TDMS Study 89029-05 Pathology Tables
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
MERGED REPORTS FINAL #3
Facility: I. I. T. Research Institute
Chemical CAS #: ELECTROMAG
Lock Date: 09/04/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Merge 001 001,011 SHAM CONTROL
Merge 002 002,012 SHAM CONTROL
Merge 003 003,013 .02 GAUSS
Merge 004 004,014 .02 GAUSS
Merge 005 005,015 2 GAUSS
Merge 006 006,016 2 GAUSS
Merge 007 009,019 10 GAUSS
Merge 008 010,020 10 GAUSS
Merge 009 007,017 10 GAUSS INTER
Merge 010 008,018 10 GAUSS INTER
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 100 100 100 100 100
Early Deaths
Natural Death 18 17 18 19 19
Moribund Sacrifice 22 15 22 18 23
Survivors
Terminal Sacrifice 58 66 60 59 58
Natural Death 1 1
Moribund Sacrifice 1 1 1
Other 1 2
Animals Examined Microscopically 100 100 100 100 100
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (100) (100) (100) (100) (97)
Polyp Adenomatous 1 (1%)
Intestine Large, Rectum (99) (100) (100) (99) (100)
Sarcoma 1 (1%)
Schwannoma Malignant, Metastatic, Uterus 1 (1%)
Intestine Large, Cecum (100) (98) (99) (100) (96)
Intestine Small, Duodenum (97) (97) (96) (100) (96)
Intestine Small, Ileum (94) (91) (93) (97) (91)
Liver (100) (100) (100) (100) (100)
Hemangiosarcoma, Metastatic, Spleen 1 (1%)
Hepatocellular Adenoma 1 (1%) 1 (1%)
Schwannoma Malignant, Metastatic, Uterus 1 (1%)
Mesentery (11) (6) (5) (13) (16)
Histiocytic Sarcoma, Metastatic, Skin 1 (17%)
Leiomyoma 1 (8%)
Schwannoma Malignant, Metastatic, Uterus 1 (9%)
Pancreas (100) (100) (99) (100) (99)
Acinus, Adenoma 1 (1%) 1 (1%)
Salivary Glands (100) (99) (100) (100) (100)
Stomach, Forestomach (100) (99) (99) (100) (100)
Squamous Cell Papilloma 1 (1%)
Stomach, Glandular (100) (100) (99) (100) (100)
Tooth (2) (1) (1) (1) (1)
Odontoma, Multiple 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (100) (100) (100) (100) (100)
Carcinosarcoma, Metastatic, Lung 1 (1%)
Schwannoma Malignant 1 (1%) 2 (2%) 2 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (100) (100) (100) (100) (100)
Adenoma 6 (6%) 2 (2%) 3 (3%) 1 (1%)
Carcinoma 1 (1%) 1 (1%)
Adrenal Medulla (96) (94) (94) (98) (97)
Pheochromocytoma Malignant 1 (1%) 1 (1%)
Pheochromocytoma Complex 2 (2%)
Pheochromocytoma Benign 7 (7%) 8 (9%) 3 (3%) 2 (2%) 3 (3%)
Bilateral, Pheochromocytoma Benign 1 (1%)
Islets, Pancreatic (100) (100) (99) (100) (99)
Adenoma 1 (1%) 3 (3%) 1 (1%) 1 (1%)
Carcinoma 1 (1%) 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Parathyroid Gland (88) (94) (91) (88) (92)
Adenoma 1 (1%) 1 (1%)
Pituitary Gland (99) (99) (98) (98) (98)
Pars Distalis, Adenoma 61 (62%) 59 (60%) 68 (69%) 51 (52%) 62 (63%)
Pars Distalis, Carcinoma 3 (3%) 1 (1%) 4 (4%) 2 (2%) 2 (2%)
Pars Intermedia, Adenoma 3 (3%) 1 (1%)
Thyroid Gland (100) (100) (100) (100) (100)
Bilateral, C-Cell, Adenoma 1 (1%) 1 (1%) 1 (1%) 1 (1%) 1 (1%)
C-Cell, Adenoma 14 (14%) 19 (19%) 18 (18%) 19 (19%) 15 (15%)
C-Cell, Carcinoma 5 (5%) 3 (3%) 3 (3%) 3 (3%) 6 (6%)
Follicular Cell, Adenoma 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2)
Abdominal, Chemodectoma Benign 1 (50%)
Nasal, Schwannoma Malignant 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (90) (96) (97) (96) (94)
Adenoma 9 (10%) 13 (14%) 10 (10%) 15 (16%) 11 (12%)
Hemangiosarcoma 1 (1%)
Bilateral, Adenoma 2 (2%) 2 (2%) 1 (1%) 1 (1%)
Ovary (100) (100) (100) (100) (99)
Granulosa Cell Tumor Malignant 1 (1%)
Page 3
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Granulosa Cell Tumor Benign 1 (1%)
Granulosa-Theca Tumor Benign 1 (1%)
Luteoma 1 (1%)
Tubulostromal Adenoma 3 (3%) 1 (1%) 2 (2%) 1 (1%) 1 (1%)
Bilateral, Granulosa Cell Tumor Benign 1 (1%) 1 (1%)
Bilateral, Tubulostromal Adenoma 1 (1%) 1 (1%)
Uterus (100) (100) (100) (100) (99)
Fibroma 1 (1%)
Leiomyosarcoma 2 (2%) 1 (1%)
Schwannoma Malignant 2 (2%)
Cervix, Polyp Stromal 1 (1%)
Cervix, Schwannoma Malignant 1 (1%)
Endometrium, Adenoma 2 (2%)
Endometrium, Deciduoma Malignant 1 (1%)
Endometrium, Polyp Stromal 13 (13%) 10 (10%) 13 (13%) 13 (13%) 10 (10%)
Endometrium, Polyp Stromal, Multiple 1 (1%) 2 (2%)
Endometrium, Sarcoma Stromal 2 (2%)
Vagina (1) (1) (2) (2)
Leiomyoma 1 (50%)
Polyp 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (100) (100) (100) (100) (100)
Lymph Node (16) (5) (5) (10) (18)
Deep Cervical, Sarcoma, Metastatic, Skin 1 (6%)
Lymph Node, Mandibular (100) (99) (100) (100) (100)
Lymph Node, Mesenteric (100) (99) (99) (99) (99)
Hemangiosarcoma 1 (1%)
Spleen (100) (100) (100) (100) (99)
Hemangiosarcoma 1 (1%)
Thymus (95) (95) (92) (91) (92)
Thymoma Benign 1 (1%) 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (100) (100) (100) (100) (100)
Adenoma 1 (1%) 2 (2%) 1 (1%) 1 (1%) 2 (2%)
Carcinoma 2 (2%) 7 (7%) 5 (5%) 1 (1%) 2 (2%)
Carcinoma, Multiple 1 (1%)
Fibroadenoma 36 (36%) 42 (42%) 32 (32%) 40 (40%) 27 (27%)
Fibroadenoma, Multiple 20 (20%) 20 (20%) 22 (22%) 24 (24%) 24 (24%)
Skin (100) (100) (100) (100) (100)
Basal Cell Adenoma 1 (1%) 1 (1%)
Hemangiopericytoma 1 (1%)
Page 4
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Keratoacanthoma 1 (1%) 1 (1%) 2 (2%) 1 (1%)
Squamous Cell Papilloma 1 (1%)
Trichoepithelioma 2 (2%)
Lip, Basal Cell Adenoma 1 (1%)
Lip, Squamous Cell Papilloma 1 (1%)
Subcutaneous Tissue, Fibroma 4 (4%) 5 (5%) 4 (4%) 1 (1%)
Subcutaneous Tissue, Fibrosarcoma 1 (1%) 2 (2%) 1 (1%)
Subcutaneous Tissue, Hemangiosarcoma 1 (1%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (1%)
Subcutaneous Tissue, Lipoma 1 (1%)
Subcutaneous Tissue, Sarcoma 1 (1%)
Subcutaneous Tissue, Schwannoma Malignant 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (100) (100) (100) (100) (100)
Vertebra, Osteosarcoma 1 (1%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (100) (100) (100) (100) (100)
Cerebellum, Meningioma Malignant 1 (1%)
Cerebellum, Meninges, Granular Cell Tumor
Malignant 1 (1%)
Cerebrum, Astrocytoma Malignant 1 (1%) 2 (2%)
Cerebrum, Glioma Malignant 1 (1%)
Meninges, Granular Cell Tumor Benign 2 (2%)
Spinal Cord (3) (4) (4) (1) (2)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (100) (100) (100) (100) (100)
Alveolar/Bronchiolar Adenoma 3 (3%) 5 (5%) 5 (5%) 1 (1%)
Alveolar/Bronchiolar Carcinoma 1 (1%)
Carcinoma, Metastatic, Zymbal's Gland 1 (1%)
Carcinosarcoma 1 (1%)
Chordoma, Metastatic, Uncertain Primary Site 1 (1%)
Osteosarcoma, Metastatic, Bone 1 (1%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (1%)
Nose (100) (100) (100) (100) (100)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (100) (100) (100) (100) (100)
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (100) (100) (100) (100) (100)
Nephroblastoma 1 (1%)
Schwannoma Malignant, Metastatic, Uterus 1 (1%)
Renal Tubule, Adenoma 1 (1%)
Urinary Bladder (99) (97) (99) (99) (96)
Transitional Epithelium, Carcinoma 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(100) *(100) *(100) *(100) *(100)
Histiocytic Sarcoma 1 (1%)
Leukemia Granulocytic 1 (1%)
Leukemia Mononuclear 20 (20%) 18 (18%) 24 (24%) 25 (25%) 22 (22%)
Lymphoma Malignant 1 (1%)
Mesothelioma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 98 97 95 91 94
Total Primary Neoplasms 227 247 244 224 212
Total Animals with Benign Neoplasms 92 94 87 85 86
Total Benign Neoplasms 184 206 199 180 169
Total Animals with Malignant Neoplasms 40 41 38 39 40
Total Malignant Neoplasms 43 41 45 44 43
Total Animals with Metastatic Neoplasms 3 3 2 1 1
Total Metastatic Neoplasm 6 3 2 1 1
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 100 100 100 100 100
Early Deaths
Moribund Sacrifice 29 32 32 36 33
Natural Death 14 21 21 16 7
Survivors
Terminal Sacrifice 57 46 47 48 59
Other 1 1
Animals Examined Microscopically 100 100 100 100 100
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (100) (99) (99) (100) (99)
Intestine Large, Rectum (99) (100) (100) (99) (100)
Polyp Adenomatous 1 (1%)
Intestine Large, Cecum (98) (99) (97) (100) (99)
Sarcoma 1 (1%)
Intestine Small, Duodenum (99) (94) (100) (100) (98)
Intestine Small, Jejunum (91) (90) (95) (98) (98)
Intestine Small, Ileum (94) (92) (97) (96) (97)
Sarcoma 1 (1%)
Liver (100) (100) (100) (100) (100)
Hepatocellular Adenoma 1 (1%) 1 (1%) 2 (2%) 2 (2%)
Hepatocellular Adenoma, Multiple 1 (1%) 1 (1%)
Leiomyosarcoma, Metastatic, Spleen 1 (1%)
Osteosarcoma, Metastatic, Bone 1 (1%)
Mesentery (17) (22) (27) (21) (16)
Leiomyosarcoma, Metastatic, Spleen 1 (5%)
Lipoma 1 (5%)
Osteosarcoma, Metastatic, Kidney 1 (4%)
Oral Mucosa (1)
Squamous Cell Carcinoma 1 (100%)
Pancreas (98) (99) (99) (99) (100)
Mixed Tumor Benign 1 (1%)
Acinus, Adenoma 3 (3%) 5 (5%) 6 (6%) 5 (5%) 2 (2%)
Salivary Glands (99) (99) (100) (100) (100)
Schwannoma Malignant, Metastatic, Skin 1 (1%)
Stomach, Forestomach (100) (100) (100) (100) (100)
Squamous Cell Papilloma 1 (1%)
Stomach, Glandular (100) (100) (100) (100) (100)
Leiomyosarcoma, Metastatic, Spleen 1 (1%)
Tooth (2) (1) (1) (1) (6)
Odontoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (100) (100) (100) (100) (100)
Osteosarcoma, Metastatic, Bone 1 (1%)
Schwannoma Malignant 2 (2%) 1 (1%) 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (99) (100) (100) (100) (100)
Adenoma 3 (3%) 1 (1%) 1 (1%) 1 (1%)
Adrenal Medulla (98) (93) (100) (100) (95)
Pheochromocytoma Malignant 2 (2%) 2 (2%) 2 (2%)
Pheochromocytoma Complex 1 (1%)
Pheochromocytoma Benign 19 (19%) 19 (20%) 15 (15%) 17 (17%) 25 (26%)
Bilateral, Pheochromocytoma Benign 5 (5%) 3 (3%) 6 (6%) 6 (6%) 8 (8%)
Islets, Pancreatic (99) (99) (99) (99) (100)
Adenoma 3 (3%) 2 (2%) 5 (5%) 3 (3%) 2 (2%)
Adenoma, Multiple 1 (1%) 1 (1%)
Carcinoma 1 (1%) 2 (2%) 1 (1%) 3 (3%)
Parathyroid Gland (85) (87) (93) (81) (89)
Adenoma 1 (1%) 2 (2%) 2 (2%)
Carcinoma, Metastatic, Skin 1 (1%)
Carcinoma, Metastatic, Thyroid Gland 1 (1%)
Pineal Gland (81) (84) (81) (79) (91)
Pituitary Gland (98) (95) (97) (100) (98)
Pars Distalis, Adenoma 34 (35%) 34 (36%) 28 (29%) 35 (35%) 40 (41%)
Pars Distalis, Adenoma, Multiple 1 (1%)
Pars Distalis, Carcinoma 1 (1%) 2 (2%) 3 (3%)
Pars Intermedia, Adenoma 1 (1%) 1 (1%) 1 (1%)
Pars Nervosa, Schwannoma Malignant 1 (1%)
Thyroid Gland (99) (100) (100) (100) (100)
Bilateral, C-Cell, Adenoma 2 (2%) 4 (4%) 1 (1%) 3 (3%)
Bilateral, C-Cell, Carcinoma 1 (1%)
C-Cell, Adenoma 15 (15%) 23 (23%) 22 (22%) 22 (22%) 15 (15%)
C-Cell, Carcinoma 1 (1%) 6 (6%) 4 (4%) 2 (2%) 5 (5%)
Follicular Cell, Adenoma 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1) (1)
Tissue NOS (3) (2) (1) (2)
Abdominal, Carcinoma 1 (50%)
Abdominal, Sarcoma 1 (33%)
Mediastinum, Schwannoma Malignant 1 (33%)
Thoracic, Squamous Cell Carcinoma,
Page 9
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont
Metastatic, Lung 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (100) (100) (100) (100) (100)
Fibrosarcoma 1 (1%)
Preputial Gland (100) (99) (100) (99) (100)
Adenoma 10 (10%) 8 (8%) 10 (10%) 12 (12%) 9 (9%)
Carcinoma 5 (5%) 2 (2%)
Fibroma 1 (1%)
Bilateral, Adenoma 3 (3%) 1 (1%) 1 (1%) 1 (1%)
Prostate (100) (99) (100) (99) (100)
Adenoma 1 (1%)
Leiomyosarcoma, Metastatic, Spleen 1 (1%)
Seminal Vesicle (100) (99) (100) (99) (100)
Adenoma 2 (2%) 1 (1%)
Leiomyosarcoma, Metastatic, Spleen 1 (1%)
Testes (100) (100) (100) (100) (100)
Bilateral, Interstitial Cell, Adenoma 82 (82%) 73 (73%) 72 (72%) 71 (71%) 67 (67%)
Interstitial Cell, Adenoma 11 (11%) 17 (17%) 19 (19%) 20 (20%) 22 (22%)
Interstitial Cell, Carcinoma 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (100) (100) (100) (99) (100)
Lymph Node (15) (7) (7) (13) (8)
Lymph Node, Mandibular (99) (99) (100) (100) (100)
Schwannoma Malignant, Metastatic, Skin 1 (1%)
Lymph Node, Mesenteric (100) (99) (100) (100) (100)
Spleen (100) (100) (100) (100) (100)
Fibroma 1 (1%) 1 (1%)
Hemangiosarcoma 1 (1%) 1 (1%)
Leiomyosarcoma, Metastatic, Spleen 1 (1%)
Sarcoma 1 (1%)
Thymus (97) (94) (95) (90) (95)
Thymoma Benign 2 (2%) 1 (1%) 1 (1%)
Thymoma Malignant 2 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (99) (97) (100) (98) (95)
Carcinoma 1 (1%)
Fibroadenoma 6 (6%) 5 (5%) 11 (11%) 8 (8%) 8 (8%)
Fibroadenoma, Multiple 1 (1%) 1 (1%)
Page 10
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Skin (99) (100) (100) (100) (100)
Basal Cell Adenoma 3 (3%) 3 (3%) 3 (3%) 2 (2%)
Keratoacanthoma 10 (10%) 4 (4%) 11 (11%) 10 (10%) 8 (8%)
Keratoacanthoma, Multiple 1 (1%) 1 (1%)
Melanoma Malignant 1 (1%)
Squamous Cell Carcinoma 1 (1%)
Squamous Cell Papilloma 1 (1%) 2 (2%) 1 (1%)
Trichoepithelioma 1 (1%) 5 (5%)
Dermis, Fibroma 3 (3%) 2 (2%) 4 (4%) 5 (5%) 4 (4%)
Dermis, Fibroma, Multiple 1 (1%)
Lip, Basal Cell Adenoma 1 (1%)
Lip, Squamous Cell Papilloma 1 (1%)
Pinna, Melanoma Malignant 1 (1%) 1 (1%)
Prepuce, Keratoacanthoma 1 (1%) 1 (1%)
Prepuce, Squamous Cell Carcinoma 1 (1%)
Sebaceous Gland, Adenoma 1 (1%) 2 (2%) 1 (1%) 1 (1%)
Sebaceous Gland, Carcinoma 1 (1%)
Subcutaneous Tissue, Fibroma 9 (9%) 6 (6%) 6 (6%) 10 (10%) 8 (8%)
Subcutaneous Tissue, Fibrosarcoma 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Subcutaneous Tissue, Leiomyosarcoma,
Metastatic, Spleen 1 (1%)
Subcutaneous Tissue, Lipoma 1 (1%) 2 (2%) 1 (1%)
Subcutaneous Tissue, Melanoma Malignant 1 (1%)
Subcutaneous Tissue, Sarcoma 1 (1%) 1 (1%) 3 (3%) 1 (1%)
Subcutaneous Tissue, Schwannoma Malignant 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (100) (100) (100) (100) (100)
Osteosarcoma 1 (1%)
Femur, Osteosarcoma, Metastatic, Bone 1 (1%)
Maxilla, Osteosarcoma 1 (1%)
Skeletal Muscle (10) (6) (11) (4) (7)
Sarcoma 1 (9%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (100) (100) (100) (100) (100)
Cerebellum, Schwannoma Malignant, Metastatic,
Skin 1 (1%)
Cerebrum, Astrocytoma Malignant 1 (1%)
Cerebrum, Oligodendroglioma Malignant 1 (1%) 1 (1%)
Cranial Nerve, Schwannoma Malignant 1 (1%)
Spinal Cord (11) (6) (9) (4) (6)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (100) (100) (100) (100) (100)
Alveolar/Bronchiolar Adenoma 3 (3%) 5 (5%) 5 (5%) 4 (4%)
Alveolar/Bronchiolar Carcinoma 2 (2%)
Carcinoma 1 (1%)
Carcinoma, Metastatic, Thyroid Gland 1 (1%)
Chordoma, Metastatic, Uncertain Primary Site 1 (1%)
Leiomyosarcoma, Metastatic, Spleen 1 (1%)
Melanoma Malignant, Metastatic, Skin 1 (1%) 1 (1%)
Osteosarcoma, Metastatic, Bone 1 (1%) 1 (1%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (1%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (1%)
Bronchus, Adenoma 1 (1%)
Bronchus, Squamous Cell Carcinoma 1 (1%)
Nose (100) (98) (100) (100) (100)
Squamous Cell Carcinoma 1 (1%)
Trachea (100) (100) (100) (100) (100)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (100) (100) (100) (100) (100)
Adenoma 1 (1%) 1 (1%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (1%)
Zymbal's Gland (1) (2) (1) (1) (1)
Adenoma 1 (50%)
Carcinoma 1 (100%) 1 (50%) 1 (100%) 1 (100%)
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URINARY SYSTEM
Kidney (100) (100) (100) (100) (100)
Fibroma 1 (1%)
Leiomyosarcoma, Metastatic, Spleen 1 (1%)
Nephroblastoma 1 (1%)
Osteosarcoma, Metastatic, Bone 1 (1%)
Sarcoma 1 (1%)
Capsule, Sarcoma 1 (1%)
Pelvis, Transitional Epithelium, Carcinoma 1 (1%)
Renal Tubule, Adenoma 1 (1%)
Renal Tubule, Carcinoma 1 (1%)
Urinary Bladder (99) (96) (100) (100) (99)
Page 12
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Transitional Epithelium, Papilloma 1 (1%) 1 (1%)
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SYSTEMIC LESIONS
Multiple Organs *(100) *(100) *(100) *(100) *(100)
Leukemia Mononuclear 50 (50%) 44 (44%) 47 (47%) 50 (50%) 36 (36%)
Lymphoma Malignant 1 (1%)
Mesothelioma Malignant 4 (4%) 6 (6%) 5 (5%) 6 (6%) 4 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 13
NTP Experiment-Test: 89029-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MAGNETIC FIELDS (EMF) Date: 01/27/98
Route: MAGNETIC FIELDS Time: 16:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE SHAM .02 2 GAUSS 10 GAUSS 10 GAUSS
CONTROL GAUSS INTER
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 100 98 98 100 98
Total Primary Neoplasms 298 304 317 327 303
Total Animals with Benign Neoplasms 99 97 97 98 94
Total Benign Neoplasms 229 230 245 253 233
Total Animals with Malignant Neoplasms 65 59 61 65 58
Total Malignant Neoplasms 69 74 72 74 70
Total Animals with Metastatic Neoplasms 1 5 2 4 2
Total Metastatic Neoplasm 1 5 4 15 4
Total Animals with Malignant Neoplasms 1 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 14
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