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Aspartame (22839-47-0)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0020107


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Aspartame (22839-47-0).
Micronucleus - Rats
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  • Male: Negative
View
  • Male: Negative
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Aspartame (22839-47-0).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
    Female: Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Aspartame (22839-47-0).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Aspartame (22839-47-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


GMM-01 Toxicology Studies of Aspartame (CASRN 22839-47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2atm1Rdp (N2) Deficient Mice and Carcinogenicity Studies of Aspartame in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Feed Studies)

Study Data


Toxicity and Carcinogenicity Studies


36-Week Evaluation of the Toxicity (C99033B) of Aspartame (22839-47-0) in P16(INK4A)/(+/-) (C57BL/6) Mice Exposed via Dosed Feed. NTP Special Study
36-Week Evaluation of the Toxicity (C99033) of Aspartame (22839-47-0) in P53 +/- (C57BL/6) Mice Exposed via Dosed Feed. NTP Special Study
26-39 Week Evaluation of the Toxicity (C99033) of Transgenic Model II (Aspartame) (22839-47-0) in P53(C57BL/6) Mice Exposed via Dosed Feed
26-39 Week Evaluation of the Toxicity (C99033) of Transgenic Model II (Aspartame) (22839-47-0) in Tg.AC Mice Exposed via Dosed Feed
26-Week Evaluation of the Toxicity (C99033B) of Transgenic Model II (Aspartame) (22839-47-0) in Tg.P16-INK4A Mice Exposed via Dosed Feed
36-Week Evaluation of the Toxicity (C99033) of Transgenic Model II (Aspartame) (22839-47-0) in Tg.AC (FVB/N) Mice Exposed via Dosed Feed. NTP Special Study

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Aspartame (22839-47-0) in Micronucleus Study A20159 in P53 +/- (C57BL/6) Mice
Genetic Toxicity Evaluation of Aspartame (22839-47-0) in Micronucleus Study A37530 in F344 Rats
Genetic Toxicity Evaluation of Aspartame (22839-47-0) in Micronucleus Study A56067 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Aspartame (22839-47-0) in Micronucleus Study A66023 in P16(INK4A)/(+/-) (C57BL/6) Mice
Genetic Toxicity Evaluation of Aspartame (22839-47-0) in Micronucleus Study F37530 in F344 Rats
Genetic Toxicity Evaluation of Aspartame in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A13862
Summary Data