TDMS Study 89029-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/28/98 EXPERIMENT: 89029 TEST: 05 TIME: 10:35:17 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029 PATHOLOGIST: KOVATCH, R. CAS: ELECTROMAG Rats(FISCHER 344) ----------------------------- FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED. ---------------- Adrenal Gland Adrenal Medulla Bone Marrow Brain Clitoral Gland Clitoral/Preputial Gland Epididymis Heart Islets, Pancreatic Kidney Liver Lung Nose Ovary Pancreas Parathyroid Gland Pituitary Gland Preputial Gland Prostate Salivary Glands Spleen Testes Thymus Thyroid Gland Urinary Bladder NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/28/98 EXPERIMENT: 89029 TEST: 05 TIME: 10:35:17 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029 PATHOLOGIST: KOVATCH, R. CAS: ELECTROMAG SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF MAGNETIC FIELDS (EMF) =============================================================== Male Rats ------------ Organ Morphology ----- ---------- Clitoral/Preputial Gland Carcinoma Kidney: Renal Tubule Carcinoma or Adenoma Skin Basal Cell Adenoma, Basosquamous Tumor Benign, or Trichoepithelioma Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, malignant or NOS), or Trichoepithelioma Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthom a, Trichoepitheliom Trichoepithelioma Thyroid Gland: C-Cell Adenoma Carcinoma Carcinoma or Adenoma =============================================================== Female Rats ------------ Organ Morphology ----- ---------- Adrenal Medulla Pheochromocytoma Benign Pheochromocytoma: Benign, Complex, Malignant, NOS Pituitary Gland: Pars Distalis or Unspecified Site Carcinoma or Adenoma Skin Fibroma All Organs Benign Tumors Malignant and Benign Tumors =============================================================== Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 1 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Adrenal Cortex | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 3/100 (3%) 1/100 (1%) 1/100 (1%) |6/100 (6%) 2/100 (2%) 3/100 (3%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 3.7% 1.2% 1.2% |7.0% 2.2% 3.4% 1.2% | |TERMINAL (d) | 0/57 (0%) 2/46 (4%) 1/47 (2%) 1/48 (2%) |4/59 (7%) 2/68 (3%) 3/60 (5%) 1/61 (2%) | |FIRST INCIDENCE | --- 639 736 (T) 736 (T) |597 737 (T) 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.566N P=0.093 P=0.462 P=0.466 |P=0.136N P=0.106N P=0.236N P=0.059N | |POLY 3 | P=0.566N P=0.113 P=0.496 P=0.489 |P=0.139N P=0.127N P=0.240N P=0.062N | |POLY 1.5 | P=0.557N P=0.117 P=0.498 P=0.494 |P=0.138N P=0.132N P=0.244N P=0.064N | |POLY 6 | P=0.573N P=0.110 P=0.494 P=0.485 |P=0.137N P=0.120N P=0.234N P=0.058N | |LOGISTIC REGRESSION| P=0.559N P=0.115 P=0.462 P=0.466 |P=0.131N P=0.126N P=0.233N P=0.063N | |COCH-ARM / FISHERS | P=0.543N P=0.125 P=0.503 P=0.503 |P=0.127N P=0.140N P=0.249N P=0.059N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Benign | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 24/98 (24%) 22/93 (24%) 21/100 (21%) 23/100 (23%)|7/96 (7%) 8/94 (9%) 4/94 (4%) 2/98 (2%) | |POLY-3 ADJUSTED (b)| 27.8% 28.3% 24.5% 27.8% |8.5% 9.5% 4.8% 2.4% | |TERMINAL (d) | 17/57 (30%) 9/43 (21%) 10/47 (21%) 14/48 (29%) |6/56 (11%) 6/63 (10%) 0/56 (0%) 1/60 (2%) | |FIRST INCIDENCE | 619 505 617 488 |655 590 648 715 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.465 P=0.418 P=0.554N P=0.419 |P=0.046N* P=0.586 P=0.256N P=0.071N | |POLY 3 | P=0.529 P=0.538 P=0.379N P=0.567 |P=0.045N* P=0.521 P=0.263N P=0.081N | |POLY 1.5 | P=0.536N P=0.567 P=0.364N P=0.529N |P=0.046N* P=0.504 P=0.272N P=0.084N | |POLY 6 | P=0.497 P=0.515 P=0.386N P=0.529 |P=0.042N* P=0.544 P=0.250N P=0.074N | |LOGISTIC REGRESSION| P=0.533 P=0.513 P=0.389N P=0.544 |P=0.044N* P=0.519 P=0.269N P=0.071N | |COCH-ARM / FISHERS | P=0.498N P=0.514N P=0.339N P=0.468N |P=0.041N* P=0.483 P=0.280N P=0.080N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 2 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Malignant | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/98 (2%) 2/93 (2%) 0/100 (0%) 0/100 (0%) |0/96 (0%) 1/94 (1%) 1/94 (1%) 0/98 (0%) | |POLY-3 ADJUSTED (b)| 2.4% 2.7% 0.0% 0.0% |0.0% 1.2% 1.2% 0.0% | |TERMINAL (d) | 2/57 (4%) 2/43 (5%) 0/47 (0%) 0/48 (0%) |0/56 (0%) 0/63 (0%) 0/56 (0%) 0/60 (0%) | |FIRST INCIDENCE | 736 (T) 736 (T) --- --- |--- 583 647 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.171N P=0.589 P=0.282N P=0.277N |P=0.507N P=0.509 P=0.517 (e) | |POLY 3 | P=0.163N P=0.649 P=0.241N P=0.248N |P=0.495N P=0.505 P=0.501 (e) | |POLY 1.5 | P=0.161N P=0.658 P=0.238N P=0.243N |P=0.497N P=0.501 P=0.498 (e) | |POLY 6 | P=0.164N P=0.639 P=0.243N P=0.253N |P=0.488N P=0.511 P=0.505 (e) | |LOGISTIC REGRESSION| P=0.171N P=0.589 (e) (e) |P=0.402N P=0.433 P=0.499 (e) | |COCH-ARM / FISHERS | P=0.158N P=0.669 P=0.244N P=0.244N |P=0.493N P=0.495 P=0.495 (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma: Benign, Complex, Malignant, NOS | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 26/98 (27%) 23/93 (25%) 21/100 (21%) 23/100 (23%)|7/96 (7%) 9/94 (10%) 5/94 (5%) 2/98 (2%) | |POLY-3 ADJUSTED (b)| 30.1% 29.6% 24.5% 27.8% |8.5% 10.6% 6.0% 2.4% | |TERMINAL (d) | 19/57 (33%) 10/43 (23%) 10/47 (21%) 14/48 (29%) |6/56 (11%) 6/63 (10%) 0/56 (0%) 1/60 (2%) | |FIRST INCIDENCE | 619 505 617 488 |655 583 647 715 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.525N P=0.456 P=0.438N P=0.537 |P=0.035N* P=0.483 P=0.364N P=0.071N | |POLY 3 | P=0.457N P=0.542N P=0.258N P=0.436N |P=0.033N* P=0.423 P=0.376N P=0.081N | |POLY 1.5 | P=0.429N P=0.511N P=0.247N P=0.397N |P=0.034N* P=0.404 P=0.387N P=0.084N | |POLY 6 | P=0.489N P=0.568N P=0.263N P=0.476N |P=0.031N* P=0.449 P=0.358N P=0.074N | |LOGISTIC REGRESSION| P=0.457N P=0.560 P=0.271N P=0.463N |P=0.032N* P=0.397 P=0.391N P=0.071N | |COCH-ARM / FISHERS | P=0.394N P=0.453N P=0.227N P=0.341N |P=0.030N* P=0.380 P=0.398N P=0.080N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 3 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Brain | | Granular Cell Tumor Benign | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |0/100 (0%) 2/100 (2%) 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 2.2% 0.0% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |0/59 (0%) 2/68 (3%) 0/60 (0%) 0/61 (0%) | |FIRST INCIDENCE | --- --- --- --- |--- 737 (T) --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) (e) (e) (e) |P=0.374N P=0.271 (e) (e) | |POLY 3 | (e) (e) (e) (e) |P=0.362N P=0.249 (e) (e) | |POLY 1.5 | (e) (e) (e) (e) |P=0.366N P=0.244 (e) (e) | |POLY 6 | (e) (e) (e) (e) |P=0.355N P=0.255 (e) (e) | |LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) P=0.271 (e) (e) | |COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.367N P=0.249 (e) (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Brain | | Oligodendroglioma, Glioma, or Astrocytoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |2/100 (2%) 0/100 (0%) 0/100 (0%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 2.3% 0.0% 0.0% 0.0% |2.3% 0.0% 0.0% 2.4% | |TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 0/48 (0%) |1/59 (2%) 0/68 (0%) 0/60 (0%) 1/61 (2%) | |FIRST INCIDENCE | 645 --- --- --- |547 --- --- 726 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.370N P=0.262N P=0.247N P=0.256N |P=0.306 P=0.222N P=0.238N P=0.683N | |POLY 3 | P=0.357N P=0.251N P=0.245N P=0.252N |P=0.300 P=0.230N P=0.235N P=0.689 | |POLY 1.5 | P=0.360N P=0.246N P=0.243N P=0.247N |P=0.302 P=0.234N P=0.237N P=0.685 | |POLY 6 | P=0.354N P=0.257N P=0.248N P=0.258N |P=0.301 P=0.225N P=0.232N P=0.688N | |LOGISTIC REGRESSION| P=0.362N P=0.231N P=0.234N P=0.231N |P=0.319 P=0.273N P=0.235N P=0.693 | |COCH-ARM / FISHERS | P=0.365N P=0.249N P=0.249N P=0.249N |P=0.314 P=0.249N P=0.249N P=0.689N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 4 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Clitoral/Preputial Gland | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 13/100 (13%) 9/99 (9%) 10/100 (10%) 13/99 (13%) |11/90 (12%) 15/96 (16%) 11/97 (11%) 16/96 (17%) | |POLY-3 ADJUSTED (b)| 15.0% 10.8% 11.6% 15.8% |14.1% 17.5% 13.0% 19.5% | |TERMINAL (d) | 7/57 (12%) 4/45 (9%) 2/47 (4%) 7/47 (15%) |7/56 (13%) 15/65 (23%) 10/58 (17%) 14/59 (24%) | |FIRST INCIDENCE | 649 396 489 445 |597 737 (T) 647 651 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.291 P=0.383N P=0.414N P=0.442 |P=0.227 P=0.398 P=0.548N P=0.247 | |POLY 3 | P=0.301 P=0.281N P=0.335N P=0.527 |P=0.242 P=0.350 P=0.507N P=0.239 | |POLY 1.5 | P=0.313 P=0.271N P=0.333N P=0.545 |P=0.242 P=0.340 P=0.512N P=0.234 | |POLY 6 | P=0.292 P=0.293N P=0.332N P=0.511 |P=0.256 P=0.361 P=0.502N P=0.256 | |LOGISTIC REGRESSION| P=0.338 P=0.250N P=0.333N P=0.537 |P=0.267 P=0.393 P=0.489N P=0.268 | |COCH-ARM / FISHERS | P=0.330 P=0.257N P=0.329N P=0.572 |P=0.275 P=0.325 P=0.515N P=0.258 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Clitoral/Preputial Gland | | Carcinoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/99 (0%) 5/100 (5%) 0/99 (0%) |0/90 (0%) 0/96 (0%) 0/97 (0%) 0/96 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 5.9% 0.0% |0.0% 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/45 (0%) 2/47 (4%) 0/47 (0%) |0/56 (0%) 0/65 (0%) 0/58 (0%) 0/59 (0%) | |FIRST INCIDENCE | --- --- 477 --- |--- --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.472N (e) P=0.030 * (e) |(e) (e) (e) (e) | |POLY 3 | P=0.475N (e) P=0.032 * (e) |(e) (e) (e) (e) | |POLY 1.5 | P=0.467N (e) P=0.033 * (e) |(e) (e) (e) (e) | |POLY 6 | P=0.480N (e) P=0.032 * (e) |(e) (e) (e) (e) | |LOGISTIC REGRESSION| P=0.451N (e) P=0.037 * (e) |(e) (e) (e) (e) | |COCH-ARM / FISHERS | P=0.458N (e) P=0.030 * (e) |(e) (e) (e) (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 5 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Clitoral/Preputial Gland | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 13/100 (13%) 9/99 (9%) 13/100 (13%) 13/99 (13%) |11/90 (12%) 15/96 (16%) 11/97 (11%) 16/96 (17%) | |POLY-3 ADJUSTED (b)| 15.0% 10.8% 15.0% 15.8% |14.1% 17.5% 13.0% 19.5% | |TERMINAL (d) | 7/57 (12%) 4/45 (9%) 4/47 (9%) 7/47 (15%) |7/56 (13%) 15/65 (23%) 10/58 (17%) 14/59 (24%) | |FIRST INCIDENCE | 649 396 477 445 |597 737 (T) 647 651 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.332 P=0.383N P=0.486 P=0.442 |P=0.227 P=0.398 P=0.548N P=0.247 | |POLY 3 | P=0.343 P=0.281N P=0.584N P=0.527 |P=0.242 P=0.350 P=0.507N P=0.239 | |POLY 1.5 | P=0.356 P=0.271N P=0.583 P=0.545 |P=0.242 P=0.340 P=0.512N P=0.234 | |POLY 6 | P=0.332 P=0.293N P=0.580N P=0.511 |P=0.256 P=0.361 P=0.502N P=0.256 | |LOGISTIC REGRESSION| P=0.387 P=0.250N P=0.583N P=0.537 |P=0.267 P=0.393 P=0.489N P=0.268 | |COCH-ARM / FISHERS | P=0.376 P=0.257N P=0.583N P=0.572 |P=0.275 P=0.325 P=0.515N P=0.258 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Heart | | Schwannoma Malignant | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 1/100 (1%) 1/100 (1%) 1/100 (1%) |0/100 (0%) 1/100 (1%) 2/100 (2%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 2.3% 1.2% 1.2% 1.2% |0.0% 1.1% 2.3% 0.0% | |TERMINAL (d) | 2/57 (4%) 0/46 (0%) 0/47 (0%) 1/48 (2%) |0/59 (0%) 1/68 (2%) 1/60 (2%) 0/61 (0%) | |FIRST INCIDENCE | 736 (T) 720 725 736 (T) |--- 737 (T) 687 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.559N P=0.562N P=0.546N P=0.560N |P=0.448N P=0.528 P=0.248 (e) | |POLY 3 | P=0.550N P=0.518N P=0.509N P=0.520N |P=0.451N P=0.509 P=0.244 (e) | |POLY 1.5 | P=0.547N P=0.511N P=0.505N P=0.512N |P=0.453N P=0.505 P=0.241 (e) | |POLY 6 | P=0.553N P=0.525N P=0.511N P=0.526N |P=0.443N P=0.514 P=0.248 (e) | |LOGISTIC REGRESSION| P=0.557N P=0.532N P=0.512N P=0.560N |P=0.449N P=0.528 P=0.243 (e) | |COCH-ARM / FISHERS | P=0.543N P=0.500N P=0.500N P=0.500N |P=0.444N P=0.500 P=0.249 (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 6 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Islets, Pancreatic | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/99 (3%) 3/99 (3%) 6/99 (6%) 3/99 (3%) |1/100 (1%) 0/100 (0%) 3/99 (3%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 3.5% 3.7% 7.2% 3.7% |1.2% 0.0% 3.5% 1.2% | |TERMINAL (d) | 2/57 (4%) 2/46 (4%) 6/47 (13%) 3/48 (6%) |1/59 (2%) 0/68 (0%) 3/60 (5%) 1/61 (2%) | |FIRST INCIDENCE | 714 659 736 (T) 736 (T) |737 (T) --- 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.561N P=0.583 P=0.172 P=0.591 |P=0.618 P=0.472N P=0.312 P=0.754N | |POLY 3 | P=0.551N P=0.636 P=0.237 P=0.633 |P=0.613 P=0.491N P=0.312 P=0.759 | |POLY 1.5 | P=0.540N P=0.645 P=0.241 P=0.644 |P=0.613 P=0.495N P=0.308 P=0.757 | |POLY 6 | P=0.559N P=0.626 P=0.232 P=0.623 |P=0.619 P=0.486N P=0.319 P=0.756N | |LOGISTIC REGRESSION| P=0.551N P=0.623 P=0.225 P=0.624 |P=0.618 (e) P=0.312 P=0.754N | |COCH-ARM / FISHERS | P=0.525N P=0.659N P=0.249 P=0.659N |P=0.630 P=0.500N P=0.307 P=0.751N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Islets, Pancreatic | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/99 (4%) 5/99 (5%) 6/99 (6%) 4/99 (4%) |2/100 (2%) 1/100 (1%) 4/99 (4%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 4.7% 6.2% 7.2% 5.0% |2.3% 1.1% 4.6% 2.4% | |TERMINAL (d) | 3/57 (5%) 2/46 (4%) 6/47 (13%) 3/48 (6%) |2/59 (3%) 1/68 (2%) 4/60 (7%) 2/61 (3%) | |FIRST INCIDENCE | 714 659 736 (T) 702 |737 (T) 737 (T) 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.516N P=0.400 P=0.272 P=0.564 |P=0.582 P=0.451N P=0.346 P=0.682N | |POLY 3 | P=0.505N P=0.467 P=0.360 P=0.609 |P=0.579 P=0.484N P=0.346 P=0.691 | |POLY 1.5 | P=0.494N P=0.479 P=0.365 P=0.621 |P=0.579 P=0.491N P=0.340 P=0.686 | |POLY 6 | P=0.515N P=0.455 P=0.354 P=0.598 |P=0.586 P=0.475N P=0.355 P=0.685N | |LOGISTIC REGRESSION| P=0.507N P=0.445 P=0.344 P=0.596 |P=0.582 P=0.451N P=0.346 P=0.682N | |COCH-ARM / FISHERS | P=0.477N P=0.500 P=0.374 P=0.640N |P=0.598 P=0.500N P=0.337 P=0.689N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 7 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Kidney: Renal Tubule | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 2/100 (2%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 2.5% |0.0% 0.0% 0.0% 1.2% | |TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 1/48 (2%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 1/61 (2%) | |FIRST INCIDENCE | --- --- --- 673 |--- --- --- 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.040 * (e) (e) P=0.215 |P=0.229 (e) (e) P=0.507 | |POLY 3 | P=0.041 * (e) (e) P=0.227 |P=0.229 (e) (e) P=0.499 | |POLY 1.5 | P=0.041 * (e) (e) P=0.231 |P=0.229 (e) (e) P=0.496 | |POLY 6 | P=0.040 * (e) (e) P=0.223 |P=0.231 (e) (e) P=0.505 | |LOGISTIC REGRESSION| P=0.040 * (e) (e) P=0.227 |(e) (e) (e) P=0.507 | |COCH-ARM / FISHERS | P=0.043 * (e) (e) P=0.249 |P=0.233 (e) (e) P=0.500 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Liver | | Hepatocellular Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/100 (1%) 2/100 (2%) 3/100 (3%) 0/100 (0%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 1.2% 2.5% 3.6% 0.0% |0.0% 0.0% 0.0% 1.2% | |TERMINAL (d) | 1/57 (2%) 1/46 (2%) 2/47 (4%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) | |FIRST INCIDENCE | 736 (T) 711 696 --- |--- --- --- 676 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.226N P=0.451 P=0.256 P=0.534N |P=0.237 (e) (e) P=0.516 | |POLY 3 | P=0.225N P=0.482 P=0.298 P=0.511N |P=0.229 (e) (e) P=0.499 | |POLY 1.5 | P=0.220N P=0.489 P=0.302 P=0.507N |P=0.229 (e) (e) P=0.497 | |POLY 6 | P=0.230N P=0.476 P=0.296 P=0.515N |P=0.232 (e) (e) P=0.506 | |LOGISTIC REGRESSION| P=0.221N P=0.470 P=0.295 (e) |P=0.240 (e) (e) P=0.503 | |COCH-ARM / FISHERS | P=0.212N P=0.500 P=0.311 P=0.500N |P=0.233 (e) (e) P=0.500 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 8 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/100 (3%) 5/100 (5%) 5/100 (5%) 4/100 (4%) |3/100 (3%) 5/100 (5%) 5/100 (5%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 3.5% 6.1% 6.0% 4.9% |3.5% 5.5% 5.7% 1.2% | |TERMINAL (d) | 3/57 (5%) 4/46 (9%) 5/47 (11%) 3/48 (6%) |3/59 (5%) 2/68 (3%) 3/60 (5%) 1/61 (2%) | |FIRST INCIDENCE | 736 (T) 647 736 (T) 673 |737 (T) 598 687 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.582 P=0.255 P=0.258 P=0.417 |P=0.125N P=0.428 P=0.373 P=0.295N | |POLY 3 | P=0.593 P=0.333 P=0.345 P=0.471 |P=0.126N P=0.389 P=0.373 P=0.309N | |POLY 1.5 | P=0.587N P=0.342 P=0.351 P=0.482 |P=0.127N P=0.376 P=0.366 P=0.313N | |POLY 6 | P=0.586 P=0.324 P=0.341 P=0.463 |P=0.121N P=0.407 P=0.383 P=0.298N | |LOGISTIC REGRESSION| P=0.594 P=0.314 P=0.258 P=0.458 |P=0.123N P=0.373 P=0.385 P=0.295N | |COCH-ARM / FISHERS | P=0.572N P=0.360 P=0.360 P=0.500 |P=0.118N P=0.360 P=0.360 P=0.311N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Carcinoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 2/100 (2%) 0/100 (0%) 1/100 (1%) |1/100 (1%) 0/100 (0%) 0/100 (0%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 2.5% 0.0% 1.2% |1.2% 0.0% 0.0% 1.2% | |TERMINAL (d) | 0/57 (0%) 2/46 (4%) 0/47 (0%) 1/48 (2%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 1/61 (2%) | |FIRST INCIDENCE | --- 736 (T) --- 736 (T) |610 --- --- 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.648 P=0.193 (e) P=0.466 |P=0.492 P=0.491N P=0.486N P=0.758N | |POLY 3 | P=0.646 P=0.227 (e) P=0.489 |P=0.489 P=0.492N P=0.496N P=0.758 | |POLY 1.5 | P=0.653 P=0.231 (e) P=0.493 |P=0.491 P=0.495N P=0.498N P=0.756 | |POLY 6 | P=0.641 P=0.223 (e) P=0.485 |P=0.490 P=0.487N P=0.494N P=0.757N | |LOGISTIC REGRESSION| (e) P=0.193 (e) P=0.466 |P=0.518 P=0.554N P=0.486N P=0.758N | |COCH-ARM / FISHERS | P=0.662 P=0.249 (e) P=0.500 |P=0.501 P=0.500N P=0.500N P=0.751N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 9 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/100 (3%) 7/100 (7%) 5/100 (5%) 5/100 (5%) |4/100 (4%) 5/100 (5%) 5/100 (5%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 3.5% 8.6% 6.0% 6.2% |4.7% 5.5% 5.7% 2.4% | |TERMINAL (d) | 3/57 (5%) 6/46 (13%) 5/47 (11%) 4/48 (8%) |3/59 (5%) 2/68 (3%) 3/60 (5%) 2/61 (3%) | |FIRST INCIDENCE | 736 (T) 647 736 (T) 673 |610 598 687 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.546 P=0.093 P=0.258 P=0.277 |P=0.205N P=0.569 P=0.518 P=0.328N | |POLY 3 | P=0.558 P=0.145 P=0.345 P=0.330 |P=0.209N P=0.530 P=0.513 P=0.344N | |POLY 1.5 | P=0.570 P=0.152 P=0.351 P=0.341 |P=0.209N P=0.517 P=0.506 P=0.349N | |POLY 6 | P=0.550 P=0.138 P=0.341 P=0.321 |P=0.204N P=0.549 P=0.522 P=0.332N | |LOGISTIC REGRESSION| P=0.561 P=0.131 P=0.258 P=0.317 |P=0.204N P=0.497 P=0.519 P=0.337N | |COCH-ARM / FISHERS | P=0.587 P=0.166 P=0.360 P=0.360 |P=0.193N P=0.500 P=0.500 P=0.341N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Mammary Gland | | Carcinoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 0/100 (0%) 1/100 (1%) 0/100 (0%) 0/100 (0%) |2/100 (2%) 7/100 (7%) 5/100 (5%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 1.2% 0.0% 0.0% |2.3% 7.8% 5.7% 2.4% | |TERMINAL (d) | 0/57 (0%) 1/46 (2%) 0/47 (0%) 0/48 (0%) |2/59 (3%) 4/68 (6%) 3/60 (5%) 2/61 (3%) | |FIRST INCIDENCE | --- 736 (T) --- --- |737 (T) 589 656 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.607N P=0.457 (e) (e) |P=0.206N P=0.120 P=0.233 P=0.682N | |POLY 3 | P=0.607N P=0.490 (e) (e) |P=0.202N P=0.098 P=0.231 P=0.691 | |POLY 1.5 | P=0.603N P=0.493 (e) (e) |P=0.205N P=0.093 P=0.226 P=0.686 | |POLY 6 | P=0.610N P=0.486 (e) (e) |P=0.193N P=0.107 P=0.240 P=0.685N | |LOGISTIC REGRESSION| (e) P=0.457 (e) (e) |P=0.203N P=0.096 P=0.236 P=0.682N | |COCH-ARM / FISHERS | P=0.597N P=0.500 (e) (e) |P=0.194N P=0.085 P=0.222 P=0.689N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 10 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Mammary Gland | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 0/100 (0%) 1/100 (1%) 0/100 (0%) 0/100 (0%) |3/100 (3%) 8/100 (8%) 6/100 (6%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| 0.0% 1.2% 0.0% 0.0% |3.5% 8.9% 6.8% 3.5% | |TERMINAL (d) | 0/57 (0%) 1/46 (2%) 0/47 (0%) 0/48 (0%) |3/59 (5%) 4/68 (6%) 3/60 (5%) 2/61 (3%) | |FIRST INCIDENCE | --- 736 (T) --- --- |737 (T) 589 637 704 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.607N P=0.457 (e) (e) |P=0.232N P=0.153 P=0.267 P=0.642N | |POLY 3 | P=0.607N P=0.490 (e) (e) |P=0.231N P=0.125 P=0.263 P=0.659 | |POLY 1.5 | P=0.603N P=0.493 (e) (e) |P=0.234N P=0.117 P=0.255 P=0.653 | |POLY 6 | P=0.610N P=0.486 (e) (e) |P=0.220N P=0.137 P=0.274 P=0.649N | |LOGISTIC REGRESSION| (e) P=0.457 (e) (e) |P=0.232N P=0.118 P=0.260 P=0.634N | |COCH-ARM / FISHERS | P=0.597N P=0.500 (e) (e) |P=0.219N P=0.107 P=0.249 P=0.659N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Mammary Gland | | Fibroadenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 6/100 (6%) 6/100 (6%) 11/100 (11%) 9/100 (9%) |56/100 (56%) 62/100 (62%) 54/100 (54%) 64/100 (64%) | |POLY-3 ADJUSTED (b)| 7.0% 7.4% 13.1% 11.0% |62.5% 67.0% 59.8% 71.8% | |TERMINAL (d) | 6/57 (11%) 4/46 (9%) 6/47 (13%) 6/48 (13%) |39/59 (66%) 49/68 (72%) 40/60 (67%) 45/61 (74%) | |FIRST INCIDENCE | 736 (T) 712 672 673 |543 522 557 522 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.256 P=0.489 P=0.091 P=0.199 |P=0.151 P=0.471N P=0.374N P=0.268 | |POLY 3 | P=0.269 P=0.583 P=0.142 P=0.259 |P=0.109 P=0.305 P=0.409N P=0.111 | |POLY 1.5 | P=0.280 P=0.595 P=0.147 P=0.273 |P=0.108 P=0.274 P=0.429N P=0.101 | |POLY 6 | P=0.263 P=0.571 P=0.140 P=0.250 |P=0.141 P=0.346 P=0.381N P=0.155 | |LOGISTIC REGRESSION| P=0.259 P=0.553 P=0.137 P=0.241 |P=0.103 P=0.405 P=0.327N P=0.128 | |COCH-ARM / FISHERS | P=0.296 P=0.616N P=0.155 P=0.296 |P=0.187 P=0.236 P=0.444N P=0.156 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 11 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Mammary Gland | | Fibroma, Fibroadenoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 6/100 (6%) 6/100 (6%) 11/100 (11%) 9/100 (9%) |56/100 (56%) 63/100 (63%) 55/100 (55%) 64/100 (64%) | |POLY-3 ADJUSTED (b)| 7.0% 7.4% 13.1% 11.0% |62.5% 67.9% 60.6% 71.8% | |TERMINAL (d) | 6/57 (11%) 4/46 (9%) 6/47 (13%) 6/48 (13%) |39/59 (66%) 49/68 (72%) 40/60 (67%) 45/61 (74%) | |FIRST INCIDENCE | 736 (T) 712 672 673 |543 522 557 522 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.256 P=0.489 P=0.091 P=0.199 |P=0.175 P=0.521N P=0.423N P=0.268 | |POLY 3 | P=0.269 P=0.583 P=0.142 P=0.259 |P=0.127 P=0.260 P=0.457N P=0.111 | |POLY 1.5 | P=0.280 P=0.595 P=0.147 P=0.273 |P=0.127 P=0.229 P=0.482N P=0.101 | |POLY 6 | P=0.263 P=0.571 P=0.140 P=0.250 |P=0.159 P=0.304 P=0.421N P=0.155 | |LOGISTIC REGRESSION| P=0.259 P=0.553 P=0.137 P=0.241 |P=0.121 P=0.343 P=0.388N P=0.128 | |COCH-ARM / FISHERS | P=0.296 P=0.616N P=0.155 P=0.296 |P=0.214 P=0.194 P=0.500N P=0.156 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Mammary Gland | | Fibroma, Fibroadenoma, Carcinoma, or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 6/100 (6%) 7/100 (7%) 11/100 (11%) 9/100 (9%) |58/100 (58%) 67/100 (67%) 55/100 (55%) 65/100 (65%) | |POLY-3 ADJUSTED (b)| 7.0% 8.6% 13.1% 11.0% |64.7% 71.7% 60.6% 72.9% | |TERMINAL (d) | 6/57 (11%) 5/46 (11%) 6/47 (13%) 6/48 (13%) |41/59 (70%) 51/68 (75%) 40/60 (67%) 46/61 (75%) | |FIRST INCIDENCE | 736 (T) 712 672 673 |543 522 557 522 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.302 P=0.363 P=0.091 P=0.199 |P=0.243 P=0.497 P=0.322N P=0.312 | |POLY 3 | P=0.316 P=0.462 P=0.142 P=0.259 |P=0.187 P=0.184 P=0.333N P=0.141 | |POLY 1.5 | P=0.328 P=0.476 P=0.147 P=0.273 |P=0.188 P=0.153 P=0.363N P=0.129 | |POLY 6 | P=0.309 P=0.449 P=0.140 P=0.250 |P=0.227 P=0.236 P=0.293N P=0.196 | |LOGISTIC REGRESSION| P=0.307 P=0.428 P=0.137 P=0.241 |P=0.184 P=0.235 P=0.272N P=0.161 | |COCH-ARM / FISHERS | P=0.346 P=0.500 P=0.155 P=0.296 |P=0.299 P=0.121 P=0.388N P=0.192 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 12 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Ovary | | Tubulostromal Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | |3/100 (3%) 2/100 (2%) 2/100 (2%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| |3.5% 2.2% 2.3% 1.2% | |TERMINAL (d) | |2/59 (3%) 1/68 (2%) 1/60 (2%) 1/61 (2%) | |FIRST INCIDENCE | |736 631 637 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.311N P=0.441N P=0.486N P=0.296N | |POLY 3 | |P=0.317N P=0.478N P=0.488N P=0.309N | |POLY 1.5 | |P=0.316N P=0.487N P=0.494N P=0.313N | |POLY 6 | |P=0.313N P=0.464N P=0.479N P=0.298N | |LOGISTIC REGRESSION| |P=0.311N P=0.477N P=0.486N P=0.296N | |COCH-ARM / FISHERS | |P=0.301N P=0.500N P=0.500N P=0.311N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pancreas | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/98 (3%) 5/99 (5%) 6/99 (6%) 5/99 (5%) |0/100 (0%) 1/100 (1%) 0/99 (0%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 3.5% 6.1% 7.2% 6.2% |0.0% 1.1% 0.0% 1.2% | |TERMINAL (d) | 2/57 (4%) 4/46 (9%) 5/47 (11%) 2/48 (4%) |0/59 (0%) 1/68 (2%) 0/60 (0%) 1/61 (2%) | |FIRST INCIDENCE | 658 329 729 565 |--- 737 (T) --- 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.443 P=0.271 P=0.174 P=0.296 |P=0.492 P=0.528 (e) P=0.507 | |POLY 3 | P=0.449 P=0.335 P=0.238 P=0.332 |P=0.497 P=0.509 (e) P=0.499 | |POLY 1.5 | P=0.461 P=0.347 P=0.244 P=0.345 |P=0.495 P=0.505 (e) P=0.496 | |POLY 6 | P=0.440 P=0.321 P=0.231 P=0.320 |P=0.503 P=0.514 (e) P=0.505 | |LOGISTIC REGRESSION| P=0.461 P=0.376 P=0.233 P=0.337 |(e) P=0.528 (e) P=0.507 | |COCH-ARM / FISHERS | P=0.480 P=0.366 P=0.254 P=0.366 |P=0.500 P=0.500 (e) P=0.500 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 13 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 34/98 (35%) 35/95 (37%) 28/97 (29%) 35/100 (35%)|61/99 (62%) 59/99 (60%) 68/98 (69%) 51/98 (52%) | |POLY-3 ADJUSTED (b)| 38.8% 42.9% 33.5% 40.4% |65.8% 62.5% 73.4% 58.4% | |TERMINAL (d) | 23/57 (40%) 20/45 (44%) 18/46 (39%) 16/48 (33%) |40/59 (68%) 36/67 (54%) 45/60 (75%) 34/61 (56%) | |FIRST INCIDENCE | 579 533 489 442 |533 563 429 522 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.349 P=0.192 P=0.482N P=0.277 |P=0.113N P=0.191N P=0.307 P=0.095N | |POLY 3 | P=0.500 P=0.349 P=0.281N P=0.479 |P=0.143N P=0.371N P=0.159 P=0.183N | |POLY 1.5 | P=0.509 P=0.380 P=0.260N P=0.503 |P=0.123N P=0.404N P=0.155 P=0.176N | |POLY 6 | P=0.505 P=0.316 P=0.307N P=0.465 |P=0.147N P=0.315N P=0.171 P=0.167N | |LOGISTIC REGRESSION| P=0.470 P=0.346 P=0.274N P=0.476 |P=0.093N P=0.408N P=0.177 P=0.138N | |COCH-ARM / FISHERS | P=0.521 P=0.436 P=0.236N P=0.541 |P=0.056N P=0.442N P=0.159 P=0.113N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Carcinoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/98 (0%) 1/95 (1%) 2/97 (2%) 0/100 (0%) |3/99 (3%) 1/99 (1%) 4/98 (4%) 2/98 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 1.3% 2.5% 0.0% |3.5% 1.1% 4.6% 2.4% | |TERMINAL (d) | 0/57 (0%) 0/45 (0%) 1/46 (2%) 0/48 (0%) |2/59 (3%) 1/67 (2%) 2/60 (3%) 2/61 (3%) | |FIRST INCIDENCE | --- 685 726 --- |655 737 (T) 678 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.456N P=0.482 P=0.211 (e) |P=0.569N P=0.267N P=0.519 P=0.485N | |POLY 3 | P=0.451N P=0.484 P=0.229 (e) |P=0.586N P=0.294N P=0.508 P=0.509N | |POLY 1.5 | P=0.444N P=0.487 P=0.232 (e) |P=0.585N P=0.300N P=0.501 P=0.514N | |POLY 6 | P=0.456N P=0.480 P=0.227 (e) |P=0.578N P=0.287N P=0.518 P=0.497N | |LOGISTIC REGRESSION| P=0.445N P=0.493 P=0.225 (e) |P=0.575N P=0.290N P=0.507 P=0.498N | |COCH-ARM / FISHERS | P=0.435N P=0.492 P=0.246 (e) |P=0.566N P=0.311N P=0.494 P=0.505N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 14 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 34/98 (35%) 36/95 (38%) 30/97 (31%) 35/100 (35%)|64/99 (65%) 60/99 (61%) 72/98 (73%) 53/98 (54%) | |POLY-3 ADJUSTED (b)| 38.8% 44.0% 35.8% 40.4% |68.8% 63.5% 77.4% 60.6% | |TERMINAL (d) | 23/57 (40%) 20/45 (44%) 19/46 (41%) 16/48 (33%) |42/59 (71%) 37/67 (55%) 47/60 (78%) 36/61 (59%) | |FIRST INCIDENCE | 579 533 489 442 |533 563 429 522 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.393 P=0.157 P=0.510 P=0.277 |P=0.108N P=0.129N P=0.272 P=0.074N | |POLY 3 | P=0.534N P=0.295 P=0.401N P=0.479 |P=0.138N P=0.266N P=0.114 P=0.153N | |POLY 1.5 | P=0.523N P=0.324 P=0.374N P=0.503 |P=0.115N P=0.295N P=0.111 P=0.143N | |POLY 6 | P=0.533N P=0.267 P=0.433N P=0.465 |P=0.146N P=0.221N P=0.125 P=0.142N | |LOGISTIC REGRESSION| P=0.522 P=0.292 P=0.391N P=0.476 |P=0.086N P=0.293N P=0.133 P=0.108N | |COCH-ARM / FISHERS | P=0.508N P=0.377 P=0.342N P=0.541 |P=0.049N* P=0.330N P=0.118 P=0.086N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Pituitary Gland: Pars Intermedia | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/98 (0%) 1/95 (1%) 1/97 (1%) 1/100 (1%) |0/99 (0%) 3/99 (3%) 1/98 (1%) 0/98 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 1.3% 1.2% 1.2% |0.0% 3.4% 1.2% 0.0% | |TERMINAL (d) | 0/57 (0%) 1/45 (2%) 1/46 (2%) 0/48 (0%) |0/59 (0%) 2/67 (3%) 1/60 (2%) 0/61 (0%) | |FIRST INCIDENCE | --- 736 (T) 736 (T) 703 |--- 682 737 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.543 P=0.453 P=0.457 P=0.490 |P=0.237N P=0.146 P=0.503 (e) | |POLY 3 | P=0.550 P=0.483 P=0.492 P=0.493 |P=0.235N P=0.129 P=0.503 (e) | |POLY 1.5 | P=0.556 P=0.487 P=0.494 P=0.497 |P=0.238N P=0.126 P=0.500 (e) | |POLY 6 | P=0.545 P=0.479 P=0.489 P=0.489 |P=0.227N P=0.133 P=0.506 (e) | |LOGISTIC REGRESSION| P=0.554 P=0.453 P=0.457 P=0.495 |P=0.237N P=0.131 P=0.503 (e) | |COCH-ARM / FISHERS | P=0.565 P=0.492 P=0.497 P=0.505 |P=0.236N P=0.123 P=0.497 (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 15 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Seminal Vesicle | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) 2/100 (2%) 0/100 (0%) | | |POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.4% 0.0% | | |TERMINAL (d) | 0/57 (0%) 0/46 (0%) 2/47 (4%) 0/48 (0%) | | |FIRST INCIDENCE | --- --- 736 (T) --- | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.648N (e) P=0.197 (e) | | |POLY 3 | P=0.644N (e) P=0.233 (e) | | |POLY 1.5 | P=0.640N (e) P=0.235 (e) | | |POLY 6 | P=0.647N (e) P=0.231 (e) | | |LOGISTIC REGRESSION| (e) (e) P=0.197 (e) | | |COCH-ARM / FISHERS | P=0.634N (e) P=0.249 (e) | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Basal Cell Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 3/100 (3%) 0/100 (0%) 3/100 (3%) 3/100 (3%) |0/100 (0%) 1/100 (1%) 1/100 (1%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 3.5% 0.0% 3.6% 3.7% |0.0% 1.1% 1.1% 0.0% | |TERMINAL (d) | 2/57 (4%) 0/46 (0%) 2/47 (4%) 1/48 (2%) |0/59 (0%) 1/68 (2%) 1/60 (2%) 0/61 (0%) | |FIRST INCIDENCE | 659 --- 586 656 |--- 737 (T) 737 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.322 P=0.155N P=0.595 P=0.609 |P=0.508N P=0.528 P=0.503 (e) | |POLY 3 | P=0.335 P=0.131N P=0.650 P=0.635 |P=0.503N P=0.509 P=0.505 (e) | |POLY 1.5 | P=0.338 P=0.128N P=0.654 P=0.645 |P=0.505N P=0.505 P=0.502 (e) | |POLY 6 | P=0.334 P=0.136N P=0.648 P=0.627 |P=0.497N P=0.514 P=0.508 (e) | |LOGISTIC REGRESSION| P=0.331 P=0.132N P=0.655 P=0.637 |(e) P=0.528 P=0.503 (e) | |COCH-ARM / FISHERS | P=0.343 P=0.123N P=0.659N P=0.659N |P=0.501N P=0.500 P=0.500 (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 16 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Basal Cell Adenoma, Basosquamous Tumor Benign, or | | Trichoepithelioma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 3/100 (3%) 1/100 (1%) 3/100 (3%) 8/100 (8%) |0/100 (0%) 1/100 (1%) 3/100 (3%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 3.5% 1.2% 3.6% 9.8% |0.0% 1.1% 3.4% 0.0% | |TERMINAL (d) | 2/57 (4%) 1/46 (2%) 2/47 (4%) 5/48 (10%) |0/59 (0%) 1/68 (2%) 2/60 (3%) 0/61 (0%) | |FIRST INCIDENCE | 659 736 (T) 586 656 |--- 737 (T) 710 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.007 ** P=0.373N P=0.595 P=0.074 |P=0.411N P=0.528 P=0.128 (e) | |POLY 3 | P=0.008 ** P=0.327N P=0.650 P=0.089 |P=0.413N P=0.509 P=0.126 (e) | |POLY 1.5 | P=0.008 ** P=0.319N P=0.654 P=0.096 |P=0.415N P=0.505 P=0.124 (e) | |POLY 6 | P=0.007 ** P=0.335N P=0.648 P=0.084 |P=0.404N P=0.514 P=0.129 (e) | |LOGISTIC REGRESSION| P=0.007 ** P=0.331N P=0.655 P=0.085 |P=0.402N P=0.528 P=0.130 (e) | |COCH-ARM / FISHERS | P=0.009 ** P=0.311N P=0.659N P=0.107 |P=0.404N P=0.500 P=0.123 (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous | | Tumor (benign, malignant or NOS), or Trichoepithelioma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 3/100 (3%) 1/100 (1%) 3/100 (3%) 8/100 (8%) |0/100 (0%) 1/100 (1%) 3/100 (3%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 3.5% 1.2% 3.6% 9.8% |0.0% 1.1% 3.4% 0.0% | |TERMINAL (d) | 2/57 (4%) 1/46 (2%) 2/47 (4%) 5/48 (10%) |0/59 (0%) 1/68 (2%) 2/60 (3%) 0/61 (0%) | |FIRST INCIDENCE | 659 736 (T) 586 656 |--- 737 (T) 710 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.007 ** P=0.373N P=0.595 P=0.074 |P=0.411N P=0.528 P=0.128 (e) | |POLY 3 | P=0.008 ** P=0.327N P=0.650 P=0.089 |P=0.413N P=0.509 P=0.126 (e) | |POLY 1.5 | P=0.008 ** P=0.319N P=0.654 P=0.096 |P=0.415N P=0.505 P=0.124 (e) | |POLY 6 | P=0.007 ** P=0.335N P=0.648 P=0.084 |P=0.404N P=0.514 P=0.129 (e) | |LOGISTIC REGRESSION| P=0.007 ** P=0.331N P=0.655 P=0.085 |P=0.402N P=0.528 P=0.130 (e) | |COCH-ARM / FISHERS | P=0.009 ** P=0.311N P=0.659N P=0.107 |P=0.404N P=0.500 P=0.123 (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 17 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor | | (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 14/100 (14%) 8/100 (8%) 14/100 (14%) 20/100 (20%)|1/100 (1%) 2/100 (2%) 6/100 (6%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 16.1% 9.8% 16.4% 24.5% |1.2% 2.2% 6.9% 1.2% | |TERMINAL (d) | 10/57 (18%) 4/46 (9%) 8/47 (17%) 14/48 (29%) |1/59 (2%) 2/68 (3%) 5/60 (8%) 1/61 (2%) | |FIRST INCIDENCE | 627 688 535 656 |737 (T) 737 (T) 710 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.018 * P=0.242N P=0.428 P=0.084 |P=0.392N P=0.549 P=0.065 P=0.754N | |POLY 3 | P=0.018 * P=0.159N P=0.563 P=0.122 |P=0.393N P=0.516 P=0.064 P=0.759 | |POLY 1.5 | P=0.020 * P=0.147N P=0.569 P=0.141 |P=0.396N P=0.509 P=0.063 P=0.757 | |POLY 6 | P=0.016 * P=0.172N P=0.560 P=0.106 |P=0.383N P=0.525 P=0.067 P=0.756N | |LOGISTIC REGRESSION| P=0.016 * P=0.169N P=0.554 P=0.110 |P=0.371N P=0.549 P=0.069 P=0.754N | |COCH-ARM / FISHERS | P=0.025 * P=0.129N P=0.581N P=0.173 |P=0.378N P=0.500 P=0.059 P=0.751N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Fibroma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 12/100 (12%) 8/100 (8%) 9/100 (9%) 13/100 (13%)|4/100 (4%) 5/100 (5%) 4/100 (4%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 13.9% 9.8% 10.6% 15.9% |4.7% 5.6% 4.6% 0.0% | |TERMINAL (d) | 9/57 (16%) 4/46 (9%) 4/47 (9%) 9/48 (19%) |2/59 (3%) 4/68 (6%) 1/60 (2%) 0/61 (0%) | |FIRST INCIDENCE | 617 619 635 614 |660 711 652 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.199 P=0.377N P=0.438N P=0.350 |P=0.035N* P=0.579 P=0.614N P=0.061N | |POLY 3 | P=0.211 P=0.278N P=0.339N P=0.438 |P=0.035N* P=0.525 P=0.629N P=0.065N | |POLY 1.5 | P=0.222 P=0.263N P=0.333N P=0.462 |P=0.036N* P=0.514 P=0.635N P=0.066N | |POLY 6 | P=0.200 P=0.292N P=0.339N P=0.416 |P=0.034N* P=0.538 P=0.620N P=0.062N | |LOGISTIC REGRESSION| P=0.201 P=0.293N P=0.346N P=0.417 |P=0.034N* P=0.536 P=0.637N P=0.066N | |COCH-ARM / FISHERS | P=0.239 P=0.240N P=0.323N P=0.500 |P=0.032N* P=0.500 P=0.640N P=0.061N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 18 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, | | or Fibrous Histiocytoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 13/100 (13%) 10/100 (10%) 11/100 (11%) 16/100 (16%)|6/100 (6%) 5/100 (5%) 4/100 (4%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 15.0% 12.1% 13.0% 19.2% |6.9% 5.6% 4.6% 2.4% | |TERMINAL (d) | 9/57 (16%) 5/46 (11%) 6/47 (13%) 9/48 (19%) |2/59 (3%) 4/68 (6%) 1/60 (2%) 2/61 (3%) | |FIRST INCIDENCE | 617 619 635 442 |613 711 652 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.123 P=0.485N P=0.543N P=0.221 |P=0.135N P=0.418N P=0.347N P=0.131N | |POLY 3 | P=0.141 P=0.374N P=0.435N P=0.303 |P=0.140N P=0.477N P=0.362N P=0.144N | |POLY 1.5 | P=0.146 P=0.357N P=0.428N P=0.319 |P=0.139N P=0.486N P=0.368N P=0.147N | |POLY 6 | P=0.137 P=0.390N P=0.438N P=0.291 |P=0.136N P=0.465N P=0.355N P=0.138N | |LOGISTIC REGRESSION| P=0.131 P=0.389N P=0.443N P=0.303 |P=0.134N P=0.481N P=0.373N P=0.143N | |COCH-ARM / FISHERS | P=0.152 P=0.329N P=0.414N P=0.344 |P=0.127N P=0.500N P=0.374N P=0.140N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 1/100 (1%) 2/100 (2%) 2/100 (2%) 3/100 (3%) |2/100 (2%) 0/100 (0%) 0/100 (0%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 1.2% 2.4% 2.4% 3.6% |2.3% 0.0% 0.0% 2.4% | |TERMINAL (d) | 0/57 (0%) 1/46 (2%) 2/47 (4%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 2/61 (3%) | |FIRST INCIDENCE | 704 624 736 (T) 442 |613 --- --- 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.282 P=0.459 P=0.456 P=0.290 |P=0.308 P=0.221N P=0.227N P=0.679N | |POLY 3 | P=0.295 P=0.483 P=0.491 P=0.295 |P=0.300 P=0.230N P=0.235N P=0.689 | |POLY 1.5 | P=0.298 P=0.489 P=0.494 P=0.299 |P=0.302 P=0.234N P=0.237N P=0.685 | |POLY 6 | P=0.293 P=0.477 P=0.488 P=0.291 |P=0.300 P=0.225N P=0.232N P=0.689N | |LOGISTIC REGRESSION| P=0.319 P=0.497 P=0.489 P=0.372 |P=0.309 P=0.261N P=0.240N P=0.690 | |COCH-ARM / FISHERS | P=0.301 P=0.500 P=0.500 P=0.311 |P=0.314 P=0.249N P=0.249N P=0.689N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 19 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Keratoacanthoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 10/100 (10%) 5/100 (5%) 11/100 (11%) 12/100 (12%)|1/100 (1%) 1/100 (1%) 2/100 (2%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 11.6% 6.1% 13.0% 14.8% |1.2% 1.1% 2.3% 1.2% | |TERMINAL (d) | 7/57 (12%) 3/46 (7%) 6/47 (13%) 8/48 (17%) |1/59 (2%) 1/68 (2%) 2/60 (3%) 1/61 (2%) | |FIRST INCIDENCE | 627 713 535 702 |737 (T) 737 (T) 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.132 P=0.238N P=0.376 P=0.285 |P=0.640N P=0.729N P=0.506 P=0.754N | |POLY 3 | P=0.139 P=0.167N P=0.481 P=0.351 |P=0.639N P=0.750N P=0.508 P=0.759 | |POLY 1.5 | P=0.148 P=0.157N P=0.488 P=0.374 |P=0.639N P=0.755N P=0.504 P=0.757 | |POLY 6 | P=0.132 P=0.179N P=0.477 P=0.330 |P=0.634N P=0.744N P=0.514 P=0.756N | |LOGISTIC REGRESSION| P=0.131 P=0.177N P=0.475 P=0.335 |P=0.640N P=0.729N P=0.506 P=0.754N | |COCH-ARM / FISHERS | P=0.161 P=0.141N P=0.500 P=0.411 |P=0.628N P=0.751N P=0.500 P=0.751N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Lipoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 1/100 (1%) 0/100 (0%) 0/100 (0%) 2/100 (2%) |0/100 (0%) 0/100 (0%) 1/100 (1%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 1.2% 0.0% 0.0% 2.5% |0.0% 0.0% 1.1% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 2/48 (4%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) | |FIRST INCIDENCE | 303 --- --- 736 (T) |--- --- 728 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.156 P=0.502N P=0.500N P=0.460 |P=0.763N (e) P=0.510 (e) | |POLY 3 | P=0.160 P=0.513N P=0.507N P=0.477 |P=0.771N (e) P=0.505 (e) | |POLY 1.5 | P=0.161 P=0.508N P=0.505N P=0.485 |P=0.771N (e) P=0.502 (e) | |POLY 6 | P=0.159 P=0.517N P=0.509N P=0.469 |P=0.769N (e) P=0.508 (e) | |LOGISTIC REGRESSION| P=0.171 P=0.307N (e) P=0.555 |P=0.767N (e) P=0.510 (e) | |COCH-ARM / FISHERS | P=0.163 P=0.500N P=0.500N P=0.500 |P=0.767N (e) P=0.500 (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 20 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Sarcoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 0/100 (0%) 1/100 (1%) 1/100 (1%) 3/100 (3%) |1/100 (1%) 0/100 (0%) 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 1.2% 1.2% 3.6% |1.2% 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/46 (0%) 1/47 (2%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) | |FIRST INCIDENCE | --- 624 736 (T) 442 |710 --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.072 P=0.478 P=0.462 P=0.116 |P=0.593N P=0.474N P=0.491N P=0.485N | |POLY 3 | P=0.075 P=0.490 P=0.495 P=0.115 |P=0.603N P=0.491N P=0.496N P=0.501N | |POLY 1.5 | P=0.076 P=0.494 P=0.497 P=0.118 |P=0.601N P=0.495N P=0.498N P=0.504N | |POLY 6 | P=0.074 P=0.487 P=0.494 P=0.114 |P=0.606N P=0.486N P=0.493N P=0.496N | |LOGISTIC REGRESSION| P=0.083 P=0.526 P=0.462 P=0.139 |P=0.600N P=0.493N P=0.496N P=0.501N | |COCH-ARM / FISHERS | P=0.078 P=0.500 P=0.500 P=0.123 |P=0.596N P=0.500N P=0.500N P=0.500N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Squamous Cell Papilloma, Papilloma, Squamous Cell | | Carcinoma or Keratoacanthoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 11/100 (11%) 7/100 (7%) 12/100 (12%) 13/100 (13%)|1/100 (1%) 1/100 (1%) 3/100 (3%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 12.7% 8.6% 14.2% 16.0% |1.2% 1.1% 3.4% 1.2% | |TERMINAL (d) | 8/57 (14%) 3/46 (7%) 7/47 (15%) 9/48 (19%) |1/59 (2%) 1/68 (2%) 3/60 (5%) 1/61 (2%) | |FIRST INCIDENCE | 627 688 535 702 |737 (T) 737 (T) 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.169 P=0.357N P=0.365 P=0.279 |P=0.592N P=0.729N P=0.312 P=0.754N | |POLY 3 | P=0.177 P=0.266N P=0.480 P=0.351 |P=0.592N P=0.750N P=0.315 P=0.759 | |POLY 1.5 | P=0.189 P=0.252N P=0.488 P=0.376 |P=0.593N P=0.755N P=0.311 P=0.757 | |POLY 6 | P=0.166 P=0.281N P=0.476 P=0.328 |P=0.586N P=0.744N P=0.321 P=0.756N | |LOGISTIC REGRESSION| P=0.169 P=0.281N P=0.472 P=0.334 |P=0.592N P=0.729N P=0.312 P=0.754N | |COCH-ARM / FISHERS | P=0.206 P=0.230N P=0.500 P=0.414 |P=0.579N P=0.751N P=0.311 P=0.751N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 21 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Squamous Cell Papilloma, Papilloma, or Keratoacanthoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 11/100 (11%) 7/100 (7%) 12/100 (12%) 13/100 (13%)|1/100 (1%) 1/100 (1%) 3/100 (3%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 12.7% 8.6% 14.2% 16.0% |1.2% 1.1% 3.4% 1.2% | |TERMINAL (d) | 8/57 (14%) 3/46 (7%) 7/47 (15%) 9/48 (19%) |1/59 (2%) 1/68 (2%) 3/60 (5%) 1/61 (2%) | |FIRST INCIDENCE | 627 688 535 702 |737 (T) 737 (T) 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.169 P=0.357N P=0.365 P=0.279 |P=0.592N P=0.729N P=0.312 P=0.754N | |POLY 3 | P=0.177 P=0.266N P=0.480 P=0.351 |P=0.592N P=0.750N P=0.315 P=0.759 | |POLY 1.5 | P=0.189 P=0.252N P=0.488 P=0.376 |P=0.593N P=0.755N P=0.311 P=0.757 | |POLY 6 | P=0.166 P=0.281N P=0.476 P=0.328 |P=0.586N P=0.744N P=0.321 P=0.756N | |LOGISTIC REGRESSION| P=0.169 P=0.281N P=0.472 P=0.334 |P=0.592N P=0.729N P=0.312 P=0.754N | |COCH-ARM / FISHERS | P=0.206 P=0.230N P=0.500 P=0.414 |P=0.579N P=0.751N P=0.311 P=0.751N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin | | Trichoepithelioma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 0/100 (0%) 1/100 (1%) 0/100 (0%) 5/100 (5%) |0/100 (0%) 0/100 (0%) 2/100 (2%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 1.2% 0.0% 6.2% |0.0% 0.0% 2.3% 0.0% | |TERMINAL (d) | 0/57 (0%) 1/46 (2%) 0/47 (0%) 4/48 (8%) |0/59 (0%) 0/68 (0%) 1/60 (2%) 0/61 (0%) | |FIRST INCIDENCE | --- 736 (T) --- 703 |--- --- 710 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.002 ** P=0.457 (e) P=0.024 * |P=0.636N (e) P=0.247 (e) | |POLY 3 | P=0.002 ** P=0.490 (e) P=0.029 * |P=0.644N (e) P=0.244 (e) | |POLY 1.5 | P=0.002 ** P=0.493 (e) P=0.031 * |P=0.644N (e) P=0.241 (e) | |POLY 6 | P=0.002 ** P=0.486 (e) P=0.027 * |P=0.639N (e) P=0.248 (e) | |LOGISTIC REGRESSION| P=0.002 ** P=0.457 (e) P=0.028 * |P=0.637N (e) P=0.248 (e) | |COCH-ARM / FISHERS | P=0.003 ** P=0.500 (e) P=0.030 * |P=0.634N (e) P=0.249 (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 22 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin: Sebaceous Gland | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 0/100 (0%) 1/100 (1%) 2/100 (2%) 1/100 (1%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 1.2% 2.4% 1.2% |0.0% 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/46 (0%) 2/47 (4%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) | |FIRST INCIDENCE | --- 696 736 (T) 716 |--- --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.585 P=0.488 P=0.197 P=0.493 |(e) (e) (e) (e) | |POLY 3 | P=0.579 P=0.490 P=0.233 P=0.489 |(e) (e) (e) (e) | |POLY 1.5 | P=0.586 P=0.494 P=0.235 P=0.493 |(e) (e) (e) (e) | |POLY 6 | P=0.574 P=0.486 P=0.231 P=0.485 |(e) (e) (e) (e) | |LOGISTIC REGRESSION| P=0.584 P=0.494 P=0.197 P=0.486 |(e) (e) (e) (e) | |COCH-ARM / FISHERS | P=0.596 P=0.500 P=0.249 P=0.500 |(e) (e) (e) (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Skin: Sebaceous Gland | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 1/100 (1%) 1/100 (1%) 2/100 (2%) 1/100 (1%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 1.2% 1.2% 2.4% 1.2% |0.0% 0.0% 0.0% 0.0% | |TERMINAL (d) | 1/57 (2%) 0/46 (0%) 2/47 (4%) 0/48 (0%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) | |FIRST INCIDENCE | 736 (T) 696 736 (T) 716 |--- --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.643N P=0.730 P=0.433 P=0.738 |(e) (e) (e) (e) | |POLY 3 | P=0.640N P=0.749 P=0.491 P=0.748 |(e) (e) (e) (e) | |POLY 1.5 | P=0.635N P=0.753 P=0.495 P=0.753 |(e) (e) (e) (e) | |POLY 6 | P=0.643N P=0.745 P=0.489 P=0.744 |(e) (e) (e) (e) | |LOGISTIC REGRESSION| P=0.644N P=0.746 P=0.433 P=0.744 |(e) (e) (e) (e) | |COCH-ARM / FISHERS | P=0.628N P=0.751N P=0.500 P=0.751N |(e) (e) (e) (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 23 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Testes | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 93/100 (93%) 90/100 (90%) 91/100 (91%) 91/100 (91%)| | |POLY-3 ADJUSTED (b)| 95.1% 94.8% 94.4% 95.8% | | |TERMINAL (d) | 54/57 (95%) 45/46 (98%) 43/47 (92%) 47/48 (98%) | | |FIRST INCIDENCE | 476 461 463 410 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.333 P=0.147 P=0.210 P=0.173 | | |POLY 3 | P=0.450 P=0.600N P=0.544N P=0.556 | | |POLY 1.5 | P=0.560 P=0.480N P=0.475N P=0.573N | | |POLY 6 | P=0.308 P=0.591 P=0.599N P=0.372 | | |LOGISTIC REGRESSION| P=0.476 P=0.521N P=0.490N P=0.593 | | |COCH-ARM / FISHERS | P=0.517N P=0.307N P=0.398N P=0.398N | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thymus | | Thymoma Benign | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/97 (2%) 1/94 (1%) 1/95 (1%) 0/90 (0%) |0/95 (0%) 0/95 (0%) 1/92 (1%) 1/91 (1%) | |POLY-3 ADJUSTED (b)| 2.4% 1.3% 1.3% 0.0% |0.0% 0.0% 1.2% 1.3% | |TERMINAL (d) | 2/55 (4%) 1/44 (2%) 1/45 (2%) 0/46 (0%) |0/56 (0%) 0/64 (0%) 1/57 (2%) 1/56 (2%) | |FIRST INCIDENCE | 736 (T) 736 (T) 736 (T) --- |--- --- 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.246N P=0.578N P=0.570N P=0.279N |P=0.351 (e) P=0.504 P=0.500 | |POLY 3 | P=0.248N P=0.529N P=0.517N P=0.267N |P=0.348 (e) P=0.500 P=0.491 | |POLY 1.5 | P=0.247N P=0.522N P=0.513N P=0.262N |P=0.347 (e) P=0.497 P=0.488 | |POLY 6 | P=0.247N P=0.536N P=0.520N P=0.269N |P=0.355 (e) P=0.505 P=0.498 | |LOGISTIC REGRESSION| P=0.246N P=0.578N P=0.570N (e) |(e) (e) P=0.504 P=0.500 | |COCH-ARM / FISHERS | P=0.244N P=0.512N P=0.508N P=0.268N |P=0.356 (e) P=0.492 P=0.489 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 24 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thymus | | Thymoma Malignant | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/97 (0%) 2/94 (2%) 0/95 (0%) 0/90 (0%) |0/95 (0%) 0/95 (0%) 0/92 (0%) 0/91 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 2.6% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/55 (0%) 0/44 (0%) 0/45 (0%) 0/46 (0%) |0/56 (0%) 0/64 (0%) 0/57 (0%) 0/56 (0%) | |FIRST INCIDENCE | --- 466 --- --- |--- --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.376N P=0.226 (e) (e) |(e) (e) (e) (e) | |POLY 3 | P=0.389N P=0.223 (e) (e) |(e) (e) (e) (e) | |POLY 1.5 | P=0.385N P=0.227 (e) (e) |(e) (e) (e) (e) | |POLY 6 | P=0.392N P=0.221 (e) (e) |(e) (e) (e) (e) | |LOGISTIC REGRESSION| P=0.378N P=0.283 (e) (e) |(e) (e) (e) (e) | |COCH-ARM / FISHERS | P=0.379N P=0.241 (e) (e) |(e) (e) (e) (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thymus | | Thymoma: Benign, Malignant, NOS | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/97 (2%) 3/94 (3%) 1/95 (1%) 0/90 (0%) |0/95 (0%) 0/95 (0%) 1/92 (1%) 1/91 (1%) | |POLY-3 ADJUSTED (b)| 2.4% 3.8% 1.3% 0.0% |0.0% 0.0% 1.2% 1.3% | |TERMINAL (d) | 2/55 (4%) 1/44 (2%) 1/45 (2%) 0/46 (0%) |0/56 (0%) 0/64 (0%) 1/57 (2%) 1/56 (2%) | |FIRST INCIDENCE | 736 (T) 466 736 (T) --- |--- --- 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.126N P=0.429 P=0.570N P=0.279N |P=0.351 (e) P=0.504 P=0.500 | |POLY 3 | P=0.131N P=0.469 P=0.517N P=0.267N |P=0.348 (e) P=0.500 P=0.491 | |POLY 1.5 | P=0.129N P=0.476 P=0.513N P=0.262N |P=0.347 (e) P=0.497 P=0.488 | |POLY 6 | P=0.132N P=0.464 P=0.520N P=0.269N |P=0.355 (e) P=0.505 P=0.498 | |LOGISTIC REGRESSION| P=0.123N P=0.512 P=0.570N (e) |(e) (e) P=0.504 P=0.500 | |COCH-ARM / FISHERS | P=0.125N P=0.485 P=0.508N P=0.268N |P=0.356 (e) P=0.492 P=0.489 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 25 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 15/99 (15%) 25/100 (25%) 26/100 (26%) 23/100 (23%)|15/100 (15%) 20/100 (20%) 19/100 (19%) 20/100 (20%) | |POLY-3 ADJUSTED (b)| 17.2% 30.0% 30.5% 27.4% |17.3% 22.0% 21.4% 23.5% | |TERMINAL (d) | 7/57 (12%) 15/46 (33%) 16/47 (34%) 13/48 (27%) |12/59 (20%) 16/68 (24%) 14/60 (23%) 17/61 (28%) | |FIRST INCIDENCE | 583 589 604 561 |561 522 497 673 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.300 P=0.022 * P=0.018 * P=0.053 |P=0.311 P=0.369 P=0.317 P=0.259 | |POLY 3 | P=0.326 P=0.035 * P=0.028 * P=0.075 |P=0.292 P=0.271 P=0.311 P=0.205 | |POLY 1.5 | P=0.348 P=0.043 * P=0.033 * P=0.087 |P=0.298 P=0.253 P=0.298 P=0.201 | |POLY 6 | P=0.309 P=0.027 * P=0.024 * P=0.064 |P=0.302 P=0.298 P=0.330 P=0.223 | |LOGISTIC REGRESSION| P=0.321 P=0.039 * P=0.033 * P=0.085 |P=0.318 P=0.270 P=0.307 P=0.249 | |COCH-ARM / FISHERS | P=0.381 P=0.059 P=0.043 * P=0.110 |P=0.353 P=0.229 P=0.286 P=0.229 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Carcinoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 7/100 (7%) 4/100 (4%) 2/100 (2%) |5/100 (5%) 3/100 (3%) 3/100 (3%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| 1.2% 8.5% 4.8% 2.5% |5.9% 3.4% 3.4% 3.5% | |TERMINAL (d) | 1/57 (2%) 2/46 (4%) 2/47 (4%) 2/48 (4%) |4/59 (7%) 3/68 (4%) 1/60 (2%) 1/61 (2%) | |FIRST INCIDENCE | 736 (T) 619 687 736 (T) |710 737 (T) 665 557 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.284N P=0.024 * P=0.146 P=0.440 |P=0.461N P=0.286N P=0.342N P=0.343N | |POLY 3 | P=0.280N P=0.030 * P=0.177 P=0.483 |P=0.463N P=0.335N P=0.344N P=0.357N | |POLY 1.5 | P=0.269N P=0.032 * P=0.180 P=0.491 |P=0.465N P=0.346N P=0.352N P=0.366N | |POLY 6 | P=0.290N P=0.029 * P=0.175 P=0.476 |P=0.454N P=0.322N P=0.333N P=0.339N | |LOGISTIC REGRESSION| P=0.271N P=0.032 * P=0.174 P=0.440 |P=0.462N P=0.300N P=0.341N P=0.364N | |COCH-ARM / FISHERS | P=0.254N P=0.033 * P=0.187 P=0.504 |P=0.447N P=0.360N P=0.360N P=0.360N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 26 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 16/99 (16%) 31/100 (31%) 30/100 (30%) 25/100 (25%)|19/100 (19%) 22/100 (22%) 22/100 (22%) 23/100 (23%) | |POLY-3 ADJUSTED (b)| 18.4% 36.8% 35.1% 29.8% |21.9% 24.3% 24.6% 26.8% | |TERMINAL (d) | 8/57 (14%) 17/46 (37%) 18/47 (38%) 15/48 (31%) |15/59 (25%) 18/68 (27%) 15/60 (25%) 18/61 (30%) | |FIRST INCIDENCE | 583 589 604 561 |561 522 497 557 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.406 P=0.003 ** P=0.006 ** P=0.037 * |P=0.318 P=0.544 P=0.404 P=0.343 | |POLY 3 | P=0.438 P=0.005 ** P=0.009 ** P=0.055 |P=0.305 P=0.422 P=0.401 P=0.283 | |POLY 1.5 | P=0.466 P=0.006 ** P=0.011 * P=0.066 |P=0.306 P=0.397 P=0.382 P=0.273 | |POLY 6 | P=0.413 P=0.003 ** P=0.007 ** P=0.046 * |P=0.323 P=0.456 P=0.430 P=0.314 | |LOGISTIC REGRESSION| P=0.438 P=0.006 ** P=0.011 * P=0.061 |P=0.318 P=0.432 P=0.392 P=0.311 | |COCH-ARM / FISHERS | P=0.507 P=0.010 * P=0.016 * P=0.086 |P=0.361 P=0.363 P=0.363 P=0.301 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Uterus | | Leiomyosarcoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | |2/100 (2%) 1/100 (1%) 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| |2.3% 1.1% 0.0% 0.0% | |TERMINAL (d) | |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) | |FIRST INCIDENCE | |533 669 --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.244N P=0.480N P=0.239N P=0.239N | |POLY 3 | |P=0.248N P=0.486N P=0.235N P=0.242N | |POLY 1.5 | |P=0.247N P=0.492N P=0.237N P=0.244N | |POLY 6 | |P=0.248N P=0.478N P=0.233N P=0.236N | |LOGISTIC REGRESSION| |P=0.175N P=0.571N P=0.221N P=0.188N | |COCH-ARM / FISHERS | |P=0.241N P=0.500N P=0.249N P=0.249N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 27 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Uterus | | Polyp Stromal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | |13/100 (13%) 11/100 (11%) 13/100 (13%) 13/100 (13%) | |POLY-3 ADJUSTED (b)| |15.1% 12.2% 14.6% 14.9% | |TERMINAL (d) | |9/59 (15%) 7/68 (10%) 6/60 (10%) 6/61 (10%) | |FIRST INCIDENCE | |620 669 557 485 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.449 P=0.295N P=0.543N P=0.547N | |POLY 3 | |P=0.457 P=0.370N P=0.548N P=0.569N | |POLY 1.5 | |P=0.445 P=0.389N P=0.565N P=0.577 | |POLY 6 | |P=0.485 P=0.345N P=0.522N P=0.529N | |LOGISTIC REGRESSION| |P=0.452 P=0.356N P=0.570N P=0.574 | |COCH-ARM / FISHERS | |P=0.471 P=0.414N P=0.583N P=0.583N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Uterus | | Sarcoma Stromal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | |0/100 (0%) 2/100 (2%) 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| |0.0% 2.2% 0.0% 0.0% | |TERMINAL (d) | |0/59 (0%) 2/68 (3%) 0/60 (0%) 0/61 (0%) | |FIRST INCIDENCE | |--- 737 (T) --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.374N P=0.271 (e) (e) | |POLY 3 | |P=0.362N P=0.249 (e) (e) | |POLY 1.5 | |P=0.366N P=0.244 (e) (e) | |POLY 6 | |P=0.355N P=0.255 (e) (e) | |LOGISTIC REGRESSION| |(e) P=0.271 (e) (e) | |COCH-ARM / FISHERS | |P=0.367N P=0.249 (e) (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 28 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Uterus | | Sarcoma Stromal or Polyp Stromal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | |13/100 (13%) 12/100 (12%) 13/100 (13%) 13/100 (13%) | |POLY-3 ADJUSTED (b)| |15.1% 13.3% 14.6% 14.9% | |TERMINAL (d) | |9/59 (15%) 8/68 (12%) 6/60 (10%) 6/61 (10%) | |FIRST INCIDENCE | |620 669 557 485 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.491 P=0.369N P=0.543N P=0.547N | |POLY 3 | |P=0.501 P=0.455N P=0.548N P=0.569N | |POLY 1.5 | |P=0.489 P=0.474N P=0.565N P=0.577 | |POLY 6 | |P=0.531 P=0.428N P=0.522N P=0.529N | |LOGISTIC REGRESSION| |P=0.494 P=0.436N P=0.570N P=0.574 | |COCH-ARM / FISHERS | |P=0.515 P=0.500N P=0.583N P=0.583N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Uterus | | Schwannoma Malignant | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | |3/100 (3%) 0/100 (0%) 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| |3.5% 0.0% 0.0% 0.0% | |TERMINAL (d) | |1/59 (2%) 0/68 (0%) 0/60 (0%) 0/61 (0%) | |FIRST INCIDENCE | |462 --- --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | |P=0.252N P=0.114N P=0.124N P=0.130N | |POLY 3 | |P=0.249N P=0.116N P=0.120N P=0.125N | |POLY 1.5 | |P=0.247N P=0.119N P=0.121N P=0.126N | |POLY 6 | |P=0.251N P=0.113N P=0.118N P=0.121N | |LOGISTIC REGRESSION| |P=0.116N P=0.180N P=0.093N P=0.065N | |COCH-ARM / FISHERS | |P=0.240N P=0.123N P=0.123N P=0.123N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 29 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |Zymbal's Gland | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 1/100 (1%) 2/100 (2%) 0/100 (0%) 1/100 (1%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 1.2% 2.5% 0.0% 1.2% |0.0% 0.0% 0.0% 1.2% | |TERMINAL (d) | 0/57 (0%) 0/46 (0%) 0/47 (0%) 1/48 (2%) |0/59 (0%) 0/68 (0%) 0/60 (0%) 0/61 (0%) | |FIRST INCIDENCE | 701 733 --- 736 (T) |--- --- --- 409 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.615N P=0.453 P=0.500N P=0.736 |P=0.225 (e) (e) P=0.490 | |POLY 3 | P=0.608N P=0.481 P=0.505N P=0.748 |P=0.230 (e) (e) P=0.501 | |POLY 1.5 | P=0.604N P=0.488 P=0.503N P=0.753 |P=0.230 (e) (e) P=0.498 | |POLY 6 | P=0.612N P=0.474 P=0.507N P=0.743 |P=0.233 (e) (e) P=0.507 | |LOGISTIC REGRESSION| P=0.611N P=0.472 P=0.503N P=0.745 |P=0.533 (e) (e) P=0.743 | |COCH-ARM / FISHERS | P=0.597N P=0.500 P=0.500N P=0.751N |P=0.233 (e) (e) P=0.500 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |All Organs | | Leukemia: Lymphocytic, Monocytic, Mononuclear, or | | Undifferentiated | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 50/100 (50%) 44/100 (44%) 47/100 (47%) 50/100 (50%)|20/100 (20%) 18/100 (18%) 24/100 (24%) 25/100 (25%) | |POLY-3 ADJUSTED (b)| 53.1% 50.0% 52.0% 56.2% |22.7% 19.6% 26.4% 28.8% | |TERMINAL (d) | 24/57 (42%) 18/46 (39%) 17/47 (36%) 22/48 (46%) |11/59 (19%) 11/68 (16%) 11/60 (18%) 16/61 (26%) | |FIRST INCIDENCE | 303 533 479 410 |495 498 488 579 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.265 P=0.519 P=0.459 P=0.288 |P=0.163 P=0.290N P=0.366 P=0.310 | |POLY 3 | P=0.265 P=0.393N P=0.502N P=0.390 |P=0.121 P=0.375N P=0.342 P=0.223 | |POLY 1.5 | P=0.297 P=0.335N P=0.459N P=0.454 |P=0.125 P=0.398N P=0.322 P=0.217 | |POLY 6 | P=0.236 P=0.450N P=0.540N P=0.333 |P=0.128 P=0.346N P=0.374 P=0.249 | |LOGISTIC REGRESSION| P=0.314 P=0.258N P=0.390N P=0.545 |P=0.146 P=0.436N P=0.304 P=0.236 | |COCH-ARM / FISHERS | P=0.340 P=0.239N P=0.389N P=0.556N |P=0.166 P=0.429N P=0.304 P=0.249 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 30 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |All Organs | | Mesothelioma: Benign, Malignant, NOS | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 4/100 (4%) 6/100 (6%) 5/100 (5%) 6/100 (6%) |0/100 (0%) 0/100 (0%) 1/100 (1%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 4.6% 7.2% 5.9% 7.2% |0.0% 0.0% 1.1% 0.0% | |TERMINAL (d) | 2/57 (4%) 1/46 (2%) 1/47 (2%) 2/48 (4%) |0/59 (0%) 0/68 (0%) 1/60 (2%) 0/61 (0%) | |FIRST INCIDENCE | 658 581 568 488 |--- --- 737 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.397 P=0.305 P=0.449 P=0.309 |P=0.771N (e) P=0.503 (e) | |POLY 3 | P=0.415 P=0.350 P=0.492 P=0.349 |P=0.771N (e) P=0.505 (e) | |POLY 1.5 | P=0.423 P=0.357 P=0.494 P=0.358 |P=0.771N (e) P=0.502 (e) | |POLY 6 | P=0.410 P=0.344 P=0.493 P=0.343 |P=0.769N (e) P=0.508 (e) | |LOGISTIC REGRESSION| P=0.449 P=0.373 P=0.504 P=0.390 |(e) (e) P=0.503 (e) | |COCH-ARM / FISHERS | P=0.435 P=0.374 P=0.500 P=0.374 |P=0.767N (e) P=0.500 (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |All Organs | | Mesothelioma: Malignant | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 4/100 (4%) 6/100 (6%) 5/100 (5%) 6/100 (6%) |0/100 (0%) 0/100 (0%) 1/100 (1%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 4.6% 7.2% 5.9% 7.2% |0.0% 0.0% 1.1% 0.0% | |TERMINAL (d) | 2/57 (4%) 1/46 (2%) 1/47 (2%) 2/48 (4%) |0/59 (0%) 0/68 (0%) 1/60 (2%) 0/61 (0%) | |FIRST INCIDENCE | 658 581 568 488 |--- --- 737 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.397 P=0.305 P=0.449 P=0.309 |P=0.771N (e) P=0.503 (e) | |POLY 3 | P=0.415 P=0.350 P=0.492 P=0.349 |P=0.771N (e) P=0.505 (e) | |POLY 1.5 | P=0.423 P=0.357 P=0.494 P=0.358 |P=0.771N (e) P=0.502 (e) | |POLY 6 | P=0.410 P=0.344 P=0.493 P=0.343 |P=0.769N (e) P=0.508 (e) | |LOGISTIC REGRESSION| P=0.449 P=0.373 P=0.504 P=0.390 |(e) (e) P=0.503 (e) | |COCH-ARM / FISHERS | P=0.435 P=0.374 P=0.500 P=0.374 |P=0.767N (e) P=0.500 (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 31 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |All Organs | | Benign Tumors | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 99/100 (99%) 97/100 (97%) 97/100 (97%) 98/100 (98%)|92/100 (92%) 94/100 (94%) 87/100 (87%) 85/100 (85%) | |POLY-3 ADJUSTED (b)| 99.8% 99.4% 99.4% 99.5% |95.6% 96.2% 90.8% 91.6% | |TERMINAL (d) | 57/57 (100%) 46/46 (100%) 47/47 (100%) 48/48 (100%)|58/59 (98%) 66/68 (97%) 57/60 (95%) 57/61 (93%) | |FIRST INCIDENCE | 303 329 463 410 |533 508 429 485 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.300 P=0.114 P=0.187 P=0.141 |P=0.253N P=0.155N P=0.211N P=0.140N | |POLY 3 | P=0.876N P=0.906N P=0.926N P=0.941N |P=0.131N P=0.564 P=0.124N P=0.182N | |POLY 1.5 | P=0.712N P=0.561N P=0.536N P=0.677N |P=0.123N P=0.482 P=0.146N P=0.187N | |POLY 6 | P=1.000N P=1.000N P=1.000N P=1.000N |P=0.098N P=0.668 P=0.110N P=0.137N | |LOGISTIC REGRESSION| P=0.640N P=0.514N P=0.285N P=0.540N |P=0.213N P=0.622N P=0.131N P=0.239N | |COCH-ARM / FISHERS | P=0.597 P=0.311N P=0.311N P=0.500N |P=0.035N* P=0.391 P=0.178N P=0.091N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |All Organs | | Malignant Tumors | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 66/100 (66%) 59/100 (59%) 61/100 (61%) 66/100 (66%)|40/100 (40%) 41/100 (41%) 38/100 (38%) 39/100 (39%) | |POLY-3 ADJUSTED (b)| 68.1% 64.7% 65.0% 69.4% |43.4% 43.4% 41.3% 44.1% | |TERMINAL (d) | 32/57 (56%) 23/46 (50%) 23/47 (49%) 26/48 (54%) |22/59 (37%) 25/68 (37%) 19/60 (32%) 24/61 (39%) | |FIRST INCIDENCE | 303 466 477 410 |462 498 488 409 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.232 P=0.471 P=0.478 P=0.255 |P=0.514N P=0.374N P=0.387N P=0.435N | |POLY 3 | P=0.325 P=0.365N P=0.380N P=0.483 |P=0.477 P=0.555N P=0.443N P=0.523 | |POLY 1.5 | P=0.319 P=0.302N P=0.344N P=0.512 |P=0.502 P=0.534 P=0.450N P=0.531 | |POLY 6 | P=0.321 P=0.414N P=0.409N P=0.454 |P=0.474 P=0.513N P=0.420N P=0.543 | |LOGISTIC REGRESSION| P=0.296 P=0.198N P=0.263N P=0.482N |P=0.493N P=0.454 P=0.446N P=0.525N | |COCH-ARM / FISHERS | P=0.291 P=0.190N P=0.279N P=0.559N |P=0.461N P=0.500 P=0.442N P=0.500N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 32 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS | | | CONTROL GAUSS |CONTROL GAUSS | |=================================================================================================================================| | | |All Organs | | Malignant and Benign Tumors | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # # |# # # # | |----------- | | | |OVERALL (a) | 100/100 (100%98/100 (98%) 98/100 (98%) 100/100 (100%98/100 (98%) 97/100 (97%) 95/100 (95%) 91/100 (91%) | |POLY-3 ADJUSTED (b)| 100.0% 99.7% 99.7% 100.0% |99.1% 97.6% 97.6% 96.9% | |TERMINAL (d) | 57/57 (100%) 46/46 (100%) 47/47 (100%) 48/48 (100%)|59/59 (100%) 66/68 (97%) 60/60 (100%) 59/61 (97%) | |FIRST INCIDENCE | 303 329 463 410 |462 498 429 409 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.261 P=0.116 P=0.189 (e) |P=0.317N P=0.089N P=0.288N P=0.148N | |POLY 3 | P=0.957 P=0.985N P=0.999N (e) |P=0.305N P=0.371N P=0.349N P=0.234N | |POLY 1.5 | P=0.608 P=0.655N P=0.636N (e) |P=0.176N P=0.429N P=0.288N P=0.150N | |POLY 6 | P=1.000 P=1.000N P=1.000N (e) |P=0.362N P=0.304N P=0.450N P=0.262N | |LOGISTIC REGRESSION| P=0.480 P=0.360N P=0.123N (e) |P=0.280N P=0.394N P=0.255N P=0.225N | |COCH-ARM / FISHERS | P=0.314 P=0.249N P=0.249N (e) |P=0.013N* P=0.500N P=0.222N P=0.029N* | |=================================================================================================================================| (a) Number of tumor-bearing animals / number of animals examined at site. (b) Poly-3 adjusted lifetime tumor incidence. (d) Observed incidence at terminal kill. (f) Beneath the control incidence are the P-values associated with the trend test. Beneath the dosed group incidence are the P-values corresponding to pairwise comparisons between the controls and that dosed group. The life table analysis regards tumors in animals dying prior to terminal kill as being (directly or indirectly) the cause of death. Logistic regression is an alternative method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage and Fishers exact tests compare directly the overall incidence rates For all tests a negative trend is indicated by N (e) Value of Statistic cannot be computed. (I) Interim sacrifice (T) Terminal sacrifice # Tumor rates based on number of animals necropsied. * To the right of any statistical result, indicates significance at (P<=0.05). ** To the right of any statistical result, indicates significance at (P<=0.01).