Nomination Summary for Ethyl alcohol and Mammary Tumors in ICR Mice (N21104)
Nominated Substances: Ethanol
Nomination Date: 01/26/2011
Nominator: National Institute on Alcohol Abuse and Alcoholism, NIH
Rationale: Relationship between alcohol consumption and breast cancer in women is a major public health concern; ethanol is classified as Carcinogenic to Humans (Group 1) by IARC, at multiple target tissues including the female breast, and based almost entirely on epidemiologic data; inadequacies in design of experimental animal studies where mammary tumors were observed; need to assess potential for ethanol to cause mammary tumors under rigorously defined and controlled studies in multiple strains of mice differing in susceptibility to chemical-induced mammary carcinogenesis
NTP Principles: not specified