TDMS Study 88070-03 Pathology Tables
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
Facility: Battelle Northwest
Chemical CAS #: 115-11-0007
Lock Date: 10/05/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3|
| 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Adenomatous | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
|__________________________________________________________________________|
Mesentery | + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3|
| 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Bilateral, Carcinoma | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3|
| 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
Polyp Stromal | X X X |
Polyp Stromal, Multiple | |
|__________________________________________________________________________|
Vagina | + |
Polyp | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
|__________________________________________________________________________|
Lymph Node | + + + + |
Pancreatic, Leukemia Mononuclear | X X X |
Renal, Leukemia Mononuclear | |
Renal, Sarcoma | X |
|__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M + + + + M + M + + + M M + + M + M + M +|
Leukemia Mononuclear | X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + M + M + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + M + + + + + M + + + + + + + M + + + + + +|
Leukemia Mononuclear | X X X X X X |
Plasma Cell Tumor Malignant | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3|
| 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | X |
Subcutaneous Tissue, Hemangioma | X |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Pinna, Melanoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Carcinoma, Metastatic, Mammary Gland | X |
Leukemia Mononuclear | X X X X X X X X X X X |
Plasma Cell Tumor Malignant, | |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3|
| 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Metastatic, Lymph Node, | |
Mediastinal | |
Mediastinum, Plasma Cell Tumor | |
Malignant, Metastatic, Lymph | |
Node, Mediastinal | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
Renal Tubule, Carcinoma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| |
| 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A A + + + + + + + + + + + + + + + + + + + I +| 47 |
Polyp Adenomatous | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A A + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A A + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A A + + + + + + + + + + + + + + + + A + + + +| 46 |
Leukemia Mononuclear | | 2 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 18 |
|__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X| 4 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| |
| 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X| 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X| 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X| 15 |
Pheochromocytoma Complex | X | 1 |
Pheochromocytoma Benign | X | 3 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X| 13 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X | 39 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Adenoma | X X X X X | 7 |
C-Cell, Carcinoma | X X | 2 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| |
| 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X | 3 |
Bilateral, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X| 8 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X| 2 |
Polyp Stromal | X X X X| 7 |
Polyp Stromal, Multiple | X | 1 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
Polyp | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X| 13 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
Pancreatic, Leukemia Mononuclear | X | 4 |
Renal, Leukemia Mononuclear | X X | 2 |
Renal, Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + M + M + + + + + + M + M + + + + +| 36 |
Leukemia Mononuclear | X X X X| 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + M + + + + + + + + + + + + + + M + +| 44 |
Leukemia Mononuclear | X X X X X X| 15 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| |
| 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X| 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + M M + M + + + + + M + +| 42 |
Leukemia Mononuclear | X X X X X X| 12 |
Plasma Cell Tumor Malignant | X | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 18 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Leukemia Mononuclear | X X X| 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Carcinoma | X | 2 |
Fibroadenoma | X X X X X X X X X X X | 16 |
Fibroadenoma, Multiple | X X | 6 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | | 1 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | | 1 |
Subcutaneous Tissue, Hemangioma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
Subcutaneous Tissue, Pinna, Melanoma | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| |
| 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosarcoma | | 1 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Leukemia Mononuclear | X X X X X X X| 18 |
Plasma Cell Tumor Malignant, | | |
Metastatic, Lymph Node, | | |
Mediastinal | X | 1 |
Mediastinum, Plasma Cell Tumor | | |
Malignant, Metastatic, Lymph | | |
Node, Mediastinal | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| |
DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| |
| 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Eye | +| 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 17 |
Renal Tubule, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3|
| 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + I I + + I + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + A + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X X X X X X X X |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3|
| 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + I + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3|
| 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
Polyp Stromal | X X X |
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
|__________________________________________________________________________|
Lymph Node | + + |
Leukemia Mononuclear | X X |
Iliac, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M + + + + + M M M M + + M + + M M M M + M|
Leukemia Mononuclear | X X X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + M + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X X X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + + + + + + + M M +|
Leukemia Mononuclear | X X X X X X X X X X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3|
| 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Fibroadenoma | X X X X X X X X X |
Fibroadenoma, Multiple | X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | X X |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Fibrosarcoma, Metastatic, Skin | X |
Leukemia Mononuclear | X X X X X X X X X X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3|
| 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Ear | + |
|__________________________________________________________________________|
Eye | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Stromal Nephroma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| |
DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| |
| 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | | 2 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X X X X | 16 |
|__________________________________________________________________________|____________|
Mesentery | + + + | 10 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 6 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| |
DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| |
| 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X X X X | 13 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 13 |
Pheochromocytoma Benign | X X| 3 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Leukemia Mononuclear | X X X | 10 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X| 33 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Adenoma | X X X | 6 |
C-Cell, Carcinoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X X | 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| |
DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| |
| 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 7 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Polyp Stromal | X X X X X X | 9 |
|__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 9 |
|__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Leukemia Mononuclear | | 2 |
Iliac, Leukemia Mononuclear | | 2 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + M + M + M M M + + M + + M + +| 31 |
Leukemia Mononuclear | X X X | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| 46 |
Leukemia Mononuclear | X X X X | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + + M + + + +| 45 |
Leukemia Mononuclear | X X X X X | 16 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| |
DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| |
| 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 16 |
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + M + + M + + + + + + +| 47 |
Leukemia Mononuclear | X | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Carcinoma | X | 2 |
Fibroadenoma | X X X X X | 14 |
Fibroadenoma, Multiple | X X X | 5 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 2 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| |
DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| |
| 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Leukemia Mononuclear | X X X X X | 16 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 13 |
Stromal Nephroma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3|
| 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + I + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A A +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A A +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + M A +|
Leiomyosarcoma | X |
Leukemia Mononuclear | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A A +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + |
Leukemia Mononuclear | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3|
| 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + A +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | X X X X X X |
Pheochromocytoma Benign | X X X |
Bilateral, Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3|
| 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Adenoma | X X X X X |
Carcinoma | X X X|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X X |
Polyp Stromal, Multiple | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | X X X X |
|__________________________________________________________________________|
Lymph Node | + |
Iliac, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
|__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + + + + + + + + + + + + M M + M + + +|
Leukemia Mononuclear | X X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | X X X X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + M + + + M M + + + + M M|
Leukemia Mononuclear | X X X X X X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | X X X X X X X X X X |
|__________________________________________________________________________|
Thymus | + + + + + M + + + + M + + + + + + + + M + + + + M|
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3|
| 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X |
Fibroadenoma | X X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Melanoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X X X X X X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3|
| 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + +|
|__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | X X X X X X X X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | |
Transitional Epithelium, Papilloma | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| |
| 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + I + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear | X X | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X| 22 |
|__________________________________________________________________________|____________|
Mesentery | + + + + | 12 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| |
| 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X| 1 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X| 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X| 13 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X| 13 |
Pheochromocytoma Benign | X X X X X X | 9 |
Bilateral, Pheochromocytoma Benign | X | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X| 7 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X| 37 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| |
| 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Carcinoma | X X| 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + M + + +| 47 |
Adenoma | X | 6 |
Carcinoma | X X | 5 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X| 7 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyp Stromal | X X | 7 |
Polyp Stromal, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X| 10 |
|__________________________________________________________________________|____________|
Lymph Node | + +| 3 |
Iliac, Leukemia Mononuclear | X | 1 |
Pancreatic, Leukemia Mononuclear | X| 2 |
Renal, Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M M M M + + + + M + + M M + + M + + + +| 36 |
Leukemia Mononuclear | X X X X X X X X| 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + M + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| |
| 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X X X X| 19 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X| 19 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + + M + M M + + + + + + + + + M + + +| 39 |
Leukemia Mononuclear | X X X X X X X X| 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X X| 22 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 45 |
Leukemia Mononuclear | X X X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Carcinoma | X X | 4 |
Fibroadenoma | X X X X X X X X X X X X X | 24 |
Fibroadenoma, Multiple | | 6 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | X | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Melanoma | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| |
| 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Thyroid Gland | X | 2 |
Leukemia Mononuclear | X X X X X X X X X X| 20 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 6 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X| 16 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
Transitional Epithelium, Papilloma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X| 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8|
| 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + I + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Leukemia Mononuclear | X X X X X X |
|__________________________________________________________________________|
Mesentery | + + + |
|__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Squamous Cell Papilloma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Tongue | |
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8|
| 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Benign | X X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
Leukemia Mononuclear | X X X |
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8|
| 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Polyp Stromal | X X |
Polyp Stromal, Multiple | X|
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
|__________________________________________________________________________|
Lymph Node | + |
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | |
Pancreatic, Leukemia Mononuclear | X |
|__________________________________________________________________________|
Lymph Node, Bronchial | M + M M + + M + + + M M + M M + + + M + M M M M +|
Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X X X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + M + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X X X X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Leukemia Mononuclear | X X X X X |
|__________________________________________________________________________|
Thymus | + + + + + M + + + + M + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X |
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8|
| 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X X |
Fibroadenoma | X X X X X X X X X X X |
Fibroadenoma, Multiple | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
|__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8|
| 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Lipoma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 5| 7| 4| 6| 6| 6| 0| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 4| 3| 5| 3| 3| 1| 3| 6| 8| 9| 7| 0| 3| 3| 2| 9| 1| 3| 3| 3| 5| 3| 3| |
| 0| 4| 2| 4| 9| 4| 4| 2| 4| 9| 1| 2| 1| 5| 4| 5| 0| 2| 1| 5| 5| 5| 7| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + I + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Hepatocellular Carcinoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X| 16 |
|__________________________________________________________________________|____________|
Mesentery | + + + + | 7 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Pharyngeal, Squamous Cell Papilloma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Leukemia Mononuclear | X | 3 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 5| 7| 4| 6| 6| 6| 0| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 4| 3| 5| 3| 3| 1| 3| 6| 8| 9| 7| 0| 3| 3| 2| 9| 1| 3| 3| 3| 5| 3| 3| |
| 0| 4| 2| 4| 9| 4| 4| 2| 4| 9| 1| 2| 1| 5| 4| 5| 0| 2| 1| 5| 5| 5| 7| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Adenoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X| 13 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X| 13 |
Pheochromocytoma Benign | X | 4 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X | 9 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| 36 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
C-Cell, Adenoma | X | 5 |
C-Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 5| 7| 4| 6| 6| 6| 0| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 4| 3| 5| 3| 3| 1| 3| 6| 8| 9| 7| 0| 3| 3| 2| 9| 1| 3| 3| 3| 5| 3| 3| |
| 0| 4| 2| 4| 9| 4| 4| 2| 4| 9| 1| 2| 1| 5| 4| 5| 0| 2| 1| 5| 5| 5| 7| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granulosa Cell Tumor Malignant | X | 1 |
Leukemia Mononuclear | X X X X X X | 9 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
Polyp Stromal | X X | 4 |
Polyp Stromal, Multiple | | 1 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X | 12 |
|__________________________________________________________________________|____________|
Lymph Node | + | 2 |
Deep Cervical, Carcinoma, Metastatic,| | |
Thyroid Gland | X | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + M + + + + M + + + + M M + + M M + M + M +| 27 |
Leukemia Mononuclear | X X X X X X X| 9 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Leukemia Mononuclear | X X X X X X X X X| 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X| 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 5| 7| 4| 6| 6| 6| 0| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 4| 3| 5| 3| 3| 1| 3| 6| 8| 9| 7| 0| 3| 3| 2| 9| 1| 3| 3| 3| 5| 3| 3| |
| 0| 4| 2| 4| 9| 4| 4| 2| 4| 9| 1| 2| 1| 5| 4| 5| 0| 2| 1| 5| 5| 5| 7| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + M + M + + + + + + + +| 45 |
Leukemia Mononuclear | X X X X X X X X| 13 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X| 16 |
|__________________________________________________________________________|____________|
Thymus | M + + M + M + M + + + M + + + + + + A + + + + + +| 41 |
Leukemia Mononuclear | X X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 4 |
Fibroadenoma | X X X X X X X X X X X| 22 |
Fibroadenoma, Multiple | X X X X | 5 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 5| 7| 4| 6| 6| 6| 0| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 4| 3| 5| 3| 3| 1| 3| 6| 8| 9| 7| 0| 3| 3| 2| 9| 1| 3| 3| 3| 5| 3| 3| |
| 0| 4| 2| 4| 9| 4| 4| 2| 4| 9| 1| 2| 1| 5| 4| 5| 0| 2| 1| 5| 5| 5| 7| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X| 16 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Leukemia Mononuclear | X X | 2 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 4 |
|__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X| 13 |
Lipoma | X | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X| 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 5| 7| 5| 6| 6| 4| 4| 3| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 5| 5| 4| 6|
DAY ON TEST | 4| 6| 3| 4| 3| 3| 6| 7| 7| 3| 3| 3| 5| 6| 5| 9| 3| 1| 2| 2| 0| 8| 7| 7| 8|
| 5| 0| 3| 4| 3| 9| 7| 7| 9| 3| 3| 3| 0| 6| 2| 1| 6| 9| 0| 8| 6| 0| 4| 6| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + I + A + + + + + + I + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Polyp Adenomatous | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + A + + + + + + + + + + + + + + + A + +|
Carcinoma | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + A + + + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X|
Osteosarcoma, Metastatic, Bone | X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Leukemia Mononuclear | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 5| 7| 5| 6| 6| 4| 4| 3| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 5| 5| 4| 6|
DAY ON TEST | 4| 6| 3| 4| 3| 3| 6| 7| 7| 3| 3| 3| 5| 6| 5| 9| 3| 1| 2| 2| 0| 8| 7| 7| 8|
| 5| 0| 3| 4| 3| 9| 7| 7| 9| 3| 3| 3| 0| 6| 2| 1| 6| 9| 0| 8| 6| 0| 4| 6| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X |
Osteosarcoma, Metastatic, Bone | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + A + +|
C-Cell, Adenoma | X X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 5| 7| 5| 6| 6| 4| 4| 3| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 5| 5| 4| 6|
DAY ON TEST | 4| 6| 3| 4| 3| 3| 6| 7| 7| 3| 3| 3| 5| 6| 5| 9| 3| 1| 2| 2| 0| 8| 7| 7| 8|
| 5| 0| 3| 4| 3| 9| 7| 7| 9| 3| 3| 3| 0| 6| 2| 1| 6| 9| 0| 8| 6| 0| 4| 6| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X |
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
|__________________________________________________________________________|
Lymph Node | + + + |
Histiocytic Sarcoma | |
Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Iliac, Osteosarcoma, Metastatic, Bone| X |
Pancreatic, Leukemia Mononuclear | X |
|__________________________________________________________________________|
Lymph Node, Bronchial | + M + M M + M M M + + M + + + + + M + M + + M + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 5| 7| 5| 6| 6| 4| 4| 3| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 5| 5| 4| 6|
DAY ON TEST | 4| 6| 3| 4| 3| 3| 6| 7| 7| 3| 3| 3| 5| 6| 5| 9| 3| 1| 2| 2| 0| 8| 7| 7| 8|
| 5| 0| 3| 4| 3| 9| 7| 7| 9| 3| 3| 3| 0| 6| 2| 1| 6| 9| 0| 8| 6| 0| 4| 6| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
|__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + M + + M + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
|__________________________________________________________________________|
Thymus | + + + + + M + M + + + M + M + + M + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + M + M + + M M M + + + + + + + + + + M + + + M +|
Carcinoma, Multiple | |
Fibroadenoma | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Lipoma | X |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Schwannoma | |
Benign | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 5| 7| 5| 6| 6| 4| 4| 3| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 5| 5| 4| 6|
DAY ON TEST | 4| 6| 3| 4| 3| 3| 6| 7| 7| 3| 3| 3| 5| 6| 5| 9| 3| 1| 2| 2| 0| 8| 7| 7| 8|
| 5| 0| 3| 4| 3| 9| 7| 7| 9| 3| 3| 3| 0| 6| 2| 1| 6| 9| 0| 8| 6| 0| 4| 6| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Astrocytoma Malignant | X |
Leukemia Mononuclear | X |
Oligodendroglioma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X|
Osteosarcoma, Metastatic, Bone | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Stromal Nephroma | |
Renal Tubule, Adenoma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X|
Mesothelioma Malignant | X X |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 5| 5| 5| 6| 6| 7| 7| 5| 7| 4| 5| 5| 6| 7| 6| 6| 5| 6| 6| 6| |
DAY ON TEST | 1| 3| 3| 7| 7| 1| 3| 9| 8| 8| 3| 0| 7| 1| 9| 3| 8| 2| 0| 8| 9| 4| 6| 4| 1| |
| 6| 3| 3| 0| 8| 6| 9| 0| 1| 4| 3| 6| 6| 9| 5| 9| 0| 1| 5| 3| 2| 0| 1| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 1 |
Polyp Adenomatous | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 21 |
Osteosarcoma, Metastatic, Bone | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 2 |
Leukemia Mononuclear | X X | 2 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 5| 5| 5| 6| 6| 7| 7| 5| 7| 4| 5| 5| 6| 7| 6| 6| 5| 6| 6| 6| |
DAY ON TEST | 1| 3| 3| 7| 7| 1| 3| 9| 8| 8| 3| 0| 7| 1| 9| 3| 8| 2| 0| 8| 9| 4| 6| 4| 1| |
| 6| 3| 3| 0| 8| 6| 9| 0| 1| 4| 3| 6| 6| 9| 5| 9| 0| 1| 5| 3| 2| 0| 1| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tongue | | 1 |
|__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X| 13 |
Osteosarcoma, Metastatic, Bone | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X| 13 |
Pheochromocytoma Benign | X X X X X X X| 13 |
Bilateral, Pheochromocytoma Benign | X X X X X X X | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X | 4 |
Carcinoma | X X | 4 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 5| 5| 5| 6| 6| 7| 7| 5| 7| 4| 5| 5| 6| 7| 6| 6| 5| 6| 6| 6| |
DAY ON TEST | 1| 3| 3| 7| 7| 1| 3| 9| 8| 8| 3| 0| 7| 1| 9| 3| 8| 2| 0| 8| 9| 4| 6| 4| 1| |
| 6| 3| 3| 0| 8| 6| 9| 0| 1| 4| 3| 6| 6| 9| 5| 9| 0| 1| 5| 3| 2| 0| 1| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X| 12 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X X X | 43 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Adenoma | X X X | 5 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant | X | 3 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 4 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant | X | 2 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X | 13 |
Interstitial Cell, Adenoma | X X X X X X X| 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 5| 5| 5| 6| 6| 7| 7| 5| 7| 4| 5| 5| 6| 7| 6| 6| 5| 6| 6| 6| |
DAY ON TEST | 1| 3| 3| 7| 7| 1| 3| 9| 8| 8| 3| 0| 7| 1| 9| 3| 8| 2| 0| 8| 9| 4| 6| 4| 1| |
| 6| 3| 3| 0| 8| 6| 9| 0| 1| 4| 3| 6| 6| 9| 5| 9| 0| 1| 5| 3| 2| 0| 1| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X X X X| 14 |
|__________________________________________________________________________|____________|
Lymph Node | + | 4 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | X | 1 |
Iliac, Osteosarcoma, Metastatic, Bone| | 1 |
Pancreatic, Leukemia Mononuclear | X | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + + + + + + M M M + M M + M + + + M M + +| 30 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X| 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X X X X X X X X X| 16 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X| 17 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + + + + + + + + + + + + + + + + + + +| 46 |
Leukemia Mononuclear | X X X X X X X X X X X| 17 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 21 |
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + M + M M + + + + + + M + +| 40 |
Leukemia Mononuclear | X X X X X | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + M + + + + + + + + +| 41 |
Carcinoma, Multiple | X | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 5| 5| 5| 6| 6| 7| 7| 5| 7| 4| 5| 5| 6| 7| 6| 6| 5| 6| 6| 6| |
DAY ON TEST | 1| 3| 3| 7| 7| 1| 3| 9| 8| 8| 3| 0| 7| 1| 9| 3| 8| 2| 0| 8| 9| 4| 6| 4| 1| |
| 6| 3| 3| 0| 8| 6| 9| 0| 1| 4| 3| 6| 6| 9| 5| 9| 0| 1| 5| 3| 2| 0| 1| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Fibroadenoma | | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | X X | 3 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Lipoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
Subcutaneous Tissue, Schwannoma | | |
Benign | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosarcoma | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Malignant | | 1 |
Leukemia Mononuclear | X X | 3 |
Oligodendroglioma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X| 19 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 5| 5| 5| 6| 6| 7| 7| 5| 7| 4| 5| 5| 6| 7| 6| 6| 5| 6| 6| 6| |
DAY ON TEST | 1| 3| 3| 7| 7| 1| 3| 9| 8| 8| 3| 0| 7| 1| 9| 3| 8| 2| 0| 8| 9| 4| 6| 4| 1| |
| 6| 3| 3| 0| 8| 6| 9| 0| 1| 4| 3| 6| 6| 9| 5| 9| 0| 1| 5| 3| 2| 0| 1| 8| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Osteosarcoma, Metastatic, Bone | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 2 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X| 15 |
Stromal Nephroma | X | 1 |
Renal Tubule, Adenoma | X | 2 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 21 |
Mesothelioma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 5| 6| 6| 7| 6| 5| 5| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 5| 5| 6| 5|
DAY ON TEST | 6| 7| 6| 4| 4| 6| 9| 3| 2| 2| 2| 6| 7| 7| 7| 7| 2| 8| 3| 1| 2| 9| 5| 8| 3|
| 4| 9| 0| 2| 7| 2| 2| 3| 4| 6| 6| 0| 1| 1| 0| 8| 7| 3| 2| 4| 3| 2| 2| 4| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
|__________________________________________________________________________|
Mesentery | + + + |
Liposarcoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 5| 6| 6| 7| 6| 5| 5| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 5| 5| 6| 5|
DAY ON TEST | 6| 7| 6| 4| 4| 6| 9| 3| 2| 2| 2| 6| 7| 7| 7| 7| 2| 8| 3| 1| 2| 9| 5| 8| 3|
| 4| 9| 0| 2| 7| 2| 2| 3| 4| 6| 6| 0| 1| 1| 0| 8| 7| 3| 2| 4| 3| 2| 2| 4| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Tooth | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X|
Bilateral, Pheochromocytoma Benign | X X X X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 5| 6| 6| 7| 6| 5| 5| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 5| 5| 6| 5|
DAY ON TEST | 6| 7| 6| 4| 4| 6| 9| 3| 2| 2| 2| 6| 7| 7| 7| 7| 2| 8| 3| 1| 2| 9| 5| 8| 3|
| 4| 9| 0| 2| 7| 2| 2| 3| 4| 6| 6| 0| 1| 1| 0| 8| 7| 3| 2| 4| 3| 2| 2| 4| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X X |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X |
Bilateral, Carcinoma | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
|__________________________________________________________________________|
Lymph Node | + + + + + +|
Pancreatic, Leukemia Mononuclear | X X X X X|
Renal, Leukemia Mononuclear | X |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + M M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 5| 6| 6| 7| 6| 5| 5| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 5| 5| 6| 5|
DAY ON TEST | 6| 7| 6| 4| 4| 6| 9| 3| 2| 2| 2| 6| 7| 7| 7| 7| 2| 8| 3| 1| 2| 9| 5| 8| 3|
| 4| 9| 0| 2| 7| 2| 2| 3| 4| 6| 6| 0| 1| 1| 0| 8| 7| 3| 2| 4| 3| 2| 2| 4| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X X|
|__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + M + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X X X X X X X X|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + M M + + M + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + M + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Keratoacanthoma | X X |
Squamous Cell Papilloma | X |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
Subcutaneous Tissue, Pinna, Melanoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 5| 6| 6| 7| 6| 5| 5| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 5| 5| 6| 5|
DAY ON TEST | 6| 7| 6| 4| 4| 6| 9| 3| 2| 2| 2| 6| 7| 7| 7| 7| 2| 8| 3| 1| 2| 9| 5| 8| 3|
| 4| 9| 0| 2| 7| 2| 2| 3| 4| 6| 6| 0| 1| 1| 0| 8| 7| 3| 2| 4| 3| 2| 2| 4| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X X|
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
Renal Tubule, Adenoma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Mesothelioma Malignant | X X |
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 3| 6| 7| 6| 6| 6| 6| 4| 7| 6| 5| 7| 4| 6| 7| 6| 5| 2| 6| 7| 4| 7| 5| 7| 5| |
DAY ON TEST | 8| 0| 3| 0| 6| 8| 4| 8| 0| 8| 8| 3| 6| 2| 0| 2| 2| 4| 9| 3| 6| 3| 0| 1| 1| |
| 9| 4| 3| 7| 4| 4| 1| 2| 2| 4| 3| 3| 9| 6| 6| 5| 7| 4| 2| 3| 0| 3| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + A + + + + + + + + + + + + + + A + +| 47 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + A A + + + + + + + + + + + + + + A + +| 46 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + A A + + + + + + + + + + + + + + A + +| 46 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X| 19 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 10 |
Liposarcoma | X | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Leukemia Mononuclear | X X X X| 7 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 3| 6| 7| 6| 6| 6| 6| 4| 7| 6| 5| 7| 4| 6| 7| 6| 5| 2| 6| 7| 4| 7| 5| 7| 5| |
DAY ON TEST | 8| 0| 3| 0| 6| 8| 4| 8| 0| 8| 8| 3| 6| 2| 0| 2| 2| 4| 9| 3| 6| 3| 0| 1| 1| |
| 9| 4| 3| 7| 4| 4| 1| 2| 2| 4| 3| 3| 9| 6| 6| 5| 7| 4| 2| 3| 0| 3| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 2 |
|__________________________________________________________________________|____________|
Tooth | + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X| 17 |
|__________________________________________________________________________|____________|
Adrenal Medulla | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X| 17 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X X X | 7 |
Bilateral, Pheochromocytoma Benign | X X X X X X | 11 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 3| 6| 7| 6| 6| 6| 6| 4| 7| 6| 5| 7| 4| 6| 7| 6| 5| 2| 6| 7| 4| 7| 5| 7| 5| |
DAY ON TEST | 8| 0| 3| 0| 6| 8| 4| 8| 0| 8| 8| 3| 6| 2| 0| 2| 2| 4| 9| 3| 6| 3| 0| 1| 1| |
| 9| 4| 3| 7| 4| 4| 1| 2| 2| 4| 3| 3| 9| 6| 6| 5| 7| 4| 2| 3| 0| 3| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X X X X| 14 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X| 40 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + A A + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Adenoma | X X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 2 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 2 |
Carcinoma | | 2 |
Bilateral, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Prostate | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Seminal Vesicle | A + + + + + A A + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 2 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X | 14 |
Interstitial Cell, Adenoma | X X X X X | 14 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 3| 6| 7| 6| 6| 6| 6| 4| 7| 6| 5| 7| 4| 6| 7| 6| 5| 2| 6| 7| 4| 7| 5| 7| 5| |
DAY ON TEST | 8| 0| 3| 0| 6| 8| 4| 8| 0| 8| 8| 3| 6| 2| 0| 2| 2| 4| 9| 3| 6| 3| 0| 1| 1| |
| 9| 4| 3| 7| 4| 4| 1| 2| 2| 4| 3| 3| 9| 6| 6| 5| 7| 4| 2| 3| 0| 3| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Bone Marrow | A + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X X X| 18 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + +| 11 |
Pancreatic, Leukemia Mononuclear | X X X X| 9 |
Renal, Leukemia Mononuclear | X | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + M + + + + M + + + M M + + + + M + +| 41 |
Leukemia Mononuclear | X X X X X X X X X| 17 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X X X X X X X| 16 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X| 19 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | A + + + + + A + + + M + + + + + M + + + M + + + +| 42 |
Leukemia Mononuclear | X X X X X X X X| 17 |
|__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X| 21 |
|__________________________________________________________________________|____________|
Thymus | A + + + + + A + + + + + + + M + + M + + + + + M +| 42 |
Leukemia Mononuclear | X X X X| 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + M + + + + M M + + + M + + + + M M +| 41 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 3| 6| 7| 6| 6| 6| 6| 4| 7| 6| 5| 7| 4| 6| 7| 6| 5| 2| 6| 7| 4| 7| 5| 7| 5| |
DAY ON TEST | 8| 0| 3| 0| 6| 8| 4| 8| 0| 8| 8| 3| 6| 2| 0| 2| 2| 4| 9| 3| 6| 3| 0| 1| 1| |
| 9| 4| 3| 7| 4| 4| 1| 2| 2| 4| 3| 3| 9| 6| 6| 5| 7| 4| 2| 3| 0| 3| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Basal Cell Carcinoma | X X | 2 |
Keratoacanthoma | X X | 4 |
Squamous Cell Papilloma | | 1 |
Sebaceous Gland, Adenoma | X X | 2 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | X | 1 |
Subcutaneous Tissue, Pinna, Melanoma | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X| 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | X X | 2 |
Leukemia Mononuclear | X X X X X X X X X| 19 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
|__________________________________________________________________________|____________|
Nose | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 3| 6| 7| 6| 6| 6| 6| 4| 7| 6| 5| 7| 4| 6| 7| 6| 5| 2| 6| 7| 4| 7| 5| 7| 5| |
DAY ON TEST | 8| 0| 3| 0| 6| 8| 4| 8| 0| 8| 8| 3| 6| 2| 0| 2| 2| 4| 9| 3| 6| 3| 0| 1| 1| |
| 9| 4| 3| 7| 4| 4| 1| 2| 2| 4| 3| 3| 9| 6| 6| 5| 7| 4| 2| 3| 0| 3| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
Carcinoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X| 18 |
Renal Tubule, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X| 21 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 4| 5| 6| 5| 6| 6| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 6| 5| 7| 7| 5| 6| 3| 7| 5|
DAY ON TEST | 9| 6| 2| 8| 1| 5| 5| 7| 1| 0| 1| 7| 7| 1| 0| 5| 7| 9| 0| 3| 2| 5| 5| 0| 8|
| 7| 5| 0| 5| 4| 0| 8| 4| 2| 6| 6| 9| 8| 4| 6| 1| 1| 0| 1| 3| 0| 4| 2| 5| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Carcinoma | |
Hemangiosarcoma | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X|
|__________________________________________________________________________|
Mesentery | + + + |
|__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Squamous Cell Papilloma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 4| 5| 6| 5| 6| 6| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 6| 5| 7| 7| 5| 6| 3| 7| 5|
DAY ON TEST | 9| 6| 2| 8| 1| 5| 5| 7| 1| 0| 1| 7| 7| 1| 0| 5| 7| 9| 0| 3| 2| 5| 5| 0| 8|
| 7| 5| 0| 5| 4| 0| 8| 4| 2| 6| 6| 9| 8| 4| 6| 1| 1| 0| 1| 3| 0| 4| 2| 5| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X X X X X|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 4| 5| 6| 5| 6| 6| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 6| 5| 7| 7| 5| 6| 3| 7| 5|
DAY ON TEST | 9| 6| 2| 8| 1| 5| 5| 7| 1| 0| 1| 7| 7| 1| 0| 5| 7| 9| 0| 3| 2| 5| 5| 0| 8|
| 7| 5| 0| 5| 4| 0| 8| 4| 2| 6| 6| 9| 8| 4| 6| 1| 1| 0| 1| 3| 0| 4| 2| 5| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Leukemia Mononuclear | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X|
|__________________________________________________________________________|
Lymph Node | + + + |
Histiocytic Sarcoma | |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | |
Pancreatic, Histiocytic Sarcoma | |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M + + + + M + M + M + + + + + + + + + M + M M M|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 4| 5| 6| 5| 6| 6| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 6| 5| 7| 7| 5| 6| 3| 7| 5|
DAY ON TEST | 9| 6| 2| 8| 1| 5| 5| 7| 1| 0| 1| 7| 7| 1| 0| 5| 7| 9| 0| 3| 2| 5| 5| 0| 8|
| 7| 5| 0| 5| 4| 0| 8| 4| 2| 6| 6| 9| 8| 4| 6| 1| 1| 0| 1| 3| 0| 4| 2| 5| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M + + M + + + + + + M + + + + M + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X|
|__________________________________________________________________________|
Thymus | M + + + + M + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + M M + + + + + + + + + M + + + + + + + + + + +|
Fibroadenoma | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Squamous Cell Papilloma | |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
Histiocytic Sarcoma | |
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 4| 5| 6| 5| 6| 6| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 6| 5| 7| 7| 5| 6| 3| 7| 5|
DAY ON TEST | 9| 6| 2| 8| 1| 5| 5| 7| 1| 0| 1| 7| 7| 1| 0| 5| 7| 9| 0| 3| 2| 5| 5| 0| 8|
| 7| 5| 0| 5| 4| 0| 8| 4| 2| 6| 6| 9| 8| 4| 6| 1| 1| 0| 1| 3| 0| 4| 2| 5| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Leukemia Mononuclear | |
|__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X|
Renal Tubule, Carcinoma | X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________|__________________________________________________________________________
| 4| 5| 6| 5| 6| 6| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 6| 5| 7| 7| 5| 6| 3| 7| 5|
DAY ON TEST | 9| 6| 2| 8| 1| 5| 5| 7| 1| 0| 1| 7| 7| 1| 0| 5| 7| 9| 0| 3| 2| 5| 5| 0| 8|
| 7| 5| 0| 5| 4| 0| 8| 4| 2| 6| 6| 9| 8| 4| 6| 1| 1| 0| 1| 3| 0| 4| 2| 5| 0|
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X|
__________________________________________|__________________________________________________________________________|
Page 70
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 4| 4| 7| 6| 5| 7| 7| 6| 7| 4| 7| 5| 6| 5| |
DAY ON TEST | 0| 3| 5| 8| 0| 3| 1| 5| 1| 2| 2| 9| 8| 3| 2| 5| 1| 3| 2| 0| 5| 3| 8| 5| 6| |
| 0| 3| 2| 0| 7| 3| 4| 2| 4| 8| 0| 6| 0| 3| 8| 5| 4| 3| 7| 0| 3| 3| 3| 4| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + A +| 47 |
Carcinoma | X | 1 |
Hemangiosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + A +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X X | 2 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 20 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Pharyngeal, Squamous Cell Papilloma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X| 4 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 4| 4| 7| 6| 5| 7| 7| 6| 7| 4| 7| 5| 6| 5| |
DAY ON TEST | 0| 3| 5| 8| 0| 3| 1| 5| 1| 2| 2| 9| 8| 3| 2| 5| 1| 3| 2| 0| 5| 3| 8| 5| 6| |
| 0| 3| 2| 0| 7| 3| 4| 2| 4| 8| 0| 6| 0| 3| 8| 5| 4| 3| 7| 0| 3| 3| 3| 4| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X| 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X| 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X| 14 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X X X X | 8 |
Bilateral, Pheochromocytoma Benign | X X X | 8 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 11 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 4| 4| 7| 6| 5| 7| 7| 6| 7| 4| 7| 5| 6| 5| |
DAY ON TEST | 0| 3| 5| 8| 0| 3| 1| 5| 1| 2| 2| 9| 8| 3| 2| 5| 1| 3| 2| 0| 5| 3| 8| 5| 6| |
| 0| 3| 2| 0| 7| 3| 4| 2| 4| 8| 0| 6| 0| 3| 8| 5| 4| 3| 7| 0| 3| 3| 3| 4| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| 40 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
C-Cell, Adenoma | X X | 5 |
C-Cell, Carcinoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 2 |
Carcinoma | X | 2 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X | 17 |
Interstitial Cell, Adenoma | X X X X X| 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 4| 4| 7| 6| 5| 7| 7| 6| 7| 4| 7| 5| 6| 5| |
DAY ON TEST | 0| 3| 5| 8| 0| 3| 1| 5| 1| 2| 2| 9| 8| 3| 2| 5| 1| 3| 2| 0| 5| 3| 8| 5| 6| |
| 0| 3| 2| 0| 7| 3| 4| 2| 4| 8| 0| 6| 0| 3| 8| 5| 4| 3| 7| 0| 3| 3| 3| 4| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocytic Sarcoma | X X | 2 |
Leukemia Mononuclear | X X X X X X X X X X| 16 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 10 |
Histiocytic Sarcoma | X | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Inguinal, Leukemia Mononuclear | X | 1 |
Pancreatic, Histiocytic Sarcoma | X | 1 |
Pancreatic, Leukemia Mononuclear | X X X X | 6 |
Renal, Leukemia Mononuclear | X | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M M + + M + + + + M + + M + M + + + + + + +| 35 |
Histiocytic Sarcoma | X X | 2 |
Leukemia Mononuclear | X X X X X X X X X| 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X X| 18 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 19 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + M + + + M| 44 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X | 18 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 20 |
|__________________________________________________________________________|____________|
Thymus | + + M M + + M + M + + M M + + + M + M + M + + + +| 38 |
Leukemia Mononuclear | X X X X| 8 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 4| 4| 7| 6| 5| 7| 7| 6| 7| 4| 7| 5| 6| 5| |
DAY ON TEST | 0| 3| 5| 8| 0| 3| 1| 5| 1| 2| 2| 9| 8| 3| 2| 5| 1| 3| 2| 0| 5| 3| 8| 5| 6| |
| 0| 3| 2| 0| 7| 3| 4| 2| 4| 8| 0| 6| 0| 3| 8| 5| 4| 3| 7| 0| 3| 3| 3| 4| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + M M + + M M + + I + + M + + + +| 40 |
Fibroadenoma | | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | X | 2 |
Squamous Cell Papilloma | X X | 2 |
Sebaceous Gland, Adenoma | X | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Histiocytic Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X| 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Histiocytic Sarcoma | X X | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 4| 4| 7| 6| 5| 7| 7| 6| 7| 4| 7| 5| 6| 5| |
DAY ON TEST | 0| 3| 5| 8| 0| 3| 1| 5| 1| 2| 2| 9| 8| 3| 2| 5| 1| 3| 2| 0| 5| 3| 8| 5| 6| |
| 0| 3| 2| 0| 7| 3| 4| 2| 4| 8| 0| 6| 0| 3| 8| 5| 4| 3| 7| 0| 3| 3| 3| 4| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X X X X X X X| 20 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 4 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 19 |
Renal Tubule, Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X X | 2 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 5| 6| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 4| 6| 3| 8| 6| 5| 3| 3| 1| 6| 7| 0| 8| 3| 6| 4| 7| 8| 0| 8| 2| 3| 3| 8| 3|
| 8| 4| 4| 8| 4| 0| 3| 3| 1| 7| 0| 1| 8| 4| 6| 7| 6| 3| 4| 8| 5| 3| 3| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leiomyosarcoma | |
Leukemia Mononuclear | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Mesentery | + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
|__________________________________________________________________________|
Tongue | |
Hemangiosarcoma | |
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 5| 6| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 4| 6| 3| 8| 6| 5| 3| 3| 1| 6| 7| 0| 8| 3| 6| 4| 7| 8| 0| 8| 2| 3| 3| 8| 3|
| 8| 4| 4| 8| 4| 0| 3| 3| 1| 7| 0| 1| 8| 4| 6| 7| 6| 3| 4| 8| 5| 3| 3| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X X X|
Bilateral, Pheochromocytoma Malignant| |
Bilateral, Pheochromocytoma Benign | X X X X X X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X X X |
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + M + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 5| 6| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 4| 6| 3| 8| 6| 5| 3| 3| 1| 6| 7| 0| 8| 3| 6| 4| 7| 8| 0| 8| 2| 3| 3| 8| 3|
| 8| 4| 4| 8| 4| 0| 3| 3| 1| 7| 0| 1| 8| 4| 6| 7| 6| 3| 4| 8| 5| 3| 3| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X |
Leukemia Mononuclear | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X X |
Renal, Leukemia Mononuclear | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 79
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 5| 6| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 4| 6| 3| 8| 6| 5| 3| 3| 1| 6| 7| 0| 8| 3| 6| 4| 7| 8| 0| 8| 2| 3| 3| 8| 3|
| 8| 4| 4| 8| 4| 0| 3| 3| 1| 7| 0| 1| 8| 4| 6| 7| 6| 3| 4| 8| 5| 3| 3| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + + M + + + M + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + M + M + + + M|
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + M + + + + + + M + + M + + +|
Fibroadenoma | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Keratoacanthoma | X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Rhabdomyosarcoma| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 5| 6| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 4| 6| 3| 8| 6| 5| 3| 3| 1| 6| 7| 0| 8| 3| 6| 4| 7| 8| 0| 8| 2| 3| 3| 8| 3|
| 8| 4| 4| 8| 4| 0| 3| 3| 1| 7| 0| 1| 8| 4| 6| 7| 6| 3| 4| 8| 5| 3| 3| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
Stromal Nephroma | X |
Renal Tubule, Adenoma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 7| 6| 7| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 6| 4| 0| 7| 6| 1| 5| 3| 3| 3| 9| 0| 3| 9| 3| 0| 1| 2| 5| 0| 0| 9| 0| 3| 0| |
| 0| 0| 8| 8| 4| 0| 8| 3| 3| 1| 0| 1| 6| 0| 3| 2| 8| 0| 0| 5| 7| 2| 4| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leiomyosarcoma | X | 1 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 30 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 11 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 3 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 7| 6| 7| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 6| 4| 0| 7| 6| 1| 5| 3| 3| 3| 9| 0| 3| 9| 3| 0| 1| 2| 5| 0| 0| 9| 0| 3| 0| |
| 0| 0| 8| 8| 4| 0| 8| 3| 3| 1| 0| 1| 6| 0| 3| 2| 8| 0| 0| 5| 7| 2| 4| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Tongue | + | 1 |
Hemangiosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | +| 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X | 20 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X | 20 |
Pheochromocytoma Malignant | X | 2 |
Pheochromocytoma Benign | X X X | 11 |
Bilateral, Pheochromocytoma Malignant| X | 1 |
Bilateral, Pheochromocytoma Benign | X X X X X| 12 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 4 |
Carcinoma | X| 4 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 83
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 7| 6| 7| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 6| 4| 0| 7| 6| 1| 5| 3| 3| 3| 9| 0| 3| 9| 3| 0| 1| 2| 5| 0| 0| 9| 0| 3| 0| |
| 0| 0| 8| 8| 4| 0| 8| 3| 3| 1| 0| 1| 6| 0| 3| 2| 8| 0| 0| 5| 7| 2| 4| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X | 14 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X X| 41 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
C-Cell, Adenoma | X | 7 |
C-Cell, Carcinoma | X | 1 |
Follicular Cell, Carcinoma | X X X| 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X| 1 |
Carcinoma | X | 3 |
Leukemia Mononuclear | X | 1 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 5 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X | 14 |
Interstitial Cell, Adenoma | X X X| 11 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 84
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 7| 6| 7| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 6| 4| 0| 7| 6| 1| 5| 3| 3| 3| 9| 0| 3| 9| 3| 0| 1| 2| 5| 0| 0| 9| 0| 3| 0| |
| 0| 0| 8| 8| 4| 0| 8| 3| 3| 1| 0| 1| 6| 0| 3| 2| 8| 0| 0| 5| 7| 2| 4| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X | 23 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 10 |
Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | X X | 3 |
Pancreatic, Leukemia Mononuclear | X X | 6 |
Renal, Leukemia Mononuclear | X X X | 4 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + M + + + + + + + + M + + + + + + + + + + +| 45 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 28 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 27 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 27 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + + + + M + + + +| 45 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X | 26 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X | 31 |
|__________________________________________________________________________|____________|
Thymus | M + + M + + + + + + + + + + + + + + M M + + + + +| 42 |
Leukemia Mononuclear | X X X X X X X | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + M + + + + + + +| 44 |
Fibroadenoma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 85
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 7| 6| 7| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 6| 4| 0| 7| 6| 1| 5| 3| 3| 3| 9| 0| 3| 9| 3| 0| 1| 2| 5| 0| 0| 9| 0| 3| 0| |
| 0| 0| 8| 8| 4| 0| 8| 3| 3| 1| 0| 1| 6| 0| 3| 2| 8| 0| 0| 5| 7| 2| 4| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Adenoma | X | 2 |
Keratoacanthoma | X X X| 4 |
Squamous Cell Papilloma | X | 1 |
Subcutaneous Tissue, Rhabdomyosarcoma| X| 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | +| 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 30 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 3 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 86
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ISOBUTENE Date: 09/14/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 7| 6| 7| 6| 5| 6| 6| 6| 6| 7| |
DAY ON TEST | 6| 4| 0| 7| 6| 1| 5| 3| 3| 3| 9| 0| 3| 9| 3| 0| 1| 2| 5| 0| 0| 9| 0| 3| 0| |
| 0| 0| 8| 8| 4| 0| 8| 3| 3| 1| 0| 1| 6| 0| 3| 2| 8| 0| 0| 5| 7| 2| 4| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 26 |
Stromal Nephroma | | 1 |
Renal Tubule, Adenoma | X | 2 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X | 31 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 87
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