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Benzoin (119-53-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1020144

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Negative, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Negative, Male, Mice
View
  • Negative, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Benzoin (119-53-9).
Rodent Cytogenetics
CA SCE
  • View
    • Negative (Nonstandard Protocol)
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Benzoin (119-53-9).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Benzoin (119-53-9).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Benzoin (119-53-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Benzoin (119-53-9).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Benzoin (119-53-9).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative
View
  • Weakly Positive

Citation Information

NTP. Benzoin (119-53-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-204 Bioassay of Benzoin for Possible Carcinogenicity (CASRN119-53-9)
McFee, A.F., and Lowe, K.W. Caprolactam and benzoin: tests for induction of chromosome aberrations and sister-chromatid exchanges in mouse bone marrow. Mutation Res. Vol. 224 (1989) 347-350
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
McFee, A.F., and Lowe, K.W. Caprolactam and benzoin: tests for induction of chromosome aberrations and sister-chromatid exchanges in mouse bone marrow. Mutation Res. Vol. 224 (1989) 347-350

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Benzoin (119-53-9) in Male F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Benzoin (119-53-9) in Female F344 Rats Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Benzoin (119-53-9) in Male B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Benzoin (119-53-9) in Female B6C3F1 Mice Exposed via Dosed Feed
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Benzoin (119-53-9) in Micronucleus Study 739526 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Benzoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 177980
Summary Data
Genetic Toxicity Evaluation of Benzoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 441926
Summary Data
Genetic Toxicity Evaluation of Benzoin in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 921535
Summary Data

NTP Data Collections