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Nomination Summary for Indole-3-carbinol (N99018)

Nominated Substances: Indole-3-carbinol

Nomination Date: 04/14/1999

Nominator: NCI

Rationale: Marketed as a dietary supplement. Substantial evidence exists that indole-3-carbinol can reduce the risk of cancers induced by several carcinogens when administered to animals. However, it also induces cytochrome P450 1A1 through the Ah receptor, a process often associated with toxicity. P450 1A1 also metabolizes several known environmental procarcinogens to their carcinogenic form.

NTP Principles: 2

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 700-06-1

Agent Name: Indole-3-carbinol