TDMS Study 89029-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/06/98
EXPERIMENT: 89029 TEST: 06 TIME: 08:58:57
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029
PATHOLOGIST: PLETCHER, J CAS: ELECTROMAG
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/06/98
EXPERIMENT: 89029 TEST: 06 TIME: 08:58:57
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029
PATHOLOGIST: PLETCHER, J CAS: ELECTROMAG
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF MAGNETIC FIELDS (EMF)
===============================================================
Male Mice
------------
Organ Morphology
----- ----------
Adrenal Medulla Hyperplasia
Intestine Small, Ileum: Muscularis Hypertrophy
Islets, Pancreatic Hyperplasia
Kidney: Cortex Infiltration Cellular Lymphocyte
Liver: Hepatocyte Vacuolization Cytoplasmic
Nose Inflammation
Pancreas Vacuolization Cytoplasmic
Preputial Gland Atrophy
Inflammation
Seminal Vesicle Cyst
Thymus Atrophy
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Bone Marrow Myelofibrosis
Brain: Thalamus Mineralization
Clitoral Gland Cyst
Lymph Node, Mesenteric Hyperplasia Reticulum Cell
Infiltration Cellular Histiocyte
Spleen Hematopoietic Cell Proliferation
Stomach, Glandular: Epithelium Atrophy
Thyroid Gland: Follicle Cyst
===============================================================
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 1
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/97 (0%) | 0/92 (0%) 2/99 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 2.2% |
|TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | --- --- | --- 607 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.237 |
|POLY 3 | (e) | P=0.243 |
|POLY 1.5 | (e) | P=0.244 |
|POLY 6 | (e) | P=0.241 |
|LOGISTIC REGRESSION| (e) | P=0.279 |
|COCH-ARM / FISHERS | (e) | P=0.267 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Adrenal Cortex: Capsule |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 86/99 (87%) 85/97 (88%) | 91/92 (99%) 99/99 (100%) |
|POLY-3 ADJUSTED (b)| 88.5% 90.4% | 99.0% 100.0% |
|TERMINAL (d) | 69/76 (91%) 67/73 (92%) | 70/70 (100%) 77/77 (100%) |
|FIRST INCIDENCE | 386 420 | 334 309 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.418 | P=0.498 |
|POLY 3 | P=0.422 | P=0.497 |
|POLY 1.5 | P=0.455 | P=0.484 |
|POLY 6 | P=0.402 | P=0.524 |
|LOGISTIC REGRESSION| P=0.441 | P=0.491 |
|COCH-ARM / FISHERS | P=0.522 | P=0.482 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 2
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Adrenal Cortex: Zona Fasciculata |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/99 (4%) 5/97 (5%) | 0/92 (0%) 3/99 (3%) |
|POLY-3 ADJUSTED (b)| 4.3% 5.7% | 0.0% 3.4% |
|TERMINAL (d) | 3/76 (4%) 5/73 (7%) | 0/70 (0%) 3/77 (4%) |
|FIRST INCIDENCE | 717 734 (T) | --- 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.475 | P=0.140 |
|POLY 3 | P=0.474 | P=0.125 |
|POLY 1.5 | P=0.479 | P=0.127 |
|POLY 6 | P=0.468 | P=0.123 |
|LOGISTIC REGRESSION| P=0.463 | P=0.140 |
|COCH-ARM / FISHERS | P=0.487 | P=0.137 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Adrenal Cortex: Zona Fasciculata |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/99 (9%) 5/97 (5%) | 0/92 (0%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 9.8% 5.7% | 0.0% 0.0% |
|TERMINAL (d) | 9/76 (12%) 5/73 (7%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 734 (T) 734 (T) | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.223N | (e) |
|POLY 3 | P=0.231N | (e) |
|POLY 1.5 | P=0.225N | (e) |
|POLY 6 | P=0.237N | (e) |
|LOGISTIC REGRESSION| P=0.223N | (e) |
|COCH-ARM / FISHERS | P=0.215N | (e) |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 3
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Adrenal Cortex: Zona Fasciculata |
| Hypertrophy Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/99 (15%) 19/97 (20%) | 2/92 (2%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 16.3% 21.7% | 2.3% 0.0% |
|TERMINAL (d) | 14/76 (18%) 18/73 (25%) | 2/70 (3%) 0/77 (0%) |
|FIRST INCIDENCE | 683 716 | 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.239 | P=0.218N |
|POLY 3 | P=0.234 | P=0.227N |
|POLY 1.5 | P=0.245 | P=0.222N |
|POLY 6 | P=0.222 | P=0.233N |
|LOGISTIC REGRESSION| P=0.219 | (e) |
|COCH-ARM / FISHERS | P=0.264 | P=0.231N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Adrenal Cortex: Zona Fasciculata |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 0/97 (0%) | 0/92 (0%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% | 0.0% 0.0% |
|TERMINAL (d) | 2/76 (3%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 734 (T) --- | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.248N | (e) |
|POLY 3 | P=0.255N | (e) |
|POLY 1.5 | P=0.251N | (e) |
|POLY 6 | P=0.258N | (e) |
|LOGISTIC REGRESSION| (e) | (e) |
|COCH-ARM / FISHERS | P=0.254N | (e) |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 4
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Adrenal Cortex: Zona Glomerulosa |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/99 (3%) 7/97 (7%) | 0/92 (0%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 3.2% 7.9% | 0.0% 0.0% |
|TERMINAL (d) | 1/76 (1%) 5/73 (7%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 579 553 | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.156 | (e) |
|POLY 3 | P=0.148 | (e) |
|POLY 1.5 | P=0.152 | (e) |
|POLY 6 | P=0.144 | (e) |
|LOGISTIC REGRESSION| P=0.164 | (e) |
|COCH-ARM / FISHERS | P=0.157 | (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Adrenal Cortex: Zona Reticularis |
| Degeneration Fatty |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 0/97 (0%) | 4/92 (4%) 3/99 (3%) |
|POLY-3 ADJUSTED (b)| 1.1% 0.0% | 4.6% 3.4% |
|TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 4/70 (6%) 3/77 (4%) |
|FIRST INCIDENCE | 683 --- | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.519N | P=0.449N |
|POLY 3 | P=0.520N | P=0.480N |
|POLY 1.5 | P=0.516N | P=0.470N |
|POLY 6 | P=0.525N | P=0.490N |
|LOGISTIC REGRESSION| P=0.494N | P=0.449N |
|COCH-ARM / FISHERS | P=0.505N | P=0.459N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 5
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/98 (0%) 5/96 (5%) | 3/90 (3%) 3/98 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.7% | 3.5% 3.4% |
|TERMINAL (d) | 0/76 (0%) 5/73 (7%) | 3/70 (4%) 3/76 (4%) |
|FIRST INCIDENCE | --- 734 (T) | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.031 * | P=0.623N |
|POLY 3 | P=0.031 * | P=0.638N |
|POLY 1.5 | P=0.031 * | P=0.628N |
|POLY 6 | P=0.030 * | P=0.648N |
|LOGISTIC REGRESSION| P=0.031 * | P=0.623N |
|COCH-ARM / FISHERS | P=0.028 * | P=0.618N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Blood Vessel: Aorta |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/97 (0%) 0/98 (0%) | 2/98 (2%) 0/96 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 2.2% 0.0% |
|TERMINAL (d) | 0/75 (0%) 0/72 (0%) | 0/70 (0%) 0/75 (0%) |
|FIRST INCIDENCE | --- --- | 625 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.242N |
|POLY 3 | (e) | P=0.245N |
|POLY 1.5 | (e) | P=0.244N |
|POLY 6 | (e) | P=0.248N |
|LOGISTIC REGRESSION| (e) | P=0.252N |
|COCH-ARM / FISHERS | (e) | P=0.254N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 6
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Bone Marrow |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 3/100 (3%) | 0/96 (0%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 0.0% 3.3% | 0.0% 1.1% |
|TERMINAL (d) | 0/76 (0%) 2/74 (3%) | 0/70 (0%) 1/77 (1%) |
|FIRST INCIDENCE | --- 729 | --- 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.119 | P=0.519 |
|POLY 3 | P=0.119 | P=0.500 |
|POLY 1.5 | P=0.121 | P=0.500 |
|POLY 6 | P=0.118 | P=0.500 |
|LOGISTIC REGRESSION| P=0.114 | P=0.519 |
|COCH-ARM / FISHERS | P=0.125 | P=0.510 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 33/99 (33%) 25/100 (25%) | 23/96 (24%) 19/100 (19%) |
|POLY-3 ADJUSTED (b)| 34.9% 26.7% | 25.3% 20.5% |
|TERMINAL (d) | 23/76 (30%) 15/74 (20%) | 12/70 (17%) 12/77 (16%) |
|FIRST INCIDENCE | 497 533 | 552 567 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.189N | P=0.256N |
|POLY 3 | P=0.145N | P=0.271N |
|POLY 1.5 | P=0.138N | P=0.259N |
|POLY 6 | P=0.153N | P=0.289N |
|LOGISTIC REGRESSION| P=0.116N | P=0.248N |
|COCH-ARM / FISHERS | P=0.128N | P=0.251N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 7
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Bone Marrow |
| Infiltration Cellular Focal Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/99 (3%) 2/100 (2%) | 0/96 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 3.3% 2.2% | 0.0% 0.0% |
|TERMINAL (d) | 2/76 (3%) 2/74 (3%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 715 734 (T) | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.515N | (e) |
|POLY 3 | P=0.511N | (e) |
|POLY 1.5 | P=0.505N | (e) |
|POLY 6 | P=0.519N | (e) |
|LOGISTIC REGRESSION| P=0.519N | (e) |
|COCH-ARM / FISHERS | P=0.495N | (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Bone Marrow |
| Myelofibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 2/100 (2%) | 10/96 (10%) 21/100 (21%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.2% | 11.3% 23.0% |
|TERMINAL (d) | 0/76 (0%) 2/74 (3%) | 10/70 (14%) 18/77 (23%) |
|FIRST INCIDENCE | --- 734 (T) | 735 (T) 576 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.233 | P=0.043 * |
|POLY 3 | P=0.236 | P=0.029 * |
|POLY 1.5 | P=0.238 | P=0.031 * |
|POLY 6 | P=0.235 | P=0.028 * |
|LOGISTIC REGRESSION| P=0.233 | P=0.027 * |
|COCH-ARM / FISHERS | P=0.251 | P=0.033 * |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 8
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Bone Marrow: Myeloid Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 0/100 (0%) | 3/96 (3%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% | 3.4% 0.0% |
|TERMINAL (d) | 2/76 (3%) 0/74 (0%) | 1/70 (1%) 0/77 (0%) |
|FIRST INCIDENCE | 734 (T) --- | 666 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.245N | P=0.116N |
|POLY 3 | P=0.245N | P=0.116N |
|POLY 1.5 | P=0.241N | P=0.114N |
|POLY 6 | P=0.250N | P=0.120N |
|LOGISTIC REGRESSION| (e) | P=0.116N |
|COCH-ARM / FISHERS | P=0.246N | P=0.116N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Brain: Thalamus |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 70/100 (70%) 63/100 (63%) | 47/99 (47%) 72/100 (72%) |
|POLY-3 ADJUSTED (b)| 71.8% 65.6% | 50.4% 73.9% |
|TERMINAL (d) | 55/76 (72%) 47/74 (64%) | 35/70 (50%) 55/77 (71%) |
|FIRST INCIDENCE | 386 415 | 461 449 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.306N | P=0.007 ** |
|POLY 3 | P=0.215N | P<0.001 ** |
|POLY 1.5 | P=0.203N | P<0.001 ** |
|POLY 6 | P=0.226N | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.187N | P<0.001 ** |
|COCH-ARM / FISHERS | P=0.184N | P<0.001 ** |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 9
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 80/89 (90%) 74/82 (90%) |
|POLY-3 ADJUSTED (b)| | 92.1% 90.7% |
|TERMINAL (d) | | 64/69 (93%) 63/69 (91%) |
|FIRST INCIDENCE | | 397 309 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | | P=0.207N |
|POLY 3 | | P=0.486N |
|POLY 1.5 | | P=0.527N |
|POLY 6 | | P=0.465N |
|LOGISTIC REGRESSION| | P=0.602 |
|COCH-ARM / FISHERS | | P=0.571 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 84/89 (94%) 71/82 (87%) |
|POLY-3 ADJUSTED (b)| | 96.0% 89.1% |
|TERMINAL (d) | | 67/69 (97%) 64/69 (93%) |
|FIRST INCIDENCE | | 397 534 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | | P=0.015N* |
|POLY 3 | | P=0.069N |
|POLY 1.5 | | P=0.064N |
|POLY 6 | | P=0.081N |
|LOGISTIC REGRESSION| | P=0.041N* |
|COCH-ARM / FISHERS | | P=0.068N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 10
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Epididymis |
| Granuloma Sperm |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/98 (2%) 0/98 (0%) | |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% | |
|TERMINAL (d) | 1/76 (1%) 0/73 (0%) | |
|FIRST INCIDENCE | 684 --- | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.254N | |
|POLY 3 | P=0.250N | |
|POLY 1.5 | P=0.245N | |
|POLY 6 | P=0.255N | |
|LOGISTIC REGRESSION| P=0.239N | |
|COCH-ARM / FISHERS | P=0.249N | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Epididymis |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/98 (24%) 24/98 (24%) | |
|POLY-3 ADJUSTED (b)| 26.1% 26.9% | |
|TERMINAL (d) | 21/76 (28%) 20/73 (27%) | |
|FIRST INCIDENCE | 624 605 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.498 | |
|POLY 3 | P=0.522 | |
|POLY 1.5 | P=0.539 | |
|POLY 6 | P=0.504 | |
|LOGISTIC REGRESSION| P=0.504 | |
|COCH-ARM / FISHERS | P=0.566N | |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 11
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Epididymis |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/98 (0%) 2/98 (2%) | |
|POLY-3 ADJUSTED (b)| 0.0% 2.3% | |
|TERMINAL (d) | 0/76 (0%) 2/73 (3%) | |
|FIRST INCIDENCE | --- 734 (T) | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.230 | |
|POLY 3 | P=0.235 | |
|POLY 1.5 | P=0.236 | |
|POLY 6 | P=0.234 | |
|LOGISTIC REGRESSION| P=0.230 | |
|COCH-ARM / FISHERS | P=0.249 | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Epididymis |
| Spermatocele |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/98 (2%) 6/98 (6%) | |
|POLY-3 ADJUSTED (b)| 2.2% 6.7% | |
|TERMINAL (d) | 2/76 (3%) 5/73 (7%) | |
|FIRST INCIDENCE | 734 (T) 547 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.129 | |
|POLY 3 | P=0.132 | |
|POLY 1.5 | P=0.135 | |
|POLY 6 | P=0.129 | |
|LOGISTIC REGRESSION| P=0.137 | |
|COCH-ARM / FISHERS | P=0.139 | |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 12
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Eye: Cornea |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 0/1 (0%) | 2/2 (100%) 0/2 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 100.0% 0.0% |
|TERMINAL (d) | 0/0 (0%) 0/1 (0%) | 2/2 (100%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- | 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=1.000N |
|POLY 3 | (e) | P=1.000N |
|POLY 1.5 | (e) | P=0.887N |
|POLY 6 | (e) | P=1.000N |
|LOGISTIC REGRESSION| (e) | (e) |
|COCH-ARM / FISHERS | (e) | P=0.167N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Gallbladder: Epithelium |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/84 (0%) 2/82 (2%) | 5/70 (7%) 11/91 (12%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.5% | 7.5% 12.8% |
|TERMINAL (d) | 0/69 (0%) 1/72 (1%) | 4/62 (7%) 9/76 (12%) |
|FIRST INCIDENCE | --- 686 | 725 309 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.239 | P=0.170 |
|POLY 3 | P=0.239 | P=0.200 |
|POLY 1.5 | P=0.238 | P=0.205 |
|POLY 6 | P=0.240 | P=0.192 |
|LOGISTIC REGRESSION| P=0.225 | P=0.234 |
|COCH-ARM / FISHERS | P=0.242 | P=0.221 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 13
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Harderian Gland |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/99 (11%) 14/99 (14%) | 27/98 (28%) 36/97 (37%) |
|POLY-3 ADJUSTED (b)| 12.0% 15.5% | 30.2% 40.3% |
|TERMINAL (d) | 11/76 (15%) 12/74 (16%) | 25/70 (36%) 33/77 (43%) |
|FIRST INCIDENCE | 734 (T) 581 | 551 458 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.308 | P=0.205 |
|POLY 3 | P=0.314 | P=0.102 |
|POLY 1.5 | P=0.322 | P=0.103 |
|POLY 6 | P=0.308 | P=0.101 |
|LOGISTIC REGRESSION| P=0.296 | P=0.097 |
|COCH-ARM / FISHERS | P=0.335 | P=0.101 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Heart |
| Inflammation Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 2/100 (2%) | 0/98 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 2.1% 2.2% | 0.0% 0.0% |
|TERMINAL (d) | 1/76 (1%) 0/74 (0%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 386 420 | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.686 | (e) |
|POLY 3 | P=0.687 | (e) |
|POLY 1.5 | P=0.689 | (e) |
|POLY 6 | P=0.685 | (e) |
|LOGISTIC REGRESSION| P=0.588N | (e) |
|COCH-ARM / FISHERS | P=0.689N | (e) |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 14
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Heart: Valve |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 2/100 (2%) | 0/98 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.2% | 0.0% 0.0% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | --- 420 | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.236 | (e) |
|POLY 3 | P=0.237 | (e) |
|POLY 1.5 | P=0.238 | (e) |
|POLY 6 | P=0.237 | (e) |
|LOGISTIC REGRESSION| P=0.293 | (e) |
|COCH-ARM / FISHERS | P=0.249 | (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Intestine Large, Cecum: Lymphoid Tissue |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 41/90 (46%) 46/85 (54%) | 25/78 (32%) 32/92 (35%) |
|POLY-3 ADJUSTED (b)| 47.4% 56.0% | 32.7% 36.2% |
|TERMINAL (d) | 37/76 (49%) 42/73 (58%) | 22/69 (32%) 26/77 (34%) |
|FIRST INCIDENCE | 624 547 | 397 449 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.196 | P=0.305 |
|POLY 3 | P=0.169 | P=0.373 |
|POLY 1.5 | P=0.169 | P=0.389 |
|POLY 6 | P=0.165 | P=0.354 |
|LOGISTIC REGRESSION| P=0.154 | P=0.450 |
|COCH-ARM / FISHERS | P=0.163 | P=0.416 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 15
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Intestine Small, Ileum |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/91 (0%) 0/84 (0%) | 1/78 (1%) 2/93 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 1.3% 2.3% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) | 1/69 (1%) 2/77 (3%) |
|FIRST INCIDENCE | --- --- | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.538 |
|POLY 3 | (e) | P=0.533 |
|POLY 1.5 | (e) | P=0.536 |
|POLY 6 | (e) | P=0.528 |
|LOGISTIC REGRESSION| (e) | P=0.538 |
|COCH-ARM / FISHERS | (e) | P=0.566 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Intestine Small, Ileum: Muscularis |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/91 (0%) 7/84 (8%) | 17/78 (22%) 15/93 (16%) |
|POLY-3 ADJUSTED (b)| 0.0% 8.6% | 22.8% 17.2% |
|TERMINAL (d) | 0/76 (0%) 4/72 (6%) | 16/69 (23%) 12/77 (16%) |
|FIRST INCIDENCE | --- 533 | 608 458 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.010 * | P=0.312N |
|POLY 3 | P=0.008 ** | P=0.242N |
|POLY 1.5 | P=0.007 ** | P=0.232N |
|POLY 6 | P=0.008 ** | P=0.257N |
|LOGISTIC REGRESSION| P=0.004 ** | P=0.235N |
|COCH-ARM / FISHERS | P=0.005 ** | P=0.227N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 16
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Intestine Small, Ileum: Peyer's Patch |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/91 (0%) 0/84 (0%) | 4/78 (5%) 5/93 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 5.3% 5.8% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) | 3/69 (4%) 5/77 (7%) |
|FIRST INCIDENCE | --- --- | 334 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.559 |
|POLY 3 | (e) | P=0.571 |
|POLY 1.5 | (e) | P=0.581 |
|POLY 6 | (e) | P=0.560 |
|LOGISTIC REGRESSION| (e) | P=0.623 |
|COCH-ARM / FISHERS | (e) | P=0.609 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Intestine Small, Jejunum: Muscularis |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/89 (0%) 2/85 (2%) | 6/79 (8%) 7/92 (8%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.5% | 7.9% 8.1% |
|TERMINAL (d) | 0/76 (0%) 1/73 (1%) | 6/69 (9%) 6/77 (8%) |
|FIRST INCIDENCE | --- 579 | 735 (T) 704 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.233 | P=0.575 |
|POLY 3 | P=0.233 | P=0.587 |
|POLY 1.5 | P=0.233 | P=0.595 |
|POLY 6 | P=0.232 | P=0.577 |
|LOGISTIC REGRESSION| P=0.207 | P=0.572 |
|COCH-ARM / FISHERS | P=0.237 | P=0.612N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 17
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Intestine Small, Jejunum: Peyer's Patch |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/89 (1%) 1/85 (1%) | 3/79 (4%) 7/92 (8%) |
|POLY-3 ADJUSTED (b)| 1.2% 1.2% | 4.0% 8.1% |
|TERMINAL (d) | 1/76 (1%) 1/73 (1%) | 3/69 (4%) 7/77 (9%) |
|FIRST INCIDENCE | 734 (T) 734 (T) | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.752 | P=0.211 |
|POLY 3 | P=0.754 | P=0.213 |
|POLY 1.5 | P=0.755 | P=0.219 |
|POLY 6 | P=0.753 | P=0.206 |
|LOGISTIC REGRESSION| P=0.752 | P=0.211 |
|COCH-ARM / FISHERS | P=0.740 | P=0.234 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 97/99 (98%) 89/98 (91%) | 40/87 (46%) 47/94 (50%) |
|POLY-3 ADJUSTED (b)| 98.2% 93.3% | 47.7% 50.9% |
|TERMINAL (d) | 75/76 (99%) 70/74 (95%) | 35/70 (50%) 36/76 (47%) |
|FIRST INCIDENCE | 386 415 | 334 309 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.264N | P=0.333 |
|POLY 3 | P=0.076N | P=0.390 |
|POLY 1.5 | P=0.051N | P=0.376 |
|POLY 6 | P=0.114N | P=0.398 |
|LOGISTIC REGRESSION| P=0.040N* | P=0.366 |
|COCH-ARM / FISHERS | P=0.028N* | P=0.347 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 18
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Cortex |
| Congestion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 0/97 (0%) | 0/92 (0%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% | 0.0% 0.0% |
|TERMINAL (d) | 2/76 (3%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 734 (T) --- | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.248N | (e) |
|POLY 3 | P=0.256N | (e) |
|POLY 1.5 | P=0.252N | (e) |
|POLY 6 | P=0.261N | (e) |
|LOGISTIC REGRESSION| (e) | (e) |
|COCH-ARM / FISHERS | P=0.254N | (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Cortex |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/99 (23%) 22/97 (23%) | 0/92 (0%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 24.7% 25.0% | 0.0% 0.0% |
|TERMINAL (d) | 19/76 (25%) 20/73 (27%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 579 579 | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.563N | (e) |
|POLY 3 | P=0.553 | (e) |
|POLY 1.5 | P=0.565N | (e) |
|POLY 6 | P=0.528 | (e) |
|LOGISTIC REGRESSION| P=0.547 | (e) |
|COCH-ARM / FISHERS | P=0.531N | (e) |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 19
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Cortex |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/99 (19%) 37/97 (38%) | 24/92 (26%) 16/99 (16%) |
|POLY-3 ADJUSTED (b)| 20.4% 41.6% | 27.5% 17.7% |
|TERMINAL (d) | 16/76 (21%) 32/73 (44%) | 20/70 (29%) 14/77 (18%) |
|FIRST INCIDENCE | 579 553 | 542 650 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.002 ** | P=0.066N |
|POLY 3 | P<0.001 ** | P=0.080N |
|POLY 1.5 | P=0.002 ** | P=0.073N |
|POLY 6 | P<0.001 ** | P=0.090N |
|LOGISTIC REGRESSION| P=0.002 ** | P=0.079N |
|COCH-ARM / FISHERS | P=0.003 ** | P=0.066N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Cortex |
| Metaplasia Focal Osseous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/99 (4%) 4/97 (4%) | 4/92 (4%) 3/99 (3%) |
|POLY-3 ADJUSTED (b)| 4.3% 4.6% | 4.6% 3.3% |
|TERMINAL (d) | 3/76 (4%) 4/73 (6%) | 1/70 (1%) 3/77 (4%) |
|FIRST INCIDENCE | 666 734 (T) | 397 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.619 | P=0.467N |
|POLY 3 | P=0.614 | P=0.481N |
|POLY 1.5 | P=0.621 | P=0.470N |
|POLY 6 | P=0.607 | P=0.493N |
|LOGISTIC REGRESSION| P=0.606 | P=0.439N |
|COCH-ARM / FISHERS | P=0.628 | P=0.459N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 20
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Cortex |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 79/99 (80%) 77/97 (79%) | 1/92 (1%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 83.6% 83.8% | 1.2% 0.0% |
|TERMINAL (d) | 66/76 (87%) 63/73 (86%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 579 505 | 625 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.489 | P=0.502N |
|POLY 3 | P=0.568 | P=0.483N |
|POLY 1.5 | P=0.579 | P=0.478N |
|POLY 6 | P=0.561 | P=0.490N |
|LOGISTIC REGRESSION| P=0.409 | P=0.474N |
|COCH-ARM / FISHERS | P=0.542N | P=0.482N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Cortex, Renal Tubule |
| Accumulation, Hyaline Droplet |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/97 (0%) | 0/92 (0%) 3/99 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 3.3% |
|TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 0/70 (0%) 1/77 (1%) |
|FIRST INCIDENCE | --- --- | --- 567 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.132 |
|POLY 3 | (e) | P=0.128 |
|POLY 1.5 | (e) | P=0.129 |
|POLY 6 | (e) | P=0.127 |
|LOGISTIC REGRESSION| (e) | P=0.143 |
|COCH-ARM / FISHERS | (e) | P=0.137 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 21
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Cortex, Renal Tubule |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 72/99 (73%) 71/97 (73%) | 4/99 (4%) 1/97 (1%) |
|POLY-3 ADJUSTED (b)| 77.0% 77.5% | 4.4% 1.1% |
|TERMINAL (d) | 62/76 (82%) 59/73 (81%) | 4/76 (5%) 1/73 (1%) |
|FIRST INCIDENCE | 603 533 | 734 (T) 734 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.446 | P=0.195N |
|POLY 3 | P=0.539 | P=0.202N |
|POLY 1.5 | P=0.533 | P=0.197N |
|POLY 6 | P=0.557 | P=0.207N |
|LOGISTIC REGRESSION| P=0.363 | P=0.195N |
|COCH-ARM / FISHERS | P=0.535 | P=0.191N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Cortex, Renal Tubule |
| Dilatation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 2/97 (2%) | 1/92 (1%) 1/99 (1%) |
|POLY-3 ADJUSTED (b)| 2.2% 2.3% | 1.2% 1.1% |
|TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 520 505 | 608 623 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.680 | P=0.759 |
|POLY 3 | P=0.679 | P=0.745N |
|POLY 1.5 | P=0.682 | P=0.741N |
|POLY 6 | P=0.675 | P=0.750N |
|LOGISTIC REGRESSION| P=0.619N | P=0.734N |
|COCH-ARM / FISHERS | P=0.682 | P=0.733N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 22
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Cortex, Renal Tubule |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/97 (0%) | 0/92 (0%) 2/99 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 2.2% |
|TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | --- --- | --- 580 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.240 |
|POLY 3 | (e) | P=0.244 |
|POLY 1.5 | (e) | P=0.245 |
|POLY 6 | (e) | P=0.243 |
|LOGISTIC REGRESSION| (e) | P=0.265 |
|COCH-ARM / FISHERS | (e) | P=0.267 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Medulla |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 54/99 (55%) 47/97 (48%) | 47/92 (51%) 57/99 (58%) |
|POLY-3 ADJUSTED (b)| 57.2% 53.4% | 52.8% 61.9% |
|TERMINAL (d) | 44/76 (58%) 45/73 (62%) | 41/70 (59%) 53/77 (69%) |
|FIRST INCIDENCE | 520 553 | 334 458 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.287N | P=0.246 |
|POLY 3 | P=0.353N | P=0.132 |
|POLY 1.5 | P=0.302N | P=0.164 |
|POLY 6 | P=0.425N | P=0.100 |
|LOGISTIC REGRESSION| P=0.337N | P=0.191 |
|COCH-ARM / FISHERS | P=0.239N | P=0.225 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 23
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Medulla |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 2/97 (2%) | 3/92 (3%) 1/99 (1%) |
|POLY-3 ADJUSTED (b)| 1.1% 2.3% | 3.5% 1.1% |
|TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 666 582 | 625 534 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.490 | P=0.301N |
|POLY 3 | P=0.489 | P=0.286N |
|POLY 1.5 | P=0.492 | P=0.281N |
|POLY 6 | P=0.487 | P=0.293N |
|LOGISTIC REGRESSION| P=0.547 | P=0.262N |
|COCH-ARM / FISHERS | P=0.492 | P=0.283N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Kidney: Pelvis |
| Calculus Micro Observation Only |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/97 (0%) | 3/92 (3%) 2/99 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.5% 2.2% |
|TERMINAL (d) | 0/76 (0%) 0/73 (0%) | 3/70 (4%) 2/77 (3%) |
|FIRST INCIDENCE | --- --- | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.457N |
|POLY 3 | (e) | P=0.475N |
|POLY 1.5 | (e) | P=0.469N |
|POLY 6 | (e) | P=0.483N |
|LOGISTIC REGRESSION| (e) | P=0.457N |
|COCH-ARM / FISHERS | (e) | P=0.465N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 24
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/99 (0%) | 1/98 (1%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 1.1% 3.3% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 1/70 (1%) 3/77 (4%) |
|FIRST INCIDENCE | --- --- | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.341 |
|POLY 3 | (e) | P=0.310 |
|POLY 1.5 | (e) | P=0.312 |
|POLY 6 | (e) | P=0.307 |
|LOGISTIC REGRESSION| (e) | P=0.341 |
|COCH-ARM / FISHERS | (e) | P=0.318 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 2/99 (2%) | 2/98 (2%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.2% | 2.2% 1.1% |
|TERMINAL (d) | 0/76 (0%) 2/74 (3%) | 2/70 (3%) 1/77 (1%) |
|FIRST INCIDENCE | --- 734 (T) | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.233 | P=0.467N |
|POLY 3 | P=0.235 | P=0.495N |
|POLY 1.5 | P=0.236 | P=0.492N |
|POLY 6 | P=0.234 | P=0.500N |
|LOGISTIC REGRESSION| P=0.233 | P=0.467N |
|COCH-ARM / FISHERS | P=0.246 | P=0.492N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 25
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/100 (14%) 14/99 (14%) | 4/98 (4%) 5/100 (5%) |
|POLY-3 ADJUSTED (b)| 15.0% 15.6% | 4.5% 5.5% |
|TERMINAL (d) | 13/76 (17%) 13/74 (18%) | 3/70 (4%) 3/77 (4%) |
|FIRST INCIDENCE | 520 582 | 608 567 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.551 | P=0.540 |
|POLY 3 | P=0.543 | P=0.507 |
|POLY 1.5 | P=0.553 | P=0.510 |
|POLY 6 | P=0.534 | P=0.503 |
|LOGISTIC REGRESSION| P=0.542 | P=0.512 |
|COCH-ARM / FISHERS | P=0.569 | P=0.513 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/100 (12%) 16/99 (16%) | 6/98 (6%) 9/100 (9%) |
|POLY-3 ADJUSTED (b)| 12.9% 17.7% | 6.6% 10.0% |
|TERMINAL (d) | 10/76 (13%) 14/74 (19%) | 5/70 (7%) 9/77 (12%) |
|FIRST INCIDENCE | 520 505 | 397 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.247 | P=0.360 |
|POLY 3 | P=0.243 | P=0.296 |
|POLY 1.5 | P=0.250 | P=0.303 |
|POLY 6 | P=0.236 | P=0.288 |
|LOGISTIC REGRESSION| P=0.250 | P=0.308 |
|COCH-ARM / FISHERS | P=0.261 | P=0.311 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 26
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Infiltration Cellular Focal Mixed Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 11/99 (11%) | 53/98 (54%) 51/100 (51%) |
|POLY-3 ADJUSTED (b)| 6.5% 12.3% | 58.9% 55.2% |
|TERMINAL (d) | 6/76 (8%) 11/74 (15%) | 47/70 (67%) 46/77 (60%) |
|FIRST INCIDENCE | 734 (T) 734 (T) | 666 534 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.139 | P=0.210N |
|POLY 3 | P=0.138 | P=0.362N |
|POLY 1.5 | P=0.143 | P=0.363N |
|POLY 6 | P=0.134 | P=0.369N |
|LOGISTIC REGRESSION| P=0.139 | P=0.447N |
|COCH-ARM / FISHERS | P=0.150 | P=0.385N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/100 (4%) 3/99 (3%) | 0/98 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 4.3% 3.4% | 0.0% 0.0% |
|TERMINAL (d) | 4/76 (5%) 3/74 (4%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 734 (T) 734 (T) | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.514N | (e) |
|POLY 3 | P=0.521N | (e) |
|POLY 1.5 | P=0.515N | (e) |
|POLY 6 | P=0.526N | (e) |
|LOGISTIC REGRESSION| P=0.514N | (e) |
|COCH-ARM / FISHERS | P=0.506N | (e) |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 27
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/100 (7%) 3/99 (3%) | 4/98 (4%) 5/100 (5%) |
|POLY-3 ADJUSTED (b)| 7.4% 3.3% | 4.4% 5.4% |
|TERMINAL (d) | 1/76 (1%) 1/74 (1%) | 0/70 (0%) 2/77 (3%) |
|FIRST INCIDENCE | 520 582 | 432 309 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.187N | P=0.508 |
|POLY 3 | P=0.187N | P=0.508 |
|POLY 1.5 | P=0.180N | P=0.511 |
|POLY 6 | P=0.195N | P=0.501 |
|LOGISTIC REGRESSION| P=0.115N | P=0.459 |
|COCH-ARM / FISHERS | P=0.170N | P=0.513 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/100 (13%) 5/99 (5%) | 14/98 (14%) 14/100 (14%) |
|POLY-3 ADJUSTED (b)| 13.7% 5.5% | 14.9% 15.2% |
|TERMINAL (d) | 8/76 (11%) 2/74 (3%) | 6/70 (9%) 10/77 (13%) |
|FIRST INCIDENCE | 386 415 | 288 534 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.052N | P=0.518N |
|POLY 3 | P=0.050N | P=0.563 |
|POLY 1.5 | P=0.048N* | P=0.578 |
|POLY 6 | P=0.053N | P=0.547 |
|LOGISTIC REGRESSION| P=0.020N* | P=0.572N |
|COCH-ARM / FISHERS | P=0.043N* | P=0.558N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 28
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/100 (20%) 16/99 (16%) | 32/95 (34%) 30/100 (30%) |
|POLY-3 ADJUSTED (b)| 21.5% 17.8% | 36.5% 32.1% |
|TERMINAL (d) | 19/76 (25%) 15/74 (20%) | 30/70 (43%) 23/77 (30%) |
|FIRST INCIDENCE | 497 620 | 667 458 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.318N | P=0.296N |
|POLY 3 | P=0.333N | P=0.318N |
|POLY 1.5 | P=0.321N | P=0.326N |
|POLY 6 | P=0.342N | P=0.314N |
|LOGISTIC REGRESSION| P=0.335N | P=0.363N |
|COCH-ARM / FISHERS | P=0.302N | P=0.345N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 2/99 (2%) | 4/95 (4%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 2.2% 2.2% | 4.5% 1.1% |
|TERMINAL (d) | 2/76 (3%) 2/74 (3%) | 3/70 (4%) 1/77 (1%) |
|FIRST INCIDENCE | 734 (T) 734 (T) | 432 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.684 | P=0.160N |
|POLY 3 | P=0.684 | P=0.173N |
|POLY 1.5 | P=0.686 | P=0.169N |
|POLY 6 | P=0.682 | P=0.178N |
|LOGISTIC REGRESSION| P=0.684 | P=0.163N |
|COCH-ARM / FISHERS | P=0.686 | P=0.169N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 29
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lung: Alveolus |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/100 (3%) 9/99 (9%) | 1/95 (1%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 3.2% 10.0% | 1.1% 0.0% |
|TERMINAL (d) | 2/76 (3%) 8/74 (11%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 715 668 | 723 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.062 | P=0.500N |
|POLY 3 | P=0.060 | P=0.486N |
|POLY 1.5 | P=0.062 | P=0.483N |
|POLY 6 | P=0.058 | P=0.491N |
|LOGISTIC REGRESSION| P=0.058 | P=0.494N |
|COCH-ARM / FISHERS | P=0.065 | P=0.487N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lung: Artery |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/99 (0%) | 2/95 (2%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 2.3% 0.0% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | --- --- | 625 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.241N |
|POLY 3 | (e) | P=0.229N |
|POLY 1.5 | (e) | P=0.225N |
|POLY 6 | (e) | P=0.234N |
|LOGISTIC REGRESSION| (e) | P=0.224N |
|COCH-ARM / FISHERS | (e) | P=0.236N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 30
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/92 (4%) 1/90 (1%) | 3/84 (4%) 3/92 (3%) |
|POLY-3 ADJUSTED (b)| 4.6% 1.2% | 3.8% 3.6% |
|TERMINAL (d) | 1/72 (1%) 1/69 (1%) | 0/66 (0%) 2/70 (3%) |
|FIRST INCIDENCE | 582 734 (T) | 707 656 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.196N | P=0.643N |
|POLY 3 | P=0.205N | P=0.630N |
|POLY 1.5 | P=0.199N | P=0.622N |
|POLY 6 | P=0.212N | P=0.641N |
|LOGISTIC REGRESSION| P=0.170N | P=0.627N |
|COCH-ARM / FISHERS | P=0.191N | P=0.615N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/92 (0%) 1/90 (1%) | 2/84 (2%) 3/92 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.2% | 2.6% 3.6% |
|TERMINAL (d) | 0/72 (0%) 1/69 (1%) | 2/66 (3%) 1/70 (1%) |
|FIRST INCIDENCE | --- 734 (T) | 735 (T) 650 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.492 | P=0.514 |
|POLY 3 | P=0.500 | P=0.522 |
|POLY 1.5 | P=0.500 | P=0.527 |
|POLY 6 | P=0.500 | P=0.517 |
|LOGISTIC REGRESSION| P=0.492 | P=0.545 |
|COCH-ARM / FISHERS | P=0.495 | P=0.543 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 31
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/92 (1%) 3/90 (3%) | 8/84 (10%) 4/92 (4%) |
|POLY-3 ADJUSTED (b)| 1.2% 3.7% | 10.2% 4.8% |
|TERMINAL (d) | 1/72 (1%) 3/69 (4%) | 8/66 (12%) 4/70 (6%) |
|FIRST INCIDENCE | 734 (T) 734 (T) | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.292 | P=0.156N |
|POLY 3 | P=0.293 | P=0.157N |
|POLY 1.5 | P=0.296 | P=0.150N |
|POLY 6 | P=0.291 | P=0.166N |
|LOGISTIC REGRESSION| P=0.292 | P=0.156N |
|COCH-ARM / FISHERS | P=0.302 | P=0.144N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia Reticulum Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/92 (0%) 0/90 (0%) | 0/84 (0%) 2/92 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 2.4% |
|TERMINAL (d) | 0/72 (0%) 0/69 (0%) | 0/66 (0%) 2/70 (3%) |
|FIRST INCIDENCE | --- --- | --- 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.252 |
|POLY 3 | (e) | P=0.244 |
|POLY 1.5 | (e) | P=0.246 |
|POLY 6 | (e) | P=0.242 |
|LOGISTIC REGRESSION| (e) | P=0.252 |
|COCH-ARM / FISHERS | (e) | P=0.272 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 32
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/92 (0%) 3/90 (3%) | 0/84 (0%) 0/92 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 3.6% | 0.0% 0.0% |
|TERMINAL (d) | 0/72 (0%) 0/69 (0%) | 0/66 (0%) 0/70 (0%) |
|FIRST INCIDENCE | --- 547 | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.121 | (e) |
|POLY 3 | P=0.118 | (e) |
|POLY 1.5 | P=0.118 | (e) |
|POLY 6 | P=0.118 | (e) |
|LOGISTIC REGRESSION| P=0.161 | (e) |
|COCH-ARM / FISHERS | P=0.119 | (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Infiltration Cellular Mixed Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/92 (4%) 1/90 (1%) | 2/84 (2%) 1/92 (1%) |
|POLY-3 ADJUSTED (b)| 4.7% 1.2% | 2.6% 1.2% |
|TERMINAL (d) | 2/72 (3%) 0/69 (0%) | 2/66 (3%) 0/70 (0%) |
|FIRST INCIDENCE | 705 729 | 735 (T) 650 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.198N | P=0.488N |
|POLY 3 | P=0.202N | P=0.473N |
|POLY 1.5 | P=0.197N | P=0.466N |
|POLY 6 | P=0.206N | P=0.481N |
|LOGISTIC REGRESSION| P=0.200N | P=0.468N |
|COCH-ARM / FISHERS | P=0.191N | P=0.466N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 33
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Infiltration Cellular Plasma Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/92 (0%) 1/90 (1%) | 2/84 (2%) 1/92 (1%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.2% | 2.6% 1.2% |
|TERMINAL (d) | 0/72 (0%) 0/69 (0%) | 2/66 (3%) 1/70 (1%) |
|FIRST INCIDENCE | --- 581 | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.496 | P=0.480N |
|POLY 3 | P=0.500 | P=0.475N |
|POLY 1.5 | P=0.500 | P=0.467N |
|POLY 6 | P=0.500 | P=0.484N |
|LOGISTIC REGRESSION| P=0.547 | P=0.480N |
|COCH-ARM / FISHERS | P=0.495 | P=0.466N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/92 (2%) 4/90 (4%) | 22/84 (26%) 18/92 (20%) |
|POLY-3 ADJUSTED (b)| 2.3% 4.9% | 27.9% 21.7% |
|TERMINAL (d) | 1/72 (1%) 2/69 (3%) | 18/66 (27%) 17/70 (24%) |
|FIRST INCIDENCE | 603 666 | 667 650 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.320 | P=0.236N |
|POLY 3 | P=0.320 | P=0.228N |
|POLY 1.5 | P=0.324 | P=0.211N |
|POLY 6 | P=0.317 | P=0.254N |
|LOGISTIC REGRESSION| P=0.347 | P=0.259N |
|COCH-ARM / FISHERS | P=0.331 | P=0.193N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 34
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/87 (7%) 12/92 (13%) | 12/83 (14%) 22/95 (23%) |
|POLY-3 ADJUSTED (b)| 7.3% 13.9% | 15.0% 25.1% |
|TERMINAL (d) | 3/70 (4%) 8/72 (11%) | 9/68 (13%) 17/74 (23%) |
|FIRST INCIDENCE | 497 553 | 667 458 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.114 | P=0.071 |
|POLY 3 | P=0.122 | P=0.075 |
|POLY 1.5 | P=0.125 | P=0.083 |
|POLY 6 | P=0.119 | P=0.066 |
|LOGISTIC REGRESSION| P=0.144 | P=0.088 |
|COCH-ARM / FISHERS | P=0.132 | P=0.099 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/87 (0%) 0/92 (0%) | 3/83 (4%) 0/95 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.8% 0.0% |
|TERMINAL (d) | 0/70 (0%) 0/72 (0%) | 3/68 (4%) 0/74 (0%) |
|FIRST INCIDENCE | --- --- | 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.108N |
|POLY 3 | (e) | P=0.102N |
|POLY 1.5 | (e) | P=0.098N |
|POLY 6 | (e) | P=0.107N |
|LOGISTIC REGRESSION| (e) | (e) |
|COCH-ARM / FISHERS | (e) | P=0.099N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 35
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/87 (3%) 5/92 (5%) | 3/83 (4%) 2/95 (2%) |
|POLY-3 ADJUSTED (b)| 3.7% 5.9% | 3.8% 2.3% |
|TERMINAL (d) | 2/70 (3%) 5/72 (7%) | 3/68 (4%) 1/74 (1%) |
|FIRST INCIDENCE | 684 734 (T) | 735 (T) 623 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.367 | P=0.469N |
|POLY 3 | P=0.376 | P=0.452N |
|POLY 1.5 | P=0.380 | P=0.442N |
|POLY 6 | P=0.371 | P=0.464N |
|LOGISTIC REGRESSION| P=0.375 | P=0.440N |
|COCH-ARM / FISHERS | P=0.392 | P=0.436N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/87 (0%) 3/92 (3%) | 2/83 (2%) 2/95 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 3.5% | 2.5% 2.3% |
|TERMINAL (d) | 0/70 (0%) 3/72 (4%) | 2/68 (3%) 2/74 (3%) |
|FIRST INCIDENCE | --- 734 (T) | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.127 | P=0.663N |
|POLY 3 | P=0.126 | P=0.655N |
|POLY 1.5 | P=0.127 | P=0.645N |
|POLY 6 | P=0.125 | P=0.666N |
|LOGISTIC REGRESSION| P=0.127 | P=0.663N |
|COCH-ARM / FISHERS | P=0.134 | P=0.637N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 36
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia Reticulum Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/87 (0%) 0/92 (0%) | 3/83 (4%) 15/95 (16%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.8% 17.4% |
|TERMINAL (d) | 0/70 (0%) 0/72 (0%) | 3/68 (4%) 14/74 (19%) |
|FIRST INCIDENCE | --- --- | 735 (T) 656 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.005 ** |
|POLY 3 | (e) | P=0.004 ** |
|POLY 1.5 | (e) | P=0.005 ** |
|POLY 6 | (e) | P=0.004 ** |
|LOGISTIC REGRESSION| (e) | P=0.004 ** |
|COCH-ARM / FISHERS | (e) | P=0.006 ** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 59/87 (68%) 72/92 (78%) | 50/83 (60%) 41/95 (43%) |
|POLY-3 ADJUSTED (b)| 70.4% 81.4% | 61.7% 46.7% |
|TERMINAL (d) | 50/70 (71%) 60/72 (83%) | 44/68 (65%) 37/74 (50%) |
|FIRST INCIDENCE | 520 533 | 397 458 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.055 | P=0.044N* |
|POLY 3 | P=0.059 | P=0.032N* |
|POLY 1.5 | P=0.065 | P=0.024N* |
|POLY 6 | P=0.056 | P=0.045N* |
|LOGISTIC REGRESSION| P=0.054 | P=0.031N* |
|COCH-ARM / FISHERS | P=0.080 | P=0.017N* |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 37
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Infiltration Cellular Mixed Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/87 (3%) 6/92 (7%) | 4/83 (5%) 5/95 (5%) |
|POLY-3 ADJUSTED (b)| 3.7% 7.1% | 5.0% 5.8% |
|TERMINAL (d) | 3/70 (4%) 5/72 (7%) | 4/68 (6%) 5/74 (7%) |
|FIRST INCIDENCE | 734 (T) 716 | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.258 | P=0.552 |
|POLY 3 | P=0.264 | P=0.545 |
|POLY 1.5 | P=0.267 | P=0.556 |
|POLY 6 | P=0.261 | P=0.532 |
|LOGISTIC REGRESSION| P=0.259 | P=0.552 |
|COCH-ARM / FISHERS | P=0.277 | P=0.584 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Infiltration Cellular Plasma Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/87 (0%) 1/92 (1%) | 5/83 (6%) 6/95 (6%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.2% | 6.3% 6.9% |
|TERMINAL (d) | 0/70 (0%) 1/72 (1%) | 5/68 (7%) 5/74 (7%) |
|FIRST INCIDENCE | --- 734 (T) | 735 (T) 650 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.506 | P=0.552 |
|POLY 3 | P=0.500 | P=0.553 |
|POLY 1.5 | P=0.500 | P=0.565 |
|POLY 6 | P=0.500 | P=0.540 |
|LOGISTIC REGRESSION| P=0.506 | P=0.547 |
|COCH-ARM / FISHERS | P=0.514 | P=0.593 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 38
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node: Lumbar |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/6 (0%) 0/7 (0%) | 3/19 (16%) 0/12 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 16.8% 0.0% |
|TERMINAL (d) | 0/6 (0%) 0/3 (0%) | 3/11 (27%) 0/7 (0%) |
|FIRST INCIDENCE | --- --- | 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.200N |
|POLY 3 | (e) | P=0.291N |
|POLY 1.5 | (e) | P=0.271N |
|POLY 6 | (e) | P=0.319N |
|LOGISTIC REGRESSION| (e) | (e) |
|COCH-ARM / FISHERS | (e) | P=0.216N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Lymph Node: Lumbar |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/6 (17%) 0/7 (0%) | 4/19 (21%) 0/12 (0%) |
|POLY-3 ADJUSTED (b)| 16.7% 0.0% | 22.3% 0.0% |
|TERMINAL (d) | 1/6 (17%) 0/3 (0%) | 4/11 (36%) 0/7 (0%) |
|FIRST INCIDENCE | 734 (T) --- | 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.638N | P=0.116N |
|POLY 3 | P=0.534N | P=0.183N |
|POLY 1.5 | P=0.487N | P=0.167N |
|POLY 6 | P=0.617N | P=0.207N |
|LOGISTIC REGRESSION| (e) | (e) |
|COCH-ARM / FISHERS | P=0.462N | P=0.123N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 39
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/2 (0%) 0/1 (0%) | 3/94 (3%) 3/98 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.5% 3.4% |
|TERMINAL (d) | 0/1 (0%) 0/1 (0%) | 1/70 (1%) 2/76 (3%) |
|FIRST INCIDENCE | --- --- | 702 656 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.644N |
|POLY 3 | (e) | P=0.647N |
|POLY 1.5 | (e) | P=0.641N |
|POLY 6 | (e) | P=0.655N |
|LOGISTIC REGRESSION| (e) | P=0.644N |
|COCH-ARM / FISHERS | (e) | P=0.639N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Mammary Gland: Duct |
| Dilatation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/2 (0%) 0/1 (0%) | 10/94 (11%) 12/98 (12%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 11.5% 13.4% |
|TERMINAL (d) | 0/1 (0%) 0/1 (0%) | 6/70 (9%) 9/76 (12%) |
|FIRST INCIDENCE | --- --- | 542 580 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.466 |
|POLY 3 | (e) | P=0.436 |
|POLY 1.5 | (e) | P=0.445 |
|POLY 6 | (e) | P=0.424 |
|LOGISTIC REGRESSION| (e) | P=0.449 |
|COCH-ARM / FISHERS | (e) | P=0.452 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 40
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/13 (8%) 0/9 (0%) | 6/36 (17%) 14/53 (26%) |
|POLY-3 ADJUSTED (b)| 8.1% 0.0% | 17.3% 28.7% |
|TERMINAL (d) | 1/10 (10%) 0/5 (0%) | 4/24 (17%) 11/37 (30%) |
|FIRST INCIDENCE | 734 (T) --- | 701 458 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.638N | P=0.172 |
|POLY 3 | P=0.716N | P=0.160 |
|POLY 1.5 | P=0.686N | P=0.173 |
|POLY 6 | P=0.754N | P=0.144 |
|LOGISTIC REGRESSION| (e) | P=0.201 |
|COCH-ARM / FISHERS | P=0.591N | P=0.207 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/13 (85%) 7/9 (78%) | 22/36 (61%) 31/53 (58%) |
|POLY-3 ADJUSTED (b)| 84.6% 90.5% | 62.5% 62.4% |
|TERMINAL (d) | 8/10 (80%) 5/5 (100%) | 17/24 (71%) 24/37 (65%) |
|FIRST INCIDENCE | 582 667 | 603 567 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.582 | P=0.563 |
|POLY 3 | P=0.689 | P=0.574N |
|POLY 1.5 | P=0.768 | P=0.533N |
|POLY 6 | P=0.586 | P=0.535 |
|LOGISTIC REGRESSION| P=0.617 | P=0.568 |
|COCH-ARM / FISHERS | P=0.550N | P=0.490N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 41
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Nose |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 7/100 (7%) | 0/99 (0%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 1.1% 7.7% | 0.0% 0.0% |
|TERMINAL (d) | 1/76 (1%) 3/74 (4%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 734 (T) 605 | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.034 * | (e) |
|POLY 3 | P=0.033 * | (e) |
|POLY 1.5 | P=0.034 * | (e) |
|POLY 6 | P=0.032 * | (e) |
|LOGISTIC REGRESSION| P=0.037 * | (e) |
|COCH-ARM / FISHERS | P=0.033 * | (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Ovary |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/79 (0%) 3/96 (3%) |
|POLY-3 ADJUSTED (b)| | 0.0% 3.4% |
|TERMINAL (d) | | 0/65 (0%) 3/77 (4%) |
|FIRST INCIDENCE | | --- 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | | P=0.154 |
|POLY 3 | | P=0.141 |
|POLY 1.5 | | P=0.143 |
|POLY 6 | | P=0.138 |
|LOGISTIC REGRESSION| | P=0.154 |
|COCH-ARM / FISHERS | | P=0.163 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 42
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Ovary |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 4/79 (5%) 3/96 (3%) |
|POLY-3 ADJUSTED (b)| | 5.4% 3.4% |
|TERMINAL (d) | | 3/65 (5%) 1/77 (1%) |
|FIRST INCIDENCE | | 703 656 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | | P=0.454N |
|POLY 3 | | P=0.396N |
|POLY 1.5 | | P=0.390N |
|POLY 6 | | P=0.404N |
|LOGISTIC REGRESSION| | P=0.397N |
|COCH-ARM / FISHERS | | P=0.393N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 22/79 (28%) 24/96 (25%) |
|POLY-3 ADJUSTED (b)| | 29.4% 27.2% |
|TERMINAL (d) | | 19/65 (29%) 23/77 (30%) |
|FIRST INCIDENCE | | 542 567 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | | P=0.458N |
|POLY 3 | | P=0.442N |
|POLY 1.5 | | P=0.421N |
|POLY 6 | | P=0.470N |
|LOGISTIC REGRESSION| | P=0.455N |
|COCH-ARM / FISHERS | | P=0.399N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 43
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Pancreas |
| Infiltration Cellular Focal Mixed Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 0/98 (0%) | 7/87 (8%) 12/95 (13%) |
|POLY-3 ADJUSTED (b)| 1.1% 0.0% | 8.5% 13.6% |
|TERMINAL (d) | 1/76 (1%) 0/74 (0%) | 7/70 (10%) 12/77 (16%) |
|FIRST INCIDENCE | 734 (T) --- | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.505N | P=0.224 |
|POLY 3 | P=0.514N | P=0.207 |
|POLY 1.5 | P=0.510N | P=0.214 |
|POLY 6 | P=0.517N | P=0.198 |
|LOGISTIC REGRESSION| (e) | P=0.224 |
|COCH-ARM / FISHERS | P=0.503N | P=0.222 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Pancreas |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 5/98 (5%) | 5/87 (6%) 5/95 (5%) |
|POLY-3 ADJUSTED (b)| 1.1% 5.6% | 6.1% 5.7% |
|TERMINAL (d) | 0/76 (0%) 5/74 (7%) | 3/70 (4%) 4/77 (5%) |
|FIRST INCIDENCE | 717 734 (T) | 667 656 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.101 | P=0.583N |
|POLY 3 | P=0.099 | P=0.578N |
|POLY 1.5 | P=0.101 | P=0.571N |
|POLY 6 | P=0.098 | P=0.587N |
|LOGISTIC REGRESSION| P=0.096 | P=0.576N |
|COCH-ARM / FISHERS | P=0.103 | P=0.570N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 44
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Pancreas |
| Lipomatosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 4/98 (4%) | 21/87 (24%) 33/95 (35%) |
|POLY-3 ADJUSTED (b)| 1.1% 4.5% | 25.1% 36.9% |
|TERMINAL (d) | 0/76 (0%) 3/74 (4%) | 16/70 (23%) 30/77 (39%) |
|FIRST INCIDENCE | 717 553 | 334 567 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.176 | P=0.082 |
|POLY 3 | P=0.175 | P=0.062 |
|POLY 1.5 | P=0.177 | P=0.069 |
|POLY 6 | P=0.174 | P=0.054 |
|LOGISTIC REGRESSION| P=0.186 | P=0.080 |
|COCH-ARM / FISHERS | P=0.181 | P=0.080 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Pancreas |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/99 (16%) 28/98 (29%) | 12/87 (14%) 15/95 (16%) |
|POLY-3 ADJUSTED (b)| 17.4% 31.5% | 14.6% 16.9% |
|TERMINAL (d) | 15/76 (20%) 27/74 (37%) | 12/70 (17%) 13/77 (17%) |
|FIRST INCIDENCE | 715 729 | 735 (T) 656 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.021 * | P=0.431 |
|POLY 3 | P=0.020 * | P=0.418 |
|POLY 1.5 | P=0.022 * | P=0.425 |
|POLY 6 | P=0.017 * | P=0.408 |
|LOGISTIC REGRESSION| P=0.018 * | P=0.398 |
|COCH-ARM / FISHERS | P=0.027 * | P=0.434 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 45
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 2/98 (2%) | 0/87 (0%) 0/95 (0%) |
|POLY-3 ADJUSTED (b)| 1.1% 2.2% | 0.0% 0.0% |
|TERMINAL (d) | 1/76 (1%) 1/74 (1%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | 734 (T) 620 | --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.491 | (e) |
|POLY 3 | P=0.493 | (e) |
|POLY 1.5 | P=0.495 | (e) |
|POLY 6 | P=0.492 | (e) |
|LOGISTIC REGRESSION| P=0.504 | (e) |
|COCH-ARM / FISHERS | P=0.496 | (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Cytoplasmic Alteration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 4/98 (4%) | 1/87 (1%) 5/95 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 4.4% | 1.2% 5.6% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 1/70 (1%) 1/77 (1%) |
|FIRST INCIDENCE | --- 579 | 735 (T) 458 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.062 | P=0.117 |
|POLY 3 | P=0.062 | P=0.124 |
|POLY 1.5 | P=0.062 | P=0.125 |
|POLY 6 | P=0.062 | P=0.123 |
|LOGISTIC REGRESSION| P=0.079 | P=0.102 |
|COCH-ARM / FISHERS | P=0.059 | P=0.127 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 46
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Pancreas: Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 0/98 (0%) | 1/87 (1%) 2/95 (2%) |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% | 1.2% 2.3% |
|TERMINAL (d) | 2/76 (3%) 0/74 (0%) | 1/70 (1%) 2/77 (3%) |
|FIRST INCIDENCE | 734 (T) --- | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.245N | P=0.533 |
|POLY 3 | P=0.250N | P=0.517 |
|POLY 1.5 | P=0.247N | P=0.519 |
|POLY 6 | P=0.253N | P=0.513 |
|LOGISTIC REGRESSION| (e) | P=0.533 |
|COCH-ARM / FISHERS | P=0.251N | P=0.533 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Parathyroid Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/66 (2%) 1/67 (1%) | 11/63 (17%) 8/58 (14%) |
|POLY-3 ADJUSTED (b)| 1.6% 1.6% | 18.3% 14.6% |
|TERMINAL (d) | 1/48 (2%) 0/53 (0%) | 10/48 (21%) 4/46 (9%) |
|FIRST INCIDENCE | 734 (T) 533 | 733 309 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.751N | P=0.334N |
|POLY 3 | P=0.747N | P=0.390N |
|POLY 1.5 | P=0.750N | P=0.388N |
|POLY 6 | P=0.743N | P=0.394N |
|LOGISTIC REGRESSION| P=0.733 | P=0.278N |
|COCH-ARM / FISHERS | P=0.748N | P=0.382N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 47
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/83 (11%) 14/86 (16%) | 0/83 (0%) 4/93 (4%) |
|POLY-3 ADJUSTED (b)| 11.5% 17.4% | 0.0% 4.7% |
|TERMINAL (d) | 7/66 (11%) 11/67 (16%) | 0/67 (0%) 4/74 (5%) |
|FIRST INCIDENCE | 617 667 | --- 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.190 | P=0.078 |
|POLY 3 | P=0.202 | P=0.073 |
|POLY 1.5 | P=0.206 | P=0.074 |
|POLY 6 | P=0.195 | P=0.072 |
|LOGISTIC REGRESSION| P=0.203 | P=0.078 |
|COCH-ARM / FISHERS | P=0.211 | P=0.076 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/83 (1%) 1/86 (1%) | 37/83 (45%) 35/93 (38%) |
|POLY-3 ADJUSTED (b)| 1.3% 1.3% | 47.8% 39.9% |
|TERMINAL (d) | 1/66 (2%) 1/67 (2%) | 35/67 (52%) 29/74 (39%) |
|FIRST INCIDENCE | 734 (T) 734 (T) | 691 449 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.758N | P=0.263N |
|POLY 3 | P=0.752N | P=0.191N |
|POLY 1.5 | P=0.750N | P=0.198N |
|POLY 6 | P=0.756N | P=0.188N |
|LOGISTIC REGRESSION| P=0.758N | P=0.234N |
|COCH-ARM / FISHERS | P=0.743N | P=0.217N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 48
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Preputial Gland |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/98 (26%) 56/99 (57%) | |
|POLY-3 ADJUSTED (b)| 27.0% 58.9% | |
|TERMINAL (d) | 15/75 (20%) 38/74 (51%) | |
|FIRST INCIDENCE | 624 533 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** | |
|POLY 3 | P<0.001 ** | |
|POLY 1.5 | P<0.001 ** | |
|POLY 6 | P<0.001 ** | |
|LOGISTIC REGRESSION| P<0.001 ** | |
|COCH-ARM / FISHERS | P<0.001 ** | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Preputial Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 84/98 (86%) 89/99 (90%) | |
|POLY-3 ADJUSTED (b)| 87.6% 90.5% | |
|TERMINAL (d) | 65/75 (87%) 65/74 (88%) | |
|FIRST INCIDENCE | 386 415 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.230 | |
|POLY 3 | P=0.331 | |
|POLY 1.5 | P=0.292 | |
|POLY 6 | P=0.386 | |
|LOGISTIC REGRESSION| P=0.233 | |
|COCH-ARM / FISHERS | P=0.249 | |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 49
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Preputial Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 46/98 (47%) 61/99 (62%) | |
|POLY-3 ADJUSTED (b)| 49.8% 66.0% | |
|TERMINAL (d) | 39/75 (52%) 52/74 (70%) | |
|FIRST INCIDENCE | 617 533 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.019 * | |
|POLY 3 | P=0.016 * | |
|POLY 1.5 | P=0.019 * | |
|POLY 6 | P=0.013 * | |
|LOGISTIC REGRESSION| P=0.015 * | |
|COCH-ARM / FISHERS | P=0.027 * | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Prostate |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/98 (2%) 6/92 (7%) | |
|POLY-3 ADJUSTED (b)| 2.2% 7.2% | |
|TERMINAL (d) | 1/76 (1%) 6/71 (9%) | |
|FIRST INCIDENCE | 684 734 (T) | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.119 | |
|POLY 3 | P=0.115 | |
|POLY 1.5 | P=0.118 | |
|POLY 6 | P=0.113 | |
|LOGISTIC REGRESSION| P=0.111 | |
|COCH-ARM / FISHERS | P=0.120 | |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 50
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Prostate: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 49/98 (50%) 45/92 (49%) | |
|POLY-3 ADJUSTED (b)| 52.9% 52.9% | |
|TERMINAL (d) | 47/76 (62%) 39/71 (55%) | |
|FIRST INCIDENCE | 386 630 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.503N | |
|POLY 3 | P=0.561 | |
|POLY 1.5 | P=0.548N | |
|POLY 6 | P=0.562N | |
|LOGISTIC REGRESSION| P=0.549 | |
|COCH-ARM / FISHERS | P=0.498N | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Salivary Glands |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 66/99 (67%) 69/99 (70%) | 74/94 (79%) 79/99 (80%) |
|POLY-3 ADJUSTED (b)| 70.1% 73.4% | 80.9% 81.9% |
|TERMINAL (d) | 58/76 (76%) 58/74 (78%) | 60/70 (86%) 64/77 (83%) |
|FIRST INCIDENCE | 520 415 | 334 309 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.281 | P=0.509N |
|POLY 3 | P=0.366 | P=0.500 |
|POLY 1.5 | P=0.371 | P=0.511 |
|POLY 6 | P=0.364 | P=0.479 |
|LOGISTIC REGRESSION| P=0.287 | P=0.487 |
|COCH-ARM / FISHERS | P=0.380 | P=0.497 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 51
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Seminal Vesicle |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 80/99 (81%) 58/98 (59%) | |
|POLY-3 ADJUSTED (b)| 82.9% 62.8% | |
|TERMINAL (d) | 65/76 (86%) 46/74 (62%) | |
|FIRST INCIDENCE | 386 415 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.006N** | |
|POLY 3 | P<0.001N** | |
|POLY 1.5 | P<0.001N** | |
|POLY 6 | P<0.001N** | |
|LOGISTIC REGRESSION| P<0.001N** | |
|COCH-ARM / FISHERS | P<0.001N** | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Seminal Vesicle |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 0/98 (0%) | |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% | |
|TERMINAL (d) | 2/76 (3%) 0/74 (0%) | |
|FIRST INCIDENCE | 734 (T) --- | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.245N | |
|POLY 3 | P=0.252N | |
|POLY 1.5 | P=0.248N | |
|POLY 6 | P=0.256N | |
|LOGISTIC REGRESSION| (e) | |
|COCH-ARM / FISHERS | P=0.251N | |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 52
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Skin |
| Ulcer Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 1/100 (1%) | 2/99 (2%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.1% | 2.2% 0.0% |
|TERMINAL (d) | 0/76 (0%) 1/74 (1%) | 1/70 (1%) 0/77 (0%) |
|FIRST INCIDENCE | --- 734 (T) | 691 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.495 | P=0.236N |
|POLY 3 | P=0.500 | P=0.237N |
|POLY 1.5 | P=0.500 | P=0.235N |
|POLY 6 | P=0.500 | P=0.240N |
|LOGISTIC REGRESSION| P=0.495 | P=0.237N |
|COCH-ARM / FISHERS | P=0.503 | P=0.246N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 37/99 (37%) 48/98 (49%) | 74/91 (81%) 92/99 (93%) |
|POLY-3 ADJUSTED (b)| 39.2% 50.7% | 84.2% 94.4% |
|TERMINAL (d) | 29/76 (38%) 34/74 (46%) | 63/70 (90%) 76/77 (99%) |
|FIRST INCIDENCE | 386 456 | 397 309 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.072 | P=0.038 * |
|POLY 3 | P=0.071 | P=0.015 * |
|POLY 1.5 | P=0.068 | P=0.015 * |
|POLY 6 | P=0.076 | P=0.013 * |
|LOGISTIC REGRESSION| P=0.071 | P=0.009 ** |
|COCH-ARM / FISHERS | P=0.067 | P=0.014 * |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 53
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Spleen |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 1/98 (1%) | 17/91 (19%) 12/99 (12%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.1% | 20.0% 13.3% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 15/70 (21%) 9/77 (12%) |
|FIRST INCIDENCE | --- 620 | 696 650 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.496 | P=0.153N |
|POLY 3 | P=0.500 | P=0.158N |
|POLY 1.5 | P=0.500 | P=0.152N |
|POLY 6 | P=0.500 | P=0.166N |
|LOGISTIC REGRESSION| P=0.511 | P=0.174N |
|COCH-ARM / FISHERS | P=0.497 | P=0.146N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Spleen: Lymphoid Follicle |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/99 (11%) 8/98 (8%) | 6/91 (7%) 3/99 (3%) |
|POLY-3 ADJUSTED (b)| 11.6% 8.8% | 6.9% 3.3% |
|TERMINAL (d) | 1/76 (1%) 1/74 (1%) | 1/70 (1%) 1/77 (1%) |
|FIRST INCIDENCE | 520 581 | 552 481 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.355N | P=0.245N |
|POLY 3 | P=0.346N | P=0.220N |
|POLY 1.5 | P=0.337N | P=0.213N |
|POLY 6 | P=0.357N | P=0.231N |
|LOGISTIC REGRESSION| P=0.269N | P=0.181N |
|COCH-ARM / FISHERS | P=0.324N | P=0.209N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 54
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Spleen: Lymphoid Follicle |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/99 (21%) 19/98 (19%) | 31/91 (34%) 40/99 (40%) |
|POLY-3 ADJUSTED (b)| 22.8% 21.3% | 36.5% 44.2% |
|TERMINAL (d) | 20/76 (26%) 19/74 (26%) | 31/70 (44%) 39/77 (51%) |
|FIRST INCIDENCE | 683 734 (T) | 735 (T) 534 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.469N | P=0.224 |
|POLY 3 | P=0.473N | P=0.185 |
|POLY 1.5 | P=0.460N | P=0.202 |
|POLY 6 | P=0.488N | P=0.166 |
|LOGISTIC REGRESSION| P=0.490N | P=0.138 |
|COCH-ARM / FISHERS | P=0.444N | P=0.226 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Spleen: Red Pulp |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 4/98 (4%) | 2/91 (2%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 4.4% | 2.3% 0.0% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 0/70 (0%) 0/77 (0%) |
|FIRST INCIDENCE | --- 581 | 542 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.062 | P=0.236N |
|POLY 3 | P=0.062 | P=0.222N |
|POLY 1.5 | P=0.062 | P=0.217N |
|POLY 6 | P=0.062 | P=0.228N |
|LOGISTIC REGRESSION| P=0.068 | P=0.206N |
|COCH-ARM / FISHERS | P=0.059 | P=0.228N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 55
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/99 (9%) 8/99 (8%) | 6/91 (7%) 6/97 (6%) |
|POLY-3 ADJUSTED (b)| 9.8% 8.9% | 7.0% 6.7% |
|TERMINAL (d) | 8/76 (11%) 6/74 (8%) | 4/70 (6%) 6/77 (8%) |
|FIRST INCIDENCE | 715 680 | 701 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.529N | P=0.565N |
|POLY 3 | P=0.522N | P=0.579N |
|POLY 1.5 | P=0.514N | P=0.573N |
|POLY 6 | P=0.530N | P=0.590N |
|LOGISTIC REGRESSION| P=0.535N | P=0.591N |
|COCH-ARM / FISHERS | P=0.500N | P=0.571N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 1/99 (1%) | 4/91 (4%) 5/97 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.1% | 4.7% 5.6% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 4/70 (6%) 4/77 (5%) |
|FIRST INCIDENCE | --- 630 | 735 (T) 701 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.496 | P=0.550 |
|POLY 3 | P=0.500 | P=0.530 |
|POLY 1.5 | P=0.500 | P=0.533 |
|POLY 6 | P=0.500 | P=0.524 |
|LOGISTIC REGRESSION| P=0.529 | P=0.521 |
|COCH-ARM / FISHERS | P=0.500 | P=0.540 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 56
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/94 (0%) 0/93 (0%) | 7/86 (8%) 5/94 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 8.6% 5.8% |
|TERMINAL (d) | 0/76 (0%) 0/74 (0%) | 7/70 (10%) 5/77 (7%) |
|FIRST INCIDENCE | --- --- | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.318N |
|POLY 3 | (e) | P=0.339N |
|POLY 1.5 | (e) | P=0.330N |
|POLY 6 | (e) | P=0.352N |
|LOGISTIC REGRESSION| (e) | P=0.318N |
|COCH-ARM / FISHERS | (e) | P=0.323N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Stomach, Glandular: Epithelium |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/94 (9%) 10/93 (11%) | 14/86 (16%) 28/94 (30%) |
|POLY-3 ADJUSTED (b)| 9.0% 11.4% | 16.7% 31.9% |
|TERMINAL (d) | 7/76 (9%) 6/74 (8%) | 8/70 (11%) 24/77 (31%) |
|FIRST INCIDENCE | 715 547 | 334 567 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.377 | P=0.026 * |
|POLY 3 | P=0.392 | P=0.015 * |
|POLY 1.5 | P=0.393 | P=0.018 * |
|POLY 6 | P=0.391 | P=0.013 * |
|LOGISTIC REGRESSION| P=0.392 | P=0.027 * |
|COCH-ARM / FISHERS | P=0.393 | P=0.024 * |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 57
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Stomach, Glandular: Epithelium |
| Cyst Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/94 (6%) 11/93 (12%) | 23/86 (27%) 20/94 (21%) |
|POLY-3 ADJUSTED (b)| 6.8% 12.7% | 28.0% 22.9% |
|TERMINAL (d) | 6/76 (8%) 10/74 (14%) | 20/70 (29%) 19/77 (25%) |
|FIRST INCIDENCE | 734 (T) 668 | 608 458 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.140 | P=0.250N |
|POLY 3 | P=0.143 | P=0.278N |
|POLY 1.5 | P=0.146 | P=0.262N |
|POLY 6 | P=0.141 | P=0.304N |
|LOGISTIC REGRESSION| P=0.136 | P=0.278N |
|COCH-ARM / FISHERS | P=0.149 | P=0.247N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Testes |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/99 (3%) 2/98 (2%) | |
|POLY-3 ADJUSTED (b)| 3.3% 2.2% | |
|TERMINAL (d) | 1/76 (1%) 0/74 (0%) | |
|FIRST INCIDENCE | 684 605 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.524N | |
|POLY 3 | P=0.517N | |
|POLY 1.5 | P=0.513N | |
|POLY 6 | P=0.521N | |
|LOGISTIC REGRESSION| P=0.483N | |
|COCH-ARM / FISHERS | P=0.505N | |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 58
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Thymus |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/69 (0%) 0/60 (0%) | 1/78 (1%) 2/89 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 1.4% 2.4% |
|TERMINAL (d) | 0/54 (0%) 0/46 (0%) | 1/62 (2%) 2/71 (3%) |
|FIRST INCIDENCE | --- --- | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.547 |
|POLY 3 | (e) | P=0.526 |
|POLY 1.5 | (e) | P=0.528 |
|POLY 6 | (e) | P=0.523 |
|LOGISTIC REGRESSION| (e) | P=0.547 |
|COCH-ARM / FISHERS | (e) | P=0.550 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 62/69 (90%) 44/60 (73%) | 22/78 (28%) 27/89 (30%) |
|POLY-3 ADJUSTED (b)| 90.1% 74.3% | 29.5% 31.2% |
|TERMINAL (d) | 48/54 (89%) 32/46 (70%) | 14/62 (23%) 16/71 (23%) |
|FIRST INCIDENCE | 386 415 | 608 309 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.060N | P=0.380 |
|POLY 3 | P=0.016N* | P=0.471 |
|POLY 1.5 | P=0.014N* | P=0.466 |
|POLY 6 | P=0.018N* | P=0.469 |
|LOGISTIC REGRESSION| P=0.013N* | P=0.471 |
|COCH-ARM / FISHERS | P=0.013N* | P=0.448 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 59
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Thymus |
| Cyst Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/69 (6%) 5/60 (8%) | 5/78 (6%) 3/89 (3%) |
|POLY-3 ADJUSTED (b)| 6.3% 9.1% | 6.8% 3.7% |
|TERMINAL (d) | 4/54 (7%) 5/46 (11%) | 5/62 (8%) 3/71 (4%) |
|FIRST INCIDENCE | 734 (T) 734 (T) | 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.401 | P=0.287N |
|POLY 3 | P=0.424 | P=0.292N |
|POLY 1.5 | P=0.424 | P=0.287N |
|POLY 6 | P=0.423 | P=0.299N |
|LOGISTIC REGRESSION| P=0.401 | P=0.287N |
|COCH-ARM / FISHERS | P=0.412 | P=0.289N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Thymus |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/69 (1%) 0/60 (0%) | 0/78 (0%) 2/89 (2%) |
|POLY-3 ADJUSTED (b)| 1.6% 0.0% | 0.0% 2.4% |
|TERMINAL (d) | 0/54 (0%) 0/46 (0%) | 0/62 (0%) 2/71 (3%) |
|FIRST INCIDENCE | 582 --- | --- 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.509N | P=0.269 |
|POLY 3 | P=0.559N | P=0.250 |
|POLY 1.5 | P=0.557N | P=0.252 |
|POLY 6 | P=0.561N | P=0.249 |
|LOGISTIC REGRESSION| P=0.533N | P=0.269 |
|COCH-ARM / FISHERS | P=0.535N | P=0.283 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 60
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Thymus |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/69 (4%) 5/60 (8%) | 31/78 (40%) 25/89 (28%) |
|POLY-3 ADJUSTED (b)| 4.7% 9.1% | 42.4% 30.2% |
|TERMINAL (d) | 2/54 (4%) 5/46 (11%) | 31/62 (50%) 23/71 (32%) |
|FIRST INCIDENCE | 534 734 (T) | 735 (T) 458 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.282 | P=0.069N |
|POLY 3 | P=0.289 | P=0.075N |
|POLY 1.5 | P=0.291 | P=0.073N |
|POLY 6 | P=0.287 | P=0.079N |
|LOGISTIC REGRESSION| P=0.284 | P=0.097N |
|COCH-ARM / FISHERS | P=0.284 | P=0.077N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Thymus: Thymocyte |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/69 (0%) 0/60 (0%) | 0/78 (0%) 3/89 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 0.0% 3.6% |
|TERMINAL (d) | 0/54 (0%) 0/46 (0%) | 0/62 (0%) 0/71 (0%) |
|FIRST INCIDENCE | --- --- | --- 458 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.125 |
|POLY 3 | (e) | P=0.136 |
|POLY 1.5 | (e) | P=0.137 |
|POLY 6 | (e) | P=0.135 |
|LOGISTIC REGRESSION| (e) | P=0.144 |
|COCH-ARM / FISHERS | (e) | P=0.149 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 61
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Inflammation Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/98 (0%) | 2/92 (2%) 2/98 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 2.3% 2.3% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) | 1/70 (1%) 2/75 (3%) |
|FIRST INCIDENCE | --- --- | 461 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.673N |
|POLY 3 | (e) | P=0.688N |
|POLY 1.5 | (e) | P=0.679N |
|POLY 6 | (e) | P=0.690 |
|LOGISTIC REGRESSION| (e) | P=0.636N |
|COCH-ARM / FISHERS | (e) | P=0.665N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicle |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/99 (5%) 9/98 (9%) | 21/92 (23%) 37/98 (38%) |
|POLY-3 ADJUSTED (b)| 5.4% 10.1% | 24.2% 41.2% |
|TERMINAL (d) | 4/76 (5%) 6/72 (8%) | 20/70 (29%) 31/75 (41%) |
|FIRST INCIDENCE | 718 579 | 701 567 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.182 | P=0.019 * |
|POLY 3 | P=0.186 | P=0.011 * |
|POLY 1.5 | P=0.190 | P=0.013 * |
|POLY 6 | P=0.181 | P=0.009 ** |
|LOGISTIC REGRESSION| P=0.188 | P=0.008 ** |
|COCH-ARM / FISHERS | P=0.198 | P=0.019 * |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 62
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/99 (0%) 0/98 (0%) | 3/92 (3%) 0/98 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% | 3.5% 0.0% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) | 3/70 (4%) 0/75 (0%) |
|FIRST INCIDENCE | --- --- | 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) | P=0.111N |
|POLY 3 | (e) | P=0.117N |
|POLY 1.5 | (e) | P=0.113N |
|POLY 6 | (e) | P=0.121N |
|LOGISTIC REGRESSION| (e) | (e) |
|COCH-ARM / FISHERS | (e) | P=0.112N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/98 (4%) 4/94 (4%) | 8/79 (10%) 5/92 (5%) |
|POLY-3 ADJUSTED (b)| 4.4% 4.6% | 10.6% 5.9% |
|TERMINAL (d) | 4/76 (5%) 4/74 (5%) | 8/67 (12%) 4/76 (5%) |
|FIRST INCIDENCE | 734 (T) 734 (T) | 735 (T) 715 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.627 | P=0.212N |
|POLY 3 | P=0.611 | P=0.203N |
|POLY 1.5 | P=0.615 | P=0.197N |
|POLY 6 | P=0.608 | P=0.212N |
|LOGISTIC REGRESSION| P=0.627 | P=0.225N |
|COCH-ARM / FISHERS | P=0.616 | P=0.194N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 63
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Uterus |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 1/92 (1%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| | 1.2% 3.3% |
|TERMINAL (d) | | 1/70 (1%) 2/77 (3%) |
|FIRST INCIDENCE | | 735 (T) 567 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | | P=0.336 |
|POLY 3 | | P=0.322 |
|POLY 1.5 | | P=0.325 |
|POLY 6 | | P=0.318 |
|LOGISTIC REGRESSION| | P=0.345 |
|COCH-ARM / FISHERS | | P=0.343 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Uterus |
| Hydrometra |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 48/92 (52%) 48/100 (48%) |
|POLY-3 ADJUSTED (b)| | 54.5% 50.5% |
|TERMINAL (d) | | 38/70 (54%) 37/77 (48%) |
|FIRST INCIDENCE | | 542 449 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | | P=0.364N |
|POLY 3 | | P=0.344N |
|POLY 1.5 | | P=0.335N |
|POLY 6 | | P=0.360N |
|LOGISTIC REGRESSION| | P=0.358N |
|COCH-ARM / FISHERS | | P=0.332N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 64
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Uterus |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/92 (2%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| | 2.3% 0.0% |
|TERMINAL (d) | | 2/70 (3%) 0/77 (0%) |
|FIRST INCIDENCE | | 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | | P=0.218N |
|POLY 3 | | P=0.222N |
|POLY 1.5 | | P=0.217N |
|POLY 6 | | P=0.228N |
|LOGISTIC REGRESSION| | (e) |
|COCH-ARM / FISHERS | | P=0.228N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 10 GAUSS | SHAM 10 GAUSS |
| | CONTROL INTER. | CONTROL INTER. |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 54/92 (59%) 62/100 (62%) |
|POLY-3 ADJUSTED (b)| | 60.4% 65.8% |
|TERMINAL (d) | | 43/70 (61%) 51/77 (66%) |
|FIRST INCIDENCE | | 334 449 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | | P=0.365 |
|POLY 3 | | P=0.270 |
|POLY 1.5 | | P=0.307 |
|POLY 6 | | P=0.233 |
|LOGISTIC REGRESSION| | P=0.337 |
|COCH-ARM / FISHERS | | P=0.374 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Poly-3 adjusted lifetime tumor incidence.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).