TDMS Study 89029-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10 LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/28/98 EXPERIMENT: 89029 TEST: 05 TIME: 10:45:12 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029 PATHOLOGIST: KOVATCH, R. CAS: ELECTROMAG NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10 LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/28/98 EXPERIMENT: 89029 TEST: 05 TIME: 10:45:12 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029 PATHOLOGIST: KOVATCH, R. CAS: ELECTROMAG SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF MAGNETIC FIELDS (EMF) =============================================================== Male Rats ------------ Organ Morphology ----- ---------- Harderian Gland Infiltration Cellular Lymphocyte Islets, Pancreatic Hyperplasia Focal Liver Infiltration Cellular Mixed Cell Necrosis Lymph Node, Mesenteric Infiltration Cellular Histiocyte Mammary Gland Galactocele Prostate Inflammation Acute Stomach, Forestomach Ulcer Testes: Interstitial Cell Hyperplasia Focal Thymus Atrophy Tooth Malformation =============================================================== Female Rats ------------ Organ Morphology ----- ---------- Kidney Mineralization Kidney: Renal Tubule Accumulation, Hyaline Droplet Pigmentation Liver Basophilic Focus Clear Cell Focus Eosinophilic Focus Nose: Nasolacrimal Duct Inflammation Chronic Pineal Gland Mineralization Spleen Hematopoietic Cell Proliferation Thyroid Gland: C-Cell Hyperplasia =============================================================== Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 1 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex | | Accessory Adrenal Cortical Nodule | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 3/100 (3%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 1.2% 3.6% | 0.0% 0.0% | |TERMINAL (d) | 0/57 (0%) 3/59 (5%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 649 736 (T) | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.308 | (e) | |POLY 3 | P=0.301 | (e) | |POLY 1.5 | P=0.304 | (e) | |POLY 6 | P=0.299 | (e) | |LOGISTIC REGRESSION| P=0.300 | (e) | |COCH-ARM / FISHERS | P=0.314 | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex | | Angiectasis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 5/99 (5%) 2/100 (2%) | 58/100 (58%) 62/100 (62%) | |POLY-3 ADJUSTED (b)| 5.8% 2.4% | 65.8% 71.8% | |TERMINAL (d) | 4/57 (7%) 2/59 (3%) | 45/59 (76%) 50/58 (86%) | |FIRST INCIDENCE | 670 736 (T) | 613 624 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.210N | P=0.280 | |POLY 3 | P=0.231N | P=0.229 | |POLY 1.5 | P=0.226N | P=0.260 | |POLY 6 | P=0.233N | P=0.221 | |LOGISTIC REGRESSION| P=0.222N | P=0.240 | |COCH-ARM / FISHERS | P=0.218N | P=0.333 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 2 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex | | Hematopoietic Cell Proliferation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/99 (3%) 9/100 (9%) | 2/100 (2%) 4/100 (4%) | |POLY-3 ADJUSTED (b)| 3.5% 10.7% | 2.3% 4.8% | |TERMINAL (d) | 1/57 (2%) 7/59 (12%) | 1/59 (2%) 3/58 (5%) | |FIRST INCIDENCE | 674 707 | 673 632 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.079 | P=0.332 | |POLY 3 | P=0.061 | P=0.332 | |POLY 1.5 | P=0.064 | P=0.334 | |POLY 6 | P=0.060 | P=0.333 | |LOGISTIC REGRESSION| P=0.063 | P=0.331 | |COCH-ARM / FISHERS | P=0.069 | P=0.341 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 12/99 (12%) 9/100 (9%) | 11/100 (11%) 16/100 (16%) | |POLY-3 ADJUSTED (b)| 13.8% 10.7% | 12.7% 19.1% | |TERMINAL (d) | 8/57 (14%) 8/59 (14%) | 6/59 (10%) 14/58 (24%) | |FIRST INCIDENCE | 573 621 | 494 713 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.313N | P=0.194 | |POLY 3 | P=0.349N | P=0.172 | |POLY 1.5 | P=0.336N | P=0.182 | |POLY 6 | P=0.359N | P=0.165 | |LOGISTIC REGRESSION| P=0.338N | P=0.187 | |COCH-ARM / FISHERS | P=0.314N | P=0.204 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 3 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex | | Hypertrophy Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/99 (3%) 0/100 (0%) | 3/100 (3%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 3.5% 0.0% | 3.5% 1.2% | |TERMINAL (d) | 2/57 (4%) 0/59 (0%) | 1/59 (2%) 1/58 (2%) | |FIRST INCIDENCE | 659 --- | 674 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.122N | P=0.312N | |POLY 3 | P=0.127N | P=0.317N | |POLY 1.5 | P=0.124N | P=0.315N | |POLY 6 | P=0.128N | P=0.317N | |LOGISTIC REGRESSION| P=0.125N | P=0.312N | |COCH-ARM / FISHERS | P=0.121N | P=0.311N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 2/100 (2%) | 2/100 (2%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 1.2% 2.4% | 2.3% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 1/59 (2%) 0/58 (0%) | |FIRST INCIDENCE | 647 470 | 655 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.488 | P=0.249N | |POLY 3 | P=0.497 | P=0.247N | |POLY 1.5 | P=0.499 | P=0.244N | |POLY 6 | P=0.497 | P=0.246N | |LOGISTIC REGRESSION| P=0.548 | P=0.241N | |COCH-ARM / FISHERS | P=0.504 | P=0.249N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 4 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex | | Vacuolization Cytoplasmic Diffuse | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 3/100 (3%) | 0/100 (0%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 3.5% | 0.0% 1.2% | |TERMINAL (d) | 0/57 (0%) 1/59 (2%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | --- 570 | --- 535 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.116 | P=0.487 | |POLY 3 | P=0.120 | P=0.500 | |POLY 1.5 | P=0.121 | P=0.500 | |POLY 6 | P=0.121 | P=0.500 | |LOGISTIC REGRESSION| P=0.139 | P=0.628 | |COCH-ARM / FISHERS | P=0.125 | P=0.500 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Cortex | | Vacuolization Cytoplasmic Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 20/99 (20%) 20/100 (20%) | 29/100 (29%) 27/100 (27%) | |POLY-3 ADJUSTED (b)| 22.7% 23.3% | 33.0% 32.0% | |TERMINAL (d) | 13/57 (23%) 13/59 (22%) | 19/59 (32%) 22/58 (38%) | |FIRST INCIDENCE | 303 489 | 613 641 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.543N | P=0.461N | |POLY 3 | P=0.537 | P=0.510N | |POLY 1.5 | P=0.552 | P=0.484N | |POLY 6 | P=0.531 | P=0.535N | |LOGISTIC REGRESSION| P=0.566 | P=0.466N | |COCH-ARM / FISHERS | P=0.556N | P=0.437N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 5 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Adrenal Medulla | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 17/98 (17%) 14/95 (15%) | 6/96 (6%) 5/97 (5%) | |POLY-3 ADJUSTED (b)| 19.6% 17.4% | 7.2% 6.0% | |TERMINAL (d) | 10/57 (18%) 10/56 (18%) | 1/56 (2%) 2/58 (3%) | |FIRST INCIDENCE | 614 558 | 610 448 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.376N | P=0.502N | |POLY 3 | P=0.431N | P=0.504N | |POLY 1.5 | P=0.414N | P=0.502N | |POLY 6 | P=0.445N | P=0.503N | |LOGISTIC REGRESSION| P=0.414N | P=0.480N | |COCH-ARM / FISHERS | P=0.383N | P=0.493N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Bone Marrow | | Depletion Cellular | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/100 (3%) 6/100 (6%) | 9/100 (9%) 11/100 (11%) | |POLY-3 ADJUSTED (b)| 3.5% 6.9% | 10.2% 12.6% | |TERMINAL (d) | 1/57 (2%) 2/59 (3%) | 2/59 (3%) 5/58 (9%) | |FIRST INCIDENCE | 583 306 | 494 434 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.247 | P=0.391 | |POLY 3 | P=0.248 | P=0.400 | |POLY 1.5 | P=0.248 | P=0.401 | |POLY 6 | P=0.250 | P=0.403 | |LOGISTIC REGRESSION| P=0.303 | P=0.519 | |COCH-ARM / FISHERS | P=0.249 | P=0.407 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 6 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Bone Marrow | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 14/100 (14%) 12/100 (12%) | 13/100 (13%) 17/100 (17%) | |POLY-3 ADJUSTED (b)| 16.0% 13.8% | 14.8% 19.4% | |TERMINAL (d) | 6/57 (11%) 4/59 (7%) | 7/59 (12%) 8/58 (14%) | |FIRST INCIDENCE | 502 558 | 462 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.425N | P=0.270 | |POLY 3 | P=0.425N | P=0.271 | |POLY 1.5 | P=0.424N | P=0.270 | |POLY 6 | P=0.417N | P=0.281 | |LOGISTIC REGRESSION| P=0.402N | P=0.319 | |COCH-ARM / FISHERS | P=0.417N | P=0.277 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Bone: Cranium | | Hyperostosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/100 (1%) 1/100 (1%) | 7/100 (7%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 1.2% 1.2% | 8.2% 2.4% | |TERMINAL (d) | 1/57 (2%) 1/59 (2%) | 6/59 (10%) 2/58 (3%) | |FIRST INCIDENCE | 736 (T) 736 (T) | 617 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.754N | P=0.089N | |POLY 3 | P=0.758 | P=0.091N | |POLY 1.5 | P=0.759 | P=0.090N | |POLY 6 | P=0.758 | P=0.091N | |LOGISTIC REGRESSION| P=0.754N | P=0.088N | |COCH-ARM / FISHERS | P=0.751N | P=0.085N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 7 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Bone: Femur | | Hyperostosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/100 (1%) 1/100 (1%) | 20/100 (20%) 13/100 (13%) | |POLY-3 ADJUSTED (b)| 1.2% 1.2% | 23.0% 15.4% | |TERMINAL (d) | 0/57 (0%) 1/59 (2%) | 13/59 (22%) 7/58 (12%) | |FIRST INCIDENCE | 649 736 (T) | 591 645 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.754 | P=0.144N | |POLY 3 | P=0.758 | P=0.144N | |POLY 1.5 | P=0.759 | P=0.139N | |POLY 6 | P=0.757 | P=0.145N | |LOGISTIC REGRESSION| P=0.760 | P=0.136N | |COCH-ARM / FISHERS | P=0.751N | P=0.126N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Bone: Turbinate | | Hyperostosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) | 7/100 (7%) 6/100 (6%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 8.1% 7.2% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 4/59 (7%) 4/58 (7%) | |FIRST INCIDENCE | --- --- | 591 715 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.512N | |POLY 3 | (e) | P=0.523N | |POLY 1.5 | (e) | P=0.516N | |POLY 6 | (e) | P=0.524N | |LOGISTIC REGRESSION| (e) | P=0.513N | |COCH-ARM / FISHERS | (e) | P=0.500N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 8 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Brain: Cerebellum | | Hemorrhage | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) | 0/100 (0%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 2.4% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 0/59 (0%) 1/58 (2%) | |FIRST INCIDENCE | --- --- | --- 526 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.231 | |POLY 3 | (e) | P=0.237 | |POLY 1.5 | (e) | P=0.237 | |POLY 6 | (e) | P=0.237 | |LOGISTIC REGRESSION| (e) | P=0.265 | |COCH-ARM / FISHERS | (e) | P=0.249 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Brain: Hypothalamus | | Compression | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 5/100 (5%) 8/100 (8%) | 16/100 (16%) 19/100 (19%) | |POLY-3 ADJUSTED (b)| 5.8% 9.3% | 18.2% 21.7% | |TERMINAL (d) | 1/57 (2%) 3/59 (5%) | 8/59 (14%) 8/58 (14%) | |FIRST INCIDENCE | 583 470 | 543 434 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.274 | P=0.342 | |POLY 3 | P=0.278 | P=0.347 | |POLY 1.5 | P=0.279 | P=0.345 | |POLY 6 | P=0.281 | P=0.361 | |LOGISTIC REGRESSION| P=0.313 | P=0.375 | |COCH-ARM / FISHERS | P=0.284 | P=0.355 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 9 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Clitoral Gland | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 1/90 (1%) 3/94 (3%) | |POLY-3 ADJUSTED (b)| | 1.3% 3.8% | |TERMINAL (d) | | 1/56 (2%) 2/56 (4%) | |FIRST INCIDENCE | | 737 (T) 718 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.307 | |POLY 3 | | P=0.317 | |POLY 1.5 | | P=0.317 | |POLY 6 | | P=0.319 | |LOGISTIC REGRESSION| | P=0.325 | |COCH-ARM / FISHERS | | P=0.327 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Clitoral Gland | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 6/90 (7%) 5/94 (5%) | |POLY-3 ADJUSTED (b)| | 7.8% 6.3% | |TERMINAL (d) | | 5/56 (9%) 3/56 (5%) | |FIRST INCIDENCE | | 673 729 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.503N | |POLY 3 | | P=0.474N | |POLY 1.5 | | P=0.474N | |POLY 6 | | P=0.470N | |LOGISTIC REGRESSION| | P=0.464N | |COCH-ARM / FISHERS | | P=0.470N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 10 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Clitoral Gland | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 25/90 (28%) 20/94 (21%) | |POLY-3 ADJUSTED (b)| | 32.1% 24.3% | |TERMINAL (d) | | 21/56 (38%) 13/56 (23%) | |FIRST INCIDENCE | | 591 526 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.254N | |POLY 3 | | P=0.175N | |POLY 1.5 | | P=0.187N | |POLY 6 | | P=0.155N | |LOGISTIC REGRESSION| | P=0.197N | |COCH-ARM / FISHERS | | P=0.197N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Epididymis | | Granuloma Sperm | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 0/100 (0%) | | |POLY-3 ADJUSTED (b)| 2.3% 0.0% | | |TERMINAL (d) | 1/57 (2%) 0/59 (0%) | | |FIRST INCIDENCE | 641 --- | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.247N | | |POLY 3 | P=0.247N | | |POLY 1.5 | P=0.244N | | |POLY 6 | P=0.249N | | |LOGISTIC REGRESSION| P=0.239N | | |COCH-ARM / FISHERS | P=0.249N | | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 11 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Epididymis | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 3/100 (3%) | | |POLY-3 ADJUSTED (b)| 2.3% 3.6% | | |TERMINAL (d) | 1/57 (2%) 2/59 (3%) | | |FIRST INCIDENCE | 617 561 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.493 | | |POLY 3 | P=0.492 | | |POLY 1.5 | P=0.495 | | |POLY 6 | P=0.492 | | |LOGISTIC REGRESSION| P=0.506 | | |COCH-ARM / FISHERS | P=0.500 | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Epididymis: Epithelium | | Degeneration Mucoid | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 82/100 (82%) 79/100 (79%) | | |POLY-3 ADJUSTED (b)| 87.1% 85.3% | | |TERMINAL (d) | 49/57 (86%) 52/59 (88%) | | |FIRST INCIDENCE | 527 552 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.360N | | |POLY 3 | P=0.433N | | |POLY 1.5 | P=0.398N | | |POLY 6 | P=0.486N | | |LOGISTIC REGRESSION| P=0.511N | | |COCH-ARM / FISHERS | P=0.361N | | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 12 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Eye: Iris | | Synechia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/0 (0%) 1/1 (100%) | 2/6 (33%) 0/3 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 100.0% | 41.7% 0.0% | |TERMINAL (d) | 0/0 (0%) 1/1 (100%) | 2/3 (67%) 0/1 (0%) | |FIRST INCIDENCE | --- 736 (T) | 737 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.500N | |POLY 3 | (e) | P=0.598N | |POLY 1.5 | (e) | P=0.546N | |POLY 6 | (e) | P=0.697N | |LOGISTIC REGRESSION| (e) | (e) | |COCH-ARM / FISHERS | (e) | P=0.417N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Eye: Lens | | Cataract | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/0 (0%) 1/1 (100%) | 6/6 (100%) 2/3 (67%) | |POLY-3 ADJUSTED (b)| 0.0% 100.0% | 100.0% 78.6% | |TERMINAL (d) | 0/0 (0%) 1/1 (100%) | 3/3 (100%) 1/1 (100%) | |FIRST INCIDENCE | --- 736 (T) | 543 591 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.317N | |POLY 3 | (e) | P=0.928N | |POLY 1.5 | (e) | P=0.730N | |POLY 6 | (e) | P=1.000N | |LOGISTIC REGRESSION| (e) | P=0.402N | |COCH-ARM / FISHERS | (e) | P=0.333N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 13 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Eye: Retina | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/0 (0%) 1/1 (100%) | 6/6 (100%) 2/3 (67%) | |POLY-3 ADJUSTED (b)| 0.0% 100.0% | 100.0% 78.6% | |TERMINAL (d) | 0/0 (0%) 1/1 (100%) | 3/3 (100%) 1/1 (100%) | |FIRST INCIDENCE | --- 736 (T) | 543 591 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.317N | |POLY 3 | (e) | P=0.928N | |POLY 1.5 | (e) | P=0.730N | |POLY 6 | (e) | P=1.000N | |LOGISTIC REGRESSION| (e) | P=0.402N | |COCH-ARM / FISHERS | (e) | P=0.333N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Harderian Gland | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 2/100 (2%) | 0/100 (0%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 2.3% 2.4% | 0.0% 2.4% | |TERMINAL (d) | 2/57 (4%) 1/59 (2%) | 0/59 (0%) 1/58 (2%) | |FIRST INCIDENCE | 736 (T) 720 | --- 730 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.678N | P=0.238 | |POLY 3 | P=0.687 | P=0.236 | |POLY 1.5 | P=0.689 | P=0.237 | |POLY 6 | P=0.687 | P=0.236 | |LOGISTIC REGRESSION| P=0.687N | P=0.238 | |COCH-ARM / FISHERS | P=0.689N | P=0.249 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 14 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Harderian Gland | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 43/100 (43%) 60/100 (60%) | 69/100 (69%) 66/100 (66%) | |POLY-3 ADJUSTED (b)| 48.0% 66.3% | 72.5% 69.8% | |TERMINAL (d) | 29/57 (51%) 38/59 (64%) | 38/59 (64%) 38/58 (66%) | |FIRST INCIDENCE | 573 470 | 494 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.029 * | P=0.464N | |POLY 3 | P=0.007 ** | P=0.397N | |POLY 1.5 | P=0.008 ** | P=0.390N | |POLY 6 | P=0.008 ** | P=0.409N | |LOGISTIC REGRESSION| P=0.007 ** | P=0.384N | |COCH-ARM / FISHERS | P=0.012 * | P=0.381N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Harderian Gland | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 10/100 (10%) 6/100 (6%) | 10/100 (10%) 15/100 (15%) | |POLY-3 ADJUSTED (b)| 11.4% 7.1% | 11.6% 17.7% | |TERMINAL (d) | 4/57 (7%) 3/59 (5%) | 7/59 (12%) 11/58 (19%) | |FIRST INCIDENCE | 527 576 | 591 602 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.221N | P=0.183 | |POLY 3 | P=0.239N | P=0.178 | |POLY 1.5 | P=0.231N | P=0.183 | |POLY 6 | P=0.244N | P=0.180 | |LOGISTIC REGRESSION| P=0.215N | P=0.181 | |COCH-ARM / FISHERS | P=0.218N | P=0.196 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 15 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Heart | | Cardiomyopathy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 88/100 (88%) 87/100 (87%) | 53/100 (53%) 60/100 (60%) | |POLY-3 ADJUSTED (b)| 92.0% 90.5% | 59.8% 67.9% | |TERMINAL (d) | 55/57 (97%) 55/59 (93%) | 39/59 (66%) 43/58 (74%) | |FIRST INCIDENCE | 476 306 | 591 462 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.442N | P=0.176 | |POLY 3 | P=0.455N | P=0.156 | |POLY 1.5 | P=0.456N | P=0.163 | |POLY 6 | P=0.468N | P=0.168 | |LOGISTIC REGRESSION| P=0.588 | P=0.127 | |COCH-ARM / FISHERS | P=0.500N | P=0.196 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Heart | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 2/100 (2%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 2.3% | 0.0% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | --- 365 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.240 | (e) | |POLY 3 | P=0.238 | (e) | |POLY 1.5 | P=0.238 | (e) | |POLY 6 | P=0.238 | (e) | |LOGISTIC REGRESSION| P=0.258 | (e) | |COCH-ARM / FISHERS | P=0.249 | (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 16 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Heart: Atrium | | Thrombosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 6/100 (6%) 4/100 (4%) | 1/100 (1%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 6.9% 4.7% | 1.2% 0.0% | |TERMINAL (d) | 2/57 (4%) 0/59 (0%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 658 576 | 729 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.374N | P=0.500N | |POLY 3 | P=0.388N | P=0.509N | |POLY 1.5 | P=0.383N | P=0.507N | |POLY 6 | P=0.388N | P=0.507N | |LOGISTIC REGRESSION| P=0.370N | P=0.501N | |COCH-ARM / FISHERS | P=0.374N | P=0.500N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Islets, Pancreatic | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 7/100 (7%) | 0/100 (0%) 1/99 (1%) | |POLY-3 ADJUSTED (b)| 1.2% 8.3% | 0.0% 1.2% | |TERMINAL (d) | 1/57 (2%) 6/59 (10%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 736 (T) 577 | --- 608 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.037 * | P=0.493 | |POLY 3 | P=0.033 * | P=0.500 | |POLY 1.5 | P=0.034 * | P=0.500 | |POLY 6 | P=0.033 * | P=0.500 | |LOGISTIC REGRESSION| P=0.034 * | P=0.537 | |COCH-ARM / FISHERS | P=0.033 * | P=0.497 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 17 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) | 3/100 (3%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.5% 1.2% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 2/59 (3%) 0/58 (0%) | |FIRST INCIDENCE | --- --- | 736 608 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.317N | |POLY 3 | (e) | P=0.314N | |POLY 1.5 | (e) | P=0.313N | |POLY 6 | (e) | P=0.310N | |LOGISTIC REGRESSION| (e) | P=0.312N | |COCH-ARM / FISHERS | (e) | P=0.311N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 39/100 (39%) 41/100 (41%) | 23/100 (23%) 39/100 (39%) | |POLY-3 ADJUSTED (b)| 43.5% 47.2% | 26.4% 44.5% | |TERMINAL (d) | 23/57 (40%) 27/59 (46%) | 16/59 (27%) 29/58 (50%) | |FIRST INCIDENCE | 406 365 | 617 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.500 | P=0.010 * | |POLY 3 | P=0.365 | P=0.008 ** | |POLY 1.5 | P=0.396 | P=0.008 ** | |POLY 6 | P=0.339 | P=0.007 ** | |LOGISTIC REGRESSION| P=0.386 | P=0.008 ** | |COCH-ARM / FISHERS | P=0.443 | P=0.011 * | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 18 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney | | Nephropathy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 92/100 (92%) 89/100 (89%) | 54/100 (54%) 51/100 (51%) | |POLY-3 ADJUSTED (b)| 94.9% 92.9% | 58.4% 55.8% | |TERMINAL (d) | 57/57 (100%) 58/59 (98%) | 34/59 (58%) 30/58 (52%) | |FIRST INCIDENCE | 303 306 | 462 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.348N | P=0.445N | |POLY 3 | P=0.378N | P=0.417N | |POLY 1.5 | P=0.343N | P=0.411N | |POLY 6 | P=0.449N | P=0.410N | |LOGISTIC REGRESSION| P=0.385N | P=0.406N | |COCH-ARM / FISHERS | P=0.315N | P=0.389N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Pelvis | | Inflammation Acute | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 2/100 (2%) | 2/100 (2%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 2.3% | 2.3% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | --- 306 | 543 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.231 | P=0.256N | |POLY 3 | P=0.238 | P=0.249N | |POLY 1.5 | P=0.238 | P=0.246N | |POLY 6 | P=0.238 | P=0.250N | |LOGISTIC REGRESSION| P=0.261 | P=0.177N | |COCH-ARM / FISHERS | P=0.249 | P=0.249N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 19 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Pelvis | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 0/100 (0%) | 2/100 (2%) 4/100 (4%) | |POLY-3 ADJUSTED (b)| 2.3% 0.0% | 2.3% 4.8% | |TERMINAL (d) | 1/57 (2%) 0/59 (0%) | 2/59 (3%) 4/58 (7%) | |FIRST INCIDENCE | 579 --- | 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.247N | P=0.330 | |POLY 3 | P=0.248N | P=0.331 | |POLY 1.5 | P=0.245N | P=0.333 | |POLY 6 | P=0.249N | P=0.332 | |LOGISTIC REGRESSION| P=0.230N | P=0.330 | |COCH-ARM / FISHERS | P=0.249N | P=0.341 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Pelvis, Transitional Epithelium | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 0/100 (0%) | 2/100 (2%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 2.3% 0.0% | 2.3% 1.2% | |TERMINAL (d) | 1/57 (2%) 0/59 (0%) | 1/59 (2%) 1/58 (2%) | |FIRST INCIDENCE | 605 --- | 462 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.252N | P=0.510N | |POLY 3 | P=0.248N | P=0.514N | |POLY 1.5 | P=0.245N | P=0.510N | |POLY 6 | P=0.249N | P=0.514N | |LOGISTIC REGRESSION| P=0.234N | P=0.468N | |COCH-ARM / FISHERS | P=0.249N | P=0.500N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 20 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Renal Tubule | | Accumulation, Hyaline Droplet | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) | 5/100 (5%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 5.8% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 4/59 (7%) 0/58 (0%) | |FIRST INCIDENCE | --- --- | 691 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.036N* | |POLY 3 | (e) | P=0.036N* | |POLY 1.5 | (e) | P=0.035N* | |POLY 6 | (e) | P=0.035N* | |LOGISTIC REGRESSION| (e) | P=0.035N* | |COCH-ARM / FISHERS | (e) | P=0.030N* | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Renal Tubule | | Degeneration | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 0/100 (0%) | 2/100 (2%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| 2.3% 0.0% | 2.3% 3.5% | |TERMINAL (d) | 1/57 (2%) 0/59 (0%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 659 --- | 553 480 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.240N | P=0.478 | |POLY 3 | P=0.247N | P=0.496 | |POLY 1.5 | P=0.244N | P=0.496 | |POLY 6 | P=0.248N | P=0.498 | |LOGISTIC REGRESSION| P=0.241N | P=0.653N | |COCH-ARM / FISHERS | P=0.249N | P=0.500 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 21 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Kidney: Renal Tubule | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 29/100 (29%) 35/100 (35%) | 26/100 (26%) 11/100 (11%) | |POLY-3 ADJUSTED (b)| 32.0% 38.5% | 28.8% 12.9% | |TERMINAL (d) | 9/57 (16%) 13/59 (22%) | 13/59 (22%) 4/58 (7%) | |FIRST INCIDENCE | 573 527 | 462 594 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.255 | P=0.011N* | |POLY 3 | P=0.218 | P=0.007N** | |POLY 1.5 | P=0.218 | P=0.006N** | |POLY 6 | P=0.225 | P=0.008N** | |LOGISTIC REGRESSION| P=0.236 | P=0.005N** | |COCH-ARM / FISHERS | P=0.224 | P=0.005N** | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Basophilic Focus | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 35/100 (35%) 36/100 (36%) | 66/100 (66%) 78/100 (78%) | |POLY-3 ADJUSTED (b)| 40.3% 42.5% | 71.7% 81.1% | |TERMINAL (d) | 31/57 (54%) 33/59 (56%) | 46/59 (78%) 48/58 (83%) | |FIRST INCIDENCE | 583 582 | 533 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.564N | P=0.070 | |POLY 3 | P=0.441 | P=0.076 | |POLY 1.5 | P=0.463 | P=0.056 | |POLY 6 | P=0.432 | P=0.124 | |LOGISTIC REGRESSION| P=0.482 | P=0.031 * | |COCH-ARM / FISHERS | P=0.500 | P=0.041 * | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 22 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Clear Cell Focus | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 44/100 (44%) 41/100 (41%) | 6/100 (6%) 18/100 (18%) | |POLY-3 ADJUSTED (b)| 51.0% 48.5% | 7.0% 21.2% | |TERMINAL (d) | 41/57 (72%) 39/59 (66%) | 6/59 (10%) 16/58 (28%) | |FIRST INCIDENCE | 647 559 | 737 (T) 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.269N | P=0.006 ** | |POLY 3 | P=0.434N | P=0.006 ** | |POLY 1.5 | P=0.418N | P=0.007 ** | |POLY 6 | P=0.434N | P=0.006 ** | |LOGISTIC REGRESSION| P=0.323N | P=0.007 ** | |COCH-ARM / FISHERS | P=0.387N | P=0.008 ** | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Degeneration Cystic Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 8/100 (8%) 5/100 (5%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 9.2% 5.9% | 0.0% 0.0% | |TERMINAL (d) | 5/57 (9%) 3/59 (5%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 579 636 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.280N | (e) | |POLY 3 | P=0.300N | (e) | |POLY 1.5 | P=0.295N | (e) | |POLY 6 | P=0.301N | (e) | |LOGISTIC REGRESSION| P=0.295N | (e) | |COCH-ARM / FISHERS | P=0.284N | (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 23 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Eosinophilic Focus | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 21/100 (21%) 17/100 (17%) | 18/100 (18%) 31/100 (31%) | |POLY-3 ADJUSTED (b)| 24.3% 20.2% | 20.6% 36.0% | |TERMINAL (d) | 17/57 (30%) 15/59 (25%) | 11/59 (19%) 24/58 (41%) | |FIRST INCIDENCE | 674 688 | 547 434 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.251N | P=0.024 * | |POLY 3 | P=0.324N | P=0.016 * | |POLY 1.5 | P=0.314N | P=0.018 * | |POLY 6 | P=0.328N | P=0.015 * | |LOGISTIC REGRESSION| P=0.283N | P=0.019 * | |COCH-ARM / FISHERS | P=0.295N | P=0.024 * | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Hematopoietic Cell Proliferation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 5/100 (5%) 2/100 (2%) | 6/100 (6%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 5.8% 2.4% | 6.9% 2.4% | |TERMINAL (d) | 2/57 (4%) 0/59 (0%) | 1/59 (2%) 1/58 (2%) | |FIRST INCIDENCE | 649 535 | 462 632 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.234N | P=0.150N | |POLY 3 | P=0.229N | P=0.153N | |POLY 1.5 | P=0.226N | P=0.149N | |POLY 6 | P=0.229N | P=0.156N | |LOGISTIC REGRESSION| P=0.205N | P=0.109N | |COCH-ARM / FISHERS | P=0.222N | P=0.140N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 24 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Hepatodiaphragmatic Nodule | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 1/100 (1%) | 8/100 (8%) 6/100 (6%) | |POLY-3 ADJUSTED (b)| 2.3% 1.2% | 9.3% 7.1% | |TERMINAL (d) | 2/57 (4%) 0/59 (0%) | 5/59 (9%) 3/58 (5%) | |FIRST INCIDENCE | 736 (T) 688 | 602 480 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.494N | P=0.408N | |POLY 3 | P=0.510N | P=0.401N | |POLY 1.5 | P=0.507N | P=0.399N | |POLY 6 | P=0.509N | P=0.396N | |LOGISTIC REGRESSION| P=0.507N | P=0.391N | |COCH-ARM / FISHERS | P=0.500N | P=0.391N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Infiltration Cellular Mixed Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 11/100 (11%) 26/100 (26%) | 32/100 (32%) 27/100 (27%) | |POLY-3 ADJUSTED (b)| 12.8% 30.6% | 35.7% 31.6% | |TERMINAL (d) | 10/57 (18%) 24/59 (41%) | 21/59 (36%) 22/58 (38%) | |FIRST INCIDENCE | 583 535 | 494 585 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.005 ** | P=0.300N | |POLY 3 | P=0.003 ** | P=0.337N | |POLY 1.5 | P=0.004 ** | P=0.312N | |POLY 6 | P=0.003 ** | P=0.357N | |LOGISTIC REGRESSION| P=0.004 ** | P=0.293N | |COCH-ARM / FISHERS | P=0.005 ** | P=0.268N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 25 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 3/100 (3%) | 1/100 (1%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 2.3% 3.5% | 1.2% 2.4% | |TERMINAL (d) | 2/57 (4%) 1/59 (2%) | 1/59 (2%) 0/58 (0%) | |FIRST INCIDENCE | 736 (T) 470 | 737 (T) 434 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.509 | P=0.495 | |POLY 3 | P=0.498 | P=0.498 | |POLY 1.5 | P=0.498 | P=0.498 | |POLY 6 | P=0.500 | P=0.501 | |LOGISTIC REGRESSION| P=0.529 | P=0.582 | |COCH-ARM / FISHERS | P=0.500 | P=0.500 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Mixed Cell Focus | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 25/100 (25%) 18/100 (18%) | 39/100 (39%) 37/100 (37%) | |POLY-3 ADJUSTED (b)| 29.0% 21.1% | 44.2% 42.5% | |TERMINAL (d) | 23/57 (40%) 15/59 (25%) | 31/59 (53%) 29/58 (50%) | |FIRST INCIDENCE | 647 535 | 533 448 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.118N | P=0.481N | |POLY 3 | P=0.153N | P=0.470N | |POLY 1.5 | P=0.154N | P=0.467N | |POLY 6 | P=0.145N | P=0.457N | |LOGISTIC REGRESSION| P=0.160N | P=0.488N | |COCH-ARM / FISHERS | P=0.151N | P=0.442N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 26 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Necrosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 8/100 (8%) 2/100 (2%) | 3/100 (3%) 4/100 (4%) | |POLY-3 ADJUSTED (b)| 9.1% 2.4% | 3.5% 4.7% | |TERMINAL (d) | 2/57 (4%) 0/59 (0%) | 1/59 (2%) 2/58 (3%) | |FIRST INCIDENCE | 406 688 | 690 575 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.054N | P=0.499 | |POLY 3 | P=0.060N | P=0.493 | |POLY 1.5 | P=0.057N | P=0.494 | |POLY 6 | P=0.061N | P=0.496 | |LOGISTIC REGRESSION| P=0.044N* | P=0.502 | |COCH-ARM / FISHERS | P=0.050N | P=0.500 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 2/100 (2%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 2.4% | 0.0% 0.0% | |TERMINAL (d) | 0/57 (0%) 2/59 (3%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | --- 736 (T) | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.246 | (e) | |POLY 3 | P=0.236 | (e) | |POLY 1.5 | P=0.237 | (e) | |POLY 6 | P=0.236 | (e) | |LOGISTIC REGRESSION| P=0.246 | (e) | |COCH-ARM / FISHERS | P=0.249 | (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 27 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver: Bile Duct | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 79/100 (79%) 79/100 (79%) | 28/100 (28%) 24/100 (24%) | |POLY-3 ADJUSTED (b)| 83.9% 87.2% | 32.2% 28.0% | |TERMINAL (d) | 49/57 (86%) 55/59 (93%) | 20/59 (34%) 12/58 (21%) | |FIRST INCIDENCE | 406 489 | 625 627 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.492N | P=0.342N | |POLY 3 | P=0.319 | P=0.335N | |POLY 1.5 | P=0.428 | P=0.333N | |POLY 6 | P=0.205 | P=0.321N | |LOGISTIC REGRESSION| P=0.380 | P=0.340N | |COCH-ARM / FISHERS | P=0.569N | P=0.314N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Liver: Hepatocyte | | Vacuolization Cytoplasmic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 14/100 (14%) 20/100 (20%) | 11/100 (11%) 9/100 (9%) | |POLY-3 ADJUSTED (b)| 15.9% 22.6% | 12.3% 10.3% | |TERMINAL (d) | 8/57 (14%) 10/59 (17%) | 1/59 (2%) 2/58 (3%) | |FIRST INCIDENCE | 476 306 | 533 480 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.189 | P=0.438N | |POLY 3 | P=0.175 | P=0.436N | |POLY 1.5 | P=0.174 | P=0.427N | |POLY 6 | P=0.181 | P=0.440N | |LOGISTIC REGRESSION| P=0.194 | P=0.259N | |COCH-ARM / FISHERS | P=0.173 | P=0.407N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 28 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung | | Congestion | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 5/100 (5%) 3/100 (3%) | 5/100 (5%) 7/100 (7%) | |POLY-3 ADJUSTED (b)| 5.8% 3.5% | 5.7% 8.1% | |TERMINAL (d) | 2/57 (4%) 1/59 (2%) | 1/59 (2%) 1/58 (2%) | |FIRST INCIDENCE | 693 559 | 494 448 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.360N | P=0.370 | |POLY 3 | P=0.369N | P=0.374 | |POLY 1.5 | P=0.366N | P=0.376 | |POLY 6 | P=0.367N | P=0.376 | |LOGISTIC REGRESSION| P=0.355N | P=0.535 | |COCH-ARM / FISHERS | P=0.360N | P=0.384 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung | | Infiltration Cellular Histiocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 8/100 (8%) 5/100 (5%) | 31/100 (31%) 35/100 (35%) | |POLY-3 ADJUSTED (b)| 9.3% 5.9% | 35.8% 41.1% | |TERMINAL (d) | 7/57 (12%) 4/59 (7%) | 26/59 (44%) 29/58 (50%) | |FIRST INCIDENCE | 722 636 | 591 594 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.267N | P=0.290 | |POLY 3 | P=0.295N | P=0.286 | |POLY 1.5 | P=0.292N | P=0.295 | |POLY 6 | P=0.293N | P=0.291 | |LOGISTIC REGRESSION| P=0.284N | P=0.291 | |COCH-ARM / FISHERS | P=0.284N | P=0.326 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 29 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 3/100 (3%) | 1/100 (1%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| 0.0% 3.6% | 1.2% 3.6% | |TERMINAL (d) | 0/57 (0%) 2/59 (3%) | 0/59 (0%) 2/58 (3%) | |FIRST INCIDENCE | --- 559 | 543 702 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.124 | P=0.302 | |POLY 3 | P=0.119 | P=0.300 | |POLY 1.5 | P=0.120 | P=0.302 | |POLY 6 | P=0.119 | P=0.300 | |LOGISTIC REGRESSION| P=0.124 | P=0.311 | |COCH-ARM / FISHERS | P=0.123 | P=0.311 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung | | Infiltration Cellular Mixed Cell | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 0/100 (0%) | 2/100 (2%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 2.3% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 2/59 (3%) 0/58 (0%) | |FIRST INCIDENCE | --- --- | 737 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.243N | |POLY 3 | (e) | P=0.245N | |POLY 1.5 | (e) | P=0.244N | |POLY 6 | (e) | P=0.244N | |LOGISTIC REGRESSION| (e) | (e) | |COCH-ARM / FISHERS | (e) | P=0.249N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 30 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung: Alveolar Epithelium | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 6/100 (6%) 4/100 (4%) | 4/100 (4%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| 7.0% 4.7% | 4.7% 3.6% | |TERMINAL (d) | 5/57 (9%) 2/59 (3%) | 4/59 (7%) 3/58 (5%) | |FIRST INCIDENCE | 699 582 | 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.369N | P=0.509N | |POLY 3 | P=0.381N | P=0.513N | |POLY 1.5 | P=0.380N | P=0.510N | |POLY 6 | P=0.377N | P=0.511N | |LOGISTIC REGRESSION| P=0.382N | P=0.509N | |COCH-ARM / FISHERS | P=0.374N | P=0.500N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung: Bronchus | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 2/100 (2%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 2.4% | 0.0% 0.0% | |TERMINAL (d) | 0/57 (0%) 2/59 (3%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | --- 736 (T) | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.246 | (e) | |POLY 3 | P=0.236 | (e) | |POLY 1.5 | P=0.237 | (e) | |POLY 6 | P=0.236 | (e) | |LOGISTIC REGRESSION| P=0.246 | (e) | |COCH-ARM / FISHERS | P=0.249 | (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 31 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lung: Interstitium | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 6/100 (6%) 3/100 (3%) | 10/100 (10%) 7/100 (7%) | |POLY-3 ADJUSTED (b)| 7.0% 3.6% | 11.6% 8.1% | |TERMINAL (d) | 4/57 (7%) 2/59 (3%) | 7/59 (12%) 2/58 (3%) | |FIRST INCIDENCE | 617 576 | 462 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.247N | P=0.330N | |POLY 3 | P=0.259N | P=0.301N | |POLY 1.5 | P=0.256N | P=0.306N | |POLY 6 | P=0.260N | P=0.289N | |LOGISTIC REGRESSION| P=0.254N | P=0.252N | |COCH-ARM / FISHERS | P=0.249N | P=0.307N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Degeneration Cystic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 15/99 (15%) 11/100 (11%) | 11/100 (11%) 15/100 (15%) | |POLY-3 ADJUSTED (b)| 17.6% 13.0% | 12.9% 17.9% | |TERMINAL (d) | 14/57 (25%) 10/59 (17%) | 10/59 (17%) 15/58 (26%) | |FIRST INCIDENCE | 658 576 | 697 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.234N | P=0.242 | |POLY 3 | P=0.272N | P=0.241 | |POLY 1.5 | P=0.267N | P=0.247 | |POLY 6 | P=0.271N | P=0.240 | |LOGISTIC REGRESSION| P=0.264N | P=0.257 | |COCH-ARM / FISHERS | P=0.255N | P=0.264 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 32 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Hemorrhage | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 1/100 (1%) | 1/100 (1%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| 2.3% 1.2% | 1.2% 3.5% | |TERMINAL (d) | 1/57 (2%) 1/59 (2%) | 1/59 (2%) 1/58 (2%) | |FIRST INCIDENCE | 704 736 (T) | 737 (T) 448 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.485N | P=0.297 | |POLY 3 | P=0.508N | P=0.306 | |POLY 1.5 | P=0.503N | P=0.305 | |POLY 6 | P=0.509N | P=0.308 | |LOGISTIC REGRESSION| P=0.502N | P=0.381 | |COCH-ARM / FISHERS | P=0.496N | P=0.311 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Hyperplasia Lymphoid | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 17/99 (17%) 14/100 (14%) | 13/100 (13%) 7/100 (7%) | |POLY-3 ADJUSTED (b)| 19.3% 16.3% | 15.0% 8.2% | |TERMINAL (d) | 10/57 (18%) 9/59 (15%) | 7/59 (12%) 3/58 (5%) | |FIRST INCIDENCE | 406 535 | 565 505 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.324N | P=0.133N | |POLY 3 | P=0.375N | P=0.128N | |POLY 1.5 | P=0.362N | P=0.126N | |POLY 6 | P=0.379N | P=0.128N | |LOGISTIC REGRESSION| P=0.333N | P=0.122N | |COCH-ARM / FISHERS | P=0.337N | P=0.119N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 33 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Infiltration Cellular Histiocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/100 (0%) | 3/100 (3%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.5% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 3/59 (5%) 0/58 (0%) | |FIRST INCIDENCE | --- --- | 737 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.125N | |POLY 3 | (e) | P=0.126N | |POLY 1.5 | (e) | P=0.125N | |POLY 6 | (e) | P=0.125N | |LOGISTIC REGRESSION| (e) | (e) | |COCH-ARM / FISHERS | (e) | P=0.123N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mandibular | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 2/100 (2%) | 0/100 (0%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| 1.2% 2.4% | 0.0% 3.6% | |TERMINAL (d) | 1/57 (2%) 1/59 (2%) | 0/59 (0%) 1/58 (2%) | |FIRST INCIDENCE | 736 (T) 582 | --- 602 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.497 | P=0.122 | |POLY 3 | P=0.498 | P=0.120 | |POLY 1.5 | P=0.499 | P=0.120 | |POLY 6 | P=0.498 | P=0.121 | |LOGISTIC REGRESSION| P=0.505 | P=0.132 | |COCH-ARM / FISHERS | P=0.504 | P=0.123 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 34 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mediastinal | | Hemorrhage | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 1/100 (1%) | 1/100 (1%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| 2.3% 1.2% | 1.2% 3.6% | |TERMINAL (d) | 1/57 (2%) 1/59 (2%) | 1/59 (2%) 2/58 (3%) | |FIRST INCIDENCE | 406 736 (T) | 737 (T) 727 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.493N | P=0.304 | |POLY 3 | P=0.515N | P=0.301 | |POLY 1.5 | P=0.510N | P=0.303 | |POLY 6 | P=0.517N | P=0.302 | |LOGISTIC REGRESSION| P=0.475N | P=0.306 | |COCH-ARM / FISHERS | P=0.500N | P=0.311 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Hemorrhage | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 1/100 (1%) | 3/100 (3%) 4/99 (4%) | |POLY-3 ADJUSTED (b)| 2.3% 1.2% | 3.5% 4.8% | |TERMINAL (d) | 1/57 (2%) 0/59 (0%) | 0/59 (0%) 3/57 (5%) | |FIRST INCIDENCE | 704 591 | 533 627 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.501N | P=0.483 | |POLY 3 | P=0.509N | P=0.479 | |POLY 1.5 | P=0.506N | P=0.484 | |POLY 6 | P=0.508N | P=0.477 | |LOGISTIC REGRESSION| P=0.495N | P=0.531 | |COCH-ARM / FISHERS | P=0.500N | P=0.494 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 35 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Hyperplasia Lymphoid | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 3/100 (3%) | 1/100 (1%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 3.6% | 1.2% 0.0% | |TERMINAL (d) | 0/57 (0%) 2/59 (3%) | 0/59 (0%) 0/57 (0%) | |FIRST INCIDENCE | --- 576 | 494 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.123 | P=0.512N | |POLY 3 | P=0.119 | P=0.517N | |POLY 1.5 | P=0.120 | P=0.513N | |POLY 6 | P=0.119 | P=0.517N | |LOGISTIC REGRESSION| P=0.123 | P=0.290N | |COCH-ARM / FISHERS | P=0.123 | P=0.503N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Lymph Node, Mesenteric | | Infiltration Cellular Histiocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 65/100 (65%) 80/100 (80%) | 85/100 (85%) 86/99 (87%) | |POLY-3 ADJUSTED (b)| 72.0% 83.1% | 88.2% 90.1% | |TERMINAL (d) | 48/57 (84%) 50/59 (85%) | 55/59 (93%) 52/57 (91%) | |FIRST INCIDENCE | 476 306 | 462 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.052 | P=0.387 | |POLY 3 | P=0.038 * | P=0.421 | |POLY 1.5 | P=0.023 * | P=0.420 | |POLY 6 | P=0.076 | P=0.442 | |LOGISTIC REGRESSION| P=0.007 ** | P=0.364 | |COCH-ARM / FISHERS | P=0.013 * | P=0.431 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 36 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 18/99 (18%) 14/95 (15%) | 47/100 (47%) 53/100 (53%) | |POLY-3 ADJUSTED (b)| 20.4% 16.8% | 51.9% 59.2% | |TERMINAL (d) | 7/57 (12%) 6/58 (10%) | 29/59 (49%) 35/58 (60%) | |FIRST INCIDENCE | 581 535 | 543 505 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.308N | P=0.238 | |POLY 3 | P=0.339N | P=0.194 | |POLY 1.5 | P=0.336N | P=0.204 | |POLY 6 | P=0.335N | P=0.198 | |LOGISTIC REGRESSION| P=0.318N | P=0.196 | |COCH-ARM / FISHERS | P=0.326N | P=0.240 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland | | Galactocele | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 5/95 (5%) | 10/100 (10%) 10/100 (10%) | |POLY-3 ADJUSTED (b)| 0.0% 6.2% | 11.4% 11.7% | |TERMINAL (d) | 0/57 (0%) 4/58 (7%) | 4/59 (7%) 5/58 (9%) | |FIRST INCIDENCE | --- 470 | 602 434 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.037 * | P=0.578 | |POLY 3 | P=0.030 * | P=0.572 | |POLY 1.5 | P=0.030 * | P=0.578 | |POLY 6 | P=0.031 * | P=0.569 | |LOGISTIC REGRESSION| P=0.032 * | P=0.585N | |COCH-ARM / FISHERS | P=0.027 * | P=0.593N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 37 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 1/95 (1%) | 0/100 (0%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 2.4% 1.2% | 0.0% 2.4% | |TERMINAL (d) | 2/57 (4%) 0/58 (0%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 736 (T) 577 | --- 608 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.506N | P=0.234 | |POLY 3 | P=0.522N | P=0.237 | |POLY 1.5 | P=0.522N | P=0.237 | |POLY 6 | P=0.516N | P=0.237 | |LOGISTIC REGRESSION| P=0.513N | P=0.247 | |COCH-ARM / FISHERS | P=0.516N | P=0.249 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 4/95 (4%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 2.3% 4.9% | 0.0% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/58 (0%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 303 558 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.325 | (e) | |POLY 3 | P=0.323 | (e) | |POLY 1.5 | P=0.321 | (e) | |POLY 6 | P=0.329 | (e) | |LOGISTIC REGRESSION| P=0.373 | (e) | |COCH-ARM / FISHERS | P=0.322 | (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 38 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mammary Gland: Epithelium | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 9/99 (9%) 4/95 (4%) | 1/100 (1%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| 10.6% 5.0% | 1.2% 3.6% | |TERMINAL (d) | 8/57 (14%) 4/58 (7%) | 1/59 (2%) 2/58 (3%) | |FIRST INCIDENCE | 722 736 (T) | 737 (T) 575 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.116N | P=0.301 | |POLY 3 | P=0.147N | P=0.303 | |POLY 1.5 | P=0.146N | P=0.304 | |POLY 6 | P=0.143N | P=0.304 | |LOGISTIC REGRESSION| P=0.111N | P=0.303 | |COCH-ARM / FISHERS | P=0.142N | P=0.311 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Mesentery: Fat | | Necrosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 14/17 (82%) 13/16 (81%) | 9/11 (82%) 15/16 (94%) | |POLY-3 ADJUSTED (b)| 84.7% 82.2% | 88.1% 96.1% | |TERMINAL (d) | 5/6 (83%) 6/8 (75%) | 6/6 (100%) 11/11 (100%) | |FIRST INCIDENCE | 581 489 | 598 591 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.375N | P=0.500 | |POLY 3 | P=0.618N | P=0.437 | |POLY 1.5 | P=0.631N | P=0.395 | |POLY 6 | P=0.594N | P=0.455 | |LOGISTIC REGRESSION| P=0.649N | P=0.599 | |COCH-ARM / FISHERS | P=0.642N | P=0.357 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 39 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Nose | | Inflammation Acute | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/100 (1%) 2/100 (2%) | 1/100 (1%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 1.2% 2.4% | 1.2% 2.3% | |TERMINAL (d) | 0/57 (0%) 1/59 (2%) | 1/59 (2%) 0/58 (0%) | |FIRST INCIDENCE | 406 579 | 737 (T) 434 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.491 | P=0.492 | |POLY 3 | P=0.494 | P=0.499 | |POLY 1.5 | P=0.496 | P=0.499 | |POLY 6 | P=0.494 | P=0.502 | |LOGISTIC REGRESSION| P=0.544 | P=0.701 | |COCH-ARM / FISHERS | P=0.500 | P=0.500 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Nose | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 27/100 (27%) 34/100 (34%) | 9/100 (9%) 10/100 (10%) | |POLY-3 ADJUSTED (b)| 30.2% 37.7% | 10.2% 11.7% | |TERMINAL (d) | 17/57 (30%) 19/59 (32%) | 3/59 (5%) 5/58 (9%) | |FIRST INCIDENCE | 502 470 | 462 505 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.200 | P=0.480 | |POLY 3 | P=0.179 | P=0.470 | |POLY 1.5 | P=0.176 | P=0.479 | |POLY 6 | P=0.192 | P=0.467 | |LOGISTIC REGRESSION| P=0.181 | P=0.558 | |COCH-ARM / FISHERS | P=0.178 | P=0.500 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 40 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Nose: Nasolacrimal Duct | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 7/100 (7%) 8/100 (8%) | 2/100 (2%) 8/100 (8%) | |POLY-3 ADJUSTED (b)| 8.1% 9.2% | 2.3% 9.5% | |TERMINAL (d) | 6/57 (11%) 3/59 (5%) | 1/59 (2%) 6/58 (10%) | |FIRST INCIDENCE | 647 306 | 591 591 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.505 | P=0.050 | |POLY 3 | P=0.504 | P=0.048 * | |POLY 1.5 | P=0.502 | P=0.049 * | |POLY 6 | P=0.512 | P=0.048 * | |LOGISTIC REGRESSION| P=0.523 | P=0.050 | |COCH-ARM / FISHERS | P=0.500 | P=0.050 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Nose: Olfactory Epithelium | | Cytoplasmic Alteration | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 36/100 (36%) 29/100 (29%) | 69/100 (69%) 77/100 (77%) | |POLY-3 ADJUSTED (b)| 40.2% 32.8% | 73.9% 82.1% | |TERMINAL (d) | 24/57 (42%) 17/59 (29%) | 46/59 (78%) 48/58 (83%) | |FIRST INCIDENCE | 406 470 | 462 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.188N | P=0.163 | |POLY 3 | P=0.189N | P=0.104 | |POLY 1.5 | P=0.189N | P=0.107 | |POLY 6 | P=0.178N | P=0.124 | |LOGISTIC REGRESSION| P=0.195N | P=0.092 | |COCH-ARM / FISHERS | P=0.183N | P=0.132 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 41 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Nose: Respiratory Epithelium | | Cytoplasmic Alteration | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/100 (3%) 1/100 (1%) | 4/100 (4%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 3.5% 1.2% | 4.6% 1.2% | |TERMINAL (d) | 2/57 (4%) 1/59 (2%) | 3/59 (5%) 1/58 (2%) | |FIRST INCIDENCE | 710 736 (T) | 495 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.293N | P=0.190N | |POLY 3 | P=0.318N | P=0.192N | |POLY 1.5 | P=0.314N | P=0.190N | |POLY 6 | P=0.318N | P=0.192N | |LOGISTIC REGRESSION| P=0.304N | P=0.182N | |COCH-ARM / FISHERS | P=0.311N | P=0.184N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Ovary | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 4/100 (4%) 4/99 (4%) | |POLY-3 ADJUSTED (b)| | 4.7% 4.8% | |TERMINAL (d) | | 4/59 (7%) 3/58 (5%) | |FIRST INCIDENCE | | 737 (T) 608 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.631 | |POLY 3 | | P=0.631 | |POLY 1.5 | | P=0.631 | |POLY 6 | | P=0.636 | |LOGISTIC REGRESSION| | P=0.631 | |COCH-ARM / FISHERS | | P=0.634 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 42 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Ovary: Follicle | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 3/100 (3%) 2/99 (2%) | |POLY-3 ADJUSTED (b)| | 3.5% 2.4% | |TERMINAL (d) | | 2/59 (3%) 1/58 (2%) | |FIRST INCIDENCE | | 553 462 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.514N | |POLY 3 | | P=0.513N | |POLY 1.5 | | P=0.512N | |POLY 6 | | P=0.510N | |LOGISTIC REGRESSION| | P=0.465N | |COCH-ARM / FISHERS | | P=0.505N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Ovary: Periovarian Tissue | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 6/100 (6%) 11/99 (11%) | |POLY-3 ADJUSTED (b)| | 7.0% 13.0% | |TERMINAL (d) | | 6/59 (10%) 7/58 (12%) | |FIRST INCIDENCE | | 737 (T) 575 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.146 | |POLY 3 | | P=0.146 | |POLY 1.5 | | P=0.146 | |POLY 6 | | P=0.153 | |LOGISTIC REGRESSION| | P=0.142 | |COCH-ARM / FISHERS | | P=0.150 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 43 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Ovary: Rete Ovarii | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 8/100 (8%) 16/99 (16%) | |POLY-3 ADJUSTED (b)| | 9.3% 19.3% | |TERMINAL (d) | | 6/59 (10%) 15/58 (26%) | |FIRST INCIDENCE | | 673 729 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.056 | |POLY 3 | | P=0.051 | |POLY 1.5 | | P=0.053 | |POLY 6 | | P=0.050 | |LOGISTIC REGRESSION| | P=0.058 | |COCH-ARM / FISHERS | | P=0.060 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pancreas | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/98 (3%) 1/100 (1%) | 0/100 (0%) 0/99 (0%) | |POLY-3 ADJUSTED (b)| 3.5% 1.2% | 0.0% 0.0% | |TERMINAL (d) | 1/57 (2%) 1/59 (2%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 647 736 (T) | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.306N | (e) | |POLY 3 | P=0.314N | (e) | |POLY 1.5 | P=0.308N | (e) | |POLY 6 | P=0.318N | (e) | |LOGISTIC REGRESSION| P=0.308N | (e) | |COCH-ARM / FISHERS | P=0.303N | (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 44 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pancreas | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 5/98 (5%) 3/100 (3%) | 14/100 (14%) 7/99 (7%) | |POLY-3 ADJUSTED (b)| 5.9% 3.5% | 16.1% 8.3% | |TERMINAL (d) | 5/57 (9%) 1/59 (2%) | 10/59 (17%) 5/58 (9%) | |FIRST INCIDENCE | 736 (T) 559 | 533 594 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.356N | P=0.094N | |POLY 3 | P=0.358N | P=0.092N | |POLY 1.5 | P=0.355N | P=0.091N | |POLY 6 | P=0.356N | P=0.089N | |LOGISTIC REGRESSION| P=0.352N | P=0.090N | |COCH-ARM / FISHERS | P=0.349N | P=0.086N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pancreas: Acinus | | Atrophy Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 33/98 (34%) 41/100 (41%) | 15/100 (15%) 20/99 (20%) | |POLY-3 ADJUSTED (b)| 36.7% 46.4% | 17.2% 23.4% | |TERMINAL (d) | 19/57 (33%) 26/59 (44%) | 10/59 (17%) 13/58 (22%) | |FIRST INCIDENCE | 303 555 | 553 505 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.194 | P=0.223 | |POLY 3 | P=0.119 | P=0.204 | |POLY 1.5 | P=0.136 | P=0.207 | |POLY 6 | P=0.112 | P=0.209 | |LOGISTIC REGRESSION| P=0.168 | P=0.209 | |COCH-ARM / FISHERS | P=0.179 | P=0.219 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 45 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pancreas: Acinus | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 20/98 (20%) 18/100 (18%) | 3/100 (3%) 2/99 (2%) | |POLY-3 ADJUSTED (b)| 23.5% 21.3% | 3.5% 2.4% | |TERMINAL (d) | 17/57 (30%) 15/59 (25%) | 2/59 (3%) 2/58 (3%) | |FIRST INCIDENCE | 670 552 | 655 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.384N | P=0.512N | |POLY 3 | P=0.437N | P=0.515N | |POLY 1.5 | P=0.424N | P=0.513N | |POLY 6 | P=0.442N | P=0.513N | |LOGISTIC REGRESSION| P=0.439N | P=0.508N | |COCH-ARM / FISHERS | P=0.401N | P=0.505N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pineal Gland | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 42/81 (52%) 57/91 (63%) | 56/85 (66%) 40/89 (45%) | |POLY-3 ADJUSTED (b)| 56.2% 68.7% | 69.9% 49.6% | |TERMINAL (d) | 21/43 (49%) 36/53 (68%) | 35/51 (69%) 27/55 (49%) | |FIRST INCIDENCE | 502 470 | 495 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.145 | P=0.014N* | |POLY 3 | P=0.065 | P=0.005N** | |POLY 1.5 | P=0.077 | P=0.004N** | |POLY 6 | P=0.056 | P=0.006N** | |LOGISTIC REGRESSION| P=0.099 | P=0.004N** | |COCH-ARM / FISHERS | P=0.101 | P=0.004N** | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 46 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis | | Angiectasis Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/98 (3%) 2/98 (2%) | 1/99 (1%) 2/98 (2%) | |POLY-3 ADJUSTED (b)| 3.6% 2.4% | 1.2% 2.4% | |TERMINAL (d) | 2/57 (4%) 1/58 (2%) | 1/59 (2%) 0/58 (0%) | |FIRST INCIDENCE | 701 577 | 737 (T) 585 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.499N | P=0.494 | |POLY 3 | P=0.509N | P=0.497 | |POLY 1.5 | P=0.506N | P=0.496 | |POLY 6 | P=0.508N | P=0.499 | |LOGISTIC REGRESSION| P=0.504N | P=0.522 | |COCH-ARM / FISHERS | P=0.500N | P=0.496 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 8/98 (8%) 7/98 (7%) | 21/99 (21%) 25/98 (26%) | |POLY-3 ADJUSTED (b)| 9.4% 8.3% | 24.2% 29.4% | |TERMINAL (d) | 4/57 (7%) 4/58 (7%) | 16/59 (27%) 19/58 (33%) | |FIRST INCIDENCE | 627 558 | 462 448 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.523N | P=0.289 | |POLY 3 | P=0.516N | P=0.276 | |POLY 1.5 | P=0.510N | P=0.279 | |POLY 6 | P=0.517N | P=0.283 | |LOGISTIC REGRESSION| P=0.492N | P=0.274 | |COCH-ARM / FISHERS | P=0.500N | P=0.293 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 47 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 11/98 (11%) 16/98 (16%) | 10/99 (10%) 7/98 (7%) | |POLY-3 ADJUSTED (b)| 12.8% 18.8% | 11.6% 8.5% | |TERMINAL (d) | 6/57 (11%) 9/58 (16%) | 6/59 (10%) 7/58 (12%) | |FIRST INCIDENCE | 502 306 | 597 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.222 | P=0.325N | |POLY 3 | P=0.196 | P=0.339N | |POLY 1.5 | P=0.200 | P=0.331N | |POLY 6 | P=0.195 | P=0.344N | |LOGISTIC REGRESSION| P=0.211 | P=0.323N | |COCH-ARM / FISHERS | P=0.204 | P=0.314N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis | | Hypertrophy Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/98 (2%) 2/98 (2%) | 0/99 (0%) 1/98 (1%) | |POLY-3 ADJUSTED (b)| 2.4% 2.4% | 0.0% 1.2% | |TERMINAL (d) | 1/57 (2%) 1/58 (2%) | 0/59 (0%) 1/58 (2%) | |FIRST INCIDENCE | 696 675 | --- 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.685N | P=0.497 | |POLY 3 | P=0.688 | P=0.500 | |POLY 1.5 | P=0.689 | P=0.500 | |POLY 6 | P=0.688 | P=0.500 | |LOGISTIC REGRESSION| P=0.687 | P=0.497 | |COCH-ARM / FISHERS | P=0.689N | P=0.497 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 48 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/98 (0%) 0/98 (0%) | 2/99 (2%) 1/98 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 2.3% 1.2% | |TERMINAL (d) | 0/57 (0%) 0/58 (0%) | 1/59 (2%) 0/58 (0%) | |FIRST INCIDENCE | --- --- | 680 505 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.507N | |POLY 3 | (e) | P=0.509N | |POLY 1.5 | (e) | P=0.509N | |POLY 6 | (e) | P=0.506N | |LOGISTIC REGRESSION| (e) | P=0.468N | |COCH-ARM / FISHERS | (e) | P=0.504N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pituitary Gland: Pars Intermedia | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/98 (3%) 2/98 (2%) | 0/99 (0%) 0/98 (0%) | |POLY-3 ADJUSTED (b)| 3.5% 2.4% | 0.0% 0.0% | |TERMINAL (d) | 2/57 (4%) 1/58 (2%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 619 561 | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.511N | (e) | |POLY 3 | P=0.510N | (e) | |POLY 1.5 | P=0.507N | (e) | |POLY 6 | P=0.510N | (e) | |LOGISTIC REGRESSION| P=0.495N | (e) | |COCH-ARM / FISHERS | P=0.500N | (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 49 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Pituitary Gland: Rathke's Cleft | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/98 (0%) 1/98 (1%) | 2/99 (2%) 0/98 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 1.2% | 2.3% 0.0% | |TERMINAL (d) | 0/57 (0%) 1/58 (2%) | 1/59 (2%) 0/58 (0%) | |FIRST INCIDENCE | --- 736 (T) | 565 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.503 | P=0.245N | |POLY 3 | P=0.500 | P=0.249N | |POLY 1.5 | P=0.500 | P=0.247N | |POLY 6 | P=0.500 | P=0.248N | |LOGISTIC REGRESSION| P=0.503 | P=0.223N | |COCH-ARM / FISHERS | P=0.500 | P=0.251N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Preputial Gland | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/100 (4%) 1/100 (1%) | | |POLY-3 ADJUSTED (b)| 4.6% 1.2% | | |TERMINAL (d) | 2/57 (4%) 0/59 (0%) | | |FIRST INCIDENCE | 647 579 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.193N | | |POLY 3 | P=0.190N | | |POLY 1.5 | P=0.188N | | |POLY 6 | P=0.191N | | |LOGISTIC REGRESSION| P=0.177N | | |COCH-ARM / FISHERS | P=0.184N | | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 50 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Preputial Gland | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 80/100 (80%) 84/100 (84%) | | |POLY-3 ADJUSTED (b)| 84.4% 88.6% | | |TERMINAL (d) | 51/57 (90%) 54/59 (92%) | | |FIRST INCIDENCE | 476 365 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.409 | | |POLY 3 | P=0.245 | | |POLY 1.5 | P=0.268 | | |POLY 6 | P=0.216 | | |LOGISTIC REGRESSION| P=0.209 | | |COCH-ARM / FISHERS | P=0.291 | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Prostate | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 48/100 (48%) 52/100 (52%) | | |POLY-3 ADJUSTED (b)| 52.8% 59.1% | | |TERMINAL (d) | 30/57 (53%) 35/59 (59%) | | |FIRST INCIDENCE | 581 557 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.384 | | |POLY 3 | P=0.236 | | |POLY 1.5 | P=0.273 | | |POLY 6 | P=0.208 | | |LOGISTIC REGRESSION| P=0.266 | | |COCH-ARM / FISHERS | P=0.336 | | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 51 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Prostate | | Inflammation Acute | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/100 (4%) 14/100 (14%) | | |POLY-3 ADJUSTED (b)| 4.6% 16.2% | | |TERMINAL (d) | 2/57 (4%) 8/59 (14%) | | |FIRST INCIDENCE | 527 489 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.015 * | | |POLY 3 | P=0.011 * | | |POLY 1.5 | P=0.011 * | | |POLY 6 | P=0.012 * | | |LOGISTIC REGRESSION| P=0.015 * | | |COCH-ARM / FISHERS | P=0.012 * | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Prostate | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 42/100 (42%) 47/100 (47%) | | |POLY-3 ADJUSTED (b)| 45.8% 50.8% | | |TERMINAL (d) | 20/57 (35%) 23/59 (39%) | | |FIRST INCIDENCE | 476 306 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.337 | | |POLY 3 | P=0.295 | | |POLY 1.5 | P=0.294 | | |POLY 6 | P=0.299 | | |LOGISTIC REGRESSION| P=0.294 | | |COCH-ARM / FISHERS | P=0.285 | | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 52 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Prostate: Epithelium | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 10/100 (10%) 12/100 (12%) | | |POLY-3 ADJUSTED (b)| 11.6% 14.3% | | |TERMINAL (d) | 9/57 (16%) 12/59 (20%) | | |FIRST INCIDENCE | 701 736 (T) | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.443 | | |POLY 3 | P=0.387 | | |POLY 1.5 | P=0.395 | | |POLY 6 | P=0.384 | | |LOGISTIC REGRESSION| P=0.447 | | |COCH-ARM / FISHERS | P=0.411 | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Salivary Glands: Parotid Gland | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 0/100 (0%) | 3/100 (3%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.5% 2.4% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 2/59 (3%) 1/58 (2%) | |FIRST INCIDENCE | --- --- | 553 641 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | (e) | P=0.511N | |POLY 3 | (e) | P=0.513N | |POLY 1.5 | (e) | P=0.510N | |POLY 6 | (e) | P=0.511N | |LOGISTIC REGRESSION| (e) | P=0.495N | |COCH-ARM / FISHERS | (e) | P=0.500N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 53 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Seminal Vesicle | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 84/100 (84%) 79/100 (79%) | | |POLY-3 ADJUSTED (b)| 87.9% 82.4% | | |TERMINAL (d) | 49/57 (86%) 47/59 (80%) | | |FIRST INCIDENCE | 549 306 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.305N | | |POLY 3 | P=0.177N | | |POLY 1.5 | P=0.186N | | |POLY 6 | P=0.189N | | |LOGISTIC REGRESSION| P=0.275N | | |COCH-ARM / FISHERS | P=0.233N | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Seminal Vesicle | | Dilatation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/100 (0%) 4/100 (4%) | | |POLY-3 ADJUSTED (b)| 0.0% 4.8% | | |TERMINAL (d) | 0/57 (0%) 3/59 (5%) | | |FIRST INCIDENCE | --- 715 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.072 | | |POLY 3 | P=0.061 | | |POLY 1.5 | P=0.062 | | |POLY 6 | P=0.061 | | |LOGISTIC REGRESSION| P=0.065 | | |COCH-ARM / FISHERS | P=0.061 | | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 54 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Skin | | Cyst Epithelial Inclusion | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 3/100 (3%) | 0/100 (0%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 0.0% 3.5% | 0.0% 1.2% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 0/59 (0%) 1/58 (2%) | |FIRST INCIDENCE | --- 557 | --- 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.126 | P=0.497 | |POLY 3 | P=0.121 | P=0.500 | |POLY 1.5 | P=0.121 | P=0.500 | |POLY 6 | P=0.121 | P=0.500 | |LOGISTIC REGRESSION| P=0.130 | P=0.497 | |COCH-ARM / FISHERS | P=0.125 | P=0.500 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Spleen | | Fibrosis | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/100 (1%) 1/100 (1%) | 0/100 (0%) 2/99 (2%) | |POLY-3 ADJUSTED (b)| 1.2% 1.2% | 0.0% 2.4% | |TERMINAL (d) | 1/57 (2%) 1/59 (2%) | 0/59 (0%) 1/58 (2%) | |FIRST INCIDENCE | 736 (T) 736 (T) | --- 701 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.754N | P=0.244 | |POLY 3 | P=0.758 | P=0.236 | |POLY 1.5 | P=0.759 | P=0.236 | |POLY 6 | P=0.758 | P=0.237 | |LOGISTIC REGRESSION| P=0.754N | P=0.234 | |COCH-ARM / FISHERS | P=0.751N | P=0.246 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 55 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Spleen | | Hematopoietic Cell Proliferation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 14/100 (14%) 16/100 (16%) | 15/100 (15%) 28/99 (28%) | |POLY-3 ADJUSTED (b)| 16.0% 18.4% | 16.8% 32.5% | |TERMINAL (d) | 7/57 (12%) 8/59 (14%) | 5/59 (9%) 21/58 (36%) | |FIRST INCIDENCE | 583 535 | 462 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.425 | P=0.022 * | |POLY 3 | P=0.415 | P=0.011 * | |POLY 1.5 | P=0.415 | P=0.013 * | |POLY 6 | P=0.422 | P=0.010 * | |LOGISTIC REGRESSION| P=0.424 | P=0.018 * | |COCH-ARM / FISHERS | P=0.422 | P=0.017 * | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Spleen | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 12/100 (12%) 19/100 (19%) | 54/100 (54%) 46/99 (46%) | |POLY-3 ADJUSTED (b)| 13.7% 21.7% | 58.5% 50.0% | |TERMINAL (d) | 7/57 (12%) 12/59 (20%) | 36/59 (61%) 26/58 (45%) | |FIRST INCIDENCE | 476 365 | 494 434 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.131 | P=0.228N | |POLY 3 | P=0.113 | P=0.150N | |POLY 1.5 | P=0.116 | P=0.164N | |POLY 6 | P=0.114 | P=0.128N | |LOGISTIC REGRESSION| P=0.131 | P=0.175N | |COCH-ARM / FISHERS | P=0.120 | P=0.178N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 56 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Spleen: Lymphoid Follicle | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/100 (1%) 3/100 (3%) | 6/100 (6%) 6/99 (6%) | |POLY-3 ADJUSTED (b)| 1.2% 3.6% | 6.8% 7.0% | |TERMINAL (d) | 0/57 (0%) 2/59 (3%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 725 577 | 543 448 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.311 | P=0.591 | |POLY 3 | P=0.302 | P=0.603 | |POLY 1.5 | P=0.304 | P=0.604 | |POLY 6 | P=0.303 | P=0.606 | |LOGISTIC REGRESSION| P=0.304 | P=0.483N | |COCH-ARM / FISHERS | P=0.311 | P=0.609 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Forestomach | | Edema | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/100 (3%) 6/100 (6%) | 3/100 (3%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 3.5% 7.1% | 3.5% 0.0% | |TERMINAL (d) | 0/57 (0%) 1/59 (2%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 674 557 | 495 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.267 | P=0.134N | |POLY 3 | P=0.239 | P=0.130N | |POLY 1.5 | P=0.242 | P=0.127N | |POLY 6 | P=0.239 | P=0.131N | |LOGISTIC REGRESSION| P=0.243 | P=0.079N | |COCH-ARM / FISHERS | P=0.249 | P=0.123N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 57 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Forestomach | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/100 (3%) 4/100 (4%) | 1/100 (1%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 3.5% 4.7% | 1.2% 2.4% | |TERMINAL (d) | 0/57 (0%) 1/59 (2%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 527 555 | 598 602 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.488 | P=0.491 | |POLY 3 | P=0.488 | P=0.495 | |POLY 1.5 | P=0.492 | P=0.496 | |POLY 6 | P=0.488 | P=0.496 | |LOGISTIC REGRESSION| P=0.530 | P=0.534 | |COCH-ARM / FISHERS | P=0.500 | P=0.500 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Forestomach | | Ulcer | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/100 (1%) 7/100 (7%) | 3/100 (3%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 1.2% 8.1% | 3.5% 1.2% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 647 535 | 553 535 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.034 * | P=0.321N | |POLY 3 | P=0.034 * | P=0.319N | |POLY 1.5 | P=0.034 * | P=0.316N | |POLY 6 | P=0.036 * | P=0.320N | |LOGISTIC REGRESSION| P=0.042 * | P=0.210N | |COCH-ARM / FISHERS | P=0.032 * | P=0.311N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 58 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Forestomach: Epithelium | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 6/100 (6%) 7/100 (7%) | 7/100 (7%) 10/100 (10%) | |POLY-3 ADJUSTED (b)| 6.9% 8.2% | 7.9% 11.5% | |TERMINAL (d) | 1/57 (2%) 1/59 (2%) | 0/59 (0%) 2/58 (3%) | |FIRST INCIDENCE | 527 535 | 553 480 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.496 | P=0.293 | |POLY 3 | P=0.486 | P=0.291 | |POLY 1.5 | P=0.490 | P=0.295 | |POLY 6 | P=0.486 | P=0.292 | |LOGISTIC REGRESSION| P=0.525 | P=0.416 | |COCH-ARM / FISHERS | P=0.500 | P=0.307 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Glandular | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/100 (3%) 0/100 (0%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 3.5% 0.0% | 0.0% 0.0% | |TERMINAL (d) | 1/57 (2%) 0/59 (0%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 649 --- | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.126N | (e) | |POLY 3 | P=0.128N | (e) | |POLY 1.5 | P=0.126N | (e) | |POLY 6 | P=0.128N | (e) | |LOGISTIC REGRESSION| P=0.125N | (e) | |COCH-ARM / FISHERS | P=0.123N | (e) | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 59 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Glandular | | Edema | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/100 (2%) 0/100 (0%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 2.3% 0.0% | 0.0% 0.0% | |TERMINAL (d) | 1/57 (2%) 0/59 (0%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 701 --- | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.231N | (e) | |POLY 3 | P=0.247N | (e) | |POLY 1.5 | P=0.244N | (e) | |POLY 6 | P=0.247N | (e) | |LOGISTIC REGRESSION| P=0.243N | (e) | |COCH-ARM / FISHERS | P=0.249N | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Glandular | | Erosion Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 9/100 (9%) 11/100 (11%) | 5/100 (5%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| 10.2% 12.6% | 5.7% 3.5% | |TERMINAL (d) | 0/57 (0%) 1/59 (2%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 527 527 | 553 575 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.396 | P=0.372N | |POLY 3 | P=0.401 | P=0.379N | |POLY 1.5 | P=0.402 | P=0.373N | |POLY 6 | P=0.406 | P=0.381N | |LOGISTIC REGRESSION| P=0.456 | P=0.269N | |COCH-ARM / FISHERS | P=0.407 | P=0.360N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 60 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Stomach, Glandular: Glands | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/100 (4%) 2/100 (2%) | 12/100 (12%) 12/100 (12%) | |POLY-3 ADJUSTED (b)| 4.7% 2.4% | 13.8% 13.8% | |TERMINAL (d) | 2/57 (4%) 1/59 (2%) | 7/59 (12%) 2/58 (3%) | |FIRST INCIDENCE | 690 716 | 597 505 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.321N | P=0.568 | |POLY 3 | P=0.353N | P=0.585 | |POLY 1.5 | P=0.348N | P=0.581 | |POLY 6 | P=0.354N | P=0.575N | |LOGISTIC REGRESSION| P=0.347N | P=0.561N | |COCH-ARM / FISHERS | P=0.341N | P=0.586N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Testes | | Mineralization | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/100 (3%) 1/100 (1%) | | |POLY-3 ADJUSTED (b)| 3.5% 1.2% | | |TERMINAL (d) | 1/57 (2%) 1/59 (2%) | | |FIRST INCIDENCE | 647 736 (T) | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.319N | | |POLY 3 | P=0.320N | | |POLY 1.5 | P=0.316N | | |POLY 6 | P=0.323N | | |LOGISTIC REGRESSION| P=0.308N | | |COCH-ARM / FISHERS | P=0.311N | | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 61 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Testes: Germinal Epithelium | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 10/100 (10%) 13/100 (13%) | | |POLY-3 ADJUSTED (b)| 11.6% 15.3% | | |TERMINAL (d) | 8/57 (14%) 8/59 (14%) | | |FIRST INCIDENCE | 647 570 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.343 | | |POLY 3 | P=0.313 | | |POLY 1.5 | P=0.318 | | |POLY 6 | P=0.317 | | |LOGISTIC REGRESSION| P=0.307 | | |COCH-ARM / FISHERS | P=0.329 | | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Testes: Interstitial Cell | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 11/100 (11%) 24/100 (24%) | | |POLY-3 ADJUSTED (b)| 12.5% 26.2% | | |TERMINAL (d) | 6/57 (11%) 8/59 (14%) | | |FIRST INCIDENCE | 502 365 | | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.016 * | | |POLY 3 | P=0.016 * | | |POLY 1.5 | P=0.014 * | | |POLY 6 | P=0.020 * | | |LOGISTIC REGRESSION| P=0.017 * | | |COCH-ARM / FISHERS | P=0.012 * | | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 62 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thymus | | Atrophy | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 58/97 (60%) 44/95 (46%) | 51/95 (54%) 43/92 (47%) | |POLY-3 ADJUSTED (b)| 65.2% 49.9% | 57.1% 50.1% | |TERMINAL (d) | 39/55 (71%) 25/56 (45%) | 28/56 (50%) 24/57 (42%) | |FIRST INCIDENCE | 406 365 | 462 430 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.053N | P=0.205N | |POLY 3 | P=0.024N* | P=0.216N | |POLY 1.5 | P=0.031N* | P=0.217N | |POLY 6 | P=0.017N* | P=0.208N | |LOGISTIC REGRESSION| P=0.046N* | P=0.205N | |COCH-ARM / FISHERS | P=0.042N* | P=0.211N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thymus | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/97 (1%) 2/95 (2%) | 1/95 (1%) 2/92 (2%) | |POLY-3 ADJUSTED (b)| 1.2% 2.5% | 1.2% 2.6% | |TERMINAL (d) | 1/55 (2%) 0/56 (0%) | 0/56 (0%) 2/57 (4%) | |FIRST INCIDENCE | 736 (T) 559 | 736 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.496 | P=0.500 | |POLY 3 | P=0.491 | P=0.493 | |POLY 1.5 | P=0.492 | P=0.492 | |POLY 6 | P=0.493 | P=0.496 | |LOGISTIC REGRESSION| P=0.507 | P=0.501 | |COCH-ARM / FISHERS | P=0.492 | P=0.488 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 63 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thymus | | Hemorrhage | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/97 (2%) 0/95 (0%) | 2/95 (2%) 5/92 (5%) | |POLY-3 ADJUSTED (b)| 2.4% 0.0% | 2.4% 6.2% | |TERMINAL (d) | 0/55 (0%) 0/56 (0%) | 0/56 (0%) 1/57 (2%) | |FIRST INCIDENCE | 695 --- | 494 434 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.233N | P=0.219 | |POLY 3 | P=0.256N | P=0.214 | |POLY 1.5 | P=0.252N | P=0.211 | |POLY 6 | P=0.257N | P=0.220 | |LOGISTIC REGRESSION| P=0.246N | P=0.271 | |COCH-ARM / FISHERS | P=0.254N | P=0.209 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thymus: Epithelial Cell | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/97 (2%) 2/95 (2%) | 3/95 (3%) 2/92 (2%) | |POLY-3 ADJUSTED (b)| 2.4% 2.5% | 3.7% 2.5% | |TERMINAL (d) | 1/55 (2%) 1/56 (2%) | 2/56 (4%) 1/57 (2%) | |FIRST INCIDENCE | 725 586 | 602 591 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.691 | P=0.502N | |POLY 3 | P=0.682 | P=0.517N | |POLY 1.5 | P=0.683 | P=0.519N | |POLY 6 | P=0.683 | P=0.509N | |LOGISTIC REGRESSION| P=0.682 | P=0.512N | |COCH-ARM / FISHERS | P=0.682 | P=0.515N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 64 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thyroid Gland | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 0/100 (0%) | 0/100 (0%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 2.3% 0.0% | 0.0% 0.0% | |TERMINAL (d) | 1/57 (2%) 0/59 (0%) | 0/59 (0%) 0/58 (0%) | |FIRST INCIDENCE | 627 --- | --- --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.248N | (e) | |POLY 3 | P=0.245N | (e) | |POLY 1.5 | P=0.241N | (e) | |POLY 6 | P=0.247N | (e) | |LOGISTIC REGRESSION| P=0.234N | (e) | |COCH-ARM / FISHERS | P=0.246N | (e) | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thyroid Gland | | Ultimobranchial Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 3/100 (3%) | 2/100 (2%) 3/100 (3%) | |POLY-3 ADJUSTED (b)| 1.2% 3.6% | 2.3% 3.5% | |TERMINAL (d) | 0/57 (0%) 3/59 (5%) | 2/59 (3%) 1/58 (2%) | |FIRST INCIDENCE | 701 736 (T) | 737 (T) 526 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.321 | P=0.491 | |POLY 3 | P=0.302 | P=0.497 | |POLY 1.5 | P=0.305 | P=0.497 | |POLY 6 | P=0.301 | P=0.501 | |LOGISTIC REGRESSION| P=0.305 | P=0.511 | |COCH-ARM / FISHERS | P=0.314 | P=0.500 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 65 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/99 (0%) 2/100 (2%) | 18/100 (18%) 0/100 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 2.4% | 20.7% 0.0% | |TERMINAL (d) | 0/57 (0%) 2/59 (3%) | 13/59 (22%) 0/58 (0%) | |FIRST INCIDENCE | --- 736 (T) | 598 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.246 | P<0.001N** | |POLY 3 | P=0.237 | P<0.001N** | |POLY 1.5 | P=0.238 | P<0.001N** | |POLY 6 | P=0.236 | P<0.001N** | |LOGISTIC REGRESSION| P=0.246 | P<0.001N** | |COCH-ARM / FISHERS | P=0.251 | P<0.001N** | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Hyperplasia Diffuse | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/99 (4%) 0/100 (0%) | 2/100 (2%) 2/100 (2%) | |POLY-3 ADJUSTED (b)| 4.7% 0.0% | 2.3% 2.4% | |TERMINAL (d) | 3/57 (5%) 0/59 (0%) | 1/59 (2%) 0/58 (0%) | |FIRST INCIDENCE | 661 --- | 655 628 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.063N | P=0.689 | |POLY 3 | P=0.066N | P=0.688 | |POLY 1.5 | P=0.065N | P=0.689 | |POLY 6 | P=0.067N | P=0.690 | |LOGISTIC REGRESSION| P=0.066N | P=0.691N | |COCH-ARM / FISHERS | P=0.059N | P=0.689N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 66 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Hyperplasia Focal | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 29/99 (29%) 31/100 (31%) | 20/100 (20%) 30/100 (30%) | |POLY-3 ADJUSTED (b)| 33.4% 35.9% | 23.1% 35.3% | |TERMINAL (d) | 23/57 (40%) 21/59 (36%) | 15/59 (25%) 23/58 (40%) | |FIRST INCIDENCE | 579 570 | 553 575 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.473 | P=0.065 | |POLY 3 | P=0.427 | P=0.053 | |POLY 1.5 | P=0.435 | P=0.057 | |POLY 6 | P=0.436 | P=0.052 | |LOGISTIC REGRESSION| P=0.401 | P=0.056 | |COCH-ARM / FISHERS | P=0.457 | P=0.071 | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Thyroid Gland: Follicle | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/99 (3%) 3/100 (3%) | 1/100 (1%) 1/100 (1%) | |POLY-3 ADJUSTED (b)| 3.5% 3.6% | 1.2% 1.2% | |TERMINAL (d) | 3/57 (5%) 2/59 (3%) | 1/59 (2%) 1/58 (2%) | |FIRST INCIDENCE | 736 (T) 535 | 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.648N | P=0.757 | |POLY 3 | P=0.658 | P=0.758 | |POLY 1.5 | P=0.660 | P=0.759 | |POLY 6 | P=0.659 | P=0.759 | |LOGISTIC REGRESSION| P=0.658 | P=0.757 | |COCH-ARM / FISHERS | P=0.654N | P=0.751N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 67 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Tooth | | Malformation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/2 (0%) 5/6 (83%) | 1/2 (50%) 0/1 (0%) | |POLY-3 ADJUSTED (b)| 0.0% 83.3% | 64.7% 0.0% | |TERMINAL (d) | 0/1 (0%) 3/4 (75%) | 1/1 (100%) 0/0 (0%) | |FIRST INCIDENCE | --- 557 | 737 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.103 | P=1.000N | |POLY 3 | P=0.020 * | P=0.682N | |POLY 1.5 | P=0.017 * | P=0.697N | |POLY 6 | P=0.028 * | P=0.670N | |LOGISTIC REGRESSION| P=0.114 | (e) | |COCH-ARM / FISHERS | P=0.107 | P=0.667N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Trachea | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 11/100 (11%) 12/100 (12%) | 6/100 (6%) 5/100 (5%) | |POLY-3 ADJUSTED (b)| 12.7% 14.2% | 7.0% 6.0% | |TERMINAL (d) | 8/57 (14%) 9/59 (15%) | 4/59 (7%) 3/58 (5%) | |FIRST INCIDENCE | 617 666 | 646 653 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.527 | P=0.515N | |POLY 3 | P=0.473 | P=0.517N | |POLY 1.5 | P=0.482 | P=0.513N | |POLY 6 | P=0.469 | P=0.516N | |LOGISTIC REGRESSION| P=0.479 | P=0.513N | |COCH-ARM / FISHERS | P=0.500 | P=0.500N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 68 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Urinary Bladder | | Edema | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/99 (2%) 0/99 (0%) | 1/99 (1%) 0/96 (0%) | |POLY-3 ADJUSTED (b)| 2.3% 0.0% | 1.2% 0.0% | |TERMINAL (d) | 1/57 (2%) 0/59 (0%) | 0/59 (0%) 0/57 (0%) | |FIRST INCIDENCE | 527 --- | 674 --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.236N | P=0.503N | |POLY 3 | P=0.249N | P=0.520N | |POLY 1.5 | P=0.245N | P=0.518N | |POLY 6 | P=0.251N | P=0.519N | |LOGISTIC REGRESSION| P=0.223N | P=0.501N | |COCH-ARM / FISHERS | P=0.249N | P=0.508N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Urinary Bladder | | Infiltration Cellular Lymphocyte | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/99 (4%) 7/99 (7%) | 10/99 (10%) 10/96 (10%) | |POLY-3 ADJUSTED (b)| 4.7% 8.4% | 11.8% 12.2% | |TERMINAL (d) | 4/57 (7%) 5/59 (9%) | 9/59 (15%) 8/57 (14%) | |FIRST INCIDENCE | 736 (T) 677 | 710 505 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.287 | P=0.566 | |POLY 3 | P=0.256 | P=0.559 | |POLY 1.5 | P=0.260 | P=0.559 | |POLY 6 | P=0.257 | P=0.566 | |LOGISTIC REGRESSION| P=0.261 | P=0.558 | |COCH-ARM / FISHERS | P=0.269 | P=0.564 | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 69 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Urinary Bladder: Transitional Epithelium | | Hyperplasia | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/99 (1%) 2/99 (2%) | 2/99 (2%) 0/96 (0%) | |POLY-3 ADJUSTED (b)| 1.2% 2.4% | 2.4% 0.0% | |TERMINAL (d) | 0/57 (0%) 0/59 (0%) | 2/59 (3%) 0/57 (0%) | |FIRST INCIDENCE | 579 306 | 737 (T) --- | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | P=0.479 | P=0.246N | |POLY 3 | P=0.497 | P=0.254N | |POLY 1.5 | P=0.498 | P=0.253N | |POLY 6 | P=0.497 | P=0.252N | |LOGISTIC REGRESSION| P=0.570 | (e) | |COCH-ARM / FISHERS | P=0.500 | P=0.256N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus | | Hydrometra | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 9/100 (9%) 6/99 (6%) | |POLY-3 ADJUSTED (b)| | 10.4% 7.2% | |TERMINAL (d) | | 7/59 (12%) 5/58 (9%) | |FIRST INCIDENCE | | 462 653 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.309N | |POLY 3 | | P=0.322N | |POLY 1.5 | | P=0.318N | |POLY 6 | | P=0.319N | |LOGISTIC REGRESSION| | P=0.312N | |COCH-ARM / FISHERS | | P=0.303N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 70 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus | | Pigmentation | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 2/100 (2%) 1/99 (1%) | |POLY-3 ADJUSTED (b)| | 2.3% 1.2% | |TERMINAL (d) | | 1/59 (2%) 0/58 (0%) | |FIRST INCIDENCE | | 565 668 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.509N | |POLY 3 | | P=0.514N | |POLY 1.5 | | P=0.512N | |POLY 6 | | P=0.512N | |LOGISTIC REGRESSION| | P=0.483N | |COCH-ARM / FISHERS | | P=0.504N | |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus: Cervix | | Inflammation Chronic | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 2/100 (2%) 1/99 (1%) | |POLY-3 ADJUSTED (b)| | 2.3% 1.2% | |TERMINAL (d) | | 2/59 (3%) 1/58 (2%) | |FIRST INCIDENCE | | 737 (T) 737 (T) | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.506N | |POLY 3 | | P=0.513N | |POLY 1.5 | | P=0.511N | |POLY 6 | | P=0.510N | |LOGISTIC REGRESSION| | P=0.506N | |COCH-ARM / FISHERS | | P=0.504N | |=================================================================================================================================| Date: 01/28/98 EXPERIMENT: 89029 TEST: 05 Page 71 Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - MAGNETIC FIELDS (EMF) Terminal Sacrifice at 105 weeks |=================================================================================================================================| | | | | | | Males | Females | |Dose | SHAM 10 GAUSS | SHAM 10 GAUSS | | | CONTROL INTER. | CONTROL INTER. | |=================================================================================================================================| | | |Uterus: Endometrium | | Cyst | | | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | | 3/100 (3%) 9/99 (9%) | |POLY-3 ADJUSTED (b)| | 3.5% 10.6% | |TERMINAL (d) | | 3/59 (5%) 4/58 (7%) | |FIRST INCIDENCE | | 737 (T) 535 | |-------------------| | | |STATISTICAL TESTS | | | |-------------------| | | |LIFE TABLE | | P=0.068 | |POLY 3 | | P=0.064 | |POLY 1.5 | | P=0.063 | |POLY 6 | | P=0.067 | |LOGISTIC REGRESSION| | P=0.063 | |COCH-ARM / FISHERS | | P=0.065 | |=================================================================================================================================| (a) Number of tumor-bearing animals / number of animals examined at site. (b) Poly-3 adjusted lifetime tumor incidence. (d) Observed incidence at terminal kill. (f) Beneath the control incidence are the P-values associated with the trend test. Beneath the dosed group incidence are the P-values corresponding to pairwise comparisons between the controls and that dosed group. The life table analysis regards tumors in animals dying prior to terminal kill as being (directly or indirectly) the cause of death. Logistic regression is an alternative method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage and Fishers exact tests compare directly the overall incidence rates For all tests a negative trend is indicated by N (e) Value of Statistic cannot be computed. (I) Interim sacrifice (T) Terminal sacrifice # Tumor rates based on number of animals necropsied. * To the right of any statistical result, indicates significance at (P<=0.05). ** To the right of any statistical result, indicates significance at (P<=0.01).