Nomination Summary for Bisphenol S (BPS) compounds (N21404)
Nominated Substances: BPS 80-09-1, 2,4-BPS 5397-34-2, BPS-MAE 97042-18-7, BPS-MPE 63134-33-8
Nomination Date: 02/06/2014
Rationale: BPS is used in plasticizers and epoxy resins and as a developer in thermal paper. BPS has been shown to have reproductive and developmental effects (NOAEL = 60 mg/kg/day) and may exhibit endocrine activity. BPS is an alternative to BPA, which is being voluntarily phased out and is the subject of a test rule. BPS has been detected in human urine samples from general populations of the U.S., indicating that it may already be in use. Data gaps for BPS include cancer and neurological studies; other BPS compounds lack data on carcinogenicity, reproductive, developmental, and neurological effects.
NTP Principles: not specified