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Nomination Summary for Aminopyridines (N20616)

Nominated Substances: 3-Aminopyridine, 2-Aminopyridine, 4-Aminopyridine

Nomination Date: 04/26/2006

Nominator: NCI

Rationale: Animal and human studies have shown that the aminopyridines are acutely toxic compounds, partly due to its ability to block K+ channels, causing convulsions, seizures, among other effects.

NTP Principles: 1, 3, 6, 7

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

CASRN: 462-08-8

Agent Name: 3-Aminopyridine

CASRN: 504-29-0

Agent Name: 2-Aminopyridine

CASRN: 504-24-5

Agent Name: 4-Aminopyridine