TDMS Study 88070-03 Pathology Tables
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:10:25
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 115-11-0007
Lock Date: 10/05/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:10:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 500 PPM 2000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 21 25 15 23
Natural Death 6 5 2 5
Accidently Killed 1
Survivors
Terminal Sacrifice 23 19 33 22
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
Intestine Large, Colon (49) (50) (49) (49)
Inflammation, Acute 1 (2%)
Parasite Metazoan 5 (10%) 1 (2%) 1 (2%)
Intestine Large, Rectum (47) (47) (47) (48)
Parasite Metazoan 8 (17%) 5 (11%) 5 (11%) 3 (6%)
Intestine Large, Cecum (48) (49) (48) (49)
Inflammation, Acute 1 (2%) 1 (2%)
Parasite Metazoan 5 (10%) 2 (4%) 4 (8%) 3 (6%)
Intestine Small, Jejunum (47) (47) (48) (47)
Inflammation, Acute 1 (2%)
Necrosis 1 (2%)
Intestine Small, Ileum (46) (47) (48) (47)
Inflammation, Acute 1 (2%)
Parasite Metazoan 1 (2%)
Liver (50) (50) (50) (49)
Angiectasis 1 (2%) 3 (6%) 4 (8%) 3 (6%)
Basophilic Focus 36 (72%) 36 (72%) 43 (86%) 36 (73%)
Clear Cell Focus 6 (12%) 9 (18%) 12 (24%) 5 (10%)
Cytomegaly 1 (2%)
Degeneration, Cystic 2 (4%)
Degeneration, Fatty 12 (24%) 10 (20%) 12 (24%) 12 (24%)
Eosinophilic Focus 6 (12%) 6 (12%) 5 (10%) 9 (18%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 4 (8%) 7 (14%) 5 (10%) 3 (6%)
Inflammation, Granulomatous 1 (2%)
Mitotic Alteration 1 (2%)
Mixed Cell Focus 7 (14%) 11 (22%) 9 (18%) 8 (16%)
Necrosis 2 (4%) 2 (4%)
Regeneration 1 (2%) 1 (2%) 2 (4%) 3 (6%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 9 (18%) 5 (10%) 7 (14%) 10 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:10:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 500 PPM 2000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Necrosis 4 (8%) 4 (8%) 5 (10%) 9 (18%)
Mesentery (8) (10) (12) (7)
Thrombosis 1 (8%)
Artery, Inflammation, Chronic Active 2 (29%)
Fat, Hemorrhage 1 (13%)
Fat, Necrosis 8 (100%) 10 (100%) 12 (100%) 6 (86%)
Pancreas (50) (50) (49) (49)
Atrophy 9 (18%) 11 (22%) 17 (35%) 10 (20%)
Basophilic Focus 1 (2%) 4 (8%) 3 (6%) 2 (4%)
Hyperplasia 1 (2%) 1 (2%)
Metaplasia, Hepatocyte 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%)
Necrosis 7 (14%) 7 (14%) 6 (12%) 5 (10%)
Stomach, Glandular (50) (50) (50) (49)
Mineralization 1 (2%)
Necrosis 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Tongue (1) (1)
Hyperplasia, Squamous 1 (100%)
Tooth (1)
Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49) (50)
Cardiomyopathy 30 (60%) 29 (58%) 37 (76%) 31 (62%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (49)
Atrophy 1 (2%) 1 (2%)
Degeneration, Cystic 2 (4%) 2 (4%) 4 (8%) 2 (4%)
Hyperplasia 15 (30%) 16 (32%) 24 (49%) 21 (43%)
Hypertrophy 11 (22%) 8 (16%) 9 (18%) 9 (18%)
Necrosis 2 (4%) 3 (6%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Adrenal Medulla (50) (50) (49) (49)
Hyperplasia 10 (20%) 5 (10%) 6 (12%) 10 (20%)
Islets, Pancreatic (50) (50) (49) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:10:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 500 PPM 2000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%)
Pituitary Gland (50) (49) (50) (49)
Angiectasis 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 1 (2%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 7 (14%) 7 (14%) 11 (22%) 5 (10%)
Thyroid Gland (50) (50) (49) (49)
C-Cell, Hyperplasia 37 (74%) 34 (68%) 38 (78%) 35 (71%)
Follicular Cell, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (49) (47) (48)
Hyperplasia 1 (2%) 5 (11%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Ovary (50) (50) (50) (50)
Cyst 9 (18%) 4 (8%) 4 (8%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Uterus (50) (50) (50) (50)
Fibrosis 1 (2%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
Cervix, Hypertrophy 1 (2%)
Vagina (1) (1) (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (49)
Atrophy 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Reticulum Cell 1 (2%)
Lymph Node (6) (3) (3) (2)
Pancreatic, Ectasia 1 (33%)
Lymph Node, Mandibular (44) (46) (47) (47)
Infiltration Cellular, Plasma Cell 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Lymph Node, Mesenteric (50) (50) (49) (49)
Infiltration Cellular, Plasma Cell 1 (2%)
Spleen (50) (50) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:10:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 500 PPM 2000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Accessory Spleen 1 (2%)
Fibrosis 3 (6%) 6 (12%) 2 (4%)
Hematopoietic Cell Proliferation 5 (10%) 2 (4%) 3 (6%) 2 (4%)
Hemorrhage 1 (2%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Hyperplasia, Atypical 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 9 (18%) 7 (14%) 11 (22%) 15 (30%)
Skeletal Muscle (1)
Artery, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Epiglottis, Metaplasia, Squamous 2 (4%)
Lung (50) (50) (50) (50)
Inflammation, Granulomatous 7 (14%) 5 (10%) 9 (18%) 11 (22%)
Inflammation, Suppurative 1 (2%)
Alveolar Epithelium, Hyperplasia 9 (18%) 9 (18%) 7 (14%) 6 (12%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%)
Bronchiole, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:10:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 500 PPM 2000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (50) (50) (50) (49)
Inflammation, Suppurative 7 (14%) 2 (4%) 8 (16%) 8 (16%)
Thrombosis 2 (4%) 3 (6%) 2 (4%) 3 (6%)
Lateral Wall, Metaplasia, Squamous 3 (6%)
Olfactory Epithelium, Degeneration, Hyaline 44 (88%) 47 (94%) 48 (96%) 47 (96%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (4) (6) (4)
Cataract 4 (100%) 3 (75%) 6 (100%) 4 (100%)
Retina, Atrophy 3 (75%) 3 (75%) 6 (100%) 4 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (49)
Infarct 1 (2%) 2 (4%)
Nephropathy 46 (92%) 46 (92%) 46 (94%) 46 (94%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (50) (49) (49) (49)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:10:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 500 PPM 2000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 39 40 37 41
Natural Death 4 5 7 1
Survivors
Terminal Sacrifice 7 5 6 8
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%) 1 (2%) 2 (4%)
Intestine Large, Colon (49) (48) (48) (49)
Diverticulum 1 (2%)
Mineralization 1 (2%)
Parasite Metazoan 4 (8%) 1 (2%) 2 (4%) 2 (4%)
Intestine Large, Rectum (47) (49) (49) (49)
Necrosis 1 (2%)
Parasite Metazoan 2 (4%) 3 (6%) 3 (6%)
Intestine Large, Cecum (48) (47) (49) (49)
Inflammation, Acute 1 (2%)
Necrosis 2 (4%) 1 (2%)
Parasite Metazoan 3 (6%) 2 (4%) 6 (12%) 4 (8%)
Intestine Small, Duodenum (49) (49) (50) (49)
Necrosis 2 (4%) 2 (4%)
Liver (50) (50) (50) (50)
Angiectasis 3 (6%) 1 (2%) 1 (2%)
Basophilic Focus 17 (34%) 14 (28%) 14 (28%) 22 (44%)
Clear Cell Focus 3 (6%) 1 (2%) 3 (6%) 3 (6%)
Cyst 2 (4%)
Degeneration, Cystic 13 (26%) 10 (20%) 14 (28%) 16 (32%)
Degeneration, Fatty 14 (28%) 18 (36%) 18 (36%) 14 (28%)
Eosinophilic Focus 6 (12%) 2 (4%) 5 (10%) 5 (10%)
Hepatodiaphragmatic Nodule 4 (8%) 2 (4%) 1 (2%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (2%) 1 (2%)
Mixed Cell Focus 3 (6%) 2 (4%) 4 (8%)
Necrosis 2 (4%) 3 (6%) 1 (2%)
Regeneration 2 (4%)
Thrombosis 2 (4%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Hyperplasia 23 (46%) 27 (54%) 23 (46%) 29 (58%)
Centrilobular, Necrosis 10 (20%) 9 (18%) 10 (20%) 15 (30%)
Mesentery (15) (10) (8) (11)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:10:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 500 PPM 2000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mineralization 1 (7%)
Pigmentation 1 (7%)
Artery, Inflammation, Chronic Active 1 (10%) 1 (9%)
Artery, Mineralization 1 (7%) 1 (10%) 1 (9%)
Fat, Hemorrhage 1 (10%) 1 (9%)
Fat, Necrosis 14 (93%) 9 (90%) 8 (100%) 8 (73%)
Pancreas (50) (50) (50) (50)
Atrophy 22 (44%) 17 (34%) 26 (52%) 18 (36%)
Basophilic Focus 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Hyperplasia 4 (8%) 3 (6%) 4 (8%) 3 (6%)
Artery, Inflammation 1 (2%)
Artery, Mineralization 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Artery, Mineralization 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Necrosis 17 (34%) 16 (32%) 19 (38%) 10 (20%)
Perforation 1 (2%)
Stomach, Glandular (50) (49) (50) (50)
Mineralization 3 (6%) 3 (6%) 5 (10%) 4 (8%)
Necrosis 8 (16%) 5 (10%) 11 (22%) 9 (18%)
Tongue (1) (1)
Necrosis 1 (100%)
Tooth (2) (3) (1) (1)
Developmental Malformation 2 (100%) 1 (33%) 1 (100%)
Inflammation, Chronic Active 2 (67%) 1 (100%)
Necrosis 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2) (2) (2) (2)
Aorta, Mineralization 2 (100%) 2 (100%) 2 (100%) 2 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 39 (78%) 39 (78%) 41 (82%) 41 (82%)
Artery, Mineralization 3 (6%) 4 (8%) 4 (8%) 5 (10%)
Atrium, Thrombosis 1 (2%) 3 (6%) 6 (12%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (50)
Atrophy 1 (2%)
Degeneration, Cystic 1 (2%)
Hyperplasia 21 (42%) 23 (47%) 24 (48%) 23 (46%)
Hypertrophy 7 (14%) 6 (12%) 7 (14%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:10:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 500 PPM 2000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Necrosis 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 3 (6%)
Adrenal Medulla (50) (49) (50) (50)
Atrophy 1 (2%)
Hyperplasia 14 (28%) 18 (37%) 28 (56%) 15 (30%)
Bilateral, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 3 (6%)
Islets, Pancreatic (50) (49) (50) (50)
Hyperplasia 4 (8%) 3 (6%) 3 (6%)
Parathyroid Gland (49) (50) (49) (47)
Hyperplasia 9 (18%) 11 (22%) 12 (24%) 10 (21%)
Pituitary Gland (50) (49) (50) (49)
Angiectasis 1 (2%)
Pars Distalis, Hyperplasia 5 (10%) 5 (10%) 3 (6%) 6 (12%)
Pars Distalis, Thrombosis 1 (2%)
Thyroid Gland (48) (48) (48) (50)
C-Cell, Hyperplasia 32 (67%) 36 (75%) 34 (71%) 26 (52%)
Follicular Cell, Hyperplasia 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%)
Preputial Gland (50) (50) (49) (50)
Hyperplasia 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 3 (6%) 3 (6%) 2 (4%)
Prostate (50) (49) (50) (50)
Hyperplasia 6 (12%) 6 (12%) 6 (12%) 7 (14%)
Inflammation, Chronic Active 4 (8%) 4 (8%) 4 (8%) 6 (12%)
Seminal Vesicle (50) (47) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 7 (14%) 3 (6%) 5 (10%)
Necrosis 3 (6%) 1 (2%)
Artery, Inflammation, Chronic Active 4 (8%) 2 (4%) 1 (2%) 3 (6%)
Artery, Mineralization 1 (2%)
Interstitial Cell, Hyperplasia 4 (8%) 4 (8%) 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:10:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 500 PPM 2000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (48) (50) (50)
Necrosis 1 (2%)
Lymph Node (4) (11) (10) (10)
Hemorrhage 1 (25%)
Iliac, Ectasia 1 (10%)
Renal, Hemorrhage 1 (9%)
Lymph Node, Mandibular (47) (47) (49) (49)
Hemorrhage 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Lymph Node, Mesenteric (50) (50) (49) (50)
Ectasia 1 (2%) 1 (2%)
Lymph Node, Mediastinal (46) (42) (44) (45)
Hemorrhage 1 (2%)
Spleen (50) (49) (50) (50)
Accessory Spleen 1 (2%) 1 (2%) 1 (2%)
Fibrosis 9 (18%) 6 (12%) 10 (20%) 11 (22%)
Hematopoietic Cell Proliferation 2 (4%) 5 (10%) 4 (8%) 3 (6%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Necrosis 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (41) (41) (40) (44)
Galactocele 2 (5%) 7 (17%) 1 (3%) 4 (9%)
Hyperplasia, Atypical 1 (2%)
Inflammation, Chronic 1 (2%) 1 (3%) 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 5 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 9 (18%) 7 (14%) 9 (18%) 6 (12%)
Hyperostosis 1 (2%) 1 (2%)
Skeletal Muscle (1) (1) (1)
Mineralization 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:10:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 500 PPM 2000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (50) (49)
Necrosis 1 (2%) 1 (2%)
Epiglottis, Metaplasia, Squamous 1 (2%)
Lung (50) (50) (50) (50)
Cyst 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Inflammation, Granulomatous 9 (18%) 3 (6%) 1 (2%) 5 (10%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Mineralization 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 9 (18%) 5 (10%) 7 (14%) 5 (10%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%)
Artery, Mediastinum, Mineralization 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Bronchiole, Hyperplasia 1 (2%)
Mediastinum, Inflammation, Suppurative 1 (2%)
Nose (49) (49) (50) (49)
Inflammation, Suppurative 14 (29%) 11 (22%) 16 (32%) 9 (18%)
Thrombosis 4 (8%) 7 (14%) 10 (20%) 6 (12%)
Lateral Wall, Metaplasia, Squamous 1 (2%)
Olfactory Epithelium, Atrophy 3 (6%)
Olfactory Epithelium, Degeneration, Hyaline 43 (88%) 45 (92%) 46 (92%) 49 (100%)
Olfactory Epithelium, Metaplasia 4 (8%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Trachea (50) (50) (50) (50)
Inflammation, Suppurative 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (4)
Cataract 2 (67%) 3 (75%)
Degeneration 1 (33%)
Inflammation, Chronic Active 2 (50%)
Retina, Atrophy 1 (33%) 3 (75%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 88070-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ISOBUTENE Date: 06/11/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:10:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 500 PPM 2000 PPM 8000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 3 (6%) 3 (6%) 1 (2%)
Hydronephrosis 1 (2%)
Hyperplasia, Oncocytic 1 (2%)
Infarct 1 (2%) 1 (2%)
Mineralization 4 (8%) 2 (4%) 3 (6%) 4 (8%)
Nephropathy 50 (100%) 48 (96%) 50 (100%) 50 (100%)
Papilla, Necrosis 1 (2%)
Pelvis, Inflammation, Acute 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Renal Tubule, Hyperplasia 2 (4%) 4 (8%) 3 (6%) 4 (8%)
Transitional Epithelium, Hyperplasia 1 (2%) 2 (4%)
Urinary Bladder (50) (49) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 3 (6%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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