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Nomination Summary for Estragole (N79475)

Nominated Substances: Estragole

Nomination Date: 09/00/1979

Nominator: NCI

Rationale: Nominated due to its structural similarity to the known carcinogen, safrole, and preliminary carcinogenicity studies in which it induced significant incidences of hepatocellular carcinomas in preweanling mice following subcutaneous injections. Estragole has the potential for wide-spread human exposure since it is used as a food flavoring agent and as a fragrance.

NTP Principles: Pre 1993 - 1, 3, 5

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

CASRN: 140-67-0

Agent Name: Estragole