TDMS Study 88050-05 Pathology Tables
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:49
FINAL#1 2 YEAR CHRONIC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 126-98-7
Lock Date: 05/05/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 4 10 9 7
Natural Death 7 6 6 7
Dosing Accident 1 1 1
Survivors
Terminal Sacrifice 38 33 34 35
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Periesophageal Tissue, Hemorrhage 1 (2%) 2 (4%)
Intestine Large, Rectum (50) (50) (50) (50)
Parasite Metazoan 2 (4%) 5 (10%) 5 (10%) 4 (8%)
Intestine Large, Cecum (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50)
Fibrosis 1 (2%)
Liver (50) (49) (48) (50)
Angiectasis 1 (2%) 2 (4%) 1 (2%)
Basophilic Focus 43 (86%) 43 (88%) 35 (73%) 39 (78%)
Clear Cell Focus 4 (8%) 2 (4%) 1 (2%) 3 (6%)
Degeneration 1 (2%)
Degeneration, Cystic 1 (2%) 1 (2%)
Eosinophilic Focus 3 (6%)
Fatty Change 21 (42%) 13 (27%) 11 (23%) 7 (14%)
Hepatodiaphragmatic Nodule 9 (18%) 7 (14%) 8 (17%) 12 (24%)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 31 (62%) 27 (55%) 27 (56%) 27 (54%)
Mixed Cell Focus 2 (4%) 7 (14%) 8 (17%) 5 (10%)
Necrosis 2 (4%) 3 (6%) 1 (2%)
Thrombosis 2 (4%) 3 (6%)
Vacuolization Cytoplasmic 7 (14%) 14 (29%) 17 (35%) 30 (60%)
Bile Duct, Hyperplasia 14 (28%) 5 (10%) 13 (27%) 9 (18%)
Mesentery (7) (2) (8) (4)
Fat, Inflammation, Chronic Active 5 (71%) 1 (50%) 2 (25%) 1 (25%)
Fat, Necrosis 1 (14%) 1 (50%) 4 (50%) 2 (50%)
Pancreas (50) (50) (50) (50)
Cytoplasmic Alteration 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Acinus, Atrophy 8 (16%) 4 (8%) 7 (14%) 10 (20%)
Stomach, Forestomach (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Edema 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%)
Ulcer 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Erosion 1 (2%) 1 (2%) 2 (4%) 5 (10%)
Mineralization 1 (2%)
Ulcer 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 24 (48%) 19 (38%) 16 (32%) 21 (42%)
Fibrosis 1 (2%)
Thrombosis 1 (2%) 2 (4%) 1 (2%)
Epicardium, Inflammation, Chronic Active 1 (2%)
Pericardium, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Angiectasis 23 (46%) 6 (12%) 12 (24%) 19 (38%)
Degeneration 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 7 (14%) 6 (12%) 10 (20%) 7 (14%)
Hypertrophy 1 (2%)
Necrosis 2 (4%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 4 (8%) 1 (2%) 2 (4%) 6 (12%)
Capsule, Fibrosis 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 2 (4%) 3 (6%) 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Angiectasis 6 (12%) 4 (8%) 3 (6%) 5 (10%)
Cyst 19 (38%) 13 (26%) 14 (28%) 15 (30%)
Hyperplasia 20 (40%) 23 (46%) 16 (32%) 16 (32%)
Craniopharyngeal Duct, Hyperplasia 1 (2%)
Pars Nervosa, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 36 (72%) 25 (50%) 37 (74%) 32 (64%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (48) (50) (48)
Cyst 1 (2%) 4 (8%) 5 (10%) 1 (2%)
Hyperplasia 10 (20%) 7 (15%) 10 (20%) 2 (4%)
Inflammation, Chronic Active 6 (12%) 2 (4%) 5 (10%) 8 (17%)
Ovary (50) (50) (50) (50)
Atrophy 1 (2%)
Cyst 1 (2%)
Mineralization 1 (2%)
Follicle, Cyst 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Periovarian Tissue, Cyst 4 (8%) 3 (6%) 2 (4%) 3 (6%)
Uterus (50) (50) (50) (50)
Hemorrhage 1 (2%)
Hydrometra 2 (4%) 2 (4%) 2 (4%) 2 (4%)
Inflammation, Chronic Active 2 (4%)
Cervix, Fibrosis 1 (2%) 1 (2%) 1 (2%)
Cervix, Inflammation, Chronic Active 3 (6%) 1 (2%)
Endometrium, Hyperplasia, Cystic 4 (8%) 1 (2%) 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 12 (24%) 11 (22%) 12 (24%) 25 (50%)
Myelofibrosis 1 (2%)
Lymph Node (6) (1) (5) (1)
Mediastinal, Hyperplasia 1 (20%)
Lymph Node, Mandibular (50) (49) (50) (50)
Ectasia 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Ectasia 1 (2%) 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 1 (2%)
Fibrosis 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 8 (16%) 7 (14%) 5 (10%)
Capsule, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 13 (26%) 9 (18%) 9 (18%) 9 (18%)
Hyperplasia 8 (16%) 11 (22%) 9 (18%) 6 (12%)
Inflammation, Chronic Active 1 (2%)
Skin (50) (50) (50) (50)
Parakeratosis 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosclerosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 1 (2%)
Hemorrhage 1 (2%) 2 (4%)
Inflammation, Chronic Active 5 (10%) 4 (8%) 4 (8%) 4 (8%)
Necrosis 1 (2%)
Pigmentation 1 (2%)
Alveolar Epithelium, Hyperplasia 6 (12%) 3 (6%) 4 (8%) 6 (12%)
Mediastinum, Inflammation 1 (2%)
Nose (50) (50) (50) (50)
Inflammation 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%)
Thrombosis 3 (6%) 1 (2%) 2 (4%)
Olfactory Epithelium, Atrophy 1 (2%) 19 (38%)
Olfactory Epithelium, Metaplasia 47 (94%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (1) (3) (1)
Cataract 4 (100%) 1 (100%) 3 (100%) 1 (100%)
Lens, Mineralization 3 (75%) 2 (67%)
Retina, Degeneration 3 (75%) 1 (100%) 3 (100%) 1 (100%)
Zymbal's Gland (1)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 2 (4%) 1 (2%)
Congestion 1 (2%)
Hydronephrosis 1 (2%)
Inflammation, Chronic Active 3 (6%) 9 (18%) 5 (10%) 3 (6%)
Necrosis 1 (2%)
Nephropathy 29 (58%) 27 (54%) 29 (58%) 25 (50%)
Pigmentation 3 (6%) 3 (6%) 2 (4%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 12 3 6 6
Moribund Sacrifice 13 13 9 12
Dosing Accident 1
Survivors
Natural Death 1
Terminal Sacrifice 25 34 34 31
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50)
Parasite Metazoan 10 (20%) 8 (16%) 7 (14%) 5 (10%)
Intestine Large, Cecum (49) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Epithelium, Atrophy 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Inflammation, Chronic Active 2 (4%)
Intestine Small, Ileum (50) (50) (49) (50)
Inflammation, Chronic Active 2 (4%)
Parasite Metazoan 1 (2%)
Liver (50) (50) (50) (49)
Angiectasis 2 (4%) 4 (8%) 7 (14%) 4 (8%)
Basophilic Focus 26 (52%) 33 (66%) 35 (70%) 13 (27%)
Clear Cell Focus 8 (16%) 16 (32%) 16 (32%) 4 (8%)
Congestion 1 (2%) 1 (2%)
Cyst 1 (2%)
Degeneration, Cystic 3 (6%) 7 (14%) 5 (10%) 6 (12%)
Eosinophilic Focus 10 (20%) 8 (16%) 9 (18%) 7 (14%)
Fatty Change 23 (46%) 18 (36%) 21 (42%) 9 (18%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 8 (16%) 5 (10%) 9 (18%) 6 (12%)
Inclusion Body Intracytoplasmic 1 (2%)
Inflammation, Chronic Active 16 (32%) 21 (42%) 29 (58%) 10 (20%)
Mixed Cell Focus 16 (32%) 23 (46%) 22 (44%) 10 (20%)
Necrosis 4 (8%) 1 (2%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 14 (28%) 18 (36%) 23 (46%) 28 (57%)
Bile Duct, Fibrosis 1 (2%)
Bile Duct, Hyperplasia 42 (84%) 48 (96%) 48 (96%) 36 (73%)
Mesentery (13) (13) (11) (12)
Artery, Inflammation, Chronic Active 1 (8%)
Fat, Inflammation, Chronic Active 8 (62%) 12 (92%) 11 (100%) 9 (75%)
Fat, Mineralization 1 (8%)
Fat, Necrosis 1 (8%) 1 (8%) 1 (8%)
Pancreas (50) (49) (50) (50)
Cytoplasmic Alteration 2 (4%) 3 (6%)
Fibrosis 1 (2%)
Hyperplasia 4 (8%) 10 (20%) 11 (22%) 12 (24%)
Acinus, Atrophy 10 (20%) 13 (27%) 12 (24%) 14 (28%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Erosion 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia 3 (6%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Perforation 1 (2%)
Ulcer 2 (4%) 2 (4%) 2 (4%)
Epithelium, Hyperplasia 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Erosion 3 (6%) 5 (10%) 2 (4%)
Mineralization 1 (2%)
Ulcer 4 (8%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (49) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy 43 (86%) 48 (96%) 41 (82%) 46 (92%)
Fibrosis 1 (2%) 1 (2%)
Thrombosis 3 (6%) 1 (2%) 1 (2%) 3 (6%)
Artery, Inflammation, Chronic Active 1 (2%)
Endocardium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Angiectasis 5 (10%) 3 (6%) 12 (24%) 9 (18%)
Atrophy 1 (2%) 1 (2%)
Degeneration, Cystic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hematopoietic Cell Proliferation 2 (4%)
Hyperplasia 9 (18%) 10 (20%) 11 (22%) 8 (16%)
Necrosis 1 (2%)
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 8 (16%) 3 (6%) 3 (6%) 5 (10%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 11 (22%) 5 (10%) 7 (14%) 7 (14%)
Mineralization 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Parathyroid Gland (46) (46) (50) (50)
Fibrosis 1 (2%)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Angiectasis 2 (4%) 3 (6%)
Atrophy 1 (2%) 1 (2%)
Cyst 5 (10%) 5 (10%) 7 (14%) 1 (2%)
Hyperplasia 13 (26%) 17 (34%) 16 (32%) 10 (20%)
Craniopharyngeal Duct, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 23 (46%) 29 (58%) 35 (70%) 29 (58%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Preputial Gland (50) (50) (50) (49)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 41 (82%) 45 (90%) 46 (92%) 45 (92%)
Prostate (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 3 (6%)
Cyst 1 (2%)
Hyperplasia 5 (10%) 2 (4%)
Inflammation 25 (50%) 25 (50%) 17 (34%) 24 (48%)
Seminal Vesicle (50) (50) (50) (50)
Atrophy 1 (2%) 2 (4%) 1 (2%) 4 (8%)
Inflammation, Chronic Active 1 (2%)
Testes (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Atrophy 6 (12%) 6 (12%) 5 (10%) 2 (4%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Interstitial Cell, Hyperplasia 9 (18%) 6 (12%) 4 (8%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 17 (34%) 14 (28%) 19 (38%) 20 (40%)
Myelofibrosis 1 (2%)
Lymph Node (7) (3) (3) (4)
Mediastinal, Congestion 1 (14%)
Mediastinal, Ectasia 1 (33%)
Mediastinal, Inflammation, Chronic Active 1 (33%)
Renal, Congestion 1 (33%)
Renal, Ectasia 1 (33%)
Renal, Inflammation, Chronic Active 1 (33%)
Lymph Node, Mandibular (49) (50) (49) (49)
Ectasia 1 (2%) 4 (8%) 1 (2%) 4 (8%)
Hyperplasia 1 (2%)
Hyperplasia, Plasma Cell 2 (4%) 1 (2%) 2 (4%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Congestion 1 (2%)
Ectasia 2 (4%) 3 (6%) 1 (2%) 4 (8%)
Inflammation, Chronic Active 2 (4%)
Spleen (50) (50) (50) (49)
Accessory Spleen 1 (2%)
Angiectasis 1 (2%)
Fibrosis 6 (12%) 4 (8%) 4 (8%) 4 (8%)
Hematopoietic Cell Proliferation 4 (8%) 3 (6%) 3 (6%) 7 (14%)
Hemorrhage 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
Capsule, Fibrosis 1 (2%)
Capsule, Inflammation, Chronic Active 1 (2%)
Thymus (49) (47) (45) (50)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (50) (49) (49)
Galactocele 5 (10%) 1 (2%)
Hyperplasia 2 (4%) 3 (6%) 4 (8%) 4 (8%)
Skin (49) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Hyperkeratosis 2 (4%) 1 (2%)
Hyperplasia 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Parakeratosis 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hydrocephalus 1 (2%)
Necrosis 2 (4%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Spinal Cord (1) (2) (1) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Angiectasis 1 (2%)
Congestion 2 (4%) 1 (2%)
Edema 1 (2%)
Hemorrhage 4 (8%) 2 (4%)
Inflammation, Chronic Active 3 (6%) 3 (6%) 4 (8%) 6 (12%)
Leukocytosis 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 8 (16%) 6 (12%) 4 (8%)
Nose (50) (50) (49) (50)
Abscess 1 (2%)
Inflammation, Chronic Active 6 (12%) 7 (14%) 6 (12%) 6 (12%)
Thrombosis 2 (4%) 1 (2%) 1 (2%)
Olfactory Epithelium, Atrophy 48 (96%)
Olfactory Epithelium, Metaplasia 47 (94%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88050-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHACRYLONITRILE Date: 02/24/00
Route: GAVAGE Time: 14:18:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cataract 1 (100%)
Degeneration 1 (100%)
Lens, Mineralization 1 (100%)
Retina, Atrophy 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 2 (4%) 1 (2%)
Fibrosis 1 (2%)
Infarct 1 (2%) 1 (2%)
Inflammation, Chronic Active 13 (26%) 25 (50%) 22 (44%) 18 (36%)
Mineralization 1 (2%)
Nephropathy 44 (88%) 48 (96%) 46 (92%) 47 (94%)
Pigmentation 2 (4%) 3 (6%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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