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Nomination Summary for Yohimbe (N20032)

Nominated Substances: Yohimbe bark extract, Yohimbine

Nomination Date: 05/31/2000

Nominator: NCI

Rationale: Yohimbe bark extract is a dietary supplement used as an aphrodisiac and to enhance athletic performance. Yohimbine, the active ingredient, can cause an increase in blood pressure. No information on the genotoxicity or carcinogenicity of yohimbe or yohimbine was found. The structurally related compound reserpine was carcinogenic in both mice and rats. Yohimbine hydrochloride is a FDA approved prescription drug for the treatment of impotence.

NTP Principles: not specified

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

CASRN: 85117-22-2

Agent Name: Yohimbe bark extract