TDMS Study 89029-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/28/98 EXPERIMENT: 89029 TEST: 05 TIME: 10:35:17 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029 PATHOLOGIST: KOVATCH, R. CAS: ELECTROMAG Rats(FISCHER 344) ----------------------------- FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED. ---------------- Adrenal Gland Adrenal Medulla Bone Marrow Brain Clitoral Gland Clitoral/Preputial Gland Epididymis Heart Islets, Pancreatic Kidney Liver Lung Nose Ovary Pancreas Parathyroid Gland Pituitary Gland Preputial Gland Prostate Salivary Glands Spleen Testes Thymus Thyroid Gland Urinary Bladder NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/28/98 EXPERIMENT: 89029 TEST: 05 TIME: 10:35:17 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029 PATHOLOGIST: KOVATCH, R. CAS: ELECTROMAG SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF MAGNETIC FIELDS (EMF) =============================================================== Male Rats ------------ Organ Morphology ----- ---------- All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated =============================================================== Female Rats ------------ Organ Morphology ----- ---------- Adrenal Cortex Adenoma =============================================================== Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 1 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 1/100 (1%) | 6/100 (6%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 1.2% | 7.0% 0.0% | |TERMINAL (d) | 0/57 (0%) 1/59 (2%) | 4/59 (7%) 0/58 (0%) | |FIRST INCIDENCE | --- 736 (T) | 597 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.507 | P=0.021N* | |POLY 3 | P=0.500 | P=0.020N* | |POLY 1.5 | P=0.500 | P=0.019N* | |POLY 6 | P=0.500 | P=0.020N* | |LOGISTIC REGRESSION| P=0.507 | P=0.020N* | |COCH-ARM / FISHERS | P=0.503 | P=0.014N* | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Benign | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 24/98 (24%) 33/95 (35%) | 7/96 (7%) 3/97 (3%) | |POLY-3 ADJUSTED (b)| 27.8% 39.9% | 8.5% 3.7% | |TERMINAL (d) | 17/57 (30%) 19/56 (34%) | 6/56 (11%) 2/58 (3%) | |FIRST INCIDENCE | 619 552 | 655 727 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.107 | P=0.156N | |POLY 3 | P=0.063 | P=0.164N | |POLY 1.5 | P=0.068 | P=0.165N | |POLY 6 | P=0.065 | P=0.159N | |LOGISTIC REGRESSION| P=0.057 | P=0.152N | |COCH-ARM / FISHERS | P=0.080 | P=0.161N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 2 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Complex | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/98 (0%) 0/95 (0%) | 0/96 (0%) 2/97 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 2.4% | |TERMINAL (d) | 0/57 (0%) 0/56 (0%) | 0/56 (0%) 1/58 (2%) | |FIRST INCIDENCE | --- --- | --- 645 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.239 | |POLY 3 | (e) | P=0.239 | |POLY 1.5 | (e) | P=0.239 | |POLY 6 | (e) | P=0.240 | |LOGISTIC REGRESSION| (e) | P=0.240 | |COCH-ARM / FISHERS | (e) | P=0.251 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Malignant | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/98 (2%) 2/95 (2%) | 0/96 (0%) 0/97 (0%) | |POLY-3 ADJUSTED (b)| 2.4% 2.5% | 0.0% 0.0% | |TERMINAL (d) | 2/57 (4%) 1/56 (2%) | 0/56 (0%) 0/58 (0%) | |FIRST INCIDENCE | 736 (T) 677 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.688 | (e) | |POLY 3 | P=0.676 | (e) | |POLY 1.5 | P=0.679 | (e) | |POLY 6 | P=0.676 | (e) | |LOGISTIC REGRESSION| P=0.670 | (e) | |COCH-ARM / FISHERS | P=0.678 | (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 3 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma: Benign, Complex, Malignant, NOS | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 26/98 (27%) 35/95 (37%) | 7/96 (7%) 5/97 (5%) | |POLY-3 ADJUSTED (b)| 30.1% 42.2% | 8.5% 6.1% | |TERMINAL (d) | 19/57 (33%) 20/56 (36%) | 6/56 (11%) 3/58 (5%) | |FIRST INCIDENCE | 619 552 | 655 645 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.111 | P=0.371N | |POLY 3 | P=0.066 | P=0.381N | |POLY 1.5 | P=0.070 | P=0.382N | |POLY 6 | P=0.070 | P=0.371N | |LOGISTIC REGRESSION| P=0.057 | P=0.372N | |COCH-ARM / FISHERS | P=0.083 | P=0.376N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Brain | | Oligodendroglioma, Glioma, or Astrocytoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 1/100 (1%) | 2/100 (2%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 2.3% 1.2% | 2.3% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 1/59 (2%) 0/58 (0%) | |FIRST INCIDENCE | 645 559 | 547 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.515N | P=0.248N | |POLY 3 | P=0.510N | P=0.248N | |POLY 1.5 | P=0.507N | P=0.245N | |POLY 6 | P=0.511N | P=0.248N | |LOGISTIC REGRESSION| P=0.477N | P=0.214N | |COCH-ARM / FISHERS | P=0.500N | P=0.249N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 4 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Clitoral/Preputial Gland | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 13/100 (13%) 10/100 (10%) | 11/90 (12%) 11/94 (12%) | |POLY-3 ADJUSTED (b)| 15.0% 11.8% | 14.1% 13.5% | |TERMINAL (d) | 7/57 (12%) 7/59 (12%) | 7/56 (13%) 8/56 (14%) | |FIRST INCIDENCE | 649 586 | 597 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.321N | P=0.587N | |POLY 3 | P=0.348N | P=0.547N | |POLY 1.5 | P=0.342N | P=0.548N | |POLY 6 | P=0.349N | P=0.540N | |LOGISTIC REGRESSION| P=0.348N | P=0.551N | |COCH-ARM / FISHERS | P=0.329N | P=0.547N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Clitoral/Preputial Gland | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 13/100 (13%) 12/100 (12%) | 11/90 (12%) 11/94 (12%) | |POLY-3 ADJUSTED (b)| 15.0% 14.0% | 14.1% 13.5% | |TERMINAL (d) | 7/57 (12%) 7/59 (12%) | 7/56 (13%) 8/56 (14%) | |FIRST INCIDENCE | 649 558 | 597 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.493N | P=0.587N | |POLY 3 | P=0.510N | P=0.547N | |POLY 1.5 | P=0.508N | P=0.548N | |POLY 6 | P=0.504N | P=0.540N | |LOGISTIC REGRESSION| P=0.514N | P=0.551N | |COCH-ARM / FISHERS | P=0.500N | P=0.547N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 5 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Islets, Pancreatic | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/99 (3%) 2/100 (2%) | 1/100 (1%) 1/99 (1%) | |POLY-3 ADJUSTED (b)| 3.5% 2.4% | 1.2% 1.2% | |TERMINAL (d) | 2/57 (4%) 0/59 (0%) | 1/59 (2%) 1/58 (2%) | |FIRST INCIDENCE | 714 675 | 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.480N | P=0.757 | |POLY 3 | P=0.506N | P=0.758 | |POLY 1.5 | P=0.503N | P=0.758 | |POLY 6 | P=0.506N | P=0.759 | |LOGISTIC REGRESSION| P=0.506N | P=0.757 | |COCH-ARM / FISHERS | P=0.495N | P=0.749 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Islets, Pancreatic | | Carcinoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 3/100 (3%) | 1/100 (1%) 1/99 (1%) | |POLY-3 ADJUSTED (b)| 1.2% 3.6% | 1.2% 1.2% | |TERMINAL (d) | 1/57 (2%) 2/59 (3%) | 1/59 (2%) 0/58 (0%) | |FIRST INCIDENCE | 736 (T) 715 | 737 (T) 729 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.325 | P=0.758 | |POLY 3 | P=0.303 | P=0.758 | |POLY 1.5 | P=0.305 | P=0.758 | |POLY 6 | P=0.302 | P=0.759 | |LOGISTIC REGRESSION| P=0.310 | P=0.762 | |COCH-ARM / FISHERS | P=0.314 | P=0.749 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 6 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Islets, Pancreatic | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/99 (4%) 5/100 (5%) | 2/100 (2%) 2/99 (2%) | |POLY-3 ADJUSTED (b)| 4.7% 5.9% | 2.3% 2.4% | |TERMINAL (d) | 3/57 (5%) 2/59 (3%) | 2/59 (3%) 1/58 (2%) | |FIRST INCIDENCE | 714 675 | 737 (T) 729 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.528 | P=0.688 | |POLY 3 | P=0.494 | P=0.687 | |POLY 1.5 | P=0.498 | P=0.687 | |POLY 6 | P=0.495 | P=0.689 | |LOGISTIC REGRESSION| P=0.491 | P=0.694N | |COCH-ARM / FISHERS | P=0.506 | P=0.686 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/100 (3%) 0/100 (0%) | 3/100 (3%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 3.5% 0.0% | 3.5% 0.0% | |TERMINAL (d) | 3/57 (5%) 0/59 (0%) | 3/59 (5%) 0/58 (0%) | |FIRST INCIDENCE | 736 (T) --- | 737 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.116N | P=0.125N | |POLY 3 | P=0.127N | P=0.126N | |POLY 1.5 | P=0.125N | P=0.125N | |POLY 6 | P=0.127N | P=0.125N | |LOGISTIC REGRESSION| (e) | (e) | |COCH-ARM / FISHERS | P=0.123N | P=0.123N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 7 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/100 (3%) 0/100 (0%) | 4/100 (4%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 3.5% 0.0% | 4.7% 0.0% | |TERMINAL (d) | 3/57 (5%) 0/59 (0%) | 3/59 (5%) 0/58 (0%) | |FIRST INCIDENCE | 736 (T) --- | 610 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.116N | P=0.068N | |POLY 3 | P=0.127N | P=0.068N | |POLY 1.5 | P=0.125N | P=0.067N | |POLY 6 | P=0.127N | P=0.067N | |LOGISTIC REGRESSION| (e) | P=0.067N | |COCH-ARM / FISHERS | P=0.123N | P=0.061N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) | 1/100 (1%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 1.2% 2.4% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 1/59 (2%) 2/58 (3%) | |FIRST INCIDENCE | --- --- | 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.494 | |POLY 3 | (e) | P=0.495 | |POLY 1.5 | (e) | P=0.496 | |POLY 6 | (e) | P=0.496 | |LOGISTIC REGRESSION| (e) | P=0.494 | |COCH-ARM / FISHERS | (e) | P=0.500 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 8 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland | | Carcinoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) | 2/100 (2%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 2.3% 2.4% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 2/59 (3%) 1/58 (2%) | |FIRST INCIDENCE | --- --- | 737 (T) 591 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.684 | |POLY 3 | (e) | P=0.689 | |POLY 1.5 | (e) | P=0.689 | |POLY 6 | (e) | P=0.691 | |LOGISTIC REGRESSION| (e) | P=0.689 | |COCH-ARM / FISHERS | (e) | P=0.689N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) | 3/100 (3%) 4/100 (4%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.5% 4.8% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 3/59 (5%) 3/58 (5%) | |FIRST INCIDENCE | --- --- | 737 (T) 591 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.489 | |POLY 3 | (e) | P=0.493 | |POLY 1.5 | (e) | P=0.494 | |POLY 6 | (e) | P=0.496 | |LOGISTIC REGRESSION| (e) | P=0.490 | |COCH-ARM / FISHERS | (e) | P=0.500 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 9 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland | | Fibroadenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 6/100 (6%) 8/100 (8%) | 56/100 (56%) 51/100 (51%) | |POLY-3 ADJUSTED (b)| 7.0% 9.5% | 62.5% 57.8% | |TERMINAL (d) | 6/57 (11%) 5/59 (9%) | 39/59 (66%) 36/58 (62%) | |FIRST INCIDENCE | 736 (T) 600 | 543 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.408 | P=0.338N | |POLY 3 | P=0.380 | P=0.306N | |POLY 1.5 | P=0.383 | P=0.306N | |POLY 6 | P=0.385 | P=0.288N | |LOGISTIC REGRESSION| P=0.376 | P=0.340N | |COCH-ARM / FISHERS | P=0.391 | P=0.285N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland | | Fibroma, Fibroadenoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 6/100 (6%) 8/100 (8%) | 56/100 (56%) 52/100 (52%) | |POLY-3 ADJUSTED (b)| 7.0% 9.5% | 62.5% 58.9% | |TERMINAL (d) | 6/57 (11%) 5/59 (9%) | 39/59 (66%) 37/58 (64%) | |FIRST INCIDENCE | 736 (T) 600 | 543 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.408 | P=0.387N | |POLY 3 | P=0.380 | P=0.364N | |POLY 1.5 | P=0.383 | P=0.361N | |POLY 6 | P=0.385 | P=0.347N | |LOGISTIC REGRESSION| P=0.376 | P=0.397N | |COCH-ARM / FISHERS | P=0.391 | P=0.335N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 10 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland | | Fibroma, Fibroadenoma, Carcinoma, or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 6/100 (6%) 8/100 (8%) | 58/100 (58%) 54/100 (54%) | |POLY-3 ADJUSTED (b)| 7.0% 9.5% | 64.7% 60.8% | |TERMINAL (d) | 6/57 (11%) 5/59 (9%) | 41/59 (70%) 38/58 (66%) | |FIRST INCIDENCE | 736 (T) 600 | 543 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.408 | P=0.389N | |POLY 3 | P=0.380 | P=0.346N | |POLY 1.5 | P=0.383 | P=0.351N | |POLY 6 | P=0.385 | P=0.316N | |LOGISTIC REGRESSION| P=0.376 | P=0.400N | |COCH-ARM / FISHERS | P=0.391 | P=0.335N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Ovary | | Tubulostromal Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 3/100 (3%) 2/99 (2%) | |POLY-3 ADJUSTED (b)| | 3.5% 2.4% | |TERMINAL (d) | | 2/59 (3%) 2/58 (3%) | |FIRST INCIDENCE | | 736 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.509N | |POLY 3 | | P=0.515N | |POLY 1.5 | | P=0.513N | |POLY 6 | | P=0.511N | |LOGISTIC REGRESSION| | P=0.507N | |COCH-ARM / FISHERS | | P=0.505N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 11 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pancreas | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/98 (3%) 2/100 (2%) | 0/100 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 3.5% 2.4% | 0.0% 0.0% | |TERMINAL (d) | 2/57 (4%) 1/59 (2%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 658 621 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.504N | (e) | |POLY 3 | P=0.505N | (e) | |POLY 1.5 | P=0.500N | (e) | |POLY 6 | P=0.507N | (e) | |LOGISTIC REGRESSION| P=0.497N | (e) | |COCH-ARM / FISHERS | P=0.490N | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 34/98 (35%) 40/98 (41%) | 61/99 (62%) 62/98 (63%) | |POLY-3 ADJUSTED (b)| 38.8% 46.0% | 65.8% 68.1% | |TERMINAL (d) | 23/57 (40%) 28/58 (48%) | 40/59 (68%) 37/58 (64%) | |FIRST INCIDENCE | 579 470 | 533 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.245 | P=0.453 | |POLY 3 | P=0.206 | P=0.429 | |POLY 1.5 | P=0.215 | P=0.438 | |POLY 6 | P=0.202 | P=0.435 | |LOGISTIC REGRESSION| P=0.203 | P=0.437 | |COCH-ARM / FISHERS | P=0.231 | P=0.463 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 12 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Carcinoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/98 (0%) 3/98 (3%) | 3/99 (3%) 2/98 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 3.6% | 3.5% 2.4% | |TERMINAL (d) | 0/57 (0%) 1/58 (2%) | 2/59 (3%) 1/58 (2%) | |FIRST INCIDENCE | --- 645 | 655 641 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.124 | P=0.512N | |POLY 3 | P=0.119 | P=0.513N | |POLY 1.5 | P=0.120 | P=0.512N | |POLY 6 | P=0.119 | P=0.510N | |LOGISTIC REGRESSION| P=0.120 | P=0.509N | |COCH-ARM / FISHERS | P=0.123 | P=0.505N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 34/98 (35%) 43/98 (44%) | 64/99 (65%) 64/98 (65%) | |POLY-3 ADJUSTED (b)| 38.8% 49.2% | 68.8% 70.1% | |TERMINAL (d) | 23/57 (40%) 29/58 (50%) | 42/59 (71%) 38/58 (66%) | |FIRST INCIDENCE | 579 470 | 533 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.139 | P=0.496 | |POLY 3 | P=0.103 | P=0.492 | |POLY 1.5 | P=0.109 | P=0.499 | |POLY 6 | P=0.102 | P=0.502 | |LOGISTIC REGRESSION| P=0.101 | P=0.491 | |COCH-ARM / FISHERS | P=0.121 | P=0.521 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 13 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Basal Cell Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 3/100 (3%) 3/100 (3%) | 0/100 (0%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 3.5% 3.6% | 0.0% 1.2% | |TERMINAL (d) | 2/57 (4%) 2/59 (3%) | 0/59 (0%) 1/58 (2%) | |FIRST INCIDENCE | 659 582 | --- 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.659N | P=0.497 | |POLY 3 | P=0.653 | P=0.500 | |POLY 1.5 | P=0.655 | P=0.500 | |POLY 6 | P=0.653 | P=0.500 | |LOGISTIC REGRESSION| P=0.656 | P=0.497 | |COCH-ARM / FISHERS | P=0.659N | P=0.500 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Basal Cell Adenoma, Basosquamous Tumor Benign, or | | Trichoepithelioma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 3/100 (3%) 3/100 (3%) | 0/100 (0%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 3.5% 3.6% | 0.0% 1.2% | |TERMINAL (d) | 2/57 (4%) 2/59 (3%) | 0/59 (0%) 1/58 (2%) | |FIRST INCIDENCE | 659 582 | --- 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.659N | P=0.497 | |POLY 3 | P=0.653 | P=0.500 | |POLY 1.5 | P=0.655 | P=0.500 | |POLY 6 | P=0.653 | P=0.500 | |LOGISTIC REGRESSION| P=0.656 | P=0.497 | |COCH-ARM / FISHERS | P=0.659N | P=0.500 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 14 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous | | Tumor (benign, malignant or NOS), or Trichoepithelioma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 3/100 (3%) 3/100 (3%) | 0/100 (0%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 3.5% 3.6% | 0.0% 1.2% | |TERMINAL (d) | 2/57 (4%) 2/59 (3%) | 0/59 (0%) 1/58 (2%) | |FIRST INCIDENCE | 659 582 | --- 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.659N | P=0.497 | |POLY 3 | P=0.653 | P=0.500 | |POLY 1.5 | P=0.655 | P=0.500 | |POLY 6 | P=0.653 | P=0.500 | |LOGISTIC REGRESSION| P=0.656 | P=0.497 | |COCH-ARM / FISHERS | P=0.659N | P=0.500 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor | | (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 14/100 (14%) 12/100 (12%) | 1/100 (1%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 16.1% 14.0% | 1.2% 2.4% | |TERMINAL (d) | 10/57 (18%) 8/59 (14%) | 1/59 (2%) 2/58 (3%) | |FIRST INCIDENCE | 627 470 | 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.400N | P=0.494 | |POLY 3 | P=0.428N | P=0.495 | |POLY 1.5 | P=0.425N | P=0.496 | |POLY 6 | P=0.425N | P=0.496 | |LOGISTIC REGRESSION| P=0.433N | P=0.494 | |COCH-ARM / FISHERS | P=0.417N | P=0.500 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 15 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Fibroma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 12/100 (12%) 12/100 (12%) | 4/100 (4%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 13.9% 14.2% | 4.7% 1.2% | |TERMINAL (d) | 9/57 (16%) 8/59 (14%) | 2/59 (3%) 1/58 (2%) | |FIRST INCIDENCE | 617 586 | 660 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.563N | P=0.193N | |POLY 3 | P=0.568 | P=0.192N | |POLY 1.5 | P=0.573 | P=0.189N | |POLY 6 | P=0.570 | P=0.192N | |LOGISTIC REGRESSION| P=0.563 | P=0.188N | |COCH-ARM / FISHERS | P=0.586N | P=0.184N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, | | or Fibrous Histiocytoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 13/100 (13%) 14/100 (14%) | 6/100 (6%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 15.0% 16.5% | 6.9% 2.4% | |TERMINAL (d) | 9/57 (16%) 10/59 (17%) | 2/59 (3%) 1/58 (2%) | |FIRST INCIDENCE | 617 586 | 613 602 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.526 | P=0.150N | |POLY 3 | P=0.477 | P=0.148N | |POLY 1.5 | P=0.484 | P=0.146N | |POLY 6 | P=0.477 | P=0.149N | |LOGISTIC REGRESSION| P=0.474 | P=0.137N | |COCH-ARM / FISHERS | P=0.500 | P=0.140N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 16 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Keratoacanthoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 10/100 (10%) 8/100 (8%) | 1/100 (1%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 11.6% 9.5% | 1.2% 0.0% | |TERMINAL (d) | 7/57 (12%) 6/59 (10%) | 1/59 (2%) 0/58 (0%) | |FIRST INCIDENCE | 627 557 | 737 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.384N | P=0.503N | |POLY 3 | P=0.423N | P=0.508N | |POLY 1.5 | P=0.416N | P=0.507N | |POLY 6 | P=0.424N | P=0.507N | |LOGISTIC REGRESSION| P=0.421N | (e) | |COCH-ARM / FISHERS | P=0.403N | P=0.500N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Melanoma Malignant | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 0/100 (0%) 2/100 (2%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 2.4% | 0.0% 0.0% | |TERMINAL (d) | 0/57 (0%) 1/59 (2%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | --- 552 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.244 | (e) | |POLY 3 | P=0.237 | (e) | |POLY 1.5 | P=0.237 | (e) | |POLY 6 | P=0.237 | (e) | |LOGISTIC REGRESSION| P=0.249 | (e) | |COCH-ARM / FISHERS | P=0.249 | (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 17 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Squamous Cell Carcinoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 0/100 (0%) 2/100 (2%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 2.4% | 0.0% 0.0% | |TERMINAL (d) | 0/57 (0%) 1/59 (2%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | --- 470 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.244 | (e) | |POLY 3 | P=0.237 | (e) | |POLY 1.5 | P=0.237 | (e) | |POLY 6 | P=0.237 | (e) | |LOGISTIC REGRESSION| P=0.258 | (e) | |COCH-ARM / FISHERS | P=0.249 | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Squamous Cell Papilloma, Papilloma, Squamous Cell | | Carcinoma or Keratoacanthoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 11/100 (11%) 10/100 (10%) | 1/100 (1%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 12.7% 11.7% | 1.2% 1.2% | |TERMINAL (d) | 8/57 (14%) 7/59 (12%) | 1/59 (2%) 1/58 (2%) | |FIRST INCIDENCE | 627 470 | 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.478N | P=0.757 | |POLY 3 | P=0.514N | P=0.758 | |POLY 1.5 | P=0.510N | P=0.759 | |POLY 6 | P=0.513N | P=0.759 | |LOGISTIC REGRESSION| P=0.517N | P=0.757 | |COCH-ARM / FISHERS | P=0.500N | P=0.751N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 18 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Squamous Cell Papilloma, Papilloma, or Keratoacanthoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 11/100 (11%) 8/100 (8%) | 1/100 (1%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 12.7% 9.5% | 1.2% 1.2% | |TERMINAL (d) | 8/57 (14%) 6/59 (10%) | 1/59 (2%) 1/58 (2%) | |FIRST INCIDENCE | 627 557 | 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.297N | P=0.757 | |POLY 3 | P=0.333N | P=0.758 | |POLY 1.5 | P=0.327N | P=0.759 | |POLY 6 | P=0.333N | P=0.759 | |LOGISTIC REGRESSION| P=0.332N | P=0.757 | |COCH-ARM / FISHERS | P=0.315N | P=0.751N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Testes | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 93/100 (93%) 89/100 (89%) | | |POLY-3 ADJUSTED (b)| 95.1% 93.8% | | |TERMINAL (d) | 54/57 (95%) 57/59 (97%) | | |FIRST INCIDENCE | 476 489 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.324N | | |POLY 3 | P=0.460N | | |POLY 1.5 | P=0.339N | | |POLY 6 | P=0.622N | | |LOGISTIC REGRESSION| P=0.320N | | |COCH-ARM / FISHERS | P=0.230N | | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 19 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thymus | | Thymoma Benign | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/97 (2%) 0/95 (0%) | 0/95 (0%) 1/92 (1%) | |POLY-3 ADJUSTED (b)| 2.4% 0.0% | 0.0% 1.3% | |TERMINAL (d) | 2/55 (4%) 0/56 (0%) | 0/56 (0%) 1/57 (2%) | |FIRST INCIDENCE | 736 (T) --- | --- 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.235N | P=0.504 | |POLY 3 | P=0.255N | P=0.500 | |POLY 1.5 | P=0.252N | P=0.500 | |POLY 6 | P=0.254N | P=0.500 | |LOGISTIC REGRESSION| (e) | P=0.504 | |COCH-ARM / FISHERS | P=0.254N | P=0.492 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thymus | | Thymoma: Benign, Malignant, NOS | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/97 (2%) 0/95 (0%) | 0/95 (0%) 1/92 (1%) | |POLY-3 ADJUSTED (b)| 2.4% 0.0% | 0.0% 1.3% | |TERMINAL (d) | 2/55 (4%) 0/56 (0%) | 0/56 (0%) 1/57 (2%) | |FIRST INCIDENCE | 736 (T) --- | --- 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.235N | P=0.504 | |POLY 3 | P=0.255N | P=0.500 | |POLY 1.5 | P=0.252N | P=0.500 | |POLY 6 | P=0.254N | P=0.500 | |LOGISTIC REGRESSION| (e) | P=0.504 | |COCH-ARM / FISHERS | P=0.254N | P=0.492 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 20 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 15/99 (15%) 18/100 (18%) | 15/100 (15%) 16/100 (16%) | |POLY-3 ADJUSTED (b)| 17.2% 21.5% | 17.3% 19.0% | |TERMINAL (d) | 7/57 (12%) 16/59 (27%) | 12/59 (20%) 14/58 (24%) | |FIRST INCIDENCE | 583 725 | 561 632 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.376 | P=0.482 | |POLY 3 | P=0.305 | P=0.463 | |POLY 1.5 | P=0.329 | P=0.474 | |POLY 6 | P=0.280 | P=0.459 | |LOGISTIC REGRESSION| P=0.330 | P=0.479 | |COCH-ARM / FISHERS | P=0.364 | P=0.500 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Carcinoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 5/100 (5%) | 5/100 (5%) 6/100 (6%) | |POLY-3 ADJUSTED (b)| 1.2% 5.9% | 5.9% 7.1% | |TERMINAL (d) | 1/57 (2%) 4/59 (7%) | 4/59 (7%) 5/58 (9%) | |FIRST INCIDENCE | 736 (T) 666 | 710 627 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.113 | P=0.495 | |POLY 3 | P=0.103 | P=0.489 | |POLY 1.5 | P=0.105 | P=0.491 | |POLY 6 | P=0.103 | P=0.493 | |LOGISTIC REGRESSION| P=0.104 | P=0.491 | |COCH-ARM / FISHERS | P=0.108 | P=0.500 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 21 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Carcinoma or Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 16/99 (16%) 22/100 (22%) | 19/100 (19%) 22/100 (22%) | |POLY-3 ADJUSTED (b)| 18.4% 26.1% | 21.9% 26.1% | |TERMINAL (d) | 8/57 (14%) 19/59 (32%) | 15/59 (25%) 19/58 (33%) | |FIRST INCIDENCE | 583 666 | 561 627 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.206 | P=0.343 | |POLY 3 | P=0.147 | P=0.322 | |POLY 1.5 | P=0.165 | P=0.334 | |POLY 6 | P=0.130 | P=0.319 | |LOGISTIC REGRESSION| P=0.164 | P=0.337 | |COCH-ARM / FISHERS | P=0.193 | P=0.363 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus | | Adenoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | | 0/100 (0%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| | 0.0% 2.4% | |TERMINAL (d) | | 0/59 (0%) 2/58 (3%) | |FIRST INCIDENCE | | --- 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.235 | |POLY 3 | | P=0.236 | |POLY 1.5 | | P=0.237 | |POLY 6 | | P=0.236 | |LOGISTIC REGRESSION| | P=0.235 | |COCH-ARM / FISHERS | | P=0.249 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 22 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus | | Leiomyosarcoma | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | | 2/100 (2%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| | 2.3% 0.0% | |TERMINAL (d) | | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | | 533 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.248N | |POLY 3 | | P=0.249N | |POLY 1.5 | | P=0.246N | |POLY 6 | | P=0.249N | |LOGISTIC REGRESSION| | P=0.189N | |COCH-ARM / FISHERS | | P=0.249N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus | | Polyp Stromal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | | 13/100 (13%) 12/100 (12%) | |POLY-3 ADJUSTED (b)| | 15.1% 14.2% | |TERMINAL (d) | | 9/59 (15%) 10/58 (17%) | |FIRST INCIDENCE | | 620 480 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.516N | |POLY 3 | | P=0.525N | |POLY 1.5 | | P=0.518N | |POLY 6 | | P=0.527N | |LOGISTIC REGRESSION| | P=0.520N | |COCH-ARM / FISHERS | | P=0.500N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 23 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus | | Sarcoma Stromal or Polyp Stromal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | | 13/100 (13%) 12/100 (12%) | |POLY-3 ADJUSTED (b)| | 15.1% 14.2% | |TERMINAL (d) | | 9/59 (15%) 10/58 (17%) | |FIRST INCIDENCE | | 620 480 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.516N | |POLY 3 | | P=0.525N | |POLY 1.5 | | P=0.518N | |POLY 6 | | P=0.527N | |LOGISTIC REGRESSION| | P=0.520N | |COCH-ARM / FISHERS | | P=0.500N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus | | Schwannoma Malignant | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | | 3/100 (3%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| | 3.5% 0.0% | |TERMINAL (d) | | 1/59 (2%) 0/58 (0%) | |FIRST INCIDENCE | | 462 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.132N | |POLY 3 | | P=0.130N | |POLY 1.5 | | P=0.128N | |POLY 6 | | P=0.131N | |LOGISTIC REGRESSION| | P=0.064N | |COCH-ARM / FISHERS | | P=0.123N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 24 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |All Organs | | Leukemia: Lymphocytic, Monocytic, Mononuclear, or | | Undifferentiated | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 50/100 (50%) 36/100 (36%) | 20/100 (20%) 22/100 (22%) | |POLY-3 ADJUSTED (b)| 53.1% 39.7% | 22.7% 25.5% | |TERMINAL (d) | 24/57 (42%) 15/59 (25%) | 11/59 (19%) 12/58 (21%) | |FIRST INCIDENCE | 303 527 | 495 526 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.063N | P=0.412 | |POLY 3 | P=0.045N* | P=0.398 | |POLY 1.5 | P=0.039N* | P=0.407 | |POLY 6 | P=0.049N* | P=0.401 | |LOGISTIC REGRESSION| P=0.028N* | P=0.414 | |COCH-ARM / FISHERS | P=0.032N* | P=0.431 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |All Organs | | Mesothelioma: Benign, Malignant, NOS | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 4/100 (4%) 4/100 (4%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 4.6% 4.7% | 0.0% 0.0% | |TERMINAL (d) | 2/57 (4%) 2/59 (3%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 658 576 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.631N | (e) | |POLY 3 | P=0.632 | (e) | |POLY 1.5 | P=0.634 | (e) | |POLY 6 | P=0.632 | (e) | |LOGISTIC REGRESSION| P=0.632 | (e) | |COCH-ARM / FISHERS | P=0.640N | (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 25 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |All Organs | | Mesothelioma: Malignant | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 4/100 (4%) 4/100 (4%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 4.6% 4.7% | 0.0% 0.0% | |TERMINAL (d) | 2/57 (4%) 2/59 (3%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 658 576 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.631N | (e) | |POLY 3 | P=0.632 | (e) | |POLY 1.5 | P=0.634 | (e) | |POLY 6 | P=0.632 | (e) | |LOGISTIC REGRESSION| P=0.632 | (e) | |COCH-ARM / FISHERS | P=0.640N | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |All Organs | | Benign Tumors | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 99/100 (99%) 94/100 (94%) | 92/100 (92%) 86/100 (86%) | |POLY-3 ADJUSTED (b)| 99.8% 96.7% | 95.6% 91.3% | |TERMINAL (d) | 57/57 (100%) 58/59 (98%) | 58/59 (98%) 55/58 (95%) | |FIRST INCIDENCE | 303 470 | 533 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.290N | P=0.335N | |POLY 3 | P=0.092N | P=0.145N | |POLY 1.5 | P=0.070N | P=0.133N | |POLY 6 | P=0.137N | P=0.176N | |LOGISTIC REGRESSION| P=0.073N | P=0.251N | |COCH-ARM / FISHERS | P=0.059N | P=0.129N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 26 Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |All Organs | | Malignant Tumors | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 66/100 (66%) 58/100 (58%) | 40/100 (40%) 40/100 (40%) | |POLY-3 ADJUSTED (b)| 68.1% 60.7% | 43.4% 44.7% | |TERMINAL (d) | 32/57 (56%) 26/59 (44%) | 22/59 (37%) 22/58 (38%) | |FIRST INCIDENCE | 303 365 | 462 480 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.229N | P=0.512 | |POLY 3 | P=0.173N | P=0.490 | |POLY 1.5 | P=0.169N | P=0.509 | |POLY 6 | P=0.171N | P=0.486 | |LOGISTIC REGRESSION| P=0.128N | P=0.557 | |COCH-ARM / FISHERS | P=0.154N | P=0.557N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |All Organs | | Malignant and Benign Tumors | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # | # # | |----------- | | | |OVERALL (a) | 100/100 (100%) 98/100 (98%) | 98/100 (98%) 94/100 (94%) | |POLY-3 ADJUSTED (b)| 100.0% 98.9% | 99.1% 96.5% | |TERMINAL (d) | 57/57 (100%) 58/59 (98%) | 59/59 (100%) 56/58 (97%) | |FIRST INCIDENCE | 303 365 | 462 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.419N | P=0.440N | |POLY 3 | P=0.471N | P=0.179N | |POLY 1.5 | P=0.397N | P=0.160N | |POLY 6 | P=0.498N | P=0.192N | |LOGISTIC REGRESSION| P=0.267N | P=0.257N | |COCH-ARM / FISHERS | P=0.249N | P=0.140N | |=================================================================================================================================| (a) Number of tumor-bearing animals / number of animals examined at site. (b) Poly-3 adjusted lifetime tumor incidence. (d) Observed incidence at terminal kill. (f) Beneath the control incidence are the P-values associated with the trend test. Beneath the dosed group incidence are the P-values corresponding to pairwise comparisons between the controls and that dosed group. The life table analysis regards tumors in animals dying prior to terminal kill as being (directly or indirectly) the cause of death. Logistic regression is an alternative method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage and Fishers exact tests compare directly the overall incidence rates For all tests a negative trend is indicated by N (e) Value of Statistic cannot be computed. (I) Interim sacrifice (T) Terminal sacrifice # Tumor rates based on number of animals necropsied. * To the right of any statistical result, indicates significance at (P<=0.05). ** To the right of any statistical result, indicates significance at (P<=0.01).