TDMS Study 88050-06 Pathology Tables
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
CORE STUDY MICE FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: 126-98-7
Lock Date: 06/26/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 14 13 4 7
Moribund Sacrifice 1 2 3 3
Accidently Killed 15
Survivors
Natural Death 1
Terminal Sacrifice 34 35 43 25
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Periesophageal Tissue, Fibrous Histiocytoma,
Metastatic, Mesentery 1 (2%)
Periesophageal Tissue, Leiomyosarcoma,
Metastatic, Intestine Small, Ileum 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50)
Adenocarcinoma 1 (2%)
Leiomyoma 3 (6%) 1 (2%)
Intestine Small, Duodenum (49) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Sarcoma NOS, Metastatic, Uncertain Primary
Site 1 (2%)
Intestine Small, Ileum (50) (50) (50) (50)
Adenocarcinoma 1 (2%)
Leiomyosarcoma 1 (2%)
Liver (50) (50) (49) (50)
Hemangiosarcoma 1 (2%) 1 (2%)
Hepatocellular Carcinoma 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%)
Hepatocellular Adenoma 6 (12%) 9 (18%) 11 (22%) 4 (8%)
Hepatocellular Adenoma, Multiple 3 (6%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
Mesentery (16) (11) (15) (4)
Fibrosarcoma, Metastatic, Skin 1 (7%)
Fibrous Histiocytoma 1 (7%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (7%)
Leiomyosarcoma, Metastatic, Uterus 1 (6%)
Leiomyosarcoma, Metastatic, Intestine Small,
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Ileum 1 (25%)
Lipoma 1 (7%)
Sarcoma NOS 1 (6%)
Sarcoma NOS, Metastatic, Uncertain Primary
Site 1 (6%)
Schwannoma Malignant, Metastatic, Skin 1 (6%)
Oral Mucosa (3) (5) (2) (1)
Squamous Cell Carcinoma 1 (100%)
Pharyngeal, Squamous Cell Papilloma 1 (33%)
Pancreas (50) (50) (50) (48)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma, Metastatic, Mesentery 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
Salivary Glands (48) (50) (50) (49)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Adrenal Medulla (49) (50) (50) (50)
Pheochromocytoma Benign 1 (2%)
Pituitary Gland (49) (49) (49) (49)
Pars Distalis, Adenoma 2 (4%) 1 (2%) 2 (4%) 2 (4%)
Pars Intermedia, Adenoma 2 (4%) 1 (2%)
Thyroid Gland (49) (50) (50) (50)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (49)
Ovary (50) (50) (50) (49)
Adenocarcinoma 1 (2%)
Cystadenoma 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Fibrous Histiocytoma, Metastatic, Mesentery 1 (2%)
Hemangioma 2 (4%)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
Luteoma 1 (2%)
Teratoma Benign 1 (2%)
Thecoma Malignant 1 (2%)
Uterus (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Mesentery 1 (2%)
Hemangiosarcoma 1 (2%)
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
Polyp Stromal 1 (2%) 1 (2%) 1 (2%)
Cervix, Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma 1 (2%)
Lymph Node (9) (6) (8) (5)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (13%)
Mediastinal, Fibrosarcoma, Metastatic, Skin 1 (13%)
Mediastinal, Sarcoma, Metastatic, Bone 1 (20%)
Renal, Leiomyosarcoma, Metastatic, Intestine
Small, Ileum 1 (20%)
Lymph Node, Mandibular (48) (49) (46) (47)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Lymph Node, Mesenteric (47) (48) (47) (46)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Sarcoma NOS, Metastatic, Uncertain Primary
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Site 1 (2%)
Spleen (50) (50) (49) (49)
Hemangiosarcoma 1 (2%) 1 (2%)
Hemangiosarcoma, Metastatic, Bone Marrow 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
Thymus (47) (43) (46) (48)
Sarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (49) (49)
Adenoacanthoma 1 (2%)
Carcinoma 2 (4%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Duct, Adenoma 1 (2%)
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%) 5 (10%) 1 (2%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma NOS, Metastatic,
Uncertain Primary Site 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 2 (4%)
Cranium, Carcinoma, Metastatic, Harderian
Gland 1 (2%)
Rib, Periosteum, Sarcoma 1 (2%)
Vertebra, Schwannoma Malignant, Metastatic,
Skin 1 (2%)
Skeletal Muscle (4) (1) (2)
Fibrosarcoma, Metastatic, Skin 2 (100%)
Leiomyosarcoma, Metastatic, Uterus 1 (25%)
Liposarcoma, Metastatic, Skin 1 (100%)
Schwannoma Malignant, Metastatic, Skin 2 (50%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hamartoma 1 (2%)
Spinal Cord (1) (2)
Fibrosarcoma, Metastatic, Skin 2 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 6 (12%) 3 (6%) 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 3 (6%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Carcinoma, Metastatic, Harderian Gland 2 (4%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 3 (6%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 3 (6%)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
Liposarcoma, Metastatic, Skin 1 (2%)
Sarcoma, Metastatic, Bone 1 (2%)
Artery, Schwannoma Malignant, Metastatic,
Skin 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinum, Fibrosarcoma, Metastatic, Skin 1 (2%)
Mediastinum, Leiomyosarcoma, Metastatic,
Uterus 1 (2%)
Mediastinum, Leiomyosarcoma, Metastatic,
Intestine Small, Ileum 1 (2%)
Mediastinum, Sarcoma, Metastatic, Bone 1 (2%)
Nose (50) (50) (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (4)
Carcinoma, Metastatic, Harderian Gland 1 (50%)
Harderian Gland (4) (2) (2) (2)
Adenoma 2 (50%) 1 (50%) 2 (100%) 2 (100%)
Carcinoma 2 (50%)
Bilateral, Adenoma 1 (50%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Hemangiosarcoma 1 (2%)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Metastatic, Bone Marrow 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Ileum 1 (2%)
Sarcoma NOS, Metastatic, Uncertain Primary
Site 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymphoma Malignant 9 (18%) 7 (14%) 7 (14%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 7
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 34 28 29 21
Total Primary Neoplasms 55 39 46 31
Total Animals with Benign Neoplasms 24 15 20 13
Total Benign Neoplasms 32 20 25 14
Total Animals with Malignant Neoplasms 20 17 17 14
Total Malignant Neoplasms 23 19 21 17
Total Animals with Metastatic Neoplasms 8 2 9 4
Total Metastatic Neoplasm 23 3 26 22
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 9 5 4 3
Moribund Sacrifice 5 2 3
Dosing Accident 1
Accidently Killed 24
Survivors
Terminal Sacrifice 34 43 41 22
Natural Death 1 2
Missing 1
Animals Examined Microscopically 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (50) (50) (50)
Adenocarcinoma 1 (2%)
Intestine Small, Duodenum (49) (49) (50) (50)
Adenocarcinoma 1 (2%) 1 (2%)
Adenoma 2 (4%) 2 (4%) 1 (2%)
Intestine Small, Jejunum (49) (50) (50) (50)
Adenocarcinoma 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Liver (49) (50) (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Carcinoma, Metastatic, Intestine Small,
Duodenum 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 10 (20%) 7 (14%) 7 (14%) 4 (8%)
Hepatocellular Carcinoma, Multiple 3 (6%)
Hepatocellular Adenoma 13 (27%) 15 (30%) 16 (32%) 6 (12%)
Hepatocellular Adenoma, Multiple 4 (8%) 12 (24%) 8 (16%) 6 (12%)
Hepatocholangiocarcinoma 1 (2%) 2 (4%) 1 (2%)
Sarcoma, Metastatic, Pancreas 1 (2%)
Mesentery (3) (6) (6) (1)
Carcinoma, Metastatic, Intestine Small,
Duodenum 1 (17%)
Hemangiosarcoma 1 (17%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (17%)
Sarcoma, Metastatic, Pancreas 1 (17%)
Pancreas (49) (50) (50) (50)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Sarcoma 1 (2%)
Salivary Glands (49) (50) (50) (50)
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Stomach, Forestomach (49) (50) (50) (50)
Squamous Cell Papilloma 1 (2%) 2 (4%) 1 (2%)
Stomach, Glandular (49) (50) (50) (50)
Tooth (6) (1) (2)
Odontoma 1 (17%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (48) (50) (50) (50)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Capsule, Adenoma 5 (10%) 4 (8%) 3 (6%)
Subcapsular, Adenoma 1 (2%)
Adrenal Medulla (49) (50) (50) (50)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (49) (50) (50) (50)
Adenoma 2 (4%) 1 (2%)
Thyroid Gland (49) (50) (50) (50)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50) (50) (50)
Preputial Gland (49) (50) (50) (49)
Prostate (49) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Sarcoma, Metastatic, Pancreas 1 (2%)
Seminal Vesicle (49) (50) (50) (50)
Carcinoma, Metastatic, Intestine Small,
Duodenum 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Sarcoma, Metastatic, Pancreas 1 (2%)
Testes (49) (50) (50) (50)
Interstitial Cell, Adenoma 1 (2%)
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Lymph Node (3) (5) (3) (1)
Bronchial, Hepatocholangiocarcinoma,
Metastatic, Liver 1 (33%)
Mediastinal, Carcinoma, Metastatic,
Intestine Small, Duodenum 1 (33%)
Mediastinal, Hepatocholangiocarcinoma,
Metastatic, Liver 1 (20%)
Pancreatic, Sarcoma, Metastatic, Pancreas 1 (20%)
Lymph Node, Mandibular (46) (48) (50) (47)
Carcinoma, Metastatic, Harderian Gland 2 (4%)
Lymph Node, Mesenteric (46) (43) (49) (47)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Spleen (49) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Thymus (40) (48) (46) (49)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (50) (50) (50)
Keratoacanthoma 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2) (1)
Carcinoma, Metastatic, Harderian Gland 1 (50%)
Carcinoma, Metastatic, Intestine Small,
Duodenum 1 (50%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 11 (22%) 7 (14%) 4 (8%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 4 (8%) 2 (4%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Carcinoma, Metastatic, Harderian Gland 2 (4%)
Carcinoma, Metastatic, Intestine Small,
Duodenum 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 6 (12%) 2 (4%) 4 (8%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) 1 (2%) 1 (2%)
Mediastinum, Carcinoma, Metastatic,
Harderian Gland 1 (2%)
Mediastinum, Hepatocholangiocarcinoma,
Metastatic, Liver 1 (2%) 1 (2%)
Serosa, Hepatocholangiocarcinoma, Metastatic,
Liver 1 (2%)
Nose (49) (50) (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (2) (7) (1)
Adenoma 3 (100%) 2 (100%) 5 (71%) 1 (100%)
Carcinoma 2 (29%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (49) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(49) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant 2 (4%) 3 (6%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99
Route: GAVAGE Time: 12:44:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 40 41 39 24
Total Primary Neoplasms 62 72 64 31
Total Animals with Benign Neoplasms 29 35 33 19
Total Benign Neoplasms 35 49 46 22
Total Animals with Malignant Neoplasms 24 17 16 8
Total Malignant Neoplasms 27 23 18 9
Total Animals with Metastatic Neoplasms 7 5 8
Total Metastatic Neoplasm 12 17 20
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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