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o-Nitrotoluene (88-72-2)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4025791


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Clear Evidence, Female, Rats
  • Clear Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to o-Nitrotoluene (88-72-2).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Equivocal
    Female: Negative
An overview of Genetic Toxicology Micronucleus Rats study conclusions related to o-Nitrotoluene (88-72-2).
Micronucleus - Rats
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to o-Nitrotoluene (88-72-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to o-Nitrotoluene (88-72-2).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information


NTP. o-Nitrotoluene (88-72-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-504 Toxicology and Carcinogenesis Studies of o-Nitrotoluene (CASRN 88-72-2) in F344/N Rats and B6C3F1 Mice (Feed Studies)
TOX-23 Toxicity Studies of o-,m-, and p- Nitrotoluenes (CASRNs 88-72-2, 99-08-1, 99-99-0) Administered in Dosed Feed to F344/N Rats and B6C3F1Mice
TOX-44 Comparative Toxicity and Carcinogenicity Studies ofo-Nitrotoluene (CASRN 88-72-2) ando-Toluidine Hydrochloride (CASRN 636-21-5) Administered in Feed to Male F344/N Rats
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data


Toxicity and Carcinogenicity Studies


26-Week Evaluation of the Toxicity (C62340C) of o-Nitrotoluene (88-72-2) in F344/N Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C62340) of o-Nitrotoluene (88-72-2) in F344 Rats Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C62340B) of NTP-88 Diet Study (o-Nitrotoluene) (88-72-2) in F344 Rats Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C62340) of o-Nitrotoluene (88-72-2) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C62340B) of NTP-88 Diet Study (o-Nitrotoluene) (88-72-2) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C62340) of o-Nitrotoluene (88-72-2) in F344/N Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C62340B) of NTP-88 Diet Study (o-Nitrotoluene) (88-72-2) in F344/N Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C62340) of o-Nitrotoluene (88-72-2) in B6C3F1 Mice Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C62340B) of NTP-88 Diet Study (o-Nitrotoluene) (88-72-2) in B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C62340D) of o-Nitrotoluene (88-72-2) in F344/N Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C62340D) of o-Nitrotoluene (88-72-2) in B6C3F1 Mice Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of o-Nitrotoluene (88-72-2) in Micronucleus Study A25222 in B6C3F1 Mice
Genetic Toxicity Evaluation of o-Nitrotoluene (88-72-2) in Micronucleus Study A29734 in B6C3F1 Mice
Genetic Toxicity Evaluation of o-Nitrotoluene (88-72-2) in Micronucleus Study A80173 in F344 Rats
Genetic Toxicity Evaluation of o-Nitrotoluene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 192331
Summary Data
Genetic Toxicity Evaluation of o-Nitrotoluene in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 692737
Summary Data

Other NTP Studies


2-Week Immunotoxicity Evaluation (IMM95002) of m-Nitrotoluene (99-08-1) in Female B6C3F1 Mice Exposed via Gavage
ADME/TK Evaluation (S0206) of o-Nitrotoluene (88-72-2) in F344 Rats and B6C3F1 Mice Exposed via Gavage