Scientific Advisory Committee on Alternative Toxicological Methods Meeting Final Documents
September 2 - 3 , 2020
Federal Register Notices September 2 - 3 , 2020
Scientific Advisory Committee on Alternative Toxicological Methods Meeting Meeting Materials
September 2 - 3 , 2020
Presentation Abstracts and Background Materials
- Session 1: ICCVAM – Past, Present, Future (Wednesday, September 2)
- Session 2a: Fostering International Partnerships (Wednesday, September 2)
- Session 2b: Moving Away from Animal-based Antibodies (Wednesday, September 2)
- Session 3: Curating and Characterizing Data for Alternative Methods Use (Thursday, September 3)
- Session 4: Computational Resources (Thursday, September 3)
Public Comments
| Agenda Topic | Name, Affiliation, Sponsorship | Technical and Scientific Public Comments |
|---|---|---|
|
ICCVAM – Past, Present and Future Fostering International Partnerships Moving Away from Animal-based Antibodies Curating and Characterizing Data for Alternative Method Use Computational Resources |
Vicki Katrinak, Humane Society of the United States and Gillian Lyons, Humane Society Legislative Fund |
Public comment received August 26, 2020 |
Scientific Advisory Committee on Alternative Toxicological Methods Meeting Presentations
September 2 - 3 , 2020
September 2, 2020
ICCVAM: Past, Present, and Future
- 20 Years of Scientific Accomplishments
Emily Reinke, PhD, U.S. Department of Defense - Implementing the Strategic Roadmap
Nicole Kleinstreuer, PhD, NIEHS/NTP - NTP Approaches to Assessment of Dermal Hypersensitivity: Using Alternative Methods to Predict Skin Sensitization
Dori Germolec, PhD, NIEHS/NTP - Measuring Success of 3Rs Initiatives
Suzanne Fitzpatrick, PhD, U.S. Food and Drug Administration (FDA) Center for Food Safety and Applied Nutrition - The Strategic Roadmap: What Lies on the Horizon?
Warren Casey, PhD, NIEHS/NTP
Fostering International Partnerships
- International Partner Updates
Anna Lowit, PhD, U.S. Environmental Protection Agency (EPA) Office of Pesticide Programs - FDA, ICH, and the 3Rs
Paul Brown, PhD, FDA Center for Drug Evaluation and Research - Nonanimal Test Methods for Hazard Classification – Update on UN GHS Activities
Janet Carter, PhD, Occupational Safety and Health Administration
Moving Away from Animal-based Antibodies
- COVID-19 Therapeutic Development with Synthetic Antibody Technology
Sachdev Sidhu, PhD, University of Toronto
September 3, 2020
Curating and Characterizing Data for Alternative Methods Use
- Incorporating Variability in Animal Studies into Regulatory Frameworks and NAM Assessment
Nicole Kleinstreuer, PhD, NIEHS/NTP - Quantitative Variability in Repeat Dose Toxicity Studies: Implications for Scientific Confidence in New Approach Methodologies
Katie Paul-Friedman, PhD, EPA Office of Research and Development - Machine Learning in Toxicology: Towards Intelligent Access to the Content of Research
Robert Patton, PhD, Oak Ridge National Laboratory - Stem Cells and Genomics for Precision Cardiovascular Medicine
Joseph Wu, MD, PhD, Stanford University School of Medicine
(This is a large presentation and will take a few moments to download)
Computational Resources
- Introduction
Nicole Kleinstreuer, PhD, NIEHS/NTP - Integrated Chemical Environment (ICE) and In Vitro to In Vivo Extrapolation (IVIVE)
Shannon Bell, PhD, ILS (contractor supporting NICEATM) - Collaborative Modeling Project for Predicting Acute Oral Toxicity (CATMoS)
Kamel Mansouri, PhD, ILS (contractor supporting NICEATM) - Toxicokinetic and Toxicological Based Geospatial Risk Mapping
Kyle Messier, PhD, NIEHS/NTP