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Nomination Summary for Polybrominated diphenyl ethers (N98021)

Nominated Substances: 2,2',4,4',5,5'-Hexabromodiphenyl ether (PBDE 153), Octabromodiphenyl ether, 2,2',4,4',5-Pentabromodiphenyl Ether, Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)], 2,2',4,4'-Tetrabromodiphenyl Ether

Nomination Date: 07/27/1998

Nominator: Private Individual

Rationale: Polybrominated diphenyl ethers were nominated based on their bioaccumulative properties, the ongoing production of PBDEs, and the possibility for widespread human exposure through the food chain. There is a lack of subchronic and chronic toxicity information and a suspicion of neuro-developmental toxicity. Studies in rodents have shown hyperplasia of the thyroid and a decrease in circulating thyroid hormone levels after exposure to technical mixtures of PBDEs.

NTP Principles: 1, 2, 5

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

CASRN: 68631-49-2

Agent Name: 2,2',4,4',5,5'-Hexabromodiphenyl ether (PBDE 153)

CASRN: 32536-52-0

Agent Name: Octabromodiphenyl ether

CASRN: 60348-60-9

Agent Name: 2,2',4,4',5-Pentabromodiphenyl Ether

CASRN: 32534-81-9

Agent Name: Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]

CASRN: 5436-43-1

Agent Name: 2,2',4,4'-Tetrabromodiphenyl Ether