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International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward Final Documents
November 28–29, 2012

International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward Presentations
November 28–29, 2012

Opening Session

Session 1: Alternatives to HIST: Methods and Evaluations: Reports on Alternative Methods to HIST and Results Using Pertussis Toxin-Spiked Vaccine Samples

Biochemical Assays: Carbohydrate-Binding Assay; Enzymatic/HPLC Assays

Biochemical and Cell-Based Assays: Carbohydrate-Binding Assay, Enzymatic/HPLC Assays, CHO Cell Clustering Assay

Genetic Assays: Differential Gene Expression in Monocyte-Derived Dendritic Cells

Session 2: The Path Forward: Gaps to Cross and Bridges to Build in the Road Toward the Adoption of Alternatives to HIST