TDMS Study 89029-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/06/98
EXPERIMENT: 89029 TEST: 06 TIME: 08:58:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029
PATHOLOGIST: PLETCHER, J CAS: ELECTROMAG
Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/06/98
EXPERIMENT: 89029 TEST: 06 TIME: 08:58:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029
PATHOLOGIST: PLETCHER, J CAS: ELECTROMAG
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF MAGNETIC FIELDS (EMF)
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
All Organs Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type
Malignant and Benign Tumors
===============================================================
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 1
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/99 (3%) 0/97 (0%) | 0/92 (0%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 3.3% 0.0% | 0.0% 0.0% |
|TERMINAL (d) | 3/76 (4%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 734 (T) --- | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.130N | (e) |
|POLY 3 | P=0.133N | (e) |
|POLY 1.5 | P=0.131N | (e) |
|POLY 6 | P=0.136N | (e) |
|LOGISTIC REGRESSION| (e) | (e) |
|COCH-ARM / FISHERS | P=0.127N | (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 12/100 (12%) 11/100 (11%) | 10/100 (10%) 13/100 (13%) |
|POLY-3 ADJUSTED (b)| 13.0% 12.0% | 11.0% 14.4% |
|TERMINAL (d) | 11/76 (15%) 8/74 (11%) | 7/70 (10%) 12/77 (16%) |
|FIRST INCIDENCE | 716 533 | 625 715 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.528N | P=0.404 |
|POLY 3 | P=0.511N | P=0.323 |
|POLY 1.5 | P=0.507N | P=0.328 |
|POLY 6 | P=0.515N | P=0.315 |
|LOGISTIC REGRESSION| P=0.514N | P=0.323 |
|COCH-ARM / FISHERS | P=0.500N | P=0.329 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 2
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 3/100 (3%) | 2/100 (2%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 3.3% | 2.2% 0.0% |
|TERMINAL (d) | 0/76 (0%) 3/74 (4%) | 2/70 (3%) 0/77 (0%) |
|FIRST INCIDENCE | --- 734 (T) | 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.118 | P=0.218N |
|POLY 3 | P=0.118 | P=0.238N |
|POLY 1.5 | P=0.120 | P=0.238N |
|POLY 6 | P=0.117 | P=0.240N |
|LOGISTIC REGRESSION| P=0.118 | (e) |
|COCH-ARM / FISHERS | P=0.123 | P=0.249N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 12/100 (12%) 14/100 (14%) | 12/100 (12%) 13/100 (13%) |
|POLY-3 ADJUSTED (b)| 13.0% 15.3% | 13.2% 14.4% |
|TERMINAL (d) | 11/76 (15%) 11/74 (15%) | 9/70 (13%) 12/77 (16%) |
|FIRST INCIDENCE | 716 533 | 625 715 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.388 | P=0.584 |
|POLY 3 | P=0.405 | P=0.495 |
|POLY 1.5 | P=0.409 | P=0.500 |
|POLY 6 | P=0.402 | P=0.486 |
|LOGISTIC REGRESSION| P=0.397 | P=0.494 |
|COCH-ARM / FISHERS | P=0.417 | P=0.500 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 3
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 1/98 (1%) | 2/87 (2%) 3/94 (3%) |
|POLY-3 ADJUSTED (b)| 1.1% 1.1% | 2.4% 3.5% |
|TERMINAL (d) | 1/76 (1%) 0/74 (0%) | 1/70 (1%) 3/76 (4%) |
|FIRST INCIDENCE | 734 (T) 666 | 542 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.754 | P=0.531 |
|POLY 3 | P=0.757 | P=0.518 |
|POLY 1.5 | P=0.758 | P=0.522 |
|POLY 6 | P=0.756 | P=0.513 |
|LOGISTIC REGRESSION| P=0.761N | P=0.541 |
|COCH-ARM / FISHERS | P=0.749 | P=0.537 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/99 (3%) 1/98 (1%) | 2/87 (2%) 3/94 (3%) |
|POLY-3 ADJUSTED (b)| 3.2% 1.1% | 2.4% 3.5% |
|TERMINAL (d) | 2/76 (3%) 0/74 (0%) | 1/70 (1%) 3/76 (4%) |
|FIRST INCIDENCE | 534 666 | 542 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.318N | P=0.531 |
|POLY 3 | P=0.324N | P=0.518 |
|POLY 1.5 | P=0.319N | P=0.522 |
|POLY 6 | P=0.328N | P=0.513 |
|LOGISTIC REGRESSION| P=0.283N | P=0.541 |
|COCH-ARM / FISHERS | P=0.314N | P=0.537 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 4
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 0/97 (0%) | 0/92 (0%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% | 0.0% 0.0% |
|TERMINAL (d) | 1/76 (1%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 534 --- | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.246N | (e) |
|POLY 3 | P=0.259N | (e) |
|POLY 1.5 | P=0.253N | (e) |
|POLY 6 | P=0.265N | (e) |
|LOGISTIC REGRESSION| P=0.207N | (e) |
|COCH-ARM / FISHERS | P=0.254N | (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/100 (4%) 4/99 (4%) | 1/98 (1%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 4.3% 4.5% | 1.1% 0.0% |
|TERMINAL (d) | 1/76 (1%) 3/74 (4%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 582 666 | 723 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.622 | P=0.500N |
|POLY 3 | P=0.622 | P=0.496N |
|POLY 1.5 | P=0.627 | P=0.493N |
|POLY 6 | P=0.616 | P=0.500N |
|LOGISTIC REGRESSION| P=0.633N | P=0.498N |
|COCH-ARM / FISHERS | P=0.634 | P=0.495N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 5
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Hepatoblastoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 5/99 (5%) | 0/98 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 2.2% 5.5% | 0.0% 0.0% |
|TERMINAL (d) | 1/76 (1%) 2/74 (3%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 731 666 | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.209 | (e) |
|POLY 3 | P=0.212 | (e) |
|POLY 1.5 | P=0.214 | (e) |
|POLY 6 | P=0.211 | (e) |
|LOGISTIC REGRESSION| P=0.217 | (e) |
|COCH-ARM / FISHERS | P=0.218 | (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 30/100 (30%) 32/99 (32%) | 17/98 (17%) 13/100 (13%) |
|POLY-3 ADJUSTED (b)| 32.3% 35.3% | 19.0% 14.3% |
|TERMINAL (d) | 28/76 (37%) 29/74 (39%) | 16/70 (23%) 11/77 (14%) |
|FIRST INCIDENCE | 646 415 | 667 679 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.385 | P=0.198N |
|POLY 3 | P=0.391 | P=0.262N |
|POLY 1.5 | P=0.403 | P=0.257N |
|POLY 6 | P=0.377 | P=0.270N |
|LOGISTIC REGRESSION| P=0.363 | P=0.277N |
|COCH-ARM / FISHERS | P=0.420 | P=0.257N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 6
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/100 (19%) 23/99 (23%) | 6/98 (6%) 6/100 (6%) |
|POLY-3 ADJUSTED (b)| 19.8% 24.4% | 6.7% 6.6% |
|TERMINAL (d) | 8/76 (11%) 9/74 (12%) | 4/70 (6%) 5/77 (7%) |
|FIRST INCIDENCE | 520 456 | 691 679 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.279 | P=0.573N |
|POLY 3 | P=0.279 | P=0.610N |
|POLY 1.5 | P=0.283 | P=0.604N |
|POLY 6 | P=0.278 | P=0.617 |
|LOGISTIC REGRESSION| P=0.366 | P=0.613N |
|COCH-ARM / FISHERS | P=0.289 | P=0.602N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/100 (21%) 27/99 (27%) | 6/98 (6%) 6/100 (6%) |
|POLY-3 ADJUSTED (b)| 21.9% 28.5% | 6.7% 6.6% |
|TERMINAL (d) | 9/76 (12%) 11/74 (15%) | 4/70 (6%) 5/77 (7%) |
|FIRST INCIDENCE | 520 456 | 691 679 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.194 | P=0.573N |
|POLY 3 | P=0.189 | P=0.610N |
|POLY 1.5 | P=0.189 | P=0.604N |
|POLY 6 | P=0.191 | P=0.617 |
|LOGISTIC REGRESSION| P=0.248 | P=0.613N |
|COCH-ARM / FISHERS | P=0.193 | P=0.602N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 7
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 46/100 (46%) 52/99 (53%) | 22/98 (22%) 18/100 (18%) |
|POLY-3 ADJUSTED (b)| 47.8% 54.5% | 24.5% 19.8% |
|TERMINAL (d) | 34/76 (45%) 36/74 (49%) | 19/70 (27%) 16/77 (21%) |
|FIRST INCIDENCE | 520 415 | 667 679 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.212 | P=0.208N |
|POLY 3 | P=0.215 | P=0.284N |
|POLY 1.5 | P=0.217 | P=0.276N |
|POLY 6 | P=0.215 | P=0.299N |
|LOGISTIC REGRESSION| P=0.231 | P=0.298N |
|COCH-ARM / FISHERS | P=0.218 | P=0.274N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, |
| or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 47/100 (47%) 55/99 (56%) | 22/98 (22%) 18/100 (18%) |
|POLY-3 ADJUSTED (b)| 48.8% 57.4% | 24.5% 19.8% |
|TERMINAL (d) | 34/76 (45%) 37/74 (50%) | 19/70 (27%) 16/77 (21%) |
|FIRST INCIDENCE | 520 415 | 667 679 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.150 | P=0.208N |
|POLY 3 | P=0.147 | P=0.284N |
|POLY 1.5 | P=0.145 | P=0.276N |
|POLY 6 | P=0.153 | P=0.299N |
|LOGISTIC REGRESSION| P=0.153 | P=0.298N |
|COCH-ARM / FISHERS | P=0.143 | P=0.274N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 8
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 26/100 (26%) 16/99 (16%) | 9/95 (9%) 6/100 (6%) |
|POLY-3 ADJUSTED (b)| 28.0% 17.9% | 10.2% 6.6% |
|TERMINAL (d) | 22/76 (29%) 15/74 (20%) | 7/70 (10%) 6/77 (8%) |
|FIRST INCIDENCE | 683 672 | 551 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.074N | P=0.239N |
|POLY 3 | P=0.073N | P=0.275N |
|POLY 1.5 | P=0.069N | P=0.267N |
|POLY 6 | P=0.078N | P=0.286N |
|LOGISTIC REGRESSION| P=0.077N | P=0.272N |
|COCH-ARM / FISHERS | P=0.063N | P=0.261N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/100 (8%) 10/99 (10%) | 2/95 (2%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 8.6% 11.2% | 2.3% 1.1% |
|TERMINAL (d) | 7/76 (9%) 9/74 (12%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 715 668 | 701 656 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.376 | P=0.504N |
|POLY 3 | P=0.377 | P=0.483N |
|POLY 1.5 | P=0.383 | P=0.480N |
|POLY 6 | P=0.371 | P=0.489N |
|LOGISTIC REGRESSION| P=0.363 | P=0.480N |
|COCH-ARM / FISHERS | P=0.394 | P=0.481N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 9
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 30/100 (30%) 23/99 (23%) | 11/95 (12%) 7/100 (7%) |
|POLY-3 ADJUSTED (b)| 32.2% 25.6% | 12.5% 7.7% |
|TERMINAL (d) | 25/76 (33%) 21/74 (28%) | 7/70 (10%) 6/77 (8%) |
|FIRST INCIDENCE | 683 668 | 551 656 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.205N | P=0.189N |
|POLY 3 | P=0.203N | P=0.208N |
|POLY 1.5 | P=0.194N | P=0.201N |
|POLY 6 | P=0.214N | P=0.218N |
|LOGISTIC REGRESSION| P=0.215N | P=0.202N |
|COCH-ARM / FISHERS | P=0.179N | P=0.196N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) | 1/100 (1%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 1.1% 2.2% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 0/70 (0%) 2/77 (3%) |
|FIRST INCIDENCE | --- --- | 707 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.521 |
|POLY 3 | (e) | P=0.500 |
|POLY 1.5 | (e) | P=0.500 |
|POLY 6 | (e) | P=0.498 |
|LOGISTIC REGRESSION| (e) | P=0.499 |
|COCH-ARM / FISHERS | (e) | P=0.500 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 10
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) | 1/100 (1%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 1.1% 2.2% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 0/70 (0%) 2/77 (3%) |
|FIRST INCIDENCE | --- --- | 707 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.521 |
|POLY 3 | (e) | P=0.500 |
|POLY 1.5 | (e) | P=0.500 |
|POLY 6 | (e) | P=0.498 |
|LOGISTIC REGRESSION| (e) | P=0.499 |
|COCH-ARM / FISHERS | (e) | P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 3/79 (4%) 0/96 (0%) |
|POLY-3 ADJUSTED (b)| | 4.0% 0.0% |
|TERMINAL (d) | | 3/65 (5%) 0/77 (0%) |
|FIRST INCIDENCE | | 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | | P=0.094N |
|POLY 3 | | P=0.085N |
|POLY 1.5 | | P=0.083N |
|POLY 6 | | P=0.088N |
|LOGISTIC REGRESSION| | (e) |
|COCH-ARM / FISHERS | | P=0.090N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 11
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Ovary |
| Hemangioma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/79 (0%) 2/96 (2%) |
|POLY-3 ADJUSTED (b)| | 0.0% 2.3% |
|TERMINAL (d) | | 0/65 (0%) 2/77 (3%) |
|FIRST INCIDENCE | | --- 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | | P=0.277 |
|POLY 3 | | P=0.256 |
|POLY 1.5 | | P=0.257 |
|POLY 6 | | P=0.254 |
|LOGISTIC REGRESSION| | P=0.277 |
|COCH-ARM / FISHERS | | P=0.300 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/83 (0%) 0/86 (0%) | 17/83 (20%) 16/93 (17%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 21.9% 18.7% |
|TERMINAL (d) | 0/66 (0%) 0/67 (0%) | 16/67 (24%) 15/74 (20%) |
|FIRST INCIDENCE | --- --- | 625 710 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.382N |
|POLY 3 | (e) | P=0.373N |
|POLY 1.5 | (e) | P=0.364N |
|POLY 6 | (e) | P=0.388N |
|LOGISTIC REGRESSION| (e) | P=0.392N |
|COCH-ARM / FISHERS | (e) | P=0.358N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 12
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Skeletal Muscle |
| Rhabdomyosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) | 3/100 (3%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.3% 1.1% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 2/70 (3%) 0/77 (0%) |
|FIRST INCIDENCE | --- --- | 707 534 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.292N |
|POLY 3 | (e) | P=0.304N |
|POLY 1.5 | (e) | P=0.304N |
|POLY 6 | (e) | P=0.306N |
|LOGISTIC REGRESSION| (e) | P=0.312N |
|COCH-ARM / FISHERS | (e) | P=0.311N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, |
| or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 1/100 (1%) | 4/100 (4%) 5/100 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.1% | 4.4% 5.4% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 1/70 (1%) 2/77 (3%) |
|FIRST INCIDENCE | --- 605 | 625 481 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.496 | P=0.512 |
|POLY 3 | P=0.500 | P=0.505 |
|POLY 1.5 | P=0.500 | P=0.504 |
|POLY 6 | P=0.500 | P=0.503 |
|LOGISTIC REGRESSION| P=0.534 | P=0.483 |
|COCH-ARM / FISHERS | P=0.500 | P=0.500 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 13
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 1/100 (1%) | 4/100 (4%) 5/100 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.1% | 4.4% 5.4% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 1/70 (1%) 2/77 (3%) |
|FIRST INCIDENCE | --- 605 | 625 481 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.496 | P=0.512 |
|POLY 3 | P=0.500 | P=0.505 |
|POLY 1.5 | P=0.500 | P=0.504 |
|POLY 6 | P=0.500 | P=0.503 |
|LOGISTIC REGRESSION| P=0.534 | P=0.483 |
|COCH-ARM / FISHERS | P=0.500 | P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Skin |
| Neurofibrosarcoma, Neurofibroma, or Schwannoma (benign, |
| malignant or NOS) |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) | 2/100 (2%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 2.2% 2.2% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 1/70 (1%) 1/77 (1%) |
|FIRST INCIDENCE | --- --- | 608 656 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.678N |
|POLY 3 | (e) | P=0.692 |
|POLY 1.5 | (e) | P=0.692N |
|POLY 6 | (e) | P=0.691 |
|LOGISTIC REGRESSION| (e) | P=0.690 |
|COCH-ARM / FISHERS | (e) | P=0.689N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 14
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 1/100 (1%) | 4/100 (4%) 4/100 (4%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.1% | 4.4% 4.4% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 1/70 (1%) 2/77 (3%) |
|FIRST INCIDENCE | --- 605 | 625 580 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.496 | P=0.628N |
|POLY 3 | P=0.500 | P=0.640N |
|POLY 1.5 | P=0.500 | P=0.639N |
|POLY 6 | P=0.500 | P=0.639 |
|LOGISTIC REGRESSION| P=0.534 | P=0.636 |
|COCH-ARM / FISHERS | P=0.500 | P=0.640N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Skin |
| Schwannoma Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) | 2/100 (2%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 2.2% 2.2% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 1/70 (1%) 1/77 (1%) |
|FIRST INCIDENCE | --- --- | 608 656 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.678N |
|POLY 3 | (e) | P=0.692 |
|POLY 1.5 | (e) | P=0.692N |
|POLY 6 | (e) | P=0.691 |
|LOGISTIC REGRESSION| (e) | P=0.690 |
|COCH-ARM / FISHERS | (e) | P=0.689N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 15
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) | 0/100 (0%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 2.2% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 0/70 (0%) 2/77 (3%) |
|FIRST INCIDENCE | --- --- | --- 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.260 |
|POLY 3 | (e) | P=0.238 |
|POLY 1.5 | (e) | P=0.239 |
|POLY 6 | (e) | P=0.238 |
|LOGISTIC REGRESSION| (e) | P=0.260 |
|COCH-ARM / FISHERS | (e) | P=0.249 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 5/100 (5%) | 2/100 (2%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 6.4% 5.5% | 2.2% 3.3% |
|TERMINAL (d) | 3/76 (4%) 4/74 (5%) | 0/70 (0%) 3/77 (4%) |
|FIRST INCIDENCE | 582 666 | 707 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.520N | P=0.524 |
|POLY 3 | P=0.524N | P=0.499 |
|POLY 1.5 | P=0.515N | P=0.501 |
|POLY 6 | P=0.535N | P=0.497 |
|LOGISTIC REGRESSION| P=0.496N | P=0.498 |
|COCH-ARM / FISHERS | P=0.500N | P=0.500 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 16
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 5/100 (5%) | 2/100 (2%) 5/100 (5%) |
|POLY-3 ADJUSTED (b)| 6.4% 5.5% | 2.2% 5.5% |
|TERMINAL (d) | 3/76 (4%) 4/74 (5%) | 0/70 (0%) 5/77 (7%) |
|FIRST INCIDENCE | 582 666 | 707 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.520N | P=0.250 |
|POLY 3 | P=0.524N | P=0.220 |
|POLY 1.5 | P=0.515N | P=0.221 |
|POLY 6 | P=0.535N | P=0.218 |
|LOGISTIC REGRESSION| P=0.496N | P=0.218 |
|COCH-ARM / FISHERS | P=0.500N | P=0.222 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 1/100 (1%) | 2/100 (2%) 6/100 (6%) |
|POLY-3 ADJUSTED (b)| 1.1% 1.1% | 2.2% 6.5% |
|TERMINAL (d) | 1/76 (1%) 1/74 (1%) | 2/70 (3%) 1/77 (1%) |
|FIRST INCIDENCE | 734 (T) 734 (T) | 735 (T) 309 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.755 | P=0.155 |
|POLY 3 | P=0.758 | P=0.146 |
|POLY 1.5 | P=0.759 | P=0.144 |
|POLY 6 | P=0.757 | P=0.147 |
|LOGISTIC REGRESSION| P=0.755 | P=0.118 |
|COCH-ARM / FISHERS | P=0.751N | P=0.140 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 17
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 8/100 (8%) 6/100 (6%) | 32/100 (32%) 20/100 (20%) |
|POLY-3 ADJUSTED (b)| 8.6% 6.6% | 34.7% 21.7% |
|TERMINAL (d) | 7/76 (9%) 3/74 (4%) | 23/70 (33%) 15/77 (20%) |
|FIRST INCIDENCE | 691 579 | 461 567 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.414N | P=0.024N* |
|POLY 3 | P=0.402N | P=0.035N* |
|POLY 1.5 | P=0.399N | P=0.035N* |
|POLY 6 | P=0.405N | P=0.035N* |
|LOGISTIC REGRESSION| P=0.391N | P=0.037N* |
|COCH-ARM / FISHERS | P=0.391N | P=0.038N* |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 54/100 (54%) 52/100 (52%) | 52/100 (52%) 44/100 (44%) |
|POLY-3 ADJUSTED (b)| 57.7% 55.9% | 56.2% 48.0% |
|TERMINAL (d) | 47/76 (62%) 44/74 (60%) | 44/70 (63%) 38/77 (49%) |
|FIRST INCIDENCE | 646 415 | 542 576 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.531N | P=0.063N |
|POLY 3 | P=0.458N | P=0.162N |
|POLY 1.5 | P=0.451N | P=0.156N |
|POLY 6 | P=0.471N | P=0.172N |
|LOGISTIC REGRESSION| P=0.534N | P=0.158N |
|COCH-ARM / FISHERS | P=0.444N | P=0.161N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 18
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 40/100 (40%) 48/100 (48%) | 55/100 (55%) 45/100 (45%) |
|POLY-3 ADJUSTED (b)| 41.3% 49.7% | 57.6% 46.2% |
|TERMINAL (d) | 25/76 (33%) 29/74 (39%) | 34/70 (49%) 27/77 (35%) |
|FIRST INCIDENCE | 520 456 | 397 309 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.155 | P=0.085N |
|POLY 3 | P=0.153 | P=0.071N |
|POLY 1.5 | P=0.154 | P=0.079N |
|POLY 6 | P=0.156 | P=0.065N |
|LOGISTIC REGRESSION| P=0.185 | P=0.103N |
|COCH-ARM / FISHERS | P=0.159 | P=0.101N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 71/100 (71%) 76/100 (76%) | 78/100 (78%) 68/100 (68%) |
|POLY-3 ADJUSTED (b)| 73.0% 77.9% | 81.0% 69.7% |
|TERMINAL (d) | 53/76 (70%) 54/74 (73%) | 54/70 (77%) 49/77 (64%) |
|FIRST INCIDENCE | 520 415 | 397 309 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.228 | P=0.053N |
|POLY 3 | P=0.266 | P=0.045N* |
|POLY 1.5 | P=0.263 | P=0.051N |
|POLY 6 | P=0.273 | P=0.042N* |
|LOGISTIC REGRESSION| P=0.246 | P=0.073N |
|COCH-ARM / FISHERS | P=0.261 | P=0.076N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Poly-3 adjusted lifetime tumor incidence.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).