Nomination Summary for Local anesthetics & metabolites (N20041)
Nomination Date: 09/00/2000
Rationale: Local anesthetics have widespread clinical use and human exposure including prenatal/postnatal exposure. Some of these compounds may be metabolized to carcinogenic and neurotoxic intermediates. NIEHS has identified for nomination local anesthetics that contain the 2,6-xylidine or o-toludine substructure for metabolism and mutagenicity studies.
Agents and Status
The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.
Agent Name: Bupivacaine
Agent Name: Bupivacaine hydrochloride
Agent Name: Mepivicaine hydrochloride
Agent Name: Prilocaine
Agent Name: Prilocaine hydrochloride