TDMS Study 88050-06 Pathology Tables
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 CORE STUDY MICE FINAL#1 Facility: Battelle Columbus Laboratory Chemical CAS #: 126-98-7 Lock Date: 06/26/98 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Natural Death 14 13 4 7 Moribund Sacrifice 1 2 3 3 Accidently Killed 15 Survivors Natural Death 1 Terminal Sacrifice 34 35 43 25 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (50) (50) (50) Periesophageal Tissue, Fibrous Histiocytoma, Metastatic, Mesentery 1 (2%) Periesophageal Tissue, Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (2%) Intestine Large, Cecum (50) (50) (50) (50) Adenocarcinoma 1 (2%) Leiomyoma 3 (6%) 1 (2%) Intestine Small, Duodenum (49) (50) (50) (50) Adenoma 1 (2%) 1 (2%) Intestine Small, Jejunum (50) (50) (50) (50) Sarcoma NOS, Metastatic, Uncertain Primary Site 1 (2%) Intestine Small, Ileum (50) (50) (50) (50) Adenocarcinoma 1 (2%) Leiomyosarcoma 1 (2%) Liver (50) (50) (49) (50) Hemangiosarcoma 1 (2%) 1 (2%) Hepatocellular Carcinoma 2 (4%) 1 (2%) 3 (6%) 1 (2%) Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%) Hepatocellular Adenoma 6 (12%) 9 (18%) 11 (22%) 4 (8%) Hepatocellular Adenoma, Multiple 3 (6%) 1 (2%) 1 (2%) Histiocytic Sarcoma 1 (2%) 1 (2%) Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (2%) Mesentery (16) (11) (15) (4) Fibrosarcoma, Metastatic, Skin 1 (7%) Fibrous Histiocytoma 1 (7%) Hepatocellular Carcinoma, Metastatic, Liver 1 (7%) Leiomyosarcoma, Metastatic, Uterus 1 (6%) Leiomyosarcoma, Metastatic, Intestine Small, NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont Ileum 1 (25%) Lipoma 1 (7%) Sarcoma NOS 1 (6%) Sarcoma NOS, Metastatic, Uncertain Primary Site 1 (6%) Schwannoma Malignant, Metastatic, Skin 1 (6%) Oral Mucosa (3) (5) (2) (1) Squamous Cell Carcinoma 1 (100%) Pharyngeal, Squamous Cell Papilloma 1 (33%) Pancreas (50) (50) (50) (48) Fibrosarcoma, Metastatic, Skin 1 (2%) Fibrous Histiocytoma, Metastatic, Mesentery 1 (2%) Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (2%) Salivary Glands (48) (50) (50) (49) Fibrosarcoma, Metastatic, Skin 1 (2%) Stomach, Forestomach (50) (50) (50) (50) Squamous Cell Papilloma 1 (2%) Stomach, Glandular (50) (50) (50) (50) Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (49) (50) (50) (50) Adrenal Medulla (49) (50) (50) (50) Pheochromocytoma Benign 1 (2%) Pituitary Gland (49) (49) (49) (49) Pars Distalis, Adenoma 2 (4%) 1 (2%) 2 (4%) 2 (4%) Pars Intermedia, Adenoma 2 (4%) 1 (2%) Thyroid Gland (49) (50) (50) (50) Follicular Cell, Adenoma 1 (2%) Follicular Cell, Carcinoma 2 (4%) ____________________________________________________________________________________________________________________________________ NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Peritoneum (1) Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (100%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (50) (50) (50) (49) Ovary (50) (50) (50) (49) Adenocarcinoma 1 (2%) Cystadenoma 2 (4%) 1 (2%) 1 (2%) 1 (2%) Fibrous Histiocytoma, Metastatic, Mesentery 1 (2%) Hemangioma 2 (4%) Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (2%) Luteoma 1 (2%) Teratoma Benign 1 (2%) Thecoma Malignant 1 (2%) Uterus (50) (50) (50) (50) Fibrous Histiocytoma, Metastatic, Mesentery 1 (2%) Hemangiosarcoma 1 (2%) Leiomyoma 1 (2%) Leiomyosarcoma 1 (2%) Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (2%) Polyp Stromal 1 (2%) 1 (2%) 1 (2%) Cervix, Hemangiosarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Fibrosarcoma, Metastatic, Skin 1 (2%) Hemangiosarcoma 1 (2%) Lymph Node (9) (6) (8) (5) Mediastinal, Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (13%) Mediastinal, Fibrosarcoma, Metastatic, Skin 1 (13%) Mediastinal, Sarcoma, Metastatic, Bone 1 (20%) Renal, Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (20%) Lymph Node, Mandibular (48) (49) (46) (47) Carcinoma, Metastatic, Harderian Gland 1 (2%) Lymph Node, Mesenteric (47) (48) (47) (46) Histiocytic Sarcoma 1 (2%) 1 (2%) Sarcoma NOS, Metastatic, Uncertain Primary NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Site 1 (2%) Spleen (50) (50) (49) (49) Hemangiosarcoma 1 (2%) 1 (2%) Hemangiosarcoma, Metastatic, Bone Marrow 1 (2%) Histiocytic Sarcoma 1 (2%) Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (2%) Thymus (47) (43) (46) (48) Sarcoma, Metastatic, Bone 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (49) (50) (49) (49) Adenoacanthoma 1 (2%) Carcinoma 2 (4%) Schwannoma Malignant, Metastatic, Skin 1 (2%) Duct, Adenoma 1 (2%) Skin (50) (50) (50) (50) Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%) 5 (10%) 1 (2%) Subcutaneous Tissue, Liposarcoma 1 (2%) Subcutaneous Tissue, Sarcoma 1 (2%) Subcutaneous Tissue, Sarcoma NOS, Metastatic, Uncertain Primary Site 1 (2%) Subcutaneous Tissue, Schwannoma Malignant 2 (4%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Fibrosarcoma, Metastatic, Skin 2 (4%) Cranium, Carcinoma, Metastatic, Harderian Gland 1 (2%) Rib, Periosteum, Sarcoma 1 (2%) Vertebra, Schwannoma Malignant, Metastatic, Skin 1 (2%) Skeletal Muscle (4) (1) (2) Fibrosarcoma, Metastatic, Skin 2 (100%) Leiomyosarcoma, Metastatic, Uterus 1 (25%) Liposarcoma, Metastatic, Skin 1 (100%) Schwannoma Malignant, Metastatic, Skin 2 (50%) ____________________________________________________________________________________________________________________________________ NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Hamartoma 1 (2%) Spinal Cord (1) (2) Fibrosarcoma, Metastatic, Skin 2 (100%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 6 (12%) 3 (6%) 1 (2%) 2 (4%) Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 3 (6%) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Carcinoma, Metastatic, Harderian Gland 2 (4%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Fibrosarcoma, Metastatic, Skin 3 (6%) Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 3 (6%) Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (2%) Liposarcoma, Metastatic, Skin 1 (2%) Sarcoma, Metastatic, Bone 1 (2%) Artery, Schwannoma Malignant, Metastatic, Skin 1 (2%) Mediastinum, Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Mediastinum, Fibrosarcoma, Metastatic, Skin 1 (2%) Mediastinum, Leiomyosarcoma, Metastatic, Uterus 1 (2%) Mediastinum, Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (2%) Mediastinum, Sarcoma, Metastatic, Bone 1 (2%) Nose (50) (50) (50) (50) Carcinoma, Metastatic, Harderian Gland 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (2) (1) (4) Carcinoma, Metastatic, Harderian Gland 1 (50%) Harderian Gland (4) (2) (2) (2) Adenoma 2 (50%) 1 (50%) 2 (100%) 2 (100%) Carcinoma 2 (50%) Bilateral, Adenoma 1 (50%) ____________________________________________________________________________________________________________________________________ NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (49) (50) Hemangiosarcoma 1 (2%) Leiomyosarcoma, Metastatic, Uterus 1 (2%) Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (2%) Urinary Bladder (50) (50) (50) (50) Hemangiosarcoma 1 (2%) Hemangiosarcoma, Metastatic, Bone Marrow 1 (2%) Leiomyosarcoma, Metastatic, Intestine Small, Ileum 1 (2%) Sarcoma NOS, Metastatic, Uncertain Primary Site 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) 1 (2%) Lymphoma Malignant 9 (18%) 7 (14%) 7 (14%) 2 (4%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 7 NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 34 28 29 21 Total Primary Neoplasms 55 39 46 31 Total Animals with Benign Neoplasms 24 15 20 13 Total Benign Neoplasms 32 20 25 14 Total Animals with Malignant Neoplasms 20 17 17 14 Total Malignant Neoplasms 23 19 21 17 Total Animals with Metastatic Neoplasms 8 2 9 4 Total Metastatic Neoplasm 23 3 26 22 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Natural Death 9 5 4 3 Moribund Sacrifice 5 2 3 Dosing Accident 1 Accidently Killed 24 Survivors Terminal Sacrifice 34 43 41 22 Natural Death 1 2 Missing 1 Animals Examined Microscopically 49 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Cecum (49) (50) (50) (50) Adenocarcinoma 1 (2%) Intestine Small, Duodenum (49) (49) (50) (50) Adenocarcinoma 1 (2%) 1 (2%) Adenoma 2 (4%) 2 (4%) 1 (2%) Intestine Small, Jejunum (49) (50) (50) (50) Adenocarcinoma 1 (2%) 1 (2%) 2 (4%) 2 (4%) Liver (49) (50) (50) (50) Carcinoma, Metastatic, Harderian Gland 1 (2%) Carcinoma, Metastatic, Intestine Small, Duodenum 1 (2%) Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%) 1 (2%) Hepatoblastoma 1 (2%) Hepatocellular Carcinoma 10 (20%) 7 (14%) 7 (14%) 4 (8%) Hepatocellular Carcinoma, Multiple 3 (6%) Hepatocellular Adenoma 13 (27%) 15 (30%) 16 (32%) 6 (12%) Hepatocellular Adenoma, Multiple 4 (8%) 12 (24%) 8 (16%) 6 (12%) Hepatocholangiocarcinoma 1 (2%) 2 (4%) 1 (2%) Sarcoma, Metastatic, Pancreas 1 (2%) Mesentery (3) (6) (6) (1) Carcinoma, Metastatic, Intestine Small, Duodenum 1 (17%) Hemangiosarcoma 1 (17%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (17%) Sarcoma, Metastatic, Pancreas 1 (17%) Pancreas (49) (50) (50) (50) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Sarcoma 1 (2%) Salivary Glands (49) (50) (50) (50) NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont Stomach, Forestomach (49) (50) (50) (50) Squamous Cell Papilloma 1 (2%) 2 (4%) 1 (2%) Stomach, Glandular (49) (50) (50) (50) Tooth (6) (1) (2) Odontoma 1 (17%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (48) (50) (50) (50) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (49) (50) (50) (50) Capsule, Adenoma 5 (10%) 4 (8%) 3 (6%) Subcapsular, Adenoma 1 (2%) Adrenal Medulla (49) (50) (50) (50) Pheochromocytoma Benign 1 (2%) Islets, Pancreatic (49) (50) (50) (50) Adenoma 2 (4%) 1 (2%) Thyroid Gland (49) (50) (50) (50) C-Cell, Carcinoma 1 (2%) Follicular Cell, Adenoma 1 (2%) 1 (2%) Follicular Cell, Carcinoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (49) (50) (50) (50) Preputial Gland (49) (50) (50) (49) Prostate (49) (50) (50) (50) Hemangiosarcoma 1 (2%) Sarcoma, Metastatic, Pancreas 1 (2%) Seminal Vesicle (49) (50) (50) (50) Carcinoma, Metastatic, Intestine Small, Duodenum 1 (2%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Sarcoma, Metastatic, Pancreas 1 (2%) Testes (49) (50) (50) (50) Interstitial Cell, Adenoma 1 (2%) NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (50) (50) (50) Lymph Node (3) (5) (3) (1) Bronchial, Hepatocholangiocarcinoma, Metastatic, Liver 1 (33%) Mediastinal, Carcinoma, Metastatic, Intestine Small, Duodenum 1 (33%) Mediastinal, Hepatocholangiocarcinoma, Metastatic, Liver 1 (20%) Pancreatic, Sarcoma, Metastatic, Pancreas 1 (20%) Lymph Node, Mandibular (46) (48) (50) (47) Carcinoma, Metastatic, Harderian Gland 2 (4%) Lymph Node, Mesenteric (46) (43) (49) (47) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) Spleen (49) (50) (50) (50) Hemangiosarcoma 1 (2%) Thymus (40) (48) (46) (49) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (49) (50) (50) (50) Keratoacanthoma 1 (2%) Subcutaneous Tissue, Hemangioma 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (1) (2) (1) Carcinoma, Metastatic, Harderian Gland 1 (50%) Carcinoma, Metastatic, Intestine Small, Duodenum 1 (50%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (50) (50) (50) Alveolar/Bronchiolar Adenoma 2 (4%) 11 (22%) 7 (14%) 4 (8%) Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 1 (2%) Alveolar/Bronchiolar Carcinoma 4 (8%) 2 (4%) 1 (2%) 1 (2%) Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Carcinoma, Metastatic, Harderian Gland 2 (4%) Carcinoma, Metastatic, Intestine Small, Duodenum 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 6 (12%) 2 (4%) 4 (8%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) 1 (2%) 1 (2%) Mediastinum, Carcinoma, Metastatic, Harderian Gland 1 (2%) Mediastinum, Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) 1 (2%) Serosa, Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Nose (49) (50) (50) (50) Carcinoma, Metastatic, Harderian Gland 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (3) (2) (7) (1) Adenoma 3 (100%) 2 (100%) 5 (71%) 1 (100%) Carcinoma 2 (29%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (50) (50) (50) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) 1 (2%) Renal Tubule, Adenoma 1 (2%) Renal Tubule, Carcinoma 1 (2%) Urinary Bladder (49) (50) (50) (50) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(49) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) Lymphoma Malignant 2 (4%) 3 (6%) 3 (6%) 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 12 NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC METHACRYLONITRILE Date: 10/19/99 Route: GAVAGE Time: 12:44:20 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 40 41 39 24 Total Primary Neoplasms 62 72 64 31 Total Animals with Benign Neoplasms 29 35 33 19 Total Benign Neoplasms 35 49 46 22 Total Animals with Malignant Neoplasms 24 17 16 8 Total Malignant Neoplasms 27 23 18 9 Total Animals with Metastatic Neoplasms 7 5 8 Total Metastatic Neoplasm 12 17 20 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------