Nomination Summary for Local anesthetics & metabolites (N20041)
Nominated Substances: Bupivacaine, Bupivacaine hydrochloride, Etidocaine, Mepivicaine, Mepivicaine hydrochloride, Prilocaine, Prilocaine hydrochloride, Ropivacaine
Nomination Date: 09/00/2000
Nominator: NIEHS
Rationale: Local anesthetics have widespread clinical use and human exposure including prenatal/postnatal exposure. Some of these compounds may be metabolized to carcinogenic and neurotoxic intermediates. NIEHS has identified for nomination local anesthetics that contain the 2,6-xylidine or o-toludine substructure for metabolism and mutagenicity studies.
Agents and Status
The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.
CASRN: 38396-39-3
Agent Name: Bupivacaine
CASRN: 14252-80-3
Agent Name: Bupivacaine hydrochloride
CASRN: 1722-62-9
Agent Name: Mepivicaine hydrochloride
CASRN: 721-50-6
Agent Name: Prilocaine
CASRN: 1786-81-8
Agent Name: Prilocaine hydrochloride