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Nomination Summary for Ethyl silicate (N97034)

Nominated Substances: Ethyl silicate

Nomination Date: 09/30/1997

Nominator: NCI

Rationale: Ethyl silicate's nomination is based on: 1) its potential for occupational exposures based on high production volume (7-20 million lbs) and estimate of potential worker exposures in the National Occupational Exposure Survey (NOES); 2) evidence of occupational exposures based on TLV and other literature documentation; 3) suspicion of carcinogenicity based on a significant increase in unscheduled DNA synthesis in rat hepatocytes, some positive genetic toxicity results in tests with structurally related chemicals, and evidence of kidney damage in animals following repeated (subacute) low level exposures; and 4) lack of a full battery of genetic toxicity tests and lack of chronic toxicity data.

NTP Principles: 2

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