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Lithocholic acid (434-13-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6020779

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Negative, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Negative, Male, Mice
View
  • Negative, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Lithocholic acid (434-13-9).
Mammalian Cell Mutagenicity
View
  • Positive
View
  • Positive
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Lithocholic acid (434-13-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Lithocholic acid (434-13-9).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Lithocholic acid (434-13-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-175 Bioassay of Lithocholic Acid for Possible Carcinogenicity (CASRN 434-13-9)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Lithocholic Acid (434-13-9) in Male F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Lithocholic Acid (434-13-9) in Female F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Lithocholic Acid (434-13-9) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Lithocholic Acid (434-13-9) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Lithocholic Acid in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 486118
Summary Data

NTP Data Collections