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Nomination Summary for Thujone (N98011)

Nominated Substances: alpha-Thujone, alpha/beta Thujone mixture

Nomination Date: 02/28/1998

Nominator: NCI

Rationale: Thujone was identified through a review of direct food additives given "GRAS" status by the FDA. Although thujone has known toxicity that has caused it to be banned from some products, 24 direct food additives in the FDA Priority-Based Assessment of Food Additives contain thujone. It has the potential for widespread consumer and worker exposure.

NTP Principles: 1, 2

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 546-80-5

Agent Name: alpha-Thujone

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CASRN: 76231-76-0

Agent Name: alpha/beta Thujone mixture