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Nomination Summary for Melatonin (N96006)

Nominated Substances: Melatonin

Nomination Date: 09/04/1995

Nominator: NIEHS

Rationale: Melatonin, a hormone produced by the pineal gland, has become very popular as an over-the-counter hormone supplement as well as being used as a chemotherapeutic agent in cancer. A literature search reveals a lack of toxicity studies. In addition, it has been suggested that melatonin may have the potential to cause ocular toxicity.

NTP Principles: 1, 2, 3, 6

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

CASRN: 73-31-4

Agent Name: Melatonin