3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine (AZTDDCCOMB)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID7030278
Publications
Final Study Report Developmental Toxicity Evaluation of 3'-Azido-3'-Deoxythymidine (AZT; CASRN 30516-87-1) and 2',3'-Dideoxycytidine (ddC; CASRN 7481-89-2) Administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 through 15
Study Data
Toxicity and Carcinogenicity Studies
Evaluation of the Chronic Toxicity and Carcinogenicity (C20311) of AZT/Drug Combinations Transplacental Carcinogenesis Study (AIDSTHERAPEU ) in Male B6C3F1/NCTR Mice via In-Utero Exposure
Study Tables
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (86 kB)
- P04 - Neoplasms by Individual Animal (775 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (75 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (856 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (96 kB)
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C20311) of AZT/Drug Combinations Transplacental Carcinogenesis Study (AIDSTHERAPEU ) in Female B6C3F1/NCTR Mice via In-Utero Exposure
Study Tables
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (85 kB)
- P04 - Neoplasms by Individual Animal (815 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (68 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (841 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (96 kB)
Individual Animal Data
Genetic Toxicology Studies
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxycytidine (AZTDDCCOMB) in Micronucleus Study 848765 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxycytidine (AZTDDCCOMB) in Micronucleus Study A72656 in CD-1 Mice
Summary and Individual Animal Data
Other NTP Studies
Prenatal Developmental Toxicity Study (TER97001) of 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine (AZTDDCCOMB) in Swiss CD-1 Mice Exposed via Gavage
Individual and Summary Data
- Dam Data: Dam Body Weights (53 kB)
- Dam Data: Dam Feed Consumption (49 kB)
- Dam Data: Dam Pregnancy Status (4 kB)
- Dam Data: Organ Weights (57 kB)
- Fetal Data: All Malformations (1 mB)
- Fetal Data: All Variations (1 mB)
- Fetal Data: Fetal Body Weights (1 mB)
- Live Litter: All Litter (1 mB)
- Live Litter: Live Litter (1 mB)
Toxicokinetic Evaluation (K89007) of 3'-Azido-3'-deoxythymidine + 2',3'-Dideoxycytidine (AIDS Initiative) (DTXSID7030278) in Mouse
Data
- Annotated Group Parameters (20 kB)
- Annotated Individual Animal Data (107 kB)
- Summary Data (847 kB)