Nomination Summary for Transgenic model evaluation (N95037)
Nominated Substances: p-Anisidine hydrochloride, Cyclosporin A, 2,4-Diaminotoluene (2,4-toluene diamine), Diethylstilbestrol, 8-Hydroxyquinoline, Melphalan, N-Methylolacrylamide, Methylphenidate hydrochloride, Resorcinol, Rotenone, 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride)
Nomination Date: 01/11/1995
Nominator: NIEHS
Rationale: The purpose of the proposed studies is to further examine the strengths and weaknesses of the Tg.AC and the p53+/- mouse models for identification of documented human and rodent carcinogens, and to explore their ability to provide information concerning the effective dosimetry for target organ mutation.
NTP Principles: 6
Agents and Status
The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.
CASRN: 20265-97-8
Agent Name: p-Anisidine hydrochloride
CASRN: 59865-13-3
Agent Name: Cyclosporin A
CASRN: 95-80-7
Agent Name: 2,4-Diaminotoluene (2,4-toluene diamine)
CASRN: 56-53-1
Agent Name: Diethylstilbestrol
CASRN: 148-24-3
Agent Name: 8-Hydroxyquinoline
CASRN: 148-82-3
Agent Name: Melphalan
CASRN: 924-42-5
Agent Name: N-Methylolacrylamide
CASRN: 298-59-9
Agent Name: Methylphenidate hydrochloride
CASRN: 108-46-3
Agent Name: Resorcinol
CASRN: 83-79-4
Agent Name: Rotenone
CASRN: 1746-01-6
Agent Name: 2,3,7,8-Tetrachlorodibenzo-p-dioxin
CASRN: 15481-70-6
Agent Name: 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride)