________________|____________|
Spleen | + | 48 |
Accessory Spleen | | 1 |
Hematopoietic Cell Proliferation | | 3 2.3|
Lymphoid Follicle, Depletion Cellular| | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + | 39 |
Atrophy | | 7 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 50 |
Dilatation | | 23 1.6|
Galactocele | | 7 2.4|
Hyperplasia, Focal | | 1 2.0|
Mineralization | | 2 2.5|
Lobular, Hyperplasia | | 35 1.4|
__________________________________________________________________________|____________|
Skin | + | 50 |
Inflammation, Chronic Active | | 1 1.0|
Parakeratosis | | 1 3.0|
Hair Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 50 |
Fibrous Osteodystrophy | | 15 2.1|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:29:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 3| | A |
150 | 6| | L |
MG/KG | 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 47 |
Congestion | | 1 2.0|
Edema | | 1 3.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | | 14 1.5|
Mineralization | 1 | 28 1.2|
Vacuolization Cytoplasmic | | 4 1.3|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + | 50 |
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Lens, Mineralization | | 2 2.0|
Retina, Degeneration | | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 49 |
Cyst | | 6 2.2|
Mineralization | 1 | 25 1.5|
Nephropathy | 3 | 48 2.7|
Pigmentation, Hemosiderin | | 4 1.8|
Renal Tubule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 49 |
Inflammation, Chronic Active | | 2 1.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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