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Nomination Summary for Bixin (N98008)

Nominated Substances: Annatto, Bixin

Nomination Date: 02/18/1998

Nominator: NCI

Rationale: The nomination of bixin is based on the high production volume and widespread exposure of the population to annatto, one of the most highly consumed colorants in the US food supply. Bixin is the ingredient that contributes this color. Despite annatto's status as an unregulated color additive, little is known about the toxicity of bixin or norbixin which are concentrated in annatto extracts and oils. A few short-term tests for genotoxicity of annatto have been described as positive.

NTP Principles: 1, 2

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 1393-63-1

Agent Name: Annatto

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CASRN: 6983-79-5

Agent Name: Bixin