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2-Biphenylamine hydrochloride (2185-92-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020163


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Negative, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Equivocal, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 2-Biphenylamine hydrochloride (2185-92-4).
Rodent Cytogenetics
CA
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 2-Biphenylamine hydrochloride (2185-92-4).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 2-Biphenylamine hydrochloride (2185-92-4).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 2-Biphenylamine hydrochloride (2185-92-4).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2-Biphenylamine hydrochloride (2185-92-4).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive

Citation Information


NTP. 2-Biphenylamine hydrochloride (2185-92-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-233 Carcinogenesis Bioassay of 2-Biphenylamine Hydrochloride (CASRN 2185-92-4) in F344/N Rats and B6C3F1 Mice (Feed Study)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of 2-Biphenylamine Hydrochloride (2185-92-4) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2-Biphenylamine Hydrochloride (2185-92-4) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2-Biphenylamine Hydrochloride (2185-92-4) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2-Biphenylamine Hydrochloride (2185-92-4) in Female B6C3F1 Mice Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 2-Biphenylamine Hydrochloride (2185-92-4) in Micronucleus Study 129459 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 2-Biphenylamine Hydrochloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 799083
Summary Data
Genetic Toxicity Evaluation of 2-Biphenylamine Hydrochloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 880943
Summary Data