Nomination Summary for Lemon oil & Lime oil (N20101)
Nominated Substances: Lemon oil, Lime oil, 5-Methoxypsoralen, Oxypeucedanin
Nomination Date: 10/10/2000
Nominator: FDA
Rationale: Lemon and lime oils are added as fragrances to cosmetic products including some products intended for use on sun-exposed skin. Studies have shown that lemon and lime oil are phototoxic. Safe use levels have been recommended for avoiding short-term phototoxicity, but long-term use and effects have not been addressed. The phototoxicity elicited by lemon and lime oils has been associated with naturally occurring furocoumarins. While the photogenotoxicity of 5- methoxypsoralen is well established, the photogenotoxicity of oxypeucedanin alone or in mixtures has not been assessed.