Nomination Summary for Ethylene (N98033)
Nominated Substances: Ethylene
Nomination Date: 08/14/1998
Nominator: International Union, UAW
Rationale: It appears that the complete series of chemicals with conjugated double bonds are highly carcinogenic (butadiene, isoprene, chloroprene, furan). Halogenation is not necessary for carcinogenic activity. It would be important to complete the structure-activity series for isolated double bonds as well. Vinyl chloride, vinylidene chloride, trichloroethylene, tetrachloroethylene, & tetrafluorethylene have been found to have some degree of carcinogenic activity. Commentators have concentrated on their organohalide bond as the moiety responsible for carcinogenic activity. It is plausible that the critical moiety is the isolated double bond.
NTP Principles: not specified