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Primidone (125-33-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7023510


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Equivocal Evidence, Male, Rats
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Primidone (125-33-7).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Primidone (125-33-7).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Primidone (125-33-7).
Bacterial Mutagenicity
View
  • Positive

Citation Information


NTP. Primidone (125-33-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-476 Toxicology and Carcinogenesis Studies of Primidone (CASRN 125-33-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C88035) of Primidone (Primaclone) (125-33-7) in F344 Rats Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C88035) of Primidone (Primaclone) (125-33-7) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C88035) of Primidone (Primaclone) (125-33-7) in F344/N Rats via Nose-Only Respiratory Exposure
3-Month Evaluation of the Toxicity (C88035) of Primidone (Primaclone) (125-33-7) in B6C3F1 Mice via Nose-Only Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C88035) of Primidone (Primaclone) (125-33-7) in F344/N Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C88035) of Primidone (Primaclone) (125-33-7) in B6C3F1 Mice Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Primidone (Primaclone) (125-33-7) in Micronucleus Study 754198 in B6C3F1 Mice
Genetic Toxicity Evaluation of Primidone (Primaclone) (125-33-7) in Micronucleus Study A69181 in B6C3F1 Mice
Genetic Toxicity Evaluation of Primidone (Primaclone) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 323716
Summary Data

Other NTP Studies


Toxicokinetic Evaluation (S0560) of Primidone (DTXSID7023510) in Rat