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Nomination Summary for Phenothiazine (N97013)

Nominated Substances: Phenothiazine

Nomination Date: 05/00/1997

Nominator: NIEHS

Rationale: The nomination of phenothiazine is based on high production volumes and limited toxicological information. It is extensively used as a veterinary insecticide and antihelmintic in farm animals, but not humans or companion animals. (Zeneca, 11/19/97, indicated phenothiazine's current use is in industrial applications; no longer used for veterinary & agricultural applications.) Several phenothiazine-derivative psychopharmacological agents are marketed in the U.S. including chlorpromazine (Thorazine). It is not currently registered under FIFRA as a pesticide, but its veterinary use has been 'grandfathered' in. Phenothiazine is a photosensitizer in humans following oral administration. Oral consumption of high doses by humans has been reported to cause a number of effects including hemolytic anemia, toxic hepatitis, gastrointestinal and dermal irritation and kidney damage.

NTP Principles: 2, 3

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

CASRN: 92-84-2

Agent Name: Phenothiazine