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tris(Aziridinyl)-phosphine sulfide (52-24-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0021339

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Positive, Male, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to tris(Aziridinyl)-phosphine sulfide (52-24-4).
Bacterial Mutagenicity
View
  • Positive

Citation Information

NTP. tris(Aziridinyl)-phosphine sulfide (52-24-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-058 Bioassay of Thio-TEPA for Possible Carcinogenicity (CASRN 52-24-4)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of tris(Aziridinyl)-phosphine Sulfide (thio-TEPA) (52-24-4) in Sprague-Dawley Rats Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of tris(Aziridinyl)-phosphine Sulfide (thio-TEPA) (52-24-4) in Sprague-Dawley Rats Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of tris(Aziridinyl)-phosphine Sulfide (thio-TEPA) (52-24-4) in B6C3F1 Mice Exposed via Intraperitoneal Injection
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of tris(Aziridinyl)-phosphine Sulfide (thio-TEPA) (52-24-4) in B6C3F1 Mice Exposed via Intraperitoneal Injection
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of tris(Aziridinyl)-phosphine Sulfide (thio-TEPA) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 373221
Summary Data

NTP Data Collections